Randall Centre of Cell & Molecular Biophysics

Research output

Research output per year 1974 2001 2002 2003 2004 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025

• 354620 Citations
• 2581 Article
• 157 Meeting abstract
• 108 Review article
• 87 Literature review
• 283 More
  • 70 Chapter
  • 65 Conference paper
  • 49 Editorial
  • 24 Comment/debate
  • 22 Letter
  • 13 Book
  • 11 Preprint
  • 8 Short survey
  • 6 Meeting Abstract
  • 5 Poster abstract
  • 2 Other contribution
  • 2 Patent
  • 1 Report
  • 1 Conference contribution
  • 1 Foreword/postscript
  • 1 Other chapter contribution
  • 1 Abstract
  • 1 Other

Research output per year

Research output per year

Search results

• 2024

  Aberrant myonuclear domains and impaired myofiber contractility despite marked hypertrophy in MYMK-related, Carey-Fineman-Ziter Syndrome

  Dugdale, H. F., Levy, Y., Jungbluth, H., Oldfors, A. & Ochala, J., Dec 2024, In: Acta Neuropathologica Communications. 12, 1, 80.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Muscle Contractility 100%
  • Proteomics 100%
  • Muscle 100%
  • Muscle Weakness 66%
  • Morphology 33%
  1 Citation (Scopus)

• Accelarated immune ageing is associated with COVID-19 disease severity

  on behalf of the PHOSP-COVID Study collaborative group, ISARIC4C Investigators, Abel, K., Ahmad, S., Ahmed, R., Ali, M., Allen, R. J., Almeida, P., Anderson, D., Armstrong, L., Armstrong, N., Ashworth, M., Ayoub, A., Baggott, R., Bailey, L., Baldwin, D., Ballard, C., Banerjee, A., Bates, A. & Begum, M. & 279 others, Bell, D., Bell, R., Berry, C., Bhui, K., Bramham, K., Breen, G., Brookes, C., Broome, M., Brown, A., Brown, A., Brown, J., Brown, J., Brown, J., Brown, M., Brown, M., Burns, A., Butt, A., Byrne, S., Carson, G., Carter, P., Chalder, T., CHambers, R. C., Chan, F., Chen, J., Cheng, Y., Chiribiri, A., Choudhury, N., Chowienczyk, P., Clark, D., Clark, C., Clarke, J., Cole, J., Coleman, C., Connolly, B., Connor, L., Cook, A., Cooper, B., Cooper, J., Cooper, S., Craig, T., Cross, A., David, A., Davies, E., Davies, G., Davies, G., Davies, K., Davies, M. J., Dawson, J., Donaldson, A., Dong, T., Dougherty, A., Dowling, R., Dunn, S., Edwards, S., Elliott, A., Elliott, K., Evans, D., Evans, H., Evans, J., Evans, R. I., Evans, R. I., Evans, T., Finch, J., Fisher, H., Flynn, M., Ford, A., Francis, R., Fu, X., Gill, M., Goodwin, C., Gooptu, B., Gregory, H., Gregory, R., Grieve, D., Griffiths, L., Gupta, A., Hall, L., Harris, E., Harris, V. C., Harrison, P., Hart, N., Harvey, A., Harvey, M., Hayday, A., Henderson, M., Ho, L. P., Holden, S., Holland, M., Holmes, M., Hosseini, A., Hotopf, M., Howard, L. S., Hughes, A. D., Hughes, J., Hughes, R., Husain, M., Ismail, K., Jackson, T., Jacob, J., James, W. Y., Jenkins, R. G., Johnson, C., Johnson, S., Jolley, C. J., Jones, D., Jones, G., Jones, H., Jones, H., Jones, I., Jones, L., Jones, M. G., Jones, S., Jose, S., Kaltsakas, G., Kelly, S., Kerr, S., Khan, F., King, B., Knight, S., Kon, S. S., Kon, S. S., Laing, C., Lasserson, D., Lawson, C., Lawson, C., Lee, D., Lee, J. H., Lewis, D., Lewis, J., Li, X., Lim, L., Lloyd, A., Major, E., Malim, M., Man, W. D. C., Mandal, S., Mangion, K., Marsh, S., Marshall, B., Marshall, M., Martin, J., Martinez, L. M., McMahon, M. J., Mehta, P., Miller, C., Mills, C., Mitchell, J., Mohamed, A., Mohammed, S., Morley, A., Morrow, A., Moss, A. J., Neal, A., Newby, D. E., Newman, J., Nicholson, T., Ostermann, M., Owen, J., Pariante, C., Parker, S., Patel, B., Patel, M., Patel, S., Payne, S., Pearce, L., Peng, Y., Pennington, C., Pfeffer, P., Plant, H., Plein, S., Porter, J. C., Porter, J., Powell, N., Pratt, J., Price, A., Price, C., Price, C., Price, D., Prickett, A., Quigley, J., Qureshi, I. N., Rahman, N. M., Reddy, A., Rees, M., Rees, T., Reynolds, W., Richards, A., Richardson, E., Richardson, M., Roberts, K., Robertson, E., Robinson, E., Robinson, L., Rodger, J., Ross, A., Rowe, A., Rowland, A., Rowland, J., Russell, R., Sage, E. K., Saunders, K., Saunders, R. M., Saunders, P., Scott, J. T., Shah, A., Shah, K., Shah, P., Shankar-Hari, M., Sharma, M., Sharpe, C., Shaw, A., Shaw, K., Simpson, J., Singh, C., Singh, S., Singh, S., Smith, A., Smith, D., Smith, S., Smith, J., Smith, L., Spencer, L. G., Stephenson, L., Stewart, I., Stockdale, S., Stone, R., Tan, A. L., Taylor, A., Taylor, C., Taylor, J., Terry, S., Thomas, C., Thomas, D. C., Thomas, S., Thomas, A. K., Thompson, T., Thompson, A. A. R., Tilley, J., Tomlinson, J., Turner, S., Turner, K., Wade, P., Wainwright, T., Walker, S., Walker, S., Walsh, J. A., Walsh, S., Ward, T. J. C., Watson, E., Watson, L., Watson, J., Weir McCall, J., Welch, C., Wessely, S., West, S., White, S., Whitney, J., Whittaker, S., Wild, J., Williams, B., Williams, N., Williams, N., Williams, J., Willoughby, J., Wilson, A., Wilson, D., Wilson, I., Wood, C., Woods, J., Wright, C., Wright, L., Wright, S., Xu, M., Yip, K. P., Young, B., Young, S., Young, A., Zhao, B. & Zheng, B., 11 Jan 2024, (E-pub ahead of print) In: Immunity and Ageing. 21, 1, 6.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • CD8 100%
  • T Cell 100%
  • COVID-19 100%
  • CD4 75%
  • Cytotoxic T-Cell 57%
  8 Citations (Scopus)

• Acinar-ductal cell rearrangement drives branching morphogenesis of the murine pancreas in an IGF/PI3K-dependent manner

  Darrigrand, J.-F., Salowka, A., Torres-Cano, A., Tapia-Rojo, R., Zhu, T., Garcia-Manyes, S. & Spagnoli, F. M., 5 Feb 2024, In: Developmental Cell. 59, 3, p. 326-338.E5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Growth Factor 100%
  • Drive 100%
  • Phosphoinositide 3-Kinase 100%
  • Branching Morphogenesis 100%
  • Mouse Model 50%
  3 Citations (Scopus)

• Age-specific and compartment-dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons

  Sleigh, J. N., Mattedi, F., Richter, S., Annuario, E., Ng, K., Steinmark, E., Ivanova, I., Daraban, I., Joshi, P., Rhymes, E. R., Awale, S., Yahioglu, G., Mitchell, J., Suhling, K., Schiavo, G. & Vagnoni, A., Oct 2024, In: AGING CELL. 23, 10, e14250.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Homeostasis 100%
  • Mitochondrion 100%
  • Nerve Fiber Transport 25%
  • Mitochondrial Transport 25%
  • Bioenergetics 25%
  3 Citations (Scopus)

  63 Downloads (Pure)

• AllergoOnkologie: Gefahrensignale in der Allergologie und Onkologie Ein Positionspapier der European Academy of Allergy and Clinical Immunology (EAACI)

  Translated title of the contribution: AllergoOncology: Danger signals in allergology and oncology. A European Academy of Allergy and Clinical Immunology (EAACI) Position PaperBergmann, C., Poli, A., Agache, I., Bianchini, R., Bax, H. J., Castells, M., Crescioli, S., Dombrowicz, D., Ferastraoaru, D., Fiebiger, E., Gould, H. J., Hartmann, K., Izquierdo, E., Jordakieva, G., Josephs, D. H., Jutel, M., Levi-Schaffer, F., de las Vecillas, L., Lotze, M. T. & Osborn, G. & 11 others, Pascal, M., Redegeld, F., Rosenstreich, D., Roth-Walter, F., Schmidt-Weber, C. B., Shamji, M., Steveling, E. H., Turner, M. C., Untersmayr, E., Jensen-Jarolim, E. & Karagiannis, S. N., Dec 2024, In: ALLERGOLOGIE. 47, 12, p. 771-801 31 p.

  Research output: Contribution to journal › Article › peer-review

  • Clinical Immunology 100%
  • Immune Response 100%
  • DAMPs 66%
  • Autoimmunity 33%
  • Adaptive Immune System 33%

• AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection

  Murakawa, T., Ito, J., Rusu, M.-C., Taneike, M., Omiya, S., Moncayo-Arlandi, J., Nakanishi, C., Sugihara, R., Nishida, H., Mine, K., Fleck, R., Zhang, M., Nishida, K., Shah, A. M., Yamaguchi, O., Sakata, Y. & Otsu, K., 24 Dec 2024, In: Cell Reports. 43, 12, p. 115001

  Research output: Contribution to journal › Article › peer-review

  • Heart Protection 100%
  • AMP-Activated Protein Kinase 100%
  • Mitophagy 100%
  • AMP-activated Protein Kinase 100%
  • Congestive Heart Failure 100%
  2 Citations (Scopus)

• A palmitoyl transferase chemical–genetic system to map ZDHHC-specific S-acylation

  Ocasio, C. A., Baggelaar, M. P., Sipthorp, J., Losada de la Lastra, A., Tavares, M., Volarić, J., Soudy, C., Storck, E. M., Houghton, J. W., Palma-Duran, S. A., MacRae, J. I., Tomić, G., Carr, L., Downward, J., Eggert, U. S. & Tate, E. W., Oct 2024, In: Nature Biotechnology. 42, 10, p. 1548-1558 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transferase 100%
  • Acylation 100%
  • Wild Type 25%
  • Proteome 25%
  • N-Acetyltransferase 25%
  24 Citations (Scopus)

• Autofluorescence lifetime flow cytometry rapidly flows from strength to strength

  Suhling, K., 20 Nov 2024, (Accepted/In press) In: Cytometry. Part A : the journal of the International Society for Analytical Cytology.

  Research output: Contribution to journal › Article › peer-review

• Bronchoconstriction damages airway epithelia by crowding-induced excess cell extrusion

  Bagley, D., Russell, T., Ortiz-Zapater, E., Stinson, S., Fox, K., Redd, P., Joseph, M., Deering-Rice, C., Reilly, C., Parsons, M., Brightling, C. & Rosenblatt, J., 4 Apr 2024, In: Science. 384, 6691, p. 66-73 8 p., 6691.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Airway 100%
  • Asthma 66%
  • Inflammatory Disorder 33%
  • Cell Death 33%
  • Mucus Secretion 33%
  21 Citations (Scopus)

  572 Downloads (Pure)

• Cell adhesion and migration in disease: translational and therapeutic opportunities

  Anderson, K., Calle-Patino, Y., Ivetic, A., Parsons, M., Valderrama, F., Wells, C. & Anton, I., 2024, In: Cell Adhesion and Migration. 18, 1, p. 1-3 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Diseases 100%
  • Cell Migration 100%
  • Cell Adhesion 100%
  • Research Community 100%
  • Migration Research 100%
  2 Citations (Scopus)

  148 Downloads (Pure)

• Cellular Imaging and Time-Domain FLIM Studies of Meso-Tetraphenylporphine Disulfonate as a Photosensitising Agent in 2D and 3D Models

  Balukova, A., Bokea, K., Barber, P. R., Ameer-Beg, S. M., MacRobert, A. J. & Yaghini, E., 11 Apr 2024, In: International Journal of Molecular Sciences. 25, 8, 4222.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lifespan 100%
  • Photosensitizer 100%
  • Cellular Imaging 100%
  • Reactive Oxygen Species 100%
  • Photosensitizing Agent 100%

• Characterisation and correction of polarisation effects in fluorescently labelled fibres

  Aggarwal, N., Marsh, R., Marcotti, S., Shaw, T., Stramer, B., Cox, S. & Culley, S., 29 Apr 2024, In: Journal of Microscopy.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Quantitative Technique 100%
  • Collagen Gel 100%
  1 Citation (Scopus)

• Circadian rhythms in muscle health and diseases

  Kelu, J. J., 12 Nov 2024, (Accepted/In press) In: International Review of Cell and Molecular Biology.

  Research output: Contribution to journal › Article › peer-review

  • Diseases 100%
  • Circadian Rhythm 100%
  • Metabolic Pathway 100%
  • Muscle Disease 66%
  • Maturity Onset Diabetes of the Young 33%

• Correlation of the treatment sensitivity of patient-derived organoids with treatment outcomes in patients with head and neck cancer (SOTO): protocol for a prospective observational study

  Vasiliadou, I., Cattaneo, C., Chan, P. Y. K., Henley-Smith, R., Gregson-Williams, H., Collins, L., Wojewodka, G., Guerrero-Urbano, T., Jeannon, J. P., Connor, S., Davis, J., Pasto, A., Mustapha, R., Ng, T. & Kong, A., 10 Oct 2024, In: BMJ Open. 14, 10, 084176.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Observational Study 100%
  • Head and Neck Cancer 100%
  • Organoid 100%
  • Head and Neck Squamous Cell Carcinoma 30%
  • Cancer Research 20%
  1 Citation (Scopus)

• Defining and modelling dynamic spatial heterogeneity within tumor microenvironments

  Bareham, B., Dibble, M. & Parsons, M., 8 Aug 2024, (Accepted/In press) In: Current Opinion in Cell Biology.

  Research output: Contribution to journal › Review article › peer-review

• Derivation and simulation of a computational model of active cell populations: How overlap avoidance, deformability, cell-cell junctions and cytoskeletal forces affect alignment

  Leech, V., Kenny, F. N., Marcotti, S., Shaw, T. J., Stramer, B. M. & Manhart, A., 5 Feb 2024, bioRxiv, 24 p.

  Research output: Working paper/Preprint › Preprint

  • Cell Population 100%
  • Cell Junction 100%
  • Fibroblast 50%
  • Scar Tissue 25%

• Derivation and simulation of a computational model of active cell populations: How overlap avoidance, deformability, cell-cell junctions and cytoskeletal forces affect alignment

  Leech, V., Kenny, F., Marcotti, S., Shaw, T., Stramer, B. & Manhart, A., 29 Jul 2024, In: PLoS Computational Biology. 20, 7 JULY, e1011879.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell Population 100%
  • Cell Junction 100%
  • Fibroblast 50%
  • Scar Tissue 25%
  2 Citations (Scopus)

• Development of a specific and potent IGF2BP1 inhibitor: A promising therapeutic agent for IGF2BP1-expressing cancers

  Singh, A., Singh, V., Wallis, N., Abis, G., Oberman, F., Wood, T., Dhamdhere, M., Gershon, T., Ramos, A., K. Yisraeli, J., S. Spiegelman, V. & K. Sharma, A., 5 Jan 2024, In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 263, 115940.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cancer 100%
  • Therapeutic Agent 100%
  • Cell Line 100%
  • Cell Migration 100%
  • Animal Models 100%
  10 Citations (Scopus)

• Development of widefield time-resolved fluorescence anisotropy imaging (TR-FAIM) using a single photon avalanche diode (SPAD) array

  Mogridge, L. O., Nedbal, J., Awale, S., Tallis, J., Johnston, E. J., Della Rocca, F. M., Rosser, S. J., Henderson, R. K. & Suhling, K., 12 Mar 2024, In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE.

  Research output: Contribution to journal › Conference paper

  • Avalanche Diodes 100%
  • Anisotropy 100%
  • Fluorescent Probe 20%
  • Blood Plasma 20%
  • Polarizers 20%

• Digenic inheritance involving a muscle-specific protein kinase and the giant titin protein causes a skeletal muscle myopathy

  Töpf, A., Cox, D., Zaharieva, I. T., Di Leo, V., Sarparanta, J., Jonson, P. H., Sealy, I. M., Smolnikov, A., White, R. J., Vihola, A., Savarese, M., Merteroglu, M., Wali, N., Laricchia, K. M., Venturini, C., Vroling, B., Stenton, S. L., Cummings, B. B., Harris, E. & Marini-Bettolo, C. & 65 others, Diaz-Manera, J., Henderson, M., Barresi, R., Duff, J., England, E. M., Patrick, J., Al-Husayni, S., Biancalana, V., Beggs, A. H., Bodi, I., Bommireddipalli, S., Bönnemann, C. G., Cairns, A., Chiew, M. T., Claeys, K. G., Cooper, S. T., Davis, M. R., Donkervoort, S., Erasmus, C. E., Fassad, M. R., Genetti, C. A., Grosmann, C., Jungbluth, H., Kamsteeg, E. J., Lornage, X., Löscher, W. N., Malfatti, E., Manzur, A., Martí, P., Mongini, T. E., Muelas, N., Nishikawa, A., O’Donnell-Luria, A., Ogonuki, N., O’Grady, G. L., O’Heir, E., Paquay, S., Phadke, R., Pletcher, B. A., Romero, N. B., Schouten, M., Shah, S., Smuts, I., Sznajer, Y., Tasca, G., Taylor, R. W., Tuite, A., Van den Bergh, P., VanNoy, G., Voermans, N. C., Wanschitz, J. V., Wraige, E., Yoshimura, K., Oates, E. C., Nakagawa, O., Nishino, I., Laporte, J., Vilchez, J. J., MacArthur, D. G., Sarkozy, A., Cordell, H. J., Udd, B., Busch-Nentwich, E. M., Muntoni, F. & Straub, V., Mar 2024, In: Nature Genetics. 56, 3, p. 395-407 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Skeletal Muscle 100%
  • Protein Kinase 100%
  • Titin 100%
  • Zebra fish 66%
  • Genetic Disorder 33%
  9 Citations (Scopus)

• DrugSynthMC: an atom based generation of drug-like molecules with Monte Carlo Search

  Roucairol, M., Georgiou, A., Cazenave, T., Prischi, F. & Pardo, O., 29 May 2024.

  Research output: Working paper/Preprint › Preprint

  Open Access

• DrugSynthMC: An Atom-Based Generation of Drug-like Molecules with Monte Carlo Search

  Roucairol, M., Georgiou, A., Cazenave, T., Prischi, F. & Pardo, O. E., 23 Sept 2024, In: JOURNAL OF CHEMICAL INFORMATION AND MODELING. 64, 18, p. 7097-7107 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Deep Learning Method 100%
  • Neural Network 100%
  • Chemical Structure 100%
  • De Novo Design 100%
  • Structure (Composition) 100%

• Effect of high-fat diet on isometric, concentric and eccentric contractile performance of skeletal muscle isolated from female CD-1 mice

  Tallis, J., James, R. S., Eyre, E. L. J., Shelley, S. P., Hill, C., Renshaw, D. & Hurst, J., 1 Jul 2024, In: Experimental Physiology. 109, 7, p. 1163-1176 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Isometrics 100%
  • Skeletal Muscle 100%
  • High Fat Food 100%
  • Mouse 100%
  • CD-1 Mouse 100%
  1 Citation (Scopus)

• Efficacy and safety of onasemnogene abeparvovec in children with spinal muscular atrophy type 1: real-world evidence from 6 infusion centres in the United Kingdom

  Gowda, V., Atherton, M., Murugan, A., Servais, L., Sheehan, J., Standing, E., Manzur, A., Scoto, M., Baranello, G., Munot, P., McCullagh, G., Willis, T., Tirupathi, S., Horrocks, I., Dhawan, A., Eyre, M., Vanegas, M., Fernandez-Garcia, M. A., Wolfe, A. & Pinches, L. & 17 others, Illingworth, M., Main, M., Abbott, L., Smith, H., Milton, E., D'Urso, S., Vijayakumar, K., Marco, S. S., Warner, S., Reading, E., Douglas, I., Muntoni, F., Ong, M., Majumdar, A., Hughes, I., Jungbluth, H. & Wraige, E., Feb 2024, In: The Lancet Regional Health - Europe. 37, 100817.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Werdnig Hoffmann Disease 100%
  • Onasemnogene Abeparvovec 100%
  • Platelet Function 12%
  20 Citations (Scopus)

• Energy Landscapes and Structural Ensembles of Glucagon-like Peptide-1 Monomers

  Keith, A. D., Brichtová, E. P., Barber, J. G., Wales, D. J., Jackson, S. E. & Röder, K., 13 Jun 2024, In: The journal of physical chemistry. B. 128, 23, p. 5601-5611 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Energy Landscape 100%
  • Glucagon-Like Peptide-1 100%
  • Amyloid Protein 20%
  • Circular Dichroism 20%

• Enhanced identification of small molecules binding to hnRNPA1 via cryptic pockets mapping coupled with X-Ray fragment screening

  Dunnett, L., Das, S., Venditti, V. & Prischi, F., 18 Dec 2024, In: bioRxiv : the preprint server for biology.

  Research output: Contribution to journal › Article

  • X Ray 100%
  • Small Molecule 100%
  • Ribonucleoprotein 66%
  • N-Terminus 33%
  • RNA 33%

• Enhancing Research Through Image Analysis Workshops: Experiences and Best Practices

  Marcotti, S., Jones, M. L., Slater, T. J. A. & Barry, D. J., 17 Dec 2024, In: Microscopy Research and Technique.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Best Practice 100%
  • Image Analysis 100%
  • Solution and Solubility 100%
  • Pythonidae 100%
  • Imaging Software 100%

• Enhancing Research Through Image Analysis Workshops: Experiences and Best Practices

  Marcotti, S., Jones, M. L., Slater, T. J. A. & Barry, D. J., 23 Sept 2024, Microscopy Research and Technique.

  Research output: Working paper/Preprint › Preprint

  • Best Practice 100%
  • Image Analysis 100%
  • Solution and Solubility 100%
  • Pythonidae 100%
  • Imaging Software 100%

• Excitatory and inhibitory synapses show a tight subcellular correlation that weakens over development

  Horton, S., Mastrolia, V., Jackson, R. E., Kemlo, S., Pereira Machado, P. M., Carbajal, M. A., Hindges, R., Fleck, R. A., Aguiar, P., Neves, G. & Burrone, J., 23 Jul 2024, In: Cell Reports. 43, 7, 114361.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Synapse 100%
  • Dendrite 25%
  • Electron Microscopy 25%
  • Brain Function 25%
  • Electroporation 25%
  2 Citations (Scopus)

• FRET Sensor-Modified Synthetic Hydrogels for Real-Time Monitoring of Cell-Derived Matrix Metalloproteinase Activity using Fluorescence Lifetime Imaging

  Yan, Z., Kavanagh, T., da Silva Harrabi, R., Lust, S., Tang, C., Beavil, R., Mueller, M. M., Beavil, A., Ameer-Beg, S., M. P. da Silva, R. & Gentleman, E., 22 May 2024, In: Advanced Functional Materials. 34, 21, 2309711.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lifespan 100%
  • Energy Transfer 100%
  • Matrix Metalloproteinase 100%
  • Fluorescence Lifetime 100%
  • Fluorescence Resonance Energy Transfer 100%
  8 Citations (Scopus)

  89 Downloads (Pure)

• FSHD muscle shows perturbation in fibroadipogenic progenitor cells, mitochondrial function and alternative splicing independently of inflammation

  Engquist, E. N., Greco, A., Joosten, L. A. B., van Engelen, B. G. M., Zammit, P. S. & Banerji, C. R. S., 15 Jan 2024, In: Human Molecular Genetics. 33, 2, p. 182-197 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • HMGB1 100%
  6 Citations (Scopus)

• Fusobacterium is toxic for head and neck squamous cell carcinoma and its presence may determine a better prognosis

  Chander, A., Iacovacci, J., Pellon, A., Kataria, R., Grigoriadis, A., Maher, J., Sears, C., Bachrach, G., Urbano, T. G., Lei, M., Petkar, I., Kong, A., Ng, T., Orlandi, E., Iacovelli, N. A., De Cecco, L., Serafini, M. S., Moyes, D., Rancati, T. & Ferreira, M. R., Aug 2024, In: Cancer Communications. 44, 8, p. 879-883 5 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access
  1 Citation (Scopus)

• GPR126 is a specifier of blood-brain barrier formation in the mouse central nervous system

  Kakogiannos, N., Scalise, A. A., Martini, E., Maderna, C., Benvenuto, A. F., D'Antonio, M., Carmignani, L., Magni, S., Gullotta, G. S., Lampugnani, M. G., Iannelli, F., Beznoussenko, G. V., Mironov, A. A., Cerutti, C., Bentley, K., Philippides, A., Zanardi, F., Bacigaluppi, M., Sigismund, S. & Bassani, C. & 7 others, Farina, C., Martino, G., De Giovanni, M., Dejana, E., Iannacone, M., Inverso, D. & Giannotta, M., 2024, In: Journal of Clinical Investigation. 134, 15, e165368.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • GPR126 100%
  • Blood Brain Barrier 100%
  • Blood-Brain Barrier 100%
  • Angiogenesis 66%
  • Integrin 33%

• Horizontal gene transfer-initiated reorganization of lipid metabolism drives lifestyle innovation in a eukaryote

  Rao, B., Gomez Gil, E., Peter, M., Balogh, G., Nunes, V., MacRae, J., Chen, Q., Rosenthal, P. & Oliferenko, S., 21 Aug 2024.

  Research output: Working paper/Preprint › Preprint

  Open Access

  • Lipid Metabolism 100%
  • Sterol 100%
  • Horizontal Gene Transfer 100%
  • Drive 100%
  • Eukaryote 100%

• IgE glycosylation and impact on structure and function: A systematic review

  McCraw, A. J., Palhares, L. C. G. F., Hendel, J. L., Gardner, R. A., Santaolalla, A., Crescioli, S., McDonnell, J., Van Hemelrijck, M., Chenoweth, A., Spencer, D. I. R., Wagner, G. K. & Karagiannis, S. N., 4 Aug 2024, In: Allergy. 79, 10, p. 2625-2661 37 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Immunoglobulin E 100%
  • Glycosylation 100%
  • Glycan 33%
  • Polysaccharides 30%
  • Hypersensitivity 11%
  5 Citations (Scopus)

  140 Downloads (Pure)

• Imaging actin organisation and dynamics in 3D

  Phillips, T., Marcotti, S., Cox, S. & Parsons, M., 18 Jan 2024, In: Journal of Cell Science. 137, 2

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Cell Architecture 100%
  • Time Dimension 100%
  • Three-Dimensional Environment 100%
  • Temporal Resolution 100%
  • Spatial Resolution 100%

• Imperfect wound healing sets the stage for chronic disease

  Martin, P. S., Pardo Pastor, C., Jenkins, R. G. & Rosenblatt, J., 5 Nov 2024, (Accepted/In press) In: Science.

  Research output: Contribution to journal › Review article › peer-review

  File

  • Diseases 100%
  • Wound Healing 100%
  • Chronic Disease 100%
  • Infectious Agent 16%
  • Inflammation 16%
  90 Downloads (Pure)

• Individuals and Families Affected by RYR1-Related Diseases: The Patient/Caregiver Perspective

  van de Camp, S. A. J. H., Stinissen, L., Huseth, A., Simon, B., Ryan, J., Sarkozy, A., Van Petegem, F., Goldberg, M. F., Jungbluth, H., Böhm, J., Oortwijn, W., Dirksen, R. T. & Voermans, N. C., 3 Sept 2024, In: Journal of Neuromuscular Diseases. 11, 5, p. 1067-1083 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Diseases 100%
  • RYR1 100%
  • Physical Activity 33%
  • Genetics 16%
  • Quantitative Technique 16%

• Inferring disease course from differential exon usage in the wide titinopathy spectrum

  Di Feo, M. F., Oghabian, A., Nippala, E., Gautel, M., Jungbluth, H., Forzano, F., Malfatti, E., Castiglioni, C., Krey, I., Gomez Andres, D., Brady, A. F., Iascone, M., Cereda, A., Pezzani, L., Natera De Benito, D., Nascimiento Osorio, A., Estévez Arias, B., Kurbatov, S. A., Attie-Bitach, T. & Nampoothiri, S. & 15 others, Ryan, E., Morrow, M., Gorokhova, S., Chabrol, B., Sinisalo, J., Tolppanen, H., Tolva, J., Munell, F., Camacho Soriano, J., Sanchez Duran, M. A., Johari, M., Tajsharghi, H., Hackman, P., Udd, B. & Savarese, M., Oct 2024, In: Annals of Clinical and Translational Neurology. 11, 10, p. 2745-2755 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Disease Course 100%
  • Exon 100%
  • Titin 50%
  • RNA Sequence 33%
  • Skeletal Muscle 33%
  2 Citations (Scopus)

• Injectable PEG Hydrogels with Tissue‐Like Viscoelasticity Formed through Reversible Alendronate–Calcium Phosphate Crosslinking for Cell–Material Interactions

  Yu, H., Yan, Z., Dreiss, C. A., Gaitano, G. G., Jarvis, J. A., Gentleman, E., Da silva, R. M. P. & Grigoriadis, A. E., 1 Sept 2024, In: Advanced Healthcare Materials. 13, 22, 2400472.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Polyethylene Glycol 100%
  • Hydrogel 100%
  • Viscoelasticity 100%
  • Stress Relaxation 33%
  • Elastic Moduli 16%
  3 Citations (Scopus)

• Integrating Porous Silicon Nanoneedles within Medical Devices for Nucleic Acid Nanoinjection

  Wang, C., Gu, C., Popp, C., Vashisth, P., Mustfa, S. A., Martella, D. A., Spiteri, C., McLennan, S., Sun, N., Riddle, M., Eide, C. R., Parsons, M., Tolar, J., McGrath, J. A. & Chiappini, C., 11 Jun 2024, In: ACS Nano. 18, 23, p. 14938-14953 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nanoneedles 100%
  • Hydrogel 14%
  • Elastomer 14%
  11 Citations (Scopus)

• Investigating the role connective tissue fibroblasts play in the altered muscle anatomy associated with the limb abnormality, Radial Dysplasia

  Murphy, G. R. F., Feneck, E., Paget, J., Sivakumar, B., Smith, G. & Logan, M. P. O., Aug 2024, In: Journal of Anatomy. 245, 2, p. 217-230 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dysplasia 100%
  • Limb 100%
  • Connective Tissue 100%
  • Fibroblast 100%
  • Upper Limb 28%

• King’s College London Centre for Biomolecular Spectroscopy (CBS) Symposium. 7 June 2024, London, UK

  Prischi, F., Jarvis, J. & Conte, M. R., 18 Oct 2024, p. 45. 1 p.

  Research output: Contribution to conference types › Other

  Open Access

• Lessons Learned From Clinical Studies in Centronuclear Myopathies: The Patient Perspective—A Qualitative Study

  Stinissen, L., Böhm, J., Bouma, S., van Tienen, J., Fischer, H., Hughes, Z., Lennox, A., Ward, E., Wood, M., Foley, A. R., Oortwijn, W., Jungbluth, H. & Voermans, N. C., Oct 2024, In: Clinical Therapeutics. 46, 10, p. 742-751 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Clinical Study 100%
  • Centronuclear Myopathy 100%
  • Muscle Disorder 100%
  • Clinical Trial 66%
  • Gene Delivery 50%
  1 Citation (Scopus)

• Microtubule association induces a Mg-free apo-like ADP pre-release conformation in kinesin-1 that is unaffected by its autoinhibitory tail

  Atherton, J., Chegkazi, M., Peirano, E., Pozzer, L., Foran, T. & Steiner, R., 11 Nov 2024, (Accepted/In press).

  Research output: Working paper/Preprint › Preprint

• Mitosis: An expanded view of mitotic mechanisms that arose in evolution

  Gu, Y. & Oliferenko, S., 5 Aug 2024, In: Current Biology. 34, 15, p. R741-R744

  Research output: Contribution to journal › Comment/debate › peer-review

  • Mitosis Spindle 100%
  • Nuclear Membrane 100%
  • Nuclear Division 100%
  • Nuclear Pore 100%
  • Eukaryotic Cell 100%

• Multimodal bioimaging across disciplines and scales: challenges, opportunities and breaking down barriers

  Bischof, J., Fletcher, G., Verkade, P., Kuntner, C., Fernandez-Rodriguez, J., Chaabane, L., Rose, L. A., Walter, A., Vandenbosch, M., van Zandvoort, M. A. M. J., Zaritsky, A., Keppler, A. & Parsons, M., 1 Mar 2024, In: npj Imaging.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

• Muscle fibre size and myonuclear positioning in trained and aged humans

  Battey, E., Levy, Y., Pollock, R., Pugh, J., Close, G. L., Kalakoutis, M., Lazarus, N. R., Harridge, S., Ochala, J. & Stroud, M., 5 Feb 2024, (Accepted/In press) In: Experimental Physiology.

  Research output: Contribution to journal › Article › peer-review

• Myopathic manifestations across the adult lifespan of patients with malignant hyperthermia susceptibility: a narrative review

  Ibarra Moreno, C. A., Silva, H. C. A., Voermans, N. C., Jungbluth, H., van den Bersselaar, L. R., Rendu, J., Cieniewicz, A., Hopkins, P. M. & Riazi, S., Oct 2024, In: British Journal of Anaesthesia. 133, 4, p. 759-767 9 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Lifespan 100%
  • Malignant Hyperthermia 100%
  • Myopathy 30%
  • Muscle Disorder 30%
  • Awareness 10%
  1 Citation (Scopus)

• N4BP1 functions as a dimerization-dependent linear ubiquitin reader which regulates TNF signalling

  Kliza, K. W., Song, W., Pinzuti, I., Schaubeck, S., Kunzelmann, S., Kuntin, D., Fornili, A., Pandini, A., Hofmann, K., Garnett, J. A., Stieglitz, B. & Husnjak, K., 20 Apr 2024, In: Cell Death Discovery. 10, 1, 183.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Binding Protein 100%
  • Dimerization 100%
  • NEDD4 100%
  • Tumor Necrosis Factor 100%
  • Synapsin I 100%
  3 Citations (Scopus)