Vascular Biology & Inflammation

Projects

Projects per year 1996 2002 2008 2009 2010 2011 2012 2013 2016 2023

• 276 Finished

Projects per year

Search results

• Finished

  Sulforaphane improves maternal glucose handling in obese insulin-resistant pregnancy; consequences for uterine blood flow, placental function and offspring metabolism

  Chapple, S. (Primary Investigator) & Nandi, M. (Co-Investigator)

  BHF British Heart Foundation

  1/03/2020 → 28/02/2023

  Project: Research

  • Cardiovascular Physiology 100%
  • Nuclear Factor 100%
  • Sulforaphane 100%
  • Prothrombin 100%
  • Offspring 100%

• Characterisation of RASA3 interaction with integrin andcytoskeletal protein in platelets

  Brain, S. (Co-Investigator) & Authi, K. (Primary Investigator)

  BHF British Heart Foundation

  20/01/2020 → 19/09/2023

  Project: Research

• The role of LOC105 in endothelial cell dysfunction in diabetes mellitus

  Zampetaki, A. (Primary Investigator), Shah, A. (Co-Investigator) & Mann, G. (Co-Investigator)

  BHF British Heart Foundation

  1/12/2019 → 30/11/2022

  Project: Research

• Identifying a therapeutic window for sulforaphane to improve glucose handling during pregnancy

  Chapple, S. (Primary Investigator)

  Royal Society

  15/10/2019 → 14/10/2021

  Project: Research

• ARK Research & Innovation Manager

  Siow, R. (Primary Investigator)

  Biogerontology Research Foundation

  1/10/2019 → 30/09/2022

  Project: Research

• Elucidating the protective potential of calcitonin gene-related peptide (CGRP) in cardiovascular disease

  Brain, S. (Primary Investigator)

  BHF British Heart Foundation

  1/10/2019 → 30/06/2023

  Project: Research

• Investigating the vascular response to a cold probe: a study of mechanisms in cardiovascular health & disease

  Brain, S. (Primary Investigator) & Gnudi, L. (Co-Investigator)

  BHF British Heart Foundation

  1/10/2019 → 30/09/2022

  Project: Research

• REMIT-DCM study: Reverse rEmodelling Markers in the serial evaluation of recenT-onset Dilated CardioMyopathy

  Mayr, M. (Primary Investigator)

  National Heart and Lung Institute Foundation

  1/09/2019 → 31/08/2022

  Project: Research

• Neurovascular protection afforded by stabilised sulforaphane in a murine model of ischaemic stroke: a role for Nrf2-regulated redox signalling in the blood-brain barrier endothelium

  Mann, G. (Primary Investigator) & Williams, S. (Co-Investigator)

  BHF British Heart Foundation

  1/08/2019 → 31/07/2022

  Project: Research

• Microvascular dysfunction and inflammation in brain ageing

  Siow, R. (Primary Investigator) & Aarsland, D. (Co-Investigator)

  Stavanger University Hospital

  1/03/2019 → 28/02/2022

  Project: Research

• Metallomic profiling and redox signalling in human coronary artery endothelial and smooth muscle cells in physiological normoxia and ischaemia/reperfusion injury

  Mann, G. (Primary Investigator), Maret, W. (Co-Investigator), Chapple, S. (Co-Investigator) & Stewart, T. (Co-Investigator)

  Heart Research UK

  2/02/2019 → 28/09/2021

  Project: Research

• Netrin-1 and macrophage phenotype: role in the pathophysiology of atherosclerosis

  Ferro, A. (Primary Investigator) & Floyd, C. (Co-Investigator)

  BHF British Heart Foundation

  1/02/2019 → 31/01/2022

  Project: Research

• Nogo-B and unfolded protein response: a protective role in diabetic glomerulopathy?

  Gnudi, L. (Primary Investigator)

  Kidney Research UK

  1/06/2018 → 31/05/2021

  Project: Research

• UK-Israel Ageing Conferences - Precision Medicine and BIRAX

  Siow, R. (Primary Investigator)

  British Council

  1/03/2018 → 31/12/2018

  Project: Research

• Activation of Nrf2 antioxidant defences by sulforaphane confers vascular protection in offspring exposed to a maternal obesogenic diet

  Chapple, S. (Primary Investigator), Mann, G. (Co-Investigator) & Taylor, P. (Co-Investigator)

  BHF British Heart Foundation

  2/01/2018 → 1/01/2021

  Project: Research

• TRPA1- inflammasome signalling in temporomandibular joint inflammatory pain

  Brain, S. (Primary Investigator)

  Arthritis Research UK

  4/09/2017 → 3/09/2019

  Project: Research

• Transient Receptor Potential Canonical 5 (TRPC5), a missing link in osteoarthritic pain and inflammation

  Brain, S. (Primary Investigator) & Williams, F. (Co-Investigator)

  Arthritis Research UK

  1/07/2017 → 31/12/2020

  Project: Research

• The influence of TRPA1signalling on the response to cold exposure as ageing occurs

  Brain, S. (Primary Investigator) & Andersson, D. (Co-Investigator)

  BBSRC Biotechnology and Biological Sciences Research Council

  1/06/2017 → 31/07/2020

  Project: Research

• The role of Inositol (1,4,5)trisphosphate receptor 2 ( IP3R2) in platelet function, thrombus formation and vascular permeability

  Authi, K. (Primary Investigator), Fraser, P. (Co-Investigator) & Mann, G. (Co-Investigator)

  1/02/2017 → 31/01/2019

  Project: Research

• AMPK-mediated vascular protection in human endothelial cells under physiological shear stress and oxygen levels

  Mann, G. (Primary Investigator)

  9/01/2017 → 8/01/2020

  Project: Research

• The Role of Kidney Resident Macrophages and circulation monocytes in diabetic Nephropathy

  Sacks, S. (Primary Investigator), Gnudi, L. (Co-Investigator) & Guermonprez, P. (Co-Investigator)

  1/01/2017 → 1/01/2020

  Project: Research

• Role of soluble Nogo-B in diabetic nephropathy: a protective role for the endothelium

  Gnudi, L. (Primary Investigator) & Mann, G. (Co-Investigator)

  BHF British Heart Foundation

  1/11/2016 → 31/10/2019

  Project: Research

• Sulforaphane induced activation of Nrf2 signalling in a murine model of obesogenic gestational diabetes: potential therapy for reducing risk of cardiometabolic disease in mothers and offspring

  Chapple, S. (Primary Investigator), Mann, G. (Co-Investigator) & Taylor, P. (Co-Investigator)

  18/10/2016 → 17/10/2018

  Project: Research

• Defining the role of Mitochondrial DNA mediated pathways of cellular damage in the development and progression of diabetic nephropathy

  Malik, A. (Primary Investigator), Gnudi, L. (Co-Investigator) & King, A. (Co-Investigator)

  1/10/2016 → 30/09/2019

  Project: Research

• Determining a role for TRPC5 in cholestasis associated cardiovascular dysfunction

  Brain, S. (Primary Investigator) & Williamson, C. (Co-Investigator)

  1/10/2016 → 30/09/2019

  Project: Research

• Nrf2-regulated redox signalling in brain endothelial cells adapted to physiological oxygen levels: consequences for ischaemia-reperfusion injury and protection by sulforaphane

  Mann, G. (Primary Investigator) & Fraser, P. (Co-Investigator)

  BHF British Heart Foundation

  1/10/2016 → 20/11/2019

  Project: Research

• Modulation of ER-mitochondria coupling by Nogo-B in diabetic glomerulopathy: a protective role?

  Gnudi, L. (Primary Investigator)

  1/09/2016 → 31/08/2019

  Project: Research

• Sulforaphane induced activation of Nrf2 signalling in a murine model of obesogenic

  Chapple, S. (Primary Investigator), Mann, G. (Co-Investigator) & Taylor, P. (Co-Investigator)

  1/08/2016 → 31/07/2019

  Project: Research

  • Cardiovascular Physiology 100%
  • Nuclear Factor 100%
  • Sulforaphane 100%
  • Prothrombin 100%
  • Offspring 100%

• The renoprotective effects of Ursodeoxycholic acid in patients with type 1 diabetes and macroalbuminuria

  Karalliedde, J. (Primary Investigator), Ayis, S. (Co-Investigator), Chowienczyk, P. (Co-Investigator), Cornelius, V. (Co-Investigator), Gnudi, L. (Co-Investigator) & Gulliford, M. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/07/2016 → 31/05/2021

  Project: Research

• Elucidation of Mitochondrial DNA mediated pathways of cellular damage indiabetic nephropathy

  Malik, A. (Primary Investigator) & Gnudi, L. (Co-Investigator)

  1/06/2016 → 31/05/2019

  Project: Research

• LONBAR - Role of Nogo-B in Renal Collecting Duct

  Gnudi, L. (Primary Investigator)

  1/06/2016 → 31/05/2018

  Project: Research

• SPARK-2D - Surrogate markers for Personalized Assessment of Risk for Kidney Disease in Diabetes

  Gnudi, L. (Primary Investigator)

  1/05/2016 → 30/04/2021

  Project: Research

• Role of Nogo-B in Podocytes

  Gnudi, L. (Primary Investigator)

  1/05/2016 → 30/04/2017

  Project: Research

• The role of inositol (1,4,5) trisphosphate receptor 2 in platelet function, thrombus formation and vascular permeability

  Authi, K. (Primary Investigator), Fraser, P. (Co-Investigator) & Mann, G. (Co-Investigator)

  1/05/2016 → 1/04/2018

  Project: Research

• The source, functionality and impact of increased circulating mitochondrial DNA in diabetes and diabetic nephropathy

  Malik, A. (Primary Investigator), Gnudi, L. (Co-Investigator) & Jones, P. (Co-Investigator)

  1/03/2016 → 1/03/2017

  Project: Research

• Elucidating the protective potential of calcitonin gene- related peptide (CGRP) at different sites in cardiovascular disease

  Brain, S. (Primary Investigator) & Aubdool, A. (Co-Investigator)

  1/02/2016 → 31/01/2019

  Project: Research

• The role of nitric oxide/cyclic GMP/ β-catenin signalling in endothelial cell survival in the vasculature

  Ferro, A. (Primary Investigator) & academic, A. (Co-Investigator)

  BHF British Heart Foundation

  1/02/2016 → 31/01/2018

  Project: Research

• The mechanisms involved in the local and systemic influence of TRP channels that act as vascular cold sensor

  Brain, S. (Primary Investigator) & Andersson, D. (Co-Investigator)

  1/01/2016 → 31/12/2018

  Project: Research

• MICA: Development and Characterization of Intracellular Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine

  Brain, S. (Primary Investigator)

  1/03/2015 → 28/02/2018

  Project: Research

• Therapeutic potential of sulforaphane in protection against blood-brain barrier breakdown and inflammation in experimental stroke

  Mann, G. (Primary Investigator) & Fraser, P. (Co-Investigator)

  BHF British Heart Foundation

  2/02/2015 → 5/02/2018

  Project: Research

• A proof of concept study to evaluate the effectiveness of laser therapy as a treatment for non-healing diabetic foot ulcers

  Maltese, G. (Primary Investigator), Gnudi, L. (Co-Investigator) & Karalliedde, J. (Co-Investigator)

  1/01/2015 → 31/12/2015

  Project: Research

• Nogo-B in diabetic glomerulopathy: novel target for treatment?

  Gnudi, L. (Primary Investigator)

  Diabetes Research & Wellness Foundation

  1/01/2015 → 31/12/2015

  Project: Research

• The renoprotective effects of Ursodeoxycholic acid in patients with type 1 diabetes and macroalbuminuria

  Karalliedde, J. (Primary Investigator) & Gnudi, L. (Co-Investigator)

  1/01/2015 → 31/12/2016

  Project: Research

• Effects of hyperglycaemia on fluid shear stress responses in human endothelial cells dysregulation of cellular redox and nitric oxide signalling

  Siow, R. (Primary Investigator) & Mann, G. (Co-Investigator)

  Unilever UK Central Resources Ltd

  1/10/2014 → 30/09/2018

  Project: Research

  • Glycocalyx 100%
  • Transcription Factor Nrf2 100%
  • Shear Stress 100%
  • Sialidase 18%
  • Neuraminidase 18%

• Investigating the role of TRPA1 and sensory nerves interaction with the cutaneous vasculature and keratinocytes in a skin inflammation model

  Brain, S. (Primary Investigator)

  British Pharmacological Society

  1/10/2014 → 30/09/2016

  Project: Research

• Interaction between microvascular endothelial cells dermal fibroblasts and stem cells in skin ageing dysregulation of cellular redox signalling

  Siow, R. (Primary Investigator) & Watt, F. (Co-Investigator)

  Unilever UK Central Resources Ltd

  1/10/2014 → 30/09/2018

  Project: Research

  • Fibroblast 100%
  • Insulin-Like Growth Factor 1 100%
  • Somatomedin C 100%
  • Fibrinogen 25%
  • Cancer Growth Factor 25%

• The organisation of plasma membrane STIM1 and Orai1 in human platelets and their role in thrombus formation.

  Authi, K. (Primary Investigator) & Mann, G. (Co-Investigator)

  1/10/2014 → 1/09/2017

  Project: Research

• Redox signalling in brain endothelial cells adapted to physiological oxygen levels: implications for Nrf2 mediated neurovascular protection in stroke

  Mann, G. (Primary Investigator)

  1/09/2014 → 30/08/2017

  Project: Research

• Cardiovascular effects of a novel treatment for obstructive sleep apnoea

  Moxham, J. (Primary Investigator) & Ferro, A. (Co-Investigator)

  1/09/2014 → 1/09/2016

  Project: Research

• Role of Nogo-B in diabetic glomerulopathy: a potential novel target for treatment

  Gnudi, L. (Primary Investigator)

  1/09/2014 → 1/09/2016

  Project: Research