Research output per year
Research output per year
Organisation profile
Organisation profile
Introduction
The Wolfson Sensory, Pain and Regeneration Centre (SPaRC) is an academic department embedded within the School of Neuroscience of the Institute of Psychiatry, Psychology and Neuroscience (IoPPN). The department is led by Professors Susan Duty and Elizabeth Bradbury.
Research in the Wolfson Sensory, Pain and Regeneration Centre (SPaRC) focuses on the molecular basis of pain and hearing loss, and on neural repair and regeneration following disease and injury. Our fundamental mission is to understand the biological mechanisms behind these neurological and sensory disorders and harness this knowledge to develop new therapeutic strategies. To achieve these goals, we conduct cutting-edge translational neuroscience research in a positive, inclusive, and collaborative environment.
A core strength of the Wolfson SPaRC is the parallel use of pre-clinical cell and in vivo models, alongside human cellular models, which provides an essential platform for us to forward- and back-translate our fundamental research to and from the clinic. Additional strengths lie in our world-leading expertise in neuroplasticity, interdisciplinary neuro-immune research, high-throughput sequencing technologies, drug discovery and advanced therapeutics.
Our research spans the following areas:
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Collaborations and top research areas from the last five years
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Profiles
Research output
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Advances in migraine prevention
Martinelli, D., De Icco, R., Al-Khazali, H. M., Ashina, S., Diener, H. C., Dodd-Glover, F., Goicochea, M. T., Jenkins, B., MaassenVanDenBrink, A., Lee, M. J., Özge, A., Peres, M. F. P., Pozo-Rosich, P., Puledda, F., Sacco, S., Schwedt, T., Terwindt, G. M. & Tassorelli, C., Mar 2026, In: The Lancet Neurology. 25, 3, p. 279-293 15 p.Research output: Contribution to journal › Review article › peer-review
3 Citations (Scopus) -
ADVANTAGE: Advanced discovery of visceral analgesics by neuroimmune targets and the genetics of extreme human phenotype, a study protocol
Alban-Paccha, M. V., Shenker, N., Teran-Perez, J., Horne, A. W., Malliaras, G., Woods, C. G., ADVANTAGE Consortium, C., Williams, A., Hughes, A., Andersson, D., Denk, F., Horne, A., Saunders, P., Tsanas, A., Malliaras, G., Nik-Zainal, S., Chinnery, P., Shenker, N., Woods, G. & St John Smith, E., 21 May 2026, In: PLoS ONE. 21, 5, e0350169.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
AhR inhibition promotes axon regeneration via a stress–growth switch
Halawani, D., Wang, Y., Li, J., Halperin, D., Ni, H., Estill, M., Ramakrishnan, A., Shen, L., Sefiani, A., Geoffroy, C. G., Friedel, R. H. & Zou, H., 1 Apr 2026, (E-pub ahead of print) In: Nature.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)8 Downloads (Pure)
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Age- and sex-dependent extracellular matrix dynamics as determinants of spinal cord injury outcome
Geoffroy, C. (Primary Investigator)
IRP International Foundation for Research in Paraplegia
1/05/2026 → 30/04/2028
Project: Research
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Reversing Deafness: Repairing the Cochlear Battery to Restore Hearing
Steel, K. (Primary Investigator), Ingham, N. (Co-Investigator) & Pyott, S. (Co-Investigator)
1/04/2026 → 1/04/2027
Project: Research
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Migraine Neuro-immune interactions Endometriosis
Denk, F. (Primary Investigator)
1/04/2026 → 31/03/2029
Project: Research
Activities
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Unpicking the genetics of fibromyalgia sheds new light on its causes
Andersson, D. (Reviewer)
24 Oct 2025Activity: Other › Types of Public engagement and outreach - Media article or participation
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Painkillers without the addiction? The new wave of non-opioid pain relief
Andersson, D. (Reviewer)
5 Apr 2025Activity: Other › Types of Public engagement and outreach - Media article or participation
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DrA_Says, Tiktok (3M views) based on interview
Andersson, D. (Reviewer)
10 Dec 2024Activity: Other › Types of Public engagement and outreach - Media article or participation
Student theses
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A Microfluidic Approach to Investigate Changes in Functional Properties of Nociceptive Axons Underlying Inflammatory Pain States
Rangwani, N. (Author), McNaughton, P. (Supervisor) & Raouf, R. (Supervisor), 2018Student thesis: Doctoral Thesis › Doctor of Philosophy
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An Investigation into the Relationships between Synaptic Biochemistry, Clinical Symptoms and Pathology in the Lewy body dementias and Alzheimer’s disease.
Whitfield, D. (Author), Francis, P. T. (Supervisor), Hortobagyi, T. (Supervisor) & Aarsland, D. (Supervisor), 2014Student thesis: Doctoral Thesis › Doctor of Philosophy
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An Investigation of Pain Mechanisms in Humans Using Psychophysics
Cummins, T. (Author), Andreou, A. (Supervisor) & McMahon, S. (Supervisor), 1 Jun 2023Student thesis: Doctoral Thesis › Doctor of Philosophy
File
Prizes
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Best poster abstract on CRPS at the IASP World Congress on pain.
Cuhadar, U. (Recipient) & Andersson, D. (Recipient), 15 Sept 2018
Prize: Prize (including medals and awards)
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BNA Outstanding Contribution to Neuroscience
McMahon, S. (Recipient), 2019
Prize: Prize (including medals and awards)
Datasets
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Spinal Cord fMRI Segmentation Database (Multi-subject)
Barry, R., Tinnermann, A., Buechel, C., Haaker, J., Kowalczyk, O., Medina, S., Tsivaka, D., McMahon, S., Williams, S., Brooks, J., Lythgoe, D., Howard, M., Dabbagh, A., Horn, U., Kaptan, M., Torald Mildner, Eippert, F., Hemmerling, K. J., Hoggarth, M. A., Parrish, T. B., Bright, M. G., Weber, K., Yufen Chen, Dhaher, Y., Smith, Z., Fauziyya Muhammad, Haynes, G., Smith, Z., Law, C., Pfyffer, D., Glover, G., Mackey, S., Martucci, K. T., Mobarak-Abadi, M., Khatibi, A., Shahabeddin Vahdat, Lungu, O., Juergen Finsterbusch, J. Cohen-Adad, Marchand-Pauvert, V., Doyon, J., Schading, S., David, G., Freund, P., Kuending, C., Kinany, N. & Van De Ville, D., OpenNeuro, 17 Jun 2024
DOI: 10.18112/openneuro.ds005143.v1.2.0
Dataset
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The spectrum of neurodevelopmental, neuromuscular and neurodegenerative disorders due to defective autophagy
Deneubourg, C., Ramm, M., Smith, L. J., Baron, O., Singh, K., Byrne, S. C., Duchen, M. R., Gautel, M., Eskelinen, E.-L., Fanto, M. & Jungbluth, H., Taylor & Francis, 19 Oct 2021
DOI: 10.6084/m9.figshare.14790043
Dataset
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Additional file 7: of Whole exome sequencing in adult-onset hearing loss reveals a high load of predicted pathogenic variants in known deafness-associated genes and identifies new candidate genes
Lewis, M., Nolan, L., Cadge, B., Matthews, L., Schulte, B., Dubno, J., Steel, K. & Dawson, S., figshare, 2018
DOI: 10.6084/m9.figshare.7047275
Dataset