King's College London

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Molecular Haematology

Organisational unit: Department

  1. AKTIP interacts with ESCRT i and is needed for the recruitment of ESCRT III subunits to the midbody

    Merigliano, C., Burla, R., La Torre, M., Del Giudice, S., Teo, H., Liew, C. W., Chojnowski, A., Goh, W. I., Olmos, Y., MacCaroni, K., Giubettini, M., Chiolo, I., Carlton, J. G., Raimondo, D., Vernì, F., Stewart, C. L., Rhodes, D., Wright, G. D., Burke, B. E. & Saggio, I., 27 Aug 2021, In: PLoS Genetics. 17, 8, e1009757.

    Research output: Contribution to journalArticlepeer-review

  2. Methodological approach for the evaluation of FOXO as a positive regulator of antioxidant genes

    Monsalve, M., Prieto, I., de Bem, A. F. & Olmos, Y., 1 Jan 2019, Methods in Molecular Biology. Humana Press Inc, Vol. 1890. p. 61-76 16 p. (Methods in Molecular Biology; vol. 1890).

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

  3. CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope

    Ventimiglia, L. N., Cuesta-Geijo, M. A., Martinelli, N., Caballe, A., Macheboeuf, P., Miguet, N., Parnham, I. M., Olmos, Y., Carlton, J. G., Weissenhorn, W. & Martin-Serrano, J., 3 Dec 2018, (E-pub ahead of print) In: Developmental Cell. 47, 5, p. 547-563.e6

    Research output: Contribution to journalArticlepeer-review

  4. Prognostic factors of disease severity in infants with sickle cell anemia: A comprehensive longitudinal cohort study

    Brousse, V., El Hoss, S., Bouazza, N., Arnaud, C., Bernaudin, F., Pellegrino, B., Guitton, C., Odièvre-Montanié, M. H., Mames, D., Brouzes, C., Picard, V., Nguyen-Khoa, T., Pereira, C., Lapouméroulie, C., Pissard, S., Gardner, K., Menzel, S., Le Van Kim, C., Colin-Aronovicz, Y., Buffet, P. & 5 others, Mohandas, N., Elie, C., Maier-Redelsperger, M., El Nemer, W. & de Montalembert, M., 1 Nov 2018, In: American Journal of Hematology. 93, 11, p. 1411-1419 9 p.

    Research output: Contribution to journalArticlepeer-review

  5. Oxidative stress and phosphatidylserine exposure in red cells from patients with sickle cell anaemia

    Hannemann, A., Rees, D. C., Brewin, J. N., Noe, A., Low, B. & Gibson, J. S., 1 Aug 2018, In: British Journal of Haematology. 182, 4, p. 567-578 12 p.

    Research output: Contribution to journalArticlepeer-review

  6. Mammalian expression vectors for metabolic biotinylation tandem affinity tagging by co-expression in cis of a mammalian codon-optimized BirA biotin ligase

    Ioannou, M., Papageorgiou, D. N., Ogryzko, V. & Strouboulis, J., 14 Jun 2018, In: BMC Research Notes. 11, 1, p. 390

    Research output: Contribution to journalArticlepeer-review

  7. Proteomic analysis of plasma from children with sickle cell anemia and silent cerebral infarction

    Tewari, S., Renney, G., Brewin, J., Gardner, K., Kirkham, F., Inusa, B., Barrett, J. E., Menzel, S., Thein, S. L., Ward, M. & Rees, D. C., 15 Mar 2018, (E-pub ahead of print) In: Haematologica.

    Research output: Contribution to journalArticlepeer-review

  8. Development and validation of the non-technical skills for urological surgeons (NoTSUS) ureteroscopy scenario curriculum

    Aydin, A., Brunckhorst, O., Raison, N., Brewin, J., Mcilhenny, C., Al-jabir, A., Aya, H., Dar, F., Iqbal, M., Lovegrove, C., Shabbir, M., Brouwers, T., Palou Redorta, J., Khan, M., Dasgupta, P. & Ahmed, K., 1 Mar 2018, In: EUROPEAN UROLOGY SUPPLEMENTS. 17, 2, p. e674-e675

    Research output: Contribution to journalMeeting abstractpeer-review

  9. The effect of xanthine oxidase and hypoxanthine on the permeability of red cells from patients with sickle cell anemia

    Al Balushi, H. W. M., Rees, D. C., Brewin, J. N., Hannemann, A. & Gibson, J. S., Mar 2018, In: Physiology Reports. 6, 5

    Research output: Contribution to journalArticlepeer-review

  10. g(HbF): a genetic model of fetal hemoglobin in sickle cell disease

    Gardner, K., Fulford, T., Silver, N., Rooks, H., Angelis, N., Allman, M., Nkya, S., Makani, J., Howard, J., Kesse-Adu, R., Rees, D. C., Stuart-Smith, S., Yeghen, T., Awogbade, M., Sangeda, R. Z., Mgaya, J., Patel, H., Newhouse, S., Menzel, S. & Thein, S. L., 13 Feb 2018, In: Blood Advances. 2, 3, p. 235-239 5 p.

    Research output: Contribution to journalArticlepeer-review

  11. How I manage red cell transfusions in patients with sickle cell disease

    Rees, D. C., Robinson, S. & Howard, J., Feb 2018, In: British Journal of Haematology. 180, 4, p. 607-617 11 p.

    Research output: Contribution to journalReview articlepeer-review

  12. Genetic Modifiers of Fetal Haemoglobin in Sickle Cell Disease

    Menzel, S. & Thein, S. L., 1 Jan 2018, (Accepted/In press) In: Molecular Diagnosis and Therapy.

    Research output: Contribution to journalReview articlepeer-review

  13. Functional interrelationship between TFII-I and E2F transcription factors at specific cell cycle gene loci

    Shen, Y., Nar, R., Fan, A. X., Aryan, M., Hossain, M. A., Gurumurthy, A., Wassel, P. C., Tang, M., Lu, J., Strouboulis, J. & Bungert, J., Jan 2018, In: Journal of Cellular Biochemistry. 119, 1, p. 712-722 11 p.

    Research output: Contribution to journalArticlepeer-review

  14. Heterogeneity of respiratory disease in children and young adults with sickle cell disease

    Lunt, A., Mortimer, L., Rees, D., Height, S., Thein, S. L. & Greenough, A., 2018, In: Thorax. 73, p. 575-577

    Research output: Contribution to journalArticlepeer-review

  15. Overnight auto-adjusting continuous airway pressure+standard care compared with standard care alone in the prevention of morbidity in sickle cell disease phase II (POMS2b): Study protocol for a randomised controlled trial

    Howard, J., Slee, A. E., Skene, S., Inusa, B., Kawadler, J., Downes, M., Gavlak, J., Koelbel, M., Stotesbury, H., Chorozoglou, M., Tebbs, S., Chakravorty, S., Awogbade, M., Rees, D. C., Gupta, A., Murphy, P. B., Hart, N., Sahota, S., Nwosu, C., Gwam, M. & 10 others, Saunders, D., Muthurangu, V., Barber, N., Ako, E., Thein, S. L., Marshall, M., Reading, I. C., Cheng, M. Y. E., Kirkham, F. J. & Liossi, C., 2018, In: Trials. 19, 1, 55.

    Research output: Contribution to journalArticlepeer-review

  16. ESCRT-dependent control of membrane remodelling during cell division

    Stoten, C. L. & Carlton, J. G., 24 Aug 2017, (E-pub ahead of print) In: Seminars in Cell and Developmental Biology.

    Research output: Contribution to journalArticlepeer-review

  17. Newborn screening for haematological disorders

    Streetly, A., Rees, D. C. & Coppinger, C., 24 Aug 2017, (E-pub ahead of print) In: Paediatrics and Child Health (United Kingdom).

    Research output: Contribution to journalArticlepeer-review

  18. Fetal Hemoglobin is Associated with Peripheral Oxygen Saturation in Sickle Cell Disease in Tanzania

    Nkya, S., Mgaya, J., Urio, F., Makubi, A., Thein, S. L., Menzel, S., Cox, S. E., Newton, C. R., Kirkham, F. J., Mmbando, B. P. & Makani, J., 8 Aug 2017, (E-pub ahead of print) In: EBioMedicine.

    Research output: Contribution to journalArticlepeer-review

  19. Sickle cell disease: An update on management

    Brewin, J. & Howard, J., 8 Aug 2017, (E-pub ahead of print) In: Paediatrics and Child Health (United Kingdom).

    Research output: Contribution to journalArticlepeer-review

  20. How I manage sickle cell patients with high transcranial doppler results

    Brewin, J., Kaya, B. & Chakravorty, S., 2 Aug 2017, (E-pub ahead of print) In: British Journal of Haematology.

    Research output: Contribution to journalArticlepeer-review

  21. Recommendations regarding splenectomy in hereditary hemolytic anemias

    Working Study Group on Red Cells and Iron of the EHA, Aug 2017, In: Haematologica. 102, 8, p. 1304-1313 10 p.

    Research output: Contribution to journalArticlepeer-review

  22. Autoimmune Liver Disease in Children with Sickle Cell Disease

    Jitraruch, S., Fitzpatrick, E., Deheragoda, M., Deganello, A., Mieli-Vergani, G., Height, S., Rees, D., Hadzic, N. & Samyn, M., 20 Jul 2017, (E-pub ahead of print) In: Journal of pediatrics.

    Research output: Contribution to journalArticlepeer-review

  23. Sickle cell disease

    Piel, F. B., Steinberg, M. H. & Rees, D. C., 20 Jul 2017, In: New England Journal of Medicine. 377, 3

    Research output: Contribution to journalLetterpeer-review

  24. The super sickling haemoglobin HbS-Oman: A study of red cell sickling, K+ permeability and associations with disease severity in patients heterozygous for HbA and HbS-Oman (HbA/S-Oman genotype)

    Al Balushi, H. W. M., Wali, Y., Al Awadi, M., Al-Subhi, T., Rees, D. C., Brewin, J. N., Hannemann, A. & Gibson, J. S., 12 Jul 2017, (E-pub ahead of print) In: British Journal of Haematology.

    Research output: Contribution to journalArticlepeer-review

  25. ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes

    Chatzinikolaou, G., Apostolou, Z., Aid-Pavlidis, T., Ioannidou, A., Karakasilioti, I., Papadopoulos, G. L., Aivaliotis, M., Tsekrekou, M., Strouboulis, J., Kosteas, T. & Garinis, G. A., 1 May 2017, In: Nature Cell Biology. 19, 5, p. 421-432 12 p.

    Research output: Contribution to journalArticlepeer-review

  26. Next-generation sequencing as a tool for breakpoint analysis in rearrangements of the globin gene clusters

    Clark, B., Shooter, C., Smith, F., Brawand, D. & Thein, S. L., 1 May 2017, In: International Journal Of Laboratory Hematology. 39, p. 111-120 10 p.

    Research output: Contribution to journalReview articlepeer-review

  27. Associations between environmental factors and hospital admissions for sickle cell disease

    Piel, F. B., Tewari, S., Brousse, V., Analitis, A., Font, A., Menzel, S., Chakravorty, S., Thein, S. L., Inusa, B., Telfer, P., de Montalembert, M., Fuller, G., Katsouyanni, K. & Rees, D., 31 Mar 2017, In: Haematologica. 102, 4, p. 666-675 10 p.

    Research output: Contribution to journalArticlepeer-review

  28. Real-time dose adjustment using point-of-care platelet reactivity testing in a double-blind study of prasugrel in children with sickle cell anaemia

    Jakubowski, J. A., Hoppe, C. C., Zhou, C., Smith, B. E., Brown, P. B., Heath, L. E., Inusa, B., Rees, D. C., Small, D. S., Gupta, N., Yao, S., Heeney, M. & Kanter, J., 28 Feb 2017, In: Thrombosis and Haemostasis. 117, 3, p. 580-588 9 p.

    Research output: Contribution to journalArticlepeer-review

  29. Interim assessment of liver damage in patients with sickle cell disease using new non-invasive techniques

    Drasar, E., Fitzpatrick, E., Gardner, K., Awogbade, M., Dhawan, A., Bomford, A., Suddle, A. & Thein, S. L., 1 Feb 2017, In: British Journal of Haematology. 176, 4, p. 643-650 8 p.

    Research output: Contribution to journalArticlepeer-review

  30. Update review of the acute porphyrias

    Stein, P. E., Badminton, M. N. & Rees, D. C., Feb 2017, In: British Journal of Haematology. 176, 4, p. 527-538

    Research output: Contribution to journalReview articlepeer-review

  31. PKCϵ switches Aurora B specificity to exit the abscission checkpoint

    Pike, T., Brownlow, N., Kjaer, S., Carlton, J. & Parker, P. J., 22 Dec 2016, In: Nature Communications. 7, 1, 10 p., 13853.

    Research output: Contribution to journalArticlepeer-review

  32. Survival in adults with sickle cell disease in a high-income setting

    Gardner, K., Douiri, A., Drasar, E., Allman, M., Mwirigi, A., Awogbade, M. & Thein, S. L., 8 Sep 2016, In: Blood. 128, 10, p. 1436-1438 3 p.

    Research output: Contribution to journalArticlepeer-review

  33. Deep-phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment

    Kordasti, S., Costantini, B., Seidl, T., Perez Abellan, P., Martinez Llordella, M., Mclornan, D., Diggins, K. E., Kulasekararaj, A., Benfatto, C., Feng, X., Smith, A., Mian, S. A., Melchiotti, R., De Rinaldis, E. D., Ellis, R., Petrov, N., Povoleri, G. A. M., Chung, S. S., Thomas, N. S. B., Farzaneh, F. & 5 others, Irish, J. M., Heck, S., Young, N. S., Marsh, J. C. W. & Mufti, G. J., 1 Sep 2016, In: Blood. 128, 9, p. 1193-1205 13 p.

    Research output: Contribution to journalArticlepeer-review

  34. Loss of Major DNase I Hypersensitive Sites in Duplicated β-globin Gene Cluster Incompletely Silences HBB Gene Expression

    Reading, N. S., Shooter, C., Song, J., Miller, R., Agarwal, A., Lanikova, L., Clark, B., Thein, S. L., Divoky, V. & Prchal, J. T., 25 Aug 2016, (E-pub ahead of print) WILEY-BLACKWELL.

    Research output: Book/ReportReportpeer-review

  35. Beta thalassaemia intermedia due to co-inheritance of three unique alpha globin cluster duplications characterised by next generation sequencing analysis

    Clark, B., Shooter, C., Smith, F., Brawand, D., Steedman, L., Oakley, M., Rushton, P., Rooks, H., Wang, X., Drousiotou, A., Kyrri, A., Hadjigavriel, M., Will, A., Fisher, C., Higgs, D. R., Phylipsen, M., Harteveld, C., Kleanthous, M. & Thein, S. L., 29 Jul 2016, (E-pub ahead of print) In: British Journal of Haematology.

    Research output: Contribution to journalArticlepeer-review

  36. ASH1L (a histone methyltransferase protein) is a novel candidate globin gene regulator revealed by genetic study of an English family with beta-thalassaemia unlinked to the beta-globin locus

    Breton, A., Theodorou, A., Aktuna, S., Sonzogni, L., Darling, D., Chan, L., Menzel, S., van der Spek, P. J., Swagemakers, S. M. A., Grosveld, F., Philipsen, S. & Thein, S. L., 19 Jul 2016, (E-pub ahead of print) In: British Journal of Haematology.

    Research output: Contribution to journalArticlepeer-review

  37. Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes

    Cereda, M., Gambardella, G., Benedetti, L. G., Iannelli, F., Patel, D., Basso, G., Guerra, R., Mourikis, T. P., Puccio, I., Sinha, S., Laghi, L., Spencer, J., Rodriguez-Justo, M. & Ciccarelli, F. D., 5 Jul 2016, In: Nature Communications. 7, 1, 12 p., 12072.

    Research output: Contribution to journalArticlepeer-review

  38. Longitudinal assessment of lung function in children with sickle cell disease

    Lunt, A., Mcghee, E., Sylvester, K., Rafferty, G., Dick, M., Rees, D., Height, S., Thein, S. L. & Greenough, A., Jul 2016, In: Pediatric Pulmonology. 51, 7, p. 717-723

    Research output: Contribution to journalArticlepeer-review

  39. RPL27A is a target of miR-595 and may contribute to the myelodysplastic phenotype through ribosomal dysgenesis

    Alkhatabi, H. A., McLornan, D. P., Kulasekararaj, A. G., Malik, F., Seidl, T., Darling, D., Gaken, J. & Mufti, G. J., 25 Jun 2016, In: Oncotarget. 7, 30, p. 47875-47890 16 p.

    Research output: Contribution to journalArticlepeer-review

  40. Reduced rate of sickle-related complications in Brazilian patients carrying HbF-promoting alleles at the BCL11A and HMIP-2 loci

    Leonardo, F. C., Brugnerotto, A. F., Domingos, I. F., Fertrin, K. Y., de Albuquerque, D. M., Bezerra, M. A. C., Araújo, A. S., Saad, S. T. O., Costa, F. F., Menzel, S., Conran, N. & Thein, S. L., May 2016, In: British Journal of Haematology. 173, 3, p. 456-460 5 p.

    Research output: Contribution to journalArticlepeer-review

  41. The investigation of resveratrol and analogs as potential inducers of fetal hemoglobin

    Theodorou, A., Phylactides, M., Forti, L., Cramarossa, M. R., Spyrou, P., Gambari, R., Thein, S. L. & Kleanthous, M., May 2016, In: Blood Cells Molecules and Diseases. 58, p. 6-12 7 p.

    Research output: Contribution to journalArticlepeer-review

  42. Parents' Experiences of Receiving the Initial Positive Newborn Screening (NBS) Result for Cystic Fibrosis and Sickle Cell Disease

    Chudleigh, J., Buckingham, S., Dignan, J., O'Driscoll, S., Johnson, K., Rees, D., Wyatt, H. & Metcalfe, A., 20 Apr 2016, (E-pub ahead of print) In: Journal of Genetic Counseling.

    Research output: Contribution to journalArticlepeer-review

  43. Genetic factors modifying sickle cell disease severity

    Gardner, K. & Thein, S. L., 30 Mar 2016, Sickle Cell Anemia: From Basic Science to Clinical Practice. Springer International Publishing Switzerland, p. 371-398 28 p.

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

  44. GATA-1 Inhibits PU.1 Gene via DNA and Histone H3K9 Methylation of Its Distal Enhancer in Erythroleukemia

    Burda, P., Vargova, J., Curik, N., Salek, C., Papadopoulos, G. L., Strouboulis, J. & Stopka, T., 24 Mar 2016, In: PLoS ONE. 11, 3, p. e0152234

    Research output: Contribution to journalArticlepeer-review

  45. Airway and alveolar nitric oxide production, lung function, and pulmonary blood flow in sickle cell disease

    Lunt, A., Ahmed, N., Rafferty, G. F., Dick, M., Rees, D., Height, S., Thein, S. L. & Greenough, A., Mar 2016, In: Pediatric Research. 79, 2, p. 313-317 5 p.

    Research output: Contribution to journalArticlepeer-review

  46. Expansion of myeloid derived suppressor cells correlates with number of T regulatory cells and disease progression in myelodysplastic syndrome

    Kittang, A. O., Kordasti, S., Sand, K. E., Costantini, B., Kramer, A. M., Perezabellan, P., Seidl, T., Rye, K. P., Hagen, K. M., Kulasekararaj, A., Bruserud, Ø. & Mufti, G. J., 28 Feb 2016, In: OncoImmunology. 5, 2, e1062208 .

    Research output: Contribution to journalArticlepeer-review

  47. SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment

    Mian, S. A., Rouault-Pierre, K., Smith, A. E., Seidl, T., Pizzitola, I., Kizilors, A., Kulasekararaj, A. G., Bonnet, D. & Mufti, G. J., 8 Dec 2015, In: Nature Communications. 6, 1, 14 p., 10004.

    Research output: Contribution to journalArticlepeer-review

  48. Survival in Sickle Cell Disease: Data from a Well-Resourced, National Health System Setting

    Gardner, K., Douiri, A., Allman, M., Drasar, E., Awogbade, M. & Thein, S. L., 3 Dec 2015, In: Blood. 126, 23

    Research output: Contribution to journalArticlepeer-review

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