Research output per year
Research output per year
Personal profile
Research interests
The main aim of my research is to explain why some people are more prone to anxiety than others with a view to explaining the causes, and improve the treatment of, anxiety and depression-related illnesses. To do this I follow several research strategies that are based around the theory orginated by Jeffrey Gray that the anxiety-prone personality is caused by high sensitivity to threat/punishment. My research strategies include measuring the effects of anti-anxiety drugs on the intensity of threat-avoidance behaviour in humans, studying neural activity during the same behaviour pattern, as well as evaluating associations between personality questionnaire scores and patterning of human defensive behaviour.
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Collaborations and top research areas from the last five years
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Flight behaviour in humans is intensified by a candidate genetic risk factor for panic disorder: evidence from a translational model of fear and anxiety
Perkins, A., Ettinger, U., Williams, S. C. R., Reuter, M., Hennig, J. & Corr, P. J., Mar 2011, In: Molecular Psychiatry. 16, 3, p. 242 - 244 3 p.Research output: Contribution to journal › Letter › peer-review
14 Citations (Scopus) -
Effects of Lorazepam and Citalopram on Human Defensive Reactions: Ethopharmacological Differentiation of Fear and Anxiety
Perkins, A., Ettinger, U., Davis, R., Foster, R., Williams, S. C. R. & Corr, P. J., 7 Oct 2009, In: Journal of Neuroscience. 29, 40, p. 12617 - 12624 8 p.Research output: Contribution to journal › Article › peer-review
52 Citations (Scopus) -
A Facial Expression for Anxiety
Perkins, A. M., Inchley-Mort, S. L., Pickering, A. D., Corr, P. J. & Burgess, A. P., May 2012, In: Journal of Personality and Social Psychology. 102, 5, p. 910-924 15 p.Research output: Contribution to journal › Article › peer-review
53 Citations (Scopus) -
A Dose of Ruthlessness: Interpersonal Moral Judgment Is Hardened by the Anti-Anxiety Drug Lorazepam
Perkins, A., Leonard, A. M., Weaver, K., Dalton, J. A., Mehta, M. A., Kumari, V., Williams, S. C. R. & Ettinger, U., 2012, (E-pub ahead of print) In: Journal of Experimental Psychology: General.Research output: Contribution to journal › Article › peer-review
39 Citations (Scopus) -
Advancing the defensive explanation for anxiety disorders: lorazepam effects on human defense are systematically modulated by personality and threat-type
Perkins, A. M., Ettinger, U., Weaver, K., Schmechtig, A., Schrantee, A., Morrison, P., Sapara, A., Kumari, V., Williams, S. C. R. & Corr, P. J., 2013, In: Translational psychiatry. 3, e246.Research output: Contribution to journal › Article › peer-review
22 Citations (Scopus)
Projects
- 10 Finished
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The neural basis of treatment response in anxiety and depression
Cleare, A. (Primary Investigator), Perkins, A. (Co-Investigator), Rebollo-Mesa, I. (Co-Investigator) & academic, A. (Co-Investigator)
1/10/2014 → 30/09/2016
Project: Research
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The neural basis of treatment-resistance in anxiety and depression
Perkins, A. (Primary Investigator), Arnone, D. (Co-Investigator), Cleare, A. (Co-Investigator), Williams, S. (Co-Investigator) & academic, A. (Co-Investigator)
1/07/2014 → 30/06/2015
Project: Research
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Manetic resonance imaging neuroanatomic machine learning algorithms to aid phenotypical differentiation in unipolar depression and bipolar disorder: towards the development of MRI based biomarkers for affective disorders - the MIDAS study
Arnone, D. (Primary Investigator), Cleare, A. (Co-Investigator), Marquand, A. (Co-Investigator) & Perkins, A. (Co-Investigator)
15/01/2014 → 14/01/2016
Project: Research
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Pharmacological and neural investigation of anxiety and threat using a Joystick Operated Runway Task
Cleare, A. (Primary Investigator), Arnone, D. (Co-Investigator), Perkins, A. (Co-Investigator) & Williams, S. (Co-Investigator)
15/01/2014 → 14/01/2016
Project: Research
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Neuroimaging treatment-resistance in depression
Perkins, A. (Primary Investigator), Cleare, A. (Co-Investigator) & Williams, S. (Co-Investigator)
1/11/2013 → 31/10/2016
Project: Research