Organisation profile
Organisation profile
About
The Basic and Clinical Neuroscience Department at King’s is committed to advancing the understanding of the nervous system in health and disease through research, education, and clinical interventions. Our mission is to provide a platform for students, faculty, and staff to explore and develop innovative ways to understand molecular and cellular basis of behaviour, uncover mechanisms and new treatment targets for neurological disorders as well as carry out clinical interventions stemming from their discoveries.
Professor Thuret and Professor Giese are co-leading the department to provide the best possible environment for world-class fundamental and clinical research in neurodegeneration and mechanisms of mental health while they strive to promote a culture of collaboration, research integrity, respect and inclusivity amongst members of the fundamental and clinical neuroscience community.
The Department of Basic & Clinical Neuroscience is situated in the Maurice Wohl Clinical Neuroscience Institute on Denmark Hill Campus. It is home to The Wohl Cellular Imaging Centre, the UK Dementia Research Institute at King's and the newly established UK Motor Neuron Disease (MND) Research Institute. Furthermore, by working closely with King’s College Hospital, Guy’s Hospital and St Thomas’ Hospital, we ensure novel treatments are both effective and practical.
Our research spans the following areas:
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Collaborations and top research areas from the last five years
Profiles
Research output
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(Poly)phenol and methylxanthine metabolites and their association with cognitive and cardiometabolic health in older people
Li, Y., Le Sayec, M., Xu, Y., Bergland, A. K., Khalifa, K., de Lucia, C., Aarsland, D., Gibson, R. & Rodriguez-Mateos, A., Jul 2026, In: JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 153, 12 p., 110300.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
ADAPT-NMD: A hybrid II feasibility study of a co-designed self-management support intervention for people living with neuromuscular disorders
Lee, L. E., Kulnik, S. T., Boaz, A. & Ramdharry, G. M., Apr 2026, In: Clinical Rehabilitation. 40, 4, p. 474-485 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Adult neurogenesis: New neurons, new opportunities
Doludda, B., Barde, W., D’Egidio, F., Fitzsimons, C. P., Frisén, J., Gage, F. H., Jessberger, S., Lazarov, O., Lie, D. C., Lucassen, P. J., de Lucia, C., Salta, E., Song, H., Song, J., Thuret, S., Toda, T. & Kempermann, G., 5 Mar 2026, In: Cell stem cell. 33, 3, p. 382-392 11 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile3 Downloads (Pure)
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EPIC: Endoscopic tissue time machine
Bergholt, M. (Primary Investigator), Bhosale, P. (Co-Investigator), Cook, R. (Co-Investigator) & Wojewodka, G. (Co-Investigator)
1/06/2026 → 31/05/2031
Project: Research
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I-DROPS (Improving Drug RespOnse Polygenic Scores)
Lewis, C. (Primary Investigator), Pain, O. (Co-Investigator) & Sanderson, S. (Co-Investigator)
NIHR National Institute For Health & Care Research
1/04/2026 → 31/03/2028
Project: Research
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Sex-Specific Target Discovery in ALS: A Data-Driven Precision Medicine Approach
Al Khleifat, A. (Primary Investigator) & Iacoangeli, A. (Co-Investigator)
NESTA National Endowment for Science, Technology and the Arts
1/04/2026 → 31/12/2026
Project: Research
Activities
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Intelligent Health Tech
Teo, J. (Interviewee)
30 Dec 2023Activity: Other › Types of Public engagement and outreach - Media article or participation
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How AI will change Neurology
Teo, J. (Speaker)
2 Oct 2023Activity: Talk or presentation › Invited talk
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Panel member on AI in healthcare
Teo, J. (Speaker)
27 Sept 2023Activity: Talk or presentation › Invited talk
Student theses
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A BLOOD-BASED SIGNATURE OF NEOCORTICAL AMYLOID BURDEN: AN EARLY DIAGNOSTIC POPULATION SCREENING TOOL FOR ALZHEIMER’S DISEASE
Ashton, N. J. (Author), Hye, A. (Supervisor) & Powell, J. F. (Supervisor), 2017Student thesis: Doctoral Thesis › Doctor of Philosophy
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Acute anti psychotic modulation of the structure and function of the brain
Hawkins, P. C. T. (Author), Mehta, M. A. (Supervisor) & Vernon, A. C. (Supervisor), 2018Student thesis: Doctoral Thesis › Doctor of Philosophy
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A developmental perspective on ZNF804A gene function: Understanding the neurobiological role of schizophrenia susceptibility gene ZNF804A in hiPSC-derived developing glutamatergic neurons
Sichlinger, L. (Author), Srivastava, D. (Supervisor) & Vernon, A. (Supervisor), 1 Sept 2023Student thesis: Doctoral Thesis › Doctor of Philosophy
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Prizes
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ALS Association Milton Safenowitz Research Fellowship
Al Khleifat, A. (Recipient), 31 Jan 2022
Prize: Fellowship awarded competitively
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Andrew Wilson National Award, UK
Ray Chaudhuri, K. (Recipient), 30 Sept 2015
Prize: National/international honour
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Datasets
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Copper adatoms mediated adsorption of benzotriazole on a gold substrate (dataset)
Grillo, F., Gattinoni, C., Larrea, C. R., Lacovig, P. & Richardson, N. V., University of St Andrews, 30 Jun 2022
DOI: 10.17630/19a5e783-c2ea-4f24-993c-d037cd602145
Dataset
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The spectrum of neurodevelopmental, neuromuscular and neurodegenerative disorders due to defective autophagy
Deneubourg, C., Ramm, M., Smith, L. J., Baron, O., Singh, K., Byrne, S. C., Duchen, M. R., Gautel, M., Eskelinen, E.-L., Fanto, M. & Jungbluth, H., Taylor & Francis, 19 Oct 2021
DOI: 10.6084/m9.figshare.14790043
Dataset