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Science Signaling, ‎1945-0877

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  1. Breast cancer-associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells

    Ng, T., Eykyn, T., Mustapha, R., Barber, P., Green, R., Male, V., Fruhwirth, G., Brindle, K. M., Gomez, V., Flores-Borja, F., Panagaki, F. & Ros, S., 6 Oct 2020, In: Science Signaling. 13, 652, 37 p., eaax4585.

    Research output: Contribution to journalArticlepeer-review

  2. 14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban

    Menzel, J., Kownatzki-Danger, D., Tokar, S., Ballone, A., Unthan-Fechner, K., Kilisch, M., Lenz, C., Urlaub, H., Mori, M., Ottmann, C., Shattock, M., Lehnart, S. & Schwappach, B., 1 Sep 2020, In: Science Signaling. 13, 647, 10.1126/scisignal.aaz1436.

    Research output: Contribution to journalArticlepeer-review

  3. An atlas of human metabolism

    Robinson, J. L., Kocabaş, P., Wang, H., Cholley, P. E., Cook, D., Nilsson, A., Anton, M., Ferreira, R., Domenzain, I., Billa, V., Limeta, A., Hedin, A., Gustafsson, J., Kerkhoven, E. J., Svensson, L. T., Palsson, B. O., Mardinoglu, A., Hansson, L., Uhlén, M. & Nielsen, J., 24 Mar 2020, In: Science Signaling. 13, 624, eaaz1482.

    Research output: Contribution to journalArticlepeer-review

  4. TNFR1 membrane reorganization promotes distinct modes of TNFα signaling

    Morton, P. E., Perrin, C., Levitt, J., Matthews, D. R., Marsh, R. J., Pike, R., McMillan, D., Maloney, A., Poland, S., Ameer-Beg, S. & Parsons, M., 30 Jul 2019, In: Science Signaling. 12, 592, eaaw2418.

    Research output: Contribution to journalArticlepeer-review

  5. GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump

    Schneditz, G., Elias, J. E., Pagano, E., Zaeem Cader, M., Saveljeva, S., Long, K., Mukhopadhyay, S., Arasteh, M., Lawley, T. D., Dougan, G., Bassett, A., Karlsen, T. H., Kaser, A. & Kaneider, N. C., 1 Jan 2019, In: Science Signaling. 12, 562, eaau9048.

    Research output: Contribution to journalArticlepeer-review

  6. Inhibition of somatosensory mechanotransduction by annexin A6

    Raouf, R., Lolignier, S., Sexton, J. E., Millet, Q., Santana-Varela, S., Biller, A., Fuller, A. M., Pereira, V., Choudhary, J. S., Collins, M. O., Moss, S. E., Lewis, R., Tordo, J., Henckaerts, E., Linden, M. & Wood, J. N., 30 Jun 2018, In: Science Signaling. 11, 535, 11 p., eaao2060 .

    Research output: Contribution to journalArticlepeer-review

  7. p38α signaling in Langerhans cells promotes the development of IL-17–producing T cells and psoriasiform skin inflammation

    Zheng, T., Zhao, W., Li, H., Xiao, S., Hu, R., Han, M., Liu, H., Liu, Y., Otsu, K., Liu, X. & Huang, G., 13 Mar 2018, In: Science Signaling. 11, 521, eaao1685.

    Research output: Contribution to journalReview articlepeer-review

  8. KIF22 coordinates CAR and EGFR dynamics to promote cancer cell proliferation

    Pike, R., Ortiz-Zapater, E., Lumicisi, B., Santis, G. & Parsons, M., 30 Jan 2018, In: Science Signaling. 11, 515, eaaq1060.

    Research output: Contribution to journalArticlepeer-review

  9. Mitotic phosphorylation by Nek6 and Nek7 reduces microtubule affinity of EML4 to alter spindle dynamics and promote chromosome congression

    Fry, A. M., Adib, R., Montgomery, J. M., Atherton, J. M., O'Regan, L., Richards, M., Straatman, K. R., Roth, D., Straube, A., Bayliss, R. & Moores, C. A., 2018, In: Science Signaling.

    Research output: Contribution to journalArticlepeer-review

  10. Dosage-dependent regulation of VAV2 expression by steroidogenic factor-1 drives adrenocortical carcinoma cell invasion

    Ruggiero, C., Doghman-Bouguerra, M., Sbiera, S., Sbiera, I., Parsons, M., Ragazzon, B., Morin, A., Robidel, E., Favier, J., Bertherat, J., Fassnacht, M. & Lalli, E., 7 Mar 2017, In: Science Signaling. 10, 469, eaal2464.

    Research output: Contribution to journalArticlepeer-review

  11. Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity

    Burn, G. L., Cornish, G. H., Potrzebowska, K., Samuelsson, M., Griffié, J., Minoughan, S., Yates, M., Ashdown, G., Pernodet, N., Morrison, V. L., Sanchez-Blanco, C., Purvis, H., Clarke, F., Brownlie, R. J., Vyse, T. J., Zamoyska, R., Owen, D. M., Svensson, L. M. & Cope, A. P., 4 Oct 2016, In: Science Signaling. 9, 448, ra99.

    Research output: Contribution to journalArticlepeer-review

  12. The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation

    Gordon, E. J., Fukuhara, D., Weström, S., Padhan, N., Sjöström, E. O., Van Meeteren, L., He, L., Orsenigo, F., Dejana, E., Bentley, K., Spurkland, A. & Lena, C. W., 19 Jul 2016, In: Science Signaling. 9, 437, ra72.

    Research output: Contribution to journalArticlepeer-review

  13. An RYR1 mutation associated with malignant hyperthermia is also associated with bleeding abnormalities

    Lopez, R. J., Byrne, S., Vukcevic, M., Sekulic-Jablanovic, M., Xu, L., Brink, M., Alamelu, J., Voermans, N., Snoeck, M., Clement, E., Muntoni, F., Zhou, H., Radunovic, A., Mohammed, S., Wraige, E., Zorzato, F., Treves, S. & Jungbluth, H., 5 Jul 2016, In: Science Signaling. 9, 435, p. 1-9 9 p., ra68.

    Research output: Contribution to journalArticlepeer-review

  14. The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility

    Kiuchi, T., Ortiz-Zapater, E., Monypenny, J., Matthews, D. R., Nguyen, L. K., Barbeau, J., Coban, O., Lawler, K., Burford, B., Rolfe, D. J., de Rinaldis, E., Dafou, D., Simpson, M. A., Woodman, N., Pinder, S., Gillett, C. E., Devauges, V., Poland, S. P., Fruhwirth, G., Marra, P., & 12 othersBoersma, Y. L., Plückthun, A., Gullick, W. J., Yarden, Y., Santis, G., Winn, M., Kholodenko, B. N., Martin-Fernandez, M. L., Parker, P., Tutt, A., Ameer-Beg, S. M. & Ng, T., 19 Aug 2014, In: Science Signaling. 7, 339, 15 p., ra78.

    Research output: Contribution to journalArticlepeer-review

  15. The Kinase LMTK3 Promotes Invasion in Breast Cancer Through GRB2-Mediated Induction of Integrin beta(1)

    Xu, Y., Zhang, H., Lit, L. C., Grothey, A., Athanasiadou, M., Kiritsi, M., Lombardo, Y., Frampton, A. E., Green, A. R., Ellis, I. O., Ali, S., Lenz, H-J., Thanou, M., Stebbing, J. & Giamas, G., 17 Jun 2014, In: Science Signaling. 7, 330, 11 p., ra58.

    Research output: Contribution to journalArticlepeer-review

  16. Antagonism of EGFR and HER3 Enhances the Response to Inhibitors of the PI3K-Akt Pathway in Triple-Negative Breast Cancer

    Tao, J. J., Castel, P., Radosevic-Robin, N., Elkabets, M., Auricchio, N., Aceto, N., Weitsman, G., Barber, P., Vojnovic, B., Ellis, H., Morse, N., Viola-Villegas, N. T., Bosch, A., Juric, D., Hazra, S., Singh, S., Kim, P., Bergamaschi, A., Maheswaran, S., Ng, T., & 6 othersPenault-Llorca, F., Lewis, J. S., Carey, L. A., Perou, C. M., Baselga, J. & Scaltriti, M., 25 Mar 2014, In: Science Signaling. 7, 318, 9 p., 29.

    Research output: Contribution to journalArticlepeer-review

  17. A Cancer-Associated Mutation in Atypical Protein Kinase C iota Occurs in a Substrate-Specific Recruitment Motif

    Linch, M., Sanz-Garcia, M., Soriano, E., Zhang, Y., Riou, P., Rosse, C., Cameron, A., Knowles, P., Purkiss, A., Kjaer, S., McDonald, N. Q. & Parker, P. J., 17 Sep 2013, In: Science Signaling. 6, 293, 11 p., ra82.

    Research output: Contribution to journalArticlepeer-review

  18. Superresolution Microscopy Reveals Nanometer-Scale Reorganization of Inhibitory Natural Killer Cell Receptors upon Activation of NKG2D

    Pageon, S. V., Cordoba, S-P., Owen, D. M., Rothery, S. M., Oszmiana, A. & Davis, D. M., 23 Jul 2013, In: Science Signaling. 6, 285, 11 p., ra62.

    Research output: Contribution to journalArticlepeer-review

  19. Lack of the Phosphatase PTPN22 Increases Adhesion of Murine Regulatory T Cells to Improve Their Immunosuppressive Function

    Brownlie, R. J., Miosge, L. A., Vassilakos, D., Svensson, L. M., Cope, A. & Zamoyska, R., 27 Nov 2012, In: Science Signaling. 5, 252, ra87.

    Research output: Contribution to journalArticlepeer-review

  20. Protein Kinase CK2 Triggers Cytosolic Zinc Signaling Pathways by Phosphorylation of Zinc Channel ZIP7

    Taylor, K. M., Hiscox, S., Nicholson, R. I., Hogstrand, C. & Kille, P., 2012, In: Science Signaling. 5, 210, ra11.

    Research output: Contribution to journalArticlepeer-review

  21. PreTCR and TCRγδ signal initiation in thymocyte progenitors does not require domains implicated in receptor oligomerization

    Mahtani-Patching, J., Neves, J. F., Pang, D. J., Stoenchev, K. V., Aguirre-Blanco, A. M., Silva-Santos, B. & Pennington, D. J., 19 Jul 2011, In: Science Signaling. 4, 182, ra47.

    Research output: Contribution to journalArticlepeer-review

  22. PI3Kβ plays a critical role in neutrophil activation by immune complexes

    Kulkarni, S., Sitaru, C., Jakus, Z., Anderson, K. E., Damoulakis, G., Davidson, K., Hirose, M., Juss, J., Oxley, D., Chessa, T. A. M., Ramadani, F., Guillou, H., Segonds-Pichon, A., Fritsch, A., Jarvis, G. E., Okkenhaug, K., Ludwig, R., Zillikens, D., Mocsai, A., Vanhaesebroeck, B., & 2 othersStephens, L. R. & Hawkins, P. T., 12 Apr 2011, In: Science Signaling. 4, 168, ra23.

    Research output: Contribution to journalArticlepeer-review

  23. Dynamics of Subsynaptic Vesicles and Surface Microclusters at the Immunological Synapse

    Purbhoo, M. A., Liu, H., Oddos, S., Owen, D., Neil, M. A. A., Pageon, S. V., French, P. M. W., Rudd, C. E. & Davis, D. M., 11 May 2010, In: Science Signaling. 3, 121, p. - 10 p., ra36.

    Research output: Contribution to journalArticlepeer-review

  24. Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species

    Xu, TR., Vyshemirsky, V., Gormand, A., von Kriegsheim, A., Girolami, M., Baillie, GS., Ketley, D., Dunlop, AJ., Milligan, G., Houslay, MD. & Kolch, W., 16 Mar 2010, In: Science Signaling. 3, 113, p. ra20

    Research output: Contribution to journalArticlepeer-review

  25. The PI3K Isoforms p110alpha and p110delta Are Essential for Pre–B Cell Receptor Signaling and B Cell Development

    Ramadani, F., Bolland, D. J., Garcon, F., Emery, J. L., Vanhaesebroeck, B., Corcoran, A. E. & Okkenhaug, K., 2010, In: Science Signaling. 3, 134, ra60.

    Research output: Contribution to journalArticlepeer-review

  26. PKC epsilon Regulation of an alpha(5) Integrin-ZO-1 Complex Controls Lamellae Formation in Migrating Cancer Cells

    Tuomi, S., Mai, A., Nevo, J., Laine, J. O., Vilkki, V., Ohman, T. J., Gahmberg, C. G., Parker, P. J. & Ivaska, J., 2009, In: Science Signaling. 2, 77, ra32.

    Research output: Contribution to journalArticlepeer-review

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