Medical & Molecular Genetics

Projects

Projects per year 1992 2008 2009 2010 2011 2013 2014 2015 2032

• 4 Not started
• 30 Active
• 452 Finished

Projects per year

Search results

• Finished

  Post-translational modification of dystrophins in the nervous system

  Roberts, R. (Primary Investigator)

  Wellcome Trust

  8/06/2009 → 7/08/2009

  Project: Research

• Genome-wide association study for migraine without aura

  Trembath, R. (Primary Investigator), Palotie, A. (Co-Investigator) & Spector, T. (Co-Investigator)

  1/06/2009 → 31/05/2010

  Project: Research

• Defining the genetic basis for interactions between donor and recipient DNA that determine early and late renal transplant dysfunction

  Lord, G. (Primary Investigator), Borrows, R. (Co-Investigator), Hernandez Fuentes, M. (Co-Investigator), Sacks, S. (Co-Investigator), Solomon, E. (Co-Investigator), Spector, T. (Co-Investigator), Trembath, R. (Co-Investigator) & Weale, M. (Co-Investigator)

  Wellcome Trust

  1/06/2009 → 31/12/2012

  Project: Research

• Adoptive immunotherapy of metastatic prostate cancer using PSMA re-targeted T-lymphocytes

  Antoniou, M. (Primary Investigator), Maher, J. (Primary Investigator), Chowdhury, P. (Co-Investigator), Farzaneh, F. (Co-Investigator), Mullen, G. (Co-Investigator) & Papa, S. (Co-Investigator)

  1/05/2009 → 30/04/2012

  Project: Research

• Evaluation of service implementation of molecular diagnostics and minimal residual disease monitoring to direct treatment of acute myeloid leukaemia

  Grimwade, D. (Primary Investigator), Burnett, A. (Co-Investigator), Buxton, M. (Co-Investigator), Freeman, S. (Co-Investigator), Hills, R. (Co-Investigator), Hunt, B. (Co-Investigator), Linch, D. (Co-Investigator), Pokhrel, S. (Co-Investigator), Russell, N. (Co-Investigator), Smith, M. (Co-Investigator), Watson, M. (Co-Investigator) & Yin, J. L. (Co-Investigator)

  1/04/2009 → 31/03/2014

  Project: Research

• Understanding the causes of childhood acute promyelocytic leukaemia

  Grimwade, D. (Primary Investigator) & Solomon, E. (Co-Investigator)

  1/04/2009 → 31/03/2012

  Project: Research

• MRC Development Pathway Funding Scheme (DPFS) Devolved Portfolio

  Barrington, S. (Primary Investigator), Bevan, S. (Primary Investigator), Beerbaum, P. (Co-Investigator), Chowienczyk, P. (Co-Investigator), Doherty, P. (Co-Investigator), French, G. (Co-Investigator), Lombardi, G. (Co-Investigator), Moon, L. (Co-Investigator), Nasim, T. (Co-Investigator), Parker, P. (Co-Investigator), Schaeffter, T. (Co-Investigator), Smith, R. (Co-Investigator), Trembath, R. (Co-Investigator), Wells, C. (Co-Investigator) & Williams, G. (Co-Investigator)

  MRC Medical Research Council

  1/04/2009 → 31/12/2013

  Project: Research

• Therapeutic resolution of BMPR2 mediated signalling defects in pulmonary arterial hypertension (PAH)

  Trembath, R. (Primary Investigator) & Nasim, T. (Co-Investigator)

  1/03/2009 → 28/02/2011

  Project: Research

• Characterisation of a novel inflammatory pathway underlying psoriasis susceptibility

  Capon, F. (Primary Investigator) & Trembath, R. (Co-Investigator)

  British Skin Foundation

  1/02/2009 → 31/03/2011

  Project: Research

• Skin barrier impairment in early life and the development of sensitisation and eczema: epidemiology, gene-environment interaction and immunology

  Flohr, C. (Primary Investigator), Lack, G. (Primary Investigator), Barker, J. (Co-Investigator), Perkin, M. (Co-Investigator), Trembath, R. (Co-Investigator) & Turcanu, V. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/02/2009 → 28/02/2014

  Project: Research

• Art forms from the invisible

  Oakey, R. (Primary Investigator)

  1/02/2009 → 31/01/2010

  Project: Research

• Optimising the generation of human iPS cell lines via UCOE-based lentiviral vectors

  Antoniou, M. (Primary Investigator), Andrews, P. (Co-Investigator), Miljan, E. (Co-Investigator) & Sinden, J. (Co-Investigator)

  1/01/2009 → 31/12/2011

  Project: Research

• Identification of a psoriasis suceptibility gene

  Capon, F. (Primary Investigator)

  1/01/2009 → 31/12/2009

  Project: Research

• Hybridisation-based targeted resequencing of OTLs contributing to reading and mathematical ability

  Simpson, M. (Co-Investigator)

  1/01/2009 → 31/12/2013

  Project: Research

• Promoter activity can influence alternative polyadenylation; a mechanism for tissue specific gene regulation that increases transcriptome diversity

  Oakey, R. (Primary Investigator)

  1/01/2009 → 31/12/2011

  Project: Research

• Clinical utility of genetic variants and biomarkers for the presymptomatic detection of Crohn's disease

  Mathew, C. (Primary Investigator), Anderson, S. (Co-Investigator), Lewis, C. (Co-Investigator) & Sanderson, J. (Co-Investigator)

  1/12/2008 → 30/11/2011

  Project: Research

• High resolution genetic analysis of interleukin (IL-12B) in susceptibility to inflammatory bowel disease

  Mathew, C. (Primary Investigator) & Prescott, N. (Co-Investigator)

  1/11/2008 → 31/10/2011

  Project: Research

• Defining the features of minimal imprinted loci generated by retrotransposition

  Oakey, R. (Primary Investigator) & Bourc'his, D. (Co-Investigator)

  Wellcome Trust

  1/10/2008 → 31/03/2013

  Project: Research

• Value in People Award 2008-2009

  Brown, K. (Primary Investigator), Parkin, M. (Primary Investigator), Schulz, R. (Primary Investigator), Snabaitis, A. (Primary Investigator) & Taylor, A. (Primary Investigator)

  Wellcome Trust

  1/10/2008 → 30/09/2009

  Project: Research

• Tissue-specific gene regulation via alternative poly-adenylation.

  Schulz, R. (Primary Investigator)

  1/10/2008 → 30/09/2013

  Project: Research

• Determination of mechanisms underlying the formation of reciprocal chromosomal translocations in leukaemia

  Grimwade, D. (Primary Investigator) & Solomon, E. (Primary Investigator)

  1/10/2008 → 30/09/2009

  Project: Research

• Epigenetic mechanisms in heart development and disease

  Oakey, R. (Primary Investigator)

  BHF British Heart Foundation

  1/10/2008 → 30/09/2011

  Project: Research

• Tissue-specific gene regulation via alternative poly-adenylation due to internal promoter activity.

  Schulz, R. (Primary Investigator)

  1/10/2008 → 30/09/2013

  Project: Research

• Proteomic analyses of complexes that underlie dominantly inherited LGMD.

  Antoniou, M. (Primary Investigator)

  1/10/2008 → 30/09/2011

  Project: Research

• Characterisation of new target genes and interacting partners for the promyelocytic leukaemia Zinc Finger (PLZF) protein.

  Guidez, F. (Primary Investigator) & Solomon, E. (Co-Investigator)

  1/10/2008 → 30/09/2012

  Project: Research

• Optimising the utility of genetic profiles for risk estimation in complex disorders

  Cherkas, L. (Co-Investigator), Collier, D. (Co-Investigator), Lewis, C. (Co-Investigator), Mathew, C. (Co-Investigator) & Price, T. (Co-Investigator)

  1/10/2008 → 30/09/2011

  Project: Research

• DISNET: identification and characterization of disease gene networks on the basis of high-throuput data and genome-wide association studies.

  Schlitt, T. (Primary Investigator)

  1/09/2008 → 31/08/2013

  Project: Research

• Towards efficient gene therapy for muscular dystrophy: Assembly and turnover of Dystrophin complex

  Hughes, S. (Primary Investigator), Garcia, L. (Co-Investigator) & Roberts, R. (Co-Investigator)

  1/09/2008 → 31/08/2011

  Project: Research

• Islet-specific T cell response genes identified by microarray analysis

  Peakman, M. (Primary Investigator) & Schulz, R. (Co-Investigator)

  JDRF Juvenile Diabetes Research Foundation

  1/09/2008 → 31/08/2011

  Project: Research

• Epigenetic regulation and protein modifications during normal and malignant haematopoiesis impact of the promyclocytic leukaemia zinc finger (PLZF) protein on leukaemogenesis

  Guidez, F. (Primary Investigator) & Solomon, E. (Primary Investigator)

  1/09/2008 → 31/08/2011

  Project: Research

• Identification and characterisation of splicing factors interactome controlling alternative splicing in human diseases

  Nasim, T. (Primary Investigator) & Trembath, R. (Co-Investigator)

  15/08/2008 → 14/08/2011

  Project: Research

• The role of the antimicrobial peptide, LL37, in immunopathogenesis of psoriasis.

  Perera, G. (Primary Investigator), Nestle, F. (Co-Investigator) & Solomon, E. (Co-Investigator)

  1/08/2008 → 31/07/2011

  Project: Research

• Investigating X chromosome hyper-transcription in the animal kingdom: a comparative approach

  Oakey, R. (Primary Investigator), Wood, A. (Primary Investigator) & academic, A. (Primary Investigator)

  Wellcome Trust

  1/08/2008 → 31/08/2012

  Project: Research

• International Cooperative Effort for Duchenne Muscular Dystrophy (ICE)

  Hughes, S. (Primary Investigator) & Roberts, R. (Co-Investigator)

  AMM Association Monégasque contre les Myopathies

  1/08/2008 → 31/08/2013

  Project: Research

• The Role of IRGM and autophagosome in inflammatory bowel disease

  Mathew, C. (Primary Investigator), Antoniou, M. (Co-Investigator), Lewis, C. (Co-Investigator), Mansfield, J. (Co-Investigator), Parkes, M. (Co-Investigator), Roberts, R. (Co-Investigator), Sanderson, J. (Co-Investigator), Satsangi, J. (Co-Investigator) & Tooze, S. (Co-Investigator)

  1/08/2008 → 31/07/2011

  Project: Research

• Developmental of therapy for nonsense-associated human diseases

  Nasim, T. (Primary Investigator) & Trembath, R. (Co-Investigator)

  1/07/2008 → 30/06/2009

  Project: Research

• The molecular genetics basis of pulmonary arterial hypertension

  Trembath, R. (Primary Investigator)

  BHF British Heart Foundation

  1/07/2008 → 30/06/2013

  Project: Research

• Development of an assay system to identify factors that promote translation readthrough in nonsense associated genetic diseases

  Nasim, T. (Primary Investigator) & Trembath, R. (Co-Investigator)

  Heptagon Proof of Concept Fund

  1/06/2008 → 31/03/2011

  Project: Research

• Genetic analysis of interleukin-23 related genes in inflammatory bowel disease.

  Mathew, C. (Primary Investigator)

  1/04/2008 → 31/03/2010

  Project: Research

• The evaluation and service implementation of molecular diagnostics and minimalresidual disease monitoring to direct treatment of acute myeloid leukaemia.

  Grimwade, D. (Primary Investigator) & Solomon, E. (Co-Investigator)

  1/04/2008 → 31/03/2013

  Project: Research

• Small Ubiquitin-like MOdifier (SUMO) targeting of BRCA1

  Morris, J. (Primary Investigator)

  CRUK Cancer Research UK

  1/03/2008 → 31/07/2011

  Project: Research

• UCOE-based lentiviral vectors for effective and safe gene therapy

  Antoniou, M. (Primary Investigator)

  BBSRC Biotechnology and Biological Sciences Research Council

  1/03/2008 → 28/02/2011

  Project: Research

• Evaluation of real-time quantitative PCR for NPM1 mutations to detect minimal residual disease and predict relapse in acute myeloid leukaemia.

  Grimwade, D. (Primary Investigator) & Solomon, E. (Co-Investigator)

  Blood Cancer UK

  1/02/2008 → 31/12/2013

  Project: Research

• Identification of Auto-Antibody Epitopes in the Pathogenesis of systematic sclerosis

  Howat, S. (Primary Investigator), Roberts, R. (Primary Investigator) & Tennant-Eyles, A. (Primary Investigator)

  1/02/2008 → 31/01/2010

  Project: Research

• unconfirmed

  Grimwade, D. (Primary Investigator)

  1/01/2008 → 31/12/2010

  Project: Research

• Antibodies for research into causes of paediatric neuromuscular disorders

  Roberts, R. (Primary Investigator)

  London Law Trust

  1/01/2008 → 31/12/2010

  Project: Research

• Tissue-specific gene regulation via alternative poly-adenylation due to internal promoter activity.

  Schulz, R. (Primary Investigator)

  1/01/2008 → 31/12/2012

  Project: Research

• The cytoplasmic domain of BMPR-II and Tctex-1 in signalling and pathogenesis of pulmonary arterial hypertension

  Machado, R. (Primary Investigator), Morrell, N. (Co-Investigator), Phuhl, M. (Co-Investigator) & Trembath, R. (Co-Investigator)

  BHF British Heart Foundation

  1/01/2008 → 31/12/2011

  Project: Research

• Role of the kinase scaffold Nbr1 in musculoskeletal and regulation of muscle and bone maintenance

  Gautel, M. (Primary Investigator), Solomon, E. (Primary Investigator) & Whitehouse, C. (Primary Investigator)

  1/01/2008 → 31/12/2010

  Project: Research

• Development of an in utero approach for thassaemia gene therapy

  Antoniou, M. (Primary Investigator) & Waddington, S. (Co-Investigator)

  UK Thalassaemia Society

  1/01/2008 → 30/04/2011

  Project: Research