Animal models of sepsis and maximising data usage: a refinement and reduction case study

Description

Invited speaker to Society of Experimental Biology meeting
Manasi Nandi from King’s College London, UK, presented an exciting collaboration inspired by an earlier NC3Rs workshop – which brought mathematicians and biologists together – that allowed Nandi and her collaborator Philip Aston from the University of Surrey, UK, to develop a mathematical method that can detect changes in cardiovascular diseases more sensitively and earlier than traditional measures. Together they have applied this to sepsis and found that fewer animals are needed to detect a clear change. Several discussions also highlighted the importance of efficient experimental design to avoid overuse of animals and cautious selection of animal models to ensure the relevance of observations to specific biomedical scenarios.

Period	Jul 2016
Held at	Society for Experimental Biology
Degree of Recognition	International