Medical & Molecular Genetics

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• Validation of the IL-36 receptor as a potential therapeutic target in pustular and plaque psoriasis

  Mahil, S. K. (Author), Capon, F. (Supervisor) & Barker, J. N. W. N. (Supervisor), 1 Dec 2017

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Validation of HDAC6 and SIRT2 Tubulin Deacetylases as therapeutic targets for Huntington’s Disease.

  Bobrowska, A. (Author), Bates, G. (Supervisor) & Antoniou, M. (Supervisor), 1 May 2012

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• The role of lupus susceptibility MHC haplotypes and interferon-alpha in gene regulation

  Salgado Teixeira Duarte, C. (Author), Fernando, M. M. A. (Supervisor) & Vyse, T. J. (Supervisor), 2017

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• The role of interleukin-36 in skin and systemic inflammation

  Catapano, M. (Author), Capon, F. (Supervisor), Ciccarelli, F. (Supervisor), Barker, J. (Supervisor) & Smith, C. (Supervisor), 17 Jul 2019

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• The role of DNA sequence signals in the epigenetic reprogramming of CpG islands during oogenesis and early embryogenesis

  Saadeh, H. (Author), Schulz, R. S. D. (Supervisor), 2014

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• The role of abnormal neutrophil activation in psoriasis

  Vergnano, M. (Author), Capon, F. (Supervisor) & Smith, C. (Supervisor), 1 Mar 2020

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• The Molecular Biology of Sickle Cell Anaemia

  Shannon, M. F. (Author), Oakey, R. (Supervisor) & Thein, S. L. (Supervisor), 2018

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• The impact of cannabis use and polygenic risk scores on symptom dimension profiles at psychosis onset

  Quattrone, D. (Author), Di Forti, M. (Supervisor), Murray, R. (Supervisor), Lewis, C. (Supervisor) & Reininghaus, U. (Supervisor), 1 Sept 2020

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• The genetics of oesophageal cancer in South African populations

  Bye, H. (Author), Mathew, C. G. P. (Supervisor) & Lewis, C. M. (Supervisor), Nov 2013

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• THE GENETIC BASIS OF PUSTULAR PSORIASIS AND ITS OVERLAP WITH PSORIASIS VULGARIS

  Berki, D. M. (Author), Capon, F. (Supervisor), Trembath, R. C. (Supervisor) & Barker, J. N. W. N. (Supervisor), 2016

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• The epigenetics and role of Dopa Decarboxylase in heart development

  Prickett, A. (Author), Oakey, R. J. (Supervisor), 2013

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• The epigenetic regulation of cerebellar granule cell development

  Riegman, K. (Author), Basson, A. (Supervisor) & Osborne, C. (Supervisor), 1 Feb 2020

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• The effect of hydroxyurea treatment on DNA methylation and gene expression in essential thrombocythaemia and polycythaemia vera: a cross-species study

  Contreras Castillo, S. (Author), Oakey, R. (Supervisor) & Schulz, R. (Supervisor), 1 Apr 2020

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• The Cks1/Cks2 Axis In Mll1-Dependent Wnt Signalling And Mixed Lineage Leukaemia

  Grey, W. G. (Author), Solomon, E. (Supervisor), 2015

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Targeting of B-cell malignancy using novel parallel chimeric antigen receptor (pCAR) engineered T-cells

  Halim, L. (Author), Maher, J. (Supervisor) & Dillon, R. (Supervisor), 1 Jul 2021

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Statistical Analysis of Genome-Genome Interaction with Reference to Kidney Transplant Outcome

  Mollon, J. (Author), Weale, M. E. (Supervisor), 2014

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Role of CD38 in chronic lymphocytic leukaemia cell motility

  Mele, S. (Author), Ridley, A. (Supervisor), Oakey, R. J. (Supervisor) & Devereux, S. (Supervisor), 2015

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Phenotypic and genetic characterisation of an extended pustular psoriasis dataset

  Twelves, S. M. (Author), Capon, F. (Supervisor) & Barker, J. (Supervisor), 1 Jul 2019

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Novel computational methods using coded patient phenotypes to enhance disease gene identification

  Saklatvala, J. R. (Author), Simpson, M. (Supervisor) & Mathew, C. (Supervisor), 1 Jul 2019

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Novel Approaches to Thalassaemia Gene Therapy

  Azevedo Ferreira, S. (Author), Antoniou, M. (Supervisor) & Waddington, S. (Supervisor), 2013

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• New statistical methodologies for improved analysis of genomic and omic data

  Elhezzani, N. S. R. (Author), 2018

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Network-Based Methods for the Analysis of Next Generation Sequencing Data in Human Genetic Disease

  Dand, N. J. (Author), Schulz, R. S. D. (Supervisor), Oakey, R. J. (Supervisor) & Simpson, M. A. (Supervisor), 2015

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Molecular mechanisms controlling the expression of the HLA-Cw*06 psoriasis susceptibility allele

  Bertoni, A. (Author), Trembath, R. C. (Supervisor) & Capon, F. (Supervisor), 1 Jan 2013

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Molecular genetics of lobular breast cancer ductal carcinoma in situ

  Petridis, C. (Author), Simpson, M. A. (Supervisor) & Sawyer, E. J. (Supervisor), 2018

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Molecular genetic exploration of frontal fibrosing alopecia and uncharacterised hair disorders

  Rayinda, T. (Author), McGrath, J. (Supervisor), Tziotzios, C. (Supervisor) & Dand, N. (Supervisor), 1 Dec 2023

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Molecular Genetic Analysis of Hidradenitis Suppurativa (Acne Inversa)

  Pink, A. E. (Author), Barker, J. N. W. N. (Supervisor) & Trembath, R. C. (Supervisor), 2014

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Molecular exploration of frontal fibrosing alopecia

  Tziotzios, C. (Author), McGrath, J. (Supervisor), Simpson, M. (Supervisor) & Watt, F. (Supervisor), 1 May 2019

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Molecular Characterisation and Tracking Disease in Acute Myeloid Leukaemia

  Ivey, A. S. (Author), Grimwade, D. J. (Supervisor) & Solomon, E. (Supervisor), 2016

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Mapping the interleukin-23 regulated transcriptome in ulcerative colitis

  Digby-Bell, J. (Author), Powell, N. (Supervisor) & Prescott, N. (Supervisor), 1 Jun 2024

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Long-range regulatory interactions in acute promyelocytic leukemia

  Villiers, W. (Author), Osborne, C. (Supervisor) & Dillon, R. (Supervisor), 1 Nov 2021

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Investigation of the molecular genetic contribution to idiopathic nephrotic syndrome using high-throughput sequencing

  Bugarin Diz, C. (Author), Koziell, A. (Supervisor) & Simpson, M. (Supervisor), 1 Feb 2022

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Investigating the role of the transcriptional regulator BCL6 in thymocyte development

  Boehme, L. (Author), Seitan, V. (Supervisor) & Mankoo, B. (Supervisor), 1 May 2021

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Investigating the genetic determinants of palmoplantar pustulosis

  Hernandez Cordero, A. (Author), Capon, F. (Supervisor) & Smith, C. (Supervisor), 1 Dec 2024

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Investigating the Genetic Architecture of Orofacial Granulomatosis

  Omar Al-Sayed, Y. (Author), Prescott, N. (Supervisor), Escudier, M. (Supervisor) & Sanderson, J. (Supervisor), 1 Dec 2021

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Investigating the complex transcriptional relationship between intragenetic CpG islands and their host genes

  Amante, S. (Author), Oakey, R. (Supervisor) & Schulz, R. (Supervisor), 1 May 2020

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Investigating the Adaptations and Regulation of Maternal Metabolism in Mice

  Amarsi, R. (Author), Charalambous, M. (Supervisor), 1 Jul 2024

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Investigating renal disease in Bardet-Biedl syndrome using induced pluripotent stem cells

  Hurling, C. A. (Author), Watt, F. (Supervisor) & Capon, F. (Supervisor), 1 Aug 2019

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Investigating imprinted DLK1 mis-regulation in human fetal growth restriction

  Vignola, L. (Author), Charalambous, M. (Supervisor) & Hodgkinson, A. (Supervisor), 1 Jun 2024

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Investigating C1QTNF4 in health and systemic lupus erythematosus

  Vester, S. (Author), Vyse, T. (Supervisor) & Cunninghame Graham, D. (Supervisor), 1 Feb 2021

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Inferring ancestral and biogeographic origin using genome-wide SNP data

  Crouch, D. (Author), Weale, M. E. (Supervisor) & Lewis, C. M. (Supervisor), 2013

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• IMPROVED ALLELE SPECIFIC EXPRESSION (ASE) DETECTION AND THE IMPLICATIONS FOR UNDERSTANDING REGULATORY AND DISEASE GENETICS

  Saukkonen, A. (Author), Hubbard, T. (Supervisor) & Hodgkinson, A. J. (Supervisor), 1 May 2023

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Identifying key genes in the formation of mammalian heart valves

  Lohiya, P. (Author), Oakey, R. J. (Supervisor) & Ellison, G. M. (Supervisor), 1 Jun 2023

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Identification of genetics and neuroimaging networks related to reinforcement psychopathology

  Tay, N. X. H. (Author), Lewis, C. (Supervisor) & Schumann, G. (Supervisor), 1 Jan 2020

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Host genetic factors underlying the link between the microbiome and rheumatoid arthritis

  Wells, P. (Author), Steves, C. (Supervisor) & Williams, F. (Supervisor), 2021

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Genomewide Analysis of Proteins that Bind to DNA and Regulate Gene Expression, With Particular Emphasis on Imprinted Genes

  Hughes, S. M. (Author), Oakey, R. J. (Supervisor) & Iliopoulos, C. (Supervisor), 2016

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Genetic variation of innate immune receptor genes in Systemic Lupus Erythematosus

  Roberts, A. L. (Author), Vyse, T. J. (Supervisor) & Rhodes, B. (Supervisor), 2015

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Genetics and Epigenetics in Systemic Lupus Erythematosus

  Chen, L. (Author), Vyse, T. (Supervisor) & Morris, D. (Supervisor), 2018

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• GENETIC EPIDEMIOLOGY OF ALLERGY TO BETALACTAM ANTIBIOTICS

  Badin, S. (Author), Weale, M. E. (Supervisor) & Rasekh Ahmadi, K. (Supervisor), 2017

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Genetic and epigenetic characterisation of phaeochromocytoma and paraganglioma tumours

  Chatzikyriakou, P. (Author), Oakey, R. (Supervisor) & Izatt, L. (Supervisor), 1 Aug 2021

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Gene therapy for haemoglobinopathies enhancing lentiviral vector therapeutic efficacy

  Flouri, C. (Author), Antoniou, M. (Supervisor), 1 Jul 2019

  Student thesis: Doctoral Thesis › Doctor of Philosophy