Chemistry

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• Towards nanoparticle rational design: a multi-scale simulation investigation of the molecular mechanisms underpinning polymer based drug-delivery vehicles

  Author: Lopez-Rios De Castro, R., 1 Apr 2024

  Supervisor: Lorenz, C. (Supervisor) & Ulmschneider, M. B. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Towards [FeFe]-H₂ase biomimics for H₂ oxidation

  Author: Orton, G., 1 Mar 2020

  Supervisor: Hogarth, G. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Toward High Throughput Screening of Assembly-Optimised Ferritin Nanocage Libraries Applied to Nanotechnology

  Author: Cornell, T. A., 2015

  Supervisor: Orner, B. P. (Supervisor) & Sutton, B. J. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• The Synthesis and Characterisation of Novel Peptidomimetic Foldamers

  Author: Stendall, R., 1 May 2023

  Supervisor: Cobb, A. (Supervisor) & Muller, M. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• The roles of the co-chaperone SGTA/Sgt2, the BAG6 complex and E3 Ubiquitin Ligase RNF126 in cytosolic quality control

  Author: Krysztofinska, E. M., 2018

  Supervisor: McDonnell, J. M. (Supervisor) & Isaacson, R. L. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Thermoelectrochemistry: potential application of gelled electrolytes, gold nanoparticles and novel redox systems

  Author: Alzahrani, H., 1 Feb 2020

  Supervisor: Aldous, L. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• The rich conformational landscape of musks and their precursors revealed by broadband rotational spectroscopy

  Author: Burevschi, C., 1 Aug 2021

  Supervisor: Sanz, M. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• The droplet interface bilayer as a platform for a compartmentalized microreactor

  Author: Allen-Benton, M., 1 Jan 2021

  Supervisor: Booth, P. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Sugar Conjugates of 3-Hydroxy-4-pyridinones : Synthesis and Investigations into their Potential for Drug Delivery to the Brain.

  Author: Fuchs, F. C., 2015

  Supervisor: Hider, R. C. (Supervisor) & Wagner, G. K. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• STUDY OF THE RELATIVE DOMAIN STABILITY OF A TWO-DOMAIN E.COLI MFS TRANSPORTER GLPT

  Author: Kedzierski, M. K., 2018

  Supervisor: Booth, P. (Supervisor) & Borysik, A. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Structural and Functional Consequences of a Protein Backbone Modification

  Author: Zhang, T., 1 Sept 2022

  Supervisor: Muller, M. (Supervisor) & Isaacson, R. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Single Molecule Interferometric Imaging of Molecular Assembly

  Author: Guo, Y., 1 May 2024

  Supervisor: Wallace, M. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Single-Molecule Imaging of Botulinum Neurotoxin/A(0) Translocation

  Author: Carniello, J., 1 Jun 2024

  Supervisor: Wallace, M. (Supervisor) & Isaacson, R. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Simulation-guided design of membrane active peptide-based therapeutics for biomedical applications

  Author: Chen, C., 1 Jul 2020

  Supervisor: Ulmschneider, M. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Rotational studies of terpene clusters of atmospheric and biological relevance

  Author: Murugachandran, S. I., 1 Mar 2023

  Supervisor: Sanz, M. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Science

• ROLE OF KINETIC MECHANISMS IN DRUG DESIGN

  Author: Badaoui, M., 1 Dec 2021

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Probing the dynamics of antibodies and membrane proteins by structural mass spectrometry

  Author: Hansen, K., 1 Oct 2021

  Supervisor: Politis, A. (Supervisor) & Sutton, B. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• p53 as a molecular time bomb: a biochemical approach to dissect its regulation by posttranslational modifications

  Author: Gerecht, K., 1 Mar 2021

  Supervisor: Muller, M. (Supervisor) & Eggert, U. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Organocatalytic access to γ-amino acids as building blocks for the synthesis of foldamers

  Author: Fanelli, R., 1 Feb 2020

  Supervisor: Cobb, A. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Novel organocatalytic conjugate additions: towards the synthesis of biologically relevant targets

  Author: Bryant, L. A., 1 Jul 2019

  Supervisor: Cobb, A. (Supervisor) & Barry, S. M. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Novel Dithiocarbamates for Applications in Materials Science

  Author: Chandra Sarker, J., 1 Jul 2022

  Supervisor: Hogarth, G. (Supervisor) & Ma, M. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Molecular simulations of membrane binding and transport mechanisms with application to realistic vasculatures

  Author: Troendle, E., 1 Feb 2022

  Supervisor: Ulmschneider, M. (Supervisor), Isaacson, R. (Supervisor) & Rosta, E. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Molecular and systems level models of the effects of protein aggregation on the cell cycle

  Author: Jenkins, K. J., 1 Jun 2019

  Supervisor: Csikasz-Nagy, A. (Supervisor) & Rosta, E. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Mitochondria targeting metallopharmaceuticals for eradicating cancer stem cells

  Author: Laws, K., 1 May 2020

  Supervisor: Suntharalingam, R. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Microsolvation and Aggregation of Polycyclic Aromatic Hydrocarbons: Structures and Interactions

  Author: Saxena, S., 1 Dec 2022

  Supervisor: Eykyn, T. R. (Supervisor) & Sanz Gonzalez, M. E. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Irreversible Markov chain Monte Carlo samplers using the lifting framework and skewed detailed balance condition: algorithms and applications in computational statistical physics

  Author: Faizi, F., 1 Aug 2021

  Supervisor: Deligiannidis, G. (Supervisor) & Rosta, E. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Investigation into the complex formation, biological action and biosynthesis of the natural products pyrrolomycins

  Author: Planchat Calle, M., 1 Jul 2020

  Supervisor: Barry, S. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Investigating the molecular mechanism of the XylE sugar transporter

  Author: Jia, R., 1 Feb 2023

  Supervisor: Politis, A. (Supervisor), Booth, P. (Supervisor) & Reading, E. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Investigating the elemental composition of peripheral sensory nerves and their function in paclitaxel-induced peripheral neuropathy

  Author: Ferguson, C., 1 Apr 2021

  Supervisor: Flatters, S. (Supervisor), McMahon, S. (Supervisor) & Fleck, R. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Investigating and exploiting the late stage functionalisation of nonribosomal peptide antibiotics

  Author: Perez Ortiz, G., 1 Sept 2020

  Supervisor: Barry, S. (Supervisor) & Isaacson, R. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Intein mediated engineering of cancer-selective toxic proteins

  Author: Wyatt, J., 1 May 2022

  Supervisor: Tavassoli, M. (Supervisor) & Muller, M. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Insights into the structure, dynamics and interactions of large protein complexes using structural mass spectrometry

  Author: Ahdash, Z., 1 May 2020

  Supervisor: Politis, A. (Supervisor) & Conte, M. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Experimental and computational dissection of serine hydroxymethyltransferases within Mycobaterium tuberculosis

  Author: Groom, D., 1 Apr 2023

  Supervisor: academic, A. (Supervisor) & Ulmschneider, M. B. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Examining the role of structural dynamics in the assembly and function of the multidrug efflux pump AcrAB-TolC

  Author: Russell Lewis, B., 1 Apr 2024

  Supervisor: Reading, E. (Supervisor) & Booth, P. J. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Encapsulation of cancer stem cell potent metal complexes into polymeric nanoparticle for delivery

  Author: Eskandari, A., 1 May 2020

  Supervisor: Suntharalingam, R. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Enantioselective, organocatalytic synthesis of carbocyclic structures pertaining to steroids

  Author: Townsend, D., 1 Sept 2020

  Supervisor: Cobb, A. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Dynamics of macromolecular complexes through computational modelling and structural mass spectrometry

  Author: Lau, A. M. C., 1 Dec 2019

  Supervisor: Politis, A. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Dissecting the PTM network of p53: a chemical approach to engineer the N-terminus of p53 using protein semi-synthesis

  Author: Margiola, S., 1 Mar 2022

  Supervisor: Muller, M. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Development of Uncharged Galactosyltransferase Inhibitors: Chemical Tools for Applications in Cells

  Author: Jiang, J., 2017

  Supervisor: Wagner, G. K. (Supervisor) & Page, C. P. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Development of hydrogen/deuterium exchange mass spectrometry simulations to enable accurate protein structure and complex selection

  Author: Harris, M., 1 Jul 2021

  Supervisor: Borysik, A. (Supervisor) & Isaacson, R. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Development of carbohydrate-based inhibitors and probes for the interrogation of the bacterial proteome

  Author: Metier, C., 1 Jan 2020

  Supervisor: Barry, S. (Supervisor) & Wagner, G. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Development of a Matrix Metalloproteinase-sensitive Förster Resonance Energy Transfer Sensor to monitor enzyme activity in 3D hydrogels in situ

  Author: Yan, Z., 1 Dec 2022

  Supervisor: Gentleman, E. (Supervisor), da Silva, R. (Supervisor) & Muller, M. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Developing novel methods for co-translational studies of membrane protein folding

  Author: Pellowe, G., 1 Mar 2021

  Supervisor: Booth, P. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Design and Analysis of Signal Processing Circuits for Molecular Communication

  Author: Bi, D., 1 Aug 2022

  Supervisor: Deng, Y. (Supervisor) & Salehi Reyhani, A. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Conformational Flexibility and Chirality Recognition of Odorants elucidated by Broadband Rotational Spectroscopy

  Author: Loru, D., 1 Feb 2018

  Supervisor: Sanz, M. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Science

• Combined single-molecule fluorescence and optical single-channel recording for electro-optical protein nanopore sensing

  Author: Vanuytsel, S., 1 Aug 2023

  Supervisor: Wallace, M. (Supervisor) & Isaacson, R. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Biophysical studies of SGTA, a protein involved in quality control

  Author: Thapaliya, A., 2017

  Supervisor: Isaacson, R. L. (Supervisor) & Eggert, U. S. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Biological and colloidal synthesis of fluorescent quantum dots

  Author: Burkitt-Gray, M., 1 Sept 2019

  Supervisor: Green, M. (Supervisor) & Fleck, R. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• A structural approach to investigate glycation effect on protein aggregation

  Author: Milordini, G., 1 Dec 2019

  Supervisor: Pastore, A. (Supervisor) & Isaacson, R. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Antibody mediated cross-reactivity of nonself pathogen glycans and the HIV-1 Envelope

  Author: Huettner, I., 1 Feb 2021

  Supervisor: Doores, K. (Supervisor) & Wagner, G. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy