Basic and Clinical Neuroscience

Projects

Projects per year 1950 2004 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2022 2043

• 3 Not started
• 115 Active
• 1587 Finished

Projects per year

Search results

• Active

  Aβ/⍺Syn comm: Uncovering a common mechanism underlying synapse loss across neurodegenerative diseases

  Killick, R. (Primary Investigator) & Svenningsson, P. (Co-Investigator)

  Alzheimer's Society

  1/07/2025 → 30/06/2029

  Project: Research

• RNA Binding Proteins and MND: From Molecular Mechanisms to Target Identification

  White, M. (Primary Investigator)

  My Name'5 Doddie Foundation

  2/06/2025 → 30/09/2026

  Project: Research

• Halting prion-like propagation of tau by astrocyte-secreted chaperones

  Jimenez Sanchez, M. (Primary Investigator) & Mitchell, J. (Co-Investigator)

  Alzheimer's Research UK

  1/06/2025 → 31/05/2028

  Project: Research

• TDPnecroptic: The role of TDP-43 mediated necroptosis in dementia

  Hirth, F. (Primary Investigator) & Tummers, B. (Co-Investigator)

  Alzheimer's Research UK

  1/06/2025 → 31/05/2028

  Project: Research

• Synaptopathy- The patho-physiological role of FUS at the presynaptic terminal in ALS.

  Clayton, E. (Primary Investigator) & Vance, C. (Co-Investigator)

  MNDA Motor Neurone Disease Association

  1/06/2025 → 30/11/2028

  Project: Research

• SCFD1 and G2: Investigating the roles of SCFD1 and G2E3 in ALS

  Sreedharan, J. (Primary Investigator), Akcay, I. (Co-Investigator) & Iacoangeli, A. (Co-Investigator)

  Darby Rimmer MND Foundation

  1/06/2025 → 31/05/2027

  Project: Research

• Virtual Clinical Trial Populations in Motor Neuron Disease

  Al-Chalabi, A. (Primary Investigator), Carter, B. (Co-Investigator) & Iacoangeli, A. (Co-Investigator)

  MRC Medical Research Council

  7/05/2025 → 6/11/2026

  Project: Research

• RNA Binding Proteins in the Pathogenesis of MND: From Molecular Mechanisms to Target Identification

  White, M. (Primary Investigator), Thuret, S. (Co-Investigator) & Ule, J. (Co-Investigator)

  MNDA Motor Neurone Disease Association

  1/05/2025 → 30/04/2029

  Project: Research

• Investigating the role of CFAP410 in DNA damage response and motor neurone survival in ALS

  Sreedharan, J. (Primary Investigator)

  Rosetrees Trust

  1/05/2025 → 30/04/2026

  Project: Research

• Investigating the role of CFAP410 in DNA damage response and motor neurone survival in ALS

  Sreedharan, J. (Primary Investigator)

  Stoneygate Trust

  1/05/2025 → 30/04/2026

  Project: Research

• RNA-trans-splicing as therapeutic modality for C9orf72 Amyotrophic Lateral Sclerosis

  Ruepp, M.-D. (Primary Investigator), Mizielinska, S. (Co-Investigator) & academic, A. (Co-Investigator)

  UKDRI UK Dementia Research Institute

  1/05/2025 → 30/04/2027

  Project: Research

• Taylor's DRI: Unravelling Spatial Mechanisms of Zn²⁺ Dyshomeostasis in Long Axons of ALS and Normal Motor Neurons

  Serio, A. (Primary Investigator) & Minckley, T. (Co-Investigator)

  UKDRI UK Dementia Research Institute

  1/04/2025 → 31/03/2026

  Project: Research

• Decoding spatio-temporal kinetics of local mRNA translation in neurons using a new single-molecule imaging platform

  Ruepp, M.-D. (Primary Investigator) & Khuperkar, D. (Co-Investigator)

  UKDRI UK Dementia Research Institute

  1/04/2025 → 31/03/2026

  Project: Research

• Nuclear to synaptic signalling dysregulation by Annexin A11 in ALS

  Smith, B. (Primary Investigator), Mitchell, J. (Co-Investigator), Mizielinska, S. (Co-Investigator), Ruepp, M.-D. (Co-Investigator), Troakes, C. (Co-Investigator) & Vance, C. (Co-Investigator)

  MNDA Motor Neurone Disease Association

  1/04/2025 → 31/03/2026

  Project: Research

• ALS: Dissecting a TDP-43 knock-in allelic series to yield diverse MND drug targets

  Sreedharan, J. (Primary Investigator)

  My Name'5 Doddie Foundation

  1/04/2025 → 31/03/2028

  Project: Research

• Advancing Understanding and Treatment of Motor Neurone Disease through Biomarker Development: UK MND RI and King’s MND Biobank Integration Project

  Al Khleifat, A. (Primary Investigator) & Al-Chalabi, A. (Co-Investigator)

  MNDA Motor Neurone Disease Association

  1/03/2025 → 30/11/2025

  Project: Research

• Synaptic dysfunction in ALS-FUS

  Vance, C. (Primary Investigator), Ruepp, M.-D. (Co-Investigator) & Shaw, C. (Co-Investigator)

  MNDA Motor Neurone Disease Association

  1/03/2025 → 29/02/2028

  Project: Research

• SEPALS: SEPALS: Surface Electromyography as a tool to fast-track diagnosis and earmark effective therapies in Patients with Amyotrophic Lateral Sclerosis

  Shaw, C. (Primary Investigator), Bashford, J. (Co-Investigator) & Iniesta, R. (Co-Investigator)

  LifeArc

  1/03/2025 → 28/02/2029

  Project: Research

• Accelerating the proof-of-concept study for FUS AAV gene therapy

  Lee, Y. (Primary Investigator), Lee, D. Y. (Co-Investigator) & lee, D. (Co-Investigator)

  My Name'5 Doddie Foundation

  3/02/2025 → 2/11/2025

  Project: Research

• Ultrasound-targeted On-demand Cell-autonomous Gene Therapy for Neurological Diseases

  Rosch, R. (Primary Investigator)

  Advanced Research & Invention Agency

  1/02/2025 → 31/01/2029

  Project: Research

• EPSRC DRIVE-Health: A bioinformatics investigation of the role of the gut-brain axis in motor cell disorders using of metagenomics, metabolomics and clinical data

  Iacoangeli, A. (Primary Investigator), Al-Chalabi, A. (Co-Investigator), Curcin, V. (Co-Investigator) & Dobson, R. (Co-Investigator)

  MNDA Motor Neurone Disease Association

  1/02/2025 → 31/01/2029

  Project: Research

• UKDRI MND Theme Funding - Contribution to PhD Studentship TDP-43 Cell Models

  Mizielinska, S. (Primary Investigator) & Ruepp, M.-D. (Co-Investigator)

  UKDRI UK Dementia Research Institute

  1/02/2025 → 31/01/2026

  Project: Research

• Alzheimer's Research UK London Network Centre Grant Year 4: Subproject Philippe Gosset

  Gosset, P. (Primary Investigator)

  Alzheimer's Research UK

  1/01/2025 → 31/12/2025

  Project: Research

• Alzheimer's Research UK London Network Centre Grant Year 4: Subproject Claire Troakes/Kaiyu Wu

  Troakes, C. (Primary Investigator)

  Alzheimer's Research UK

  1/01/2025 → 31/12/2025

  Project: Research

• A Large-scale Multi-omics Study To Investigate The Role Of Human Endogenous Retroviruses And Structural Variants In Amyotrophic Lateral Sclerosis

  Iacoangeli, A. (Primary Investigator), Al-Chalabi, A. (Co-Investigator), Breen, G. (Co-Investigator) & Dobson, R. (Co-Investigator)

  MRC Medical Research Council

  1/01/2025 → 31/12/2027

  Project: Research

• Validating ALS Molecular Subtypes For Diagnostics And Disease Stratification

  Iacoangeli, A. (Primary Investigator), Al Khleifat, A. (Co-Investigator) & Al-Chalabi, A. (Co-Investigator)

  MRC Medical Research Council

  1/01/2025 → 30/06/2026

  Project: Research

• Alzheimer's Research UK London Network Centre Grant Year 4

  Giese, P. (Primary Investigator)

  Alzheimer's Research UK

  1/01/2025 → 31/12/2025

  Project: Research

• Establishing sex-specific mechanisms in ALS using isogenic male and female motor neurons.

  Sreedharan, J. (Primary Investigator) & Akcay, I. (Co-Investigator)

  MNDA Motor Neurone Disease Association

  1/01/2025 → 31/12/2027

  Project: Research

• Parallelised ultra high-density electrophysiological assays to power epilepsy precision medicine

  Bateman, J. (Primary Investigator)

  TSB Technology Strategy Board

  1/12/2024 → 30/11/2026

  Project: Research

• Grand challenge: Define causal transcription factor networks that drive protective or pathogenic microglia phenotypes in Alzheimer’s Disease

  Marzi, S. (Primary Investigator)

  Alzheimer's Association

  1/12/2024 → 30/11/2026

  Project: Research

• NEURO_MIA: Inflammation-induced neuro-epigenetic mechanisms of resilience and susceptibility to maternal immune activation

  Vernon, A. (Primary Investigator)

  BBSRC Biotechnology and Biological Sciences Research Council

  1/11/2024 → 31/10/2027

  Project: Research

• Disentangling a new paradigm for mutual homeostasis of aggregation-prone proteins

  Miller, A. (Primary Investigator) & Ule, J. (Co-Investigator)

  Wellcome Trust

  1/11/2024 → 31/10/2029

  Project: Research

• NEXT-REL: Next Generation EU-UK Relations: Towards new common objectives (NEXT-REL)

  Talani, S. (Primary Investigator), Biondi, A. (Co-Investigator), James, S. (Co-Investigator) & Stefan, O. (Co-Investigator)

  EC European Commission

  1/11/2024 → 31/10/2027

  Project: Research

• Alzheimer's and Parkinson's share a common disease process: Increasing our understanding of mechanisms will move us closer effective treatments

  Aarsland, D. (Primary Investigator), Hirth, F. (Co-Investigator) & Killick, R. (Co-Investigator)

  Rosetrees Trust

  1/11/2024 → 31/10/2029

  Project: Research

• Targeted induction of the cold-shock protein RBM3 to prevent synapse loss and neurodegeneration in ALS/FTD

  Ruepp, M.-D. (Primary Investigator) & Serio, A. (Co-Investigator)

  MRC Medical Research Council

  14/10/2024 → 13/05/2026

  Project: Research

• The Role of Amyloid Pathology in the Thalamus in the Early Stages of Alzheimer's Disease

  Delogu, A. (Primary Investigator) & Giese, P. (Co-Investigator)

  Alzheimer's Research UK

  1/10/2024 → 30/09/2026

  Project: Research

• Elucidating the non-cell autonomous role of FTD/ALS-linked mutations in p62 in iPSCs-derived astrocytes

  Jimenez Sanchez, M. (Primary Investigator), Mizielinska, S. (Co-Investigator) & Ruepp, M.-D. (Co-Investigator)

  Alzheimer's Research UK

  1/10/2024 → 30/09/2025

  Project: Research

• Optical Functional Imaging For Metabolic Cell Model Engineering and Profiling

  Ameer-Beg, S. (Primary Investigator), Culley, S. (Co-Investigator), Fruhwirth, G. (Co-Investigator), Mann, Z. (Co-Investigator), Poland, S. (Co-Investigator) & Serio, A. (Co-Investigator)

  Wellcome Trust

  1/10/2024 → 31/03/2026

  Project: Research

• The role of nuclear speckles in the mutual homeostasis of aggregation-prone proteins

  Miller, A. (Primary Investigator) & Ule, J. (Co-Investigator)

  UKDRI UK Dementia Research Institute

  1/10/2024 → 30/04/2026

  Project: Research

• ThermoRad wIRA study: Prospective study to assess the real-world implementation of Thermotherapy using wIRA (water-filtered infrared A superficial hyperthermia) in addition to standard of care (SOC) palliative Radiotherapy (RT) in patients with inoperable or incurable cancers

  Kong, A. (Primary Investigator), Vasiliadou, I. (Co-Investigator), Wojewodka, G. (Co-Investigator) & academic, A. (Co-Investigator)

  Dr. med. h.c. Erwin Braun Foundation

  1/09/2024 → 31/08/2026

  Project: Research

• NIHR Pre-doctoral Fellowship Round 6 Mandegarsadat Miresmaeili

  Iacoangeli, A. (Primary Investigator) & Al-Chalabi, A. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/09/2024 → 28/02/2026

  Project: Research

• Post CCT Fellowship in Neuro-oncology for Neurologists

  Finnerty, G. (Primary Investigator)

  King’s College Hospital Charity

  1/09/2024 → 31/08/2025

  Project: Research

• Post CCT Fellowship in Neuro-oncology for Neurologists (Tessa Jowell)

  Finnerty, G. (Primary Investigator)

  Tessa Jowell Brain Cancer Mission

  31/08/2024 → 30/08/2025

  Project: Research

• SMART-DBS: Sensing, Modulating & Adapting in Real-Time in Deep Brain Stimulation

  Valentin Huete, A. (Primary Investigator) & Stavropoulos, I. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/08/2024 → 31/07/2027

  Project: Research

• MNDA Non-Cli: Perturbation of chaperones regulating FG nucleoporin homeostasis in C9ORF72 ALS/FTD: Therapeutic implications for C9ORF72 ALS/FTD. (MNDA Non-Clinical Junior Fellowship Full Application)

  Ruepp, M.-D. (Primary Investigator) & Solomon, D. (Co-Investigator)

  Motor Neurone Disease Association

  1/07/2024 → 30/06/2027

  Project: Research

• Identifying factors that regulate neuroprotective cold-shock protein RBM3

  Khuperkar, D. (Primary Investigator)

  UKDRI UK Dementia Research Institute

  1/06/2024 → 31/01/2026

  Project: Research

• Vectorised U7 snRNAs as gene therapy approach for ALS/FTD

  Ruepp, M.-D. (Primary Investigator)

  UKDRI UK Dementia Research Institute

  28/05/2024 → 27/05/2027

  Project: Research

• MRC Human Functional Genomics

  Marin, O. (Primary Investigator), Berninger, B. (Co-Investigator), Burrone, J. (Co-Investigator), Cocks, G. (Co-Investigator), Hamid, F. (Co-Investigator), Hindges, R. (Co-Investigator), Houart, C. (Co-Investigator), Long, K. (Co-Investigator), Moran, R. (Co-Investigator), Rico, B. (Co-Investigator), Srivastava, D. (Co-Investigator) & Vernon, A. (Co-Investigator)

  MRC Medical Research Council

  14/05/2024 → 13/05/2028

  Project: Research

• MNDSTaR (MND: MNDSTaR: The King's-LifeArc Solution for Motor Neurone Disease Target Validation

  Al Khleifat, A. (Primary Investigator), Al-Chalabi, A. (Co-Investigator), Iacoangeli, A. (Co-Investigator), Mitchell, J. (Co-Investigator) & Smith, B. (Co-Investigator)

  LifeArc

  1/05/2024 → 30/04/2026

  Project: Research

• Developing AAV Gene therapy for C9orf72 ALS/FTD

  Lee, Y. (Primary Investigator)

  My Name'5 Doddie Foundation

  1/05/2024 → 30/04/2027

  Project: Research