King's College London

Research portal

Professor Adil Mardinoglu

  1. Genome-Scale Metabolic Modeling of Glioblastoma Reveals Promising Targets for Drug Development

    Larsson, I., Uhlén, M., Zhang, C. & Mardinoglu, A., 17 Apr 2020, In : Frontiers in Genetics. 11, 381.

    Research output: Contribution to journalArticle

  2. An adipocyte-specific defect in oxidative phosphorylation increases systemic energy expenditure and protects against diet-induced obesity in mouse models

    Choi, M. J., Jung, S. B., Lee, S. E., Kang, S. G., Lee, J. H., Ryu, M. J., Chung, H. K., Chang, J. Y., Kim, Y. K., Hong, H. J., Kim, H., Kim, H. J., Lee, C. H., Mardinoglu, A., Yi, H. S. & Shong, M., 1 Apr 2020, In : Diabetologia. 63, 4, p. 837-852 16 p.

    Research output: Contribution to journalArticle

  3. An atlas of human metabolism

    Robinson, J. L., Kocabaş, P., Wang, H., Cholley, P. E., Cook, D., Nilsson, A., Anton, M., Ferreira, R., Domenzain, I., Billa, V., Limeta, A., Hedin, A., Gustafsson, J., Kerkhoven, E. J., Svensson, L. T., Palsson, B. O., Mardinoglu, A., Hansson, L., Uhlén, M. & Nielsen, J., 24 Mar 2020, In : Science Signaling. 13, 624

    Research output: Contribution to journalArticle

  4. MEMOTE for standardized genome-scale metabolic model testing

    Lieven, C., Beber, M. E., Olivier, B. G., Bergmann, F. T., Ataman, M., Babaei, P., Bartell, J. A., Blank, L. M., Chauhan, S., Correia, K., Diener, C., Dräger, A., Ebert, B. E., Edirisinghe, J. N., Faria, J. P., Feist, A. M., Fengos, G., Fleming, R. M. T., García-Jiménez, B., Hatzimanikatis, V. & 49 others, van Helvoirt, W., Henry, C. S., Hermjakob, H., Herrgård, M. J., Kaafarani, A., Kim, H. U., King, Z., Klamt, S., Klipp, E., Koehorst, J. J., König, M., Lakshmanan, M., Lee, D. Y., Lee, S. Y., Lee, S., Lewis, N. E., Liu, F., Ma, H., Machado, D., Mahadevan, R., Maia, P., Mardinoglu, A., Medlock, G. L., Monk, J. M., Nielsen, J., Nielsen, L. K., Nogales, J., Nookaew, I., Palsson, B. O., Papin, J. A., Patil, K. R., Poolman, M., Price, N. D., Resendis-Antonio, O., Richelle, A., Rocha, I., Sánchez, B. J., Schaap, P. J., Malik Sheriff, R. S., Shoaie, S., Sonnenschein, N., Teusink, B., Vilaça, P., Vik, J. O., Wodke, J. A. H., Xavier, J. C., Yuan, Q., Zakhartsev, M. & Zhang, C., 1 Mar 2020, In : Nature Biotechnology. 38, 3, p. 272-276 5 p.

    Research output: Contribution to journalLetter

  5. Classification of clear cell renal cell carcinoma based on PKM alternative splicing

    Li, X., Turanli, B., Juszczak, K., Kim, W., Arif, M., Sato, Y., Ogawa, S., Turkez, H., Nielsen, J., Boren, J., Uhlen, M., Zhang, C. & Mardinoglu, A., Feb 2020, In : Heliyon. 6, 2, e03440.

    Research output: Contribution to journalArticle

  6. Boosting Natural Killer Cell-Mediated Targeting of Sarcoma Through DNAM-1 and NKG2D

    Sayitoglu, E. C., Georgoudaki, A. M., Chrobok, M., Ozkazanc, D., Josey, B. J., Arif, M., Kusser, K., Hartman, M., Chinn, T. M., Potens, R., Pamukcu, C., Krueger, R., Zhang, C., Mardinoglu, A., Alici, E., Temple, H. T., Sutlu, T. & Duru, A. D., 28 Jan 2020, In : Frontiers in Immunology. 11, 40.

    Research output: Contribution to journalArticle

  7. Novel anti-Alzheimer phenol-lipoyl hybrids: Synthesis, physico-chemical characterization, and biological evaluation

    Pagoni, A., Marinelli, L., Di Stefano, A., Ciulla, M., Turkez, H., Mardinoglu, A., Vassiliou, S. & Cacciatore, I., 15 Jan 2020, In : EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 186, 111880.

    Research output: Contribution to journalArticle

  8. Accepted/In press

    Improvement in the Current Therapies for Hepatocellular Carcinoma Using a Systems Medicine Approach

    Ozcan, M., Altay, O., Lam, S., Turkez, H., Aksoy, Y., Nielsen, J., Uhlen, M., Boren, J. & Mardinoglu, A., 1 Jan 2020, (Accepted/In press) In : Advanced Biosystems.

    Research output: Contribution to journalReview article

  9. Accepted/In press

    Neuroprotective effects of boron nitride nanoparticles in the experimental Parkinson’s disease model against MPP+ induced apoptosis

    Küçükdoğru, R., Türkez, H., Arslan, M. E., Tozlu, Ö. Ö., Sönmez, E., Mardinoğlu, A., Cacciatore, I. & Di Stefano, A., 1 Jan 2020, (Accepted/In press) In : Metabolic Brain Disease.

    Research output: Contribution to journalArticle

  10. Nonpharmacological treatment options for alzheimer’s disease: From animal testing to clinical studies

    Türkez, H., Arslan, M. E., Di Stefano, A., Cacciatore, I. & Mardinoğlu, A., 1 Jan 2020, In : Turkish Journal of Zoology. 44, 2, p. 81-89 9 p.

    Research output: Contribution to journalReview article

  11. The in vitro cytotoxic, genotoxic, and oxidative damage potentials of the oral artificial sweetener aspartame on cultured human blood cells

    Çadirci, K., Özdemır Tozlu, Ö., Türkez, H. & Mardınoğlu, A., 1 Jan 2020, In : Turkish Journal of Medical Sciences. 50, 2, p. 448-454 7 p.

    Research output: Contribution to journalArticle

  12. A genome-wide transcriptomic analysis of protein-coding genes in human blood cells

    Uhlen, M., Karlsson, M. J., Zhong, W., Tebani, A., Pou, C., Mikes, J., Lakshmikanth, T., Forsström, B., Edfors, F., Odeberg, J., Mardinoglu, A., Zhang, C., von Feilitzen, K., Mulder, J., Sjöstedt, E., Hober, A., Oksvold, P., Zwahlen, M., Ponten, F., Lindskog, C. & 3 others, Sivertsson, Å., Fagerberg, L. & Brodin, P., 20 Dec 2019, In : Science. 366, 6472, eaax9198.

    Research output: Contribution to journalArticle

  13. Systems biology perspective for studying the gut microbiota in human physiology and liver diseases

    Altay, O., Nielsen, J., Uhlen, M., Boren, J. & Mardinoglu, A., 1 Nov 2019, In : EBioMedicine. 49, p. 364-373 10 p.

    Research output: Contribution to journalReview article

  14. LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer

    Cadenas, C., Vosbeck, S., Edlund, K., Grgas, K., Madjar, K., Hellwig, B., Adawy, A., Glotzbach, A., Stewart, J. D., Lesjak, M. S., Franckenstein, D., Claus, M., Hayen, H., Schriewer, A., Gianmoena, K., Thaler, S., Schmidt, M., Micke, P., Pontén, F., Mardinoglu, A. & 7 others, Zhang, C., Käfferlein, H. U., Watzl, C., Frank, S., Rahnenführer, J., Marchan, R. & Hengstler, J. G., 15 Aug 2019, In : International Journal of Cancer. 145, 4, p. 901-915 15 p.

    Research output: Contribution to journalArticle

  15. Elucidating the Reprograming of Colorectal Cancer Metabolism Using Genome-Scale Metabolic Modeling

    Zhang, C., Aldrees, M., Arif, M., Li, X., Mardinoglu, A. & Aziz, M. A., 30 Jul 2019, In : Frontiers in oncology. 9, 681.

    Research output: Contribution to journalArticle

  16. The Potential Use of Metabolic Cofactors in Treatment of NAFLD

    Mardinoglu, A., Ural, D., Zeybel, M., Yuksel, H. H., Uhlén, M. & Borén, J., 12 Jul 2019, In : Nutrients. 11, 7, 1578.

    Research output: Contribution to journalReview article

  17. Plasma Proteomics Analysis Reveals Dysregulation of Complement Proteins and Inflammation in Acquired Obesity—A Study on Rare BMI-Discordant Monozygotic Twin Pairs

    Sahebekhtiari, N., Saraswat, M., Joenväärä, S., Jokinen, R., Lovric, A., Kaye, S., Mardinoglu, A., Rissanen, A., Kaprio, J., Renkonen, R. & Pietiläinen, K. H., 1 Jul 2019, In : Proteomics - Clinical Applications. 13, 4, p. 1-29 29 p., 1800173.

    Research output: Contribution to journalArticle

  18. Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes

    Harms, M. J., Li, Q., Lee, S., Zhang, C., Kull, B., Hallen, S., Thorell, A., Alexandersson, I., Hagberg, C. E., Peng, X-R., Mardinoglu, A., Spalding, K. L. & Boucher, J., 2 Apr 2019, In : Cell Reports. 27, 1, p. 213-225

    Research output: Contribution to journalArticle

  19. Discovery of therapeutic agents for prostate cancer using genome-scale metabolic modeling and drug repositioning

    Turanli, B., Zhang, C., Kim, W., Benfeitas, R., Uhlen, M., Arga, K. Y. & Mardinoglu, A., 1 Apr 2019, In : EBioMedicine. 42, p. 386-396 11 p.

    Research output: Contribution to journalArticle

  20. Expression of PD-L1 and PD-1 in Chemoradiotherapy-Naïve Esophageal and Gastric Adenocarcinoma: Relationship With Mismatch Repair Status and Survival

    Svensson, M. C., Borg, D., Zhang, C., Hedner, C., Nodin, B., Uhlén, M., Mardinoglu, A., Leandersson, K. & Jirström, K., 13 Mar 2019, In : Frontiers in oncology. 9, MAR, p. 136 136.

    Research output: Contribution to journalArticle

  21. Pyruvate kinase L/R is a regulator of lipid metabolism and mitochondrial function

    Liu, Z., Zhang, C., Lee, S., Kim, W., Klevstig, M., Harzandi, A. M., Sikanic, N., Arif, M., Ståhlman, M., Nielsen, J., Uhlen, M., Boren, J. & Mardinoglu, A., 1 Mar 2019, In : METABOLIC ENGINEERING. 52, p. 263-272 10 p.

    Research output: Contribution to journalArticle

  22. Discovery of KIRREL as a biomarker for prognostic stratification of patients with thin melanoma

    Lundgren, S., Fagerstrom-Vahman, H., Zhang, C., Ben-Dror, L., Mardinoglu, A., Uhlen, M., Nodin, B. & Jirstrom, K., 14 Jan 2019, In : BIOMARKER RESEARCH. 7, 1, 1.

    Research output: Contribution to journalArticle

  23. Multi-omic data interpretation to repurpose subtype specific drug candidates for breast cancer

    Turanli, B., Karagoz, K., Bidkhori, G., Sinha, R., Gatza, M. L., Uhlen, M., Mardinoglu, A. & Arga, K. Y., 1 Jan 2019, In : Frontiers in Genetics. 10, MAY, 420.

    Research output: Contribution to journalArticle

  24. Systems biology based drug repositioning for development of cancer therapy

    Turanli, B., Altay, O., Borén, J., Turkez, H., Nielsen, J., Uhlen, M., Arga, K. Y. & Mardinoglu, A., 1 Jan 2019, In : Seminars in Cancer Biology.

    Research output: Contribution to journalReview article

  25. Characterization of heterogeneous redox responses in hepatocellular carcinoma patients using network analysis

    Benfeitas, R., Bidkhori, G., Mukhopadhyay, B., Klevstig, M., Arif, M., Zhang, C., Lee, S., Cinar, R., Nielsen, J., Uhlen, M., Boren, J., Kunos, G. & Mardinoglu, A., 31 Dec 2018, In : EBioMedicine.

    Research output: Contribution to journalArticle

  26. Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor subtypes

    Bidkhori, G., Benfeitas, R., Klevstig, M., Zhang, C., Nielsen, J., Uhlen, M., Boren, J. & Mardinoglu, A., 11 Dec 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 50, p. E11874-E11883

    Research output: Contribution to journalArticle

  27. Vimentin deficiency in macrophages induces increased oxidative stress and vascular inflammation but attenuates atherosclerosis in mice

    Håversen, L., Sundelin, J. P., Mardinoglu, A., Rutberg, M., Ståhlman, M., Wilhelmsson, U., Hultén, L. M., Pekny, M., Fogelstrand, P., Bentzon, J. F., Levin, M. & Borén, J., 1 Dec 2018, In : Scientific Reports. 8, 1, 16973.

    Research output: Contribution to journalArticle

  28. High Cell Density Perfusion Culture has a Maintained Exoproteome and Metabolome

    Zamani, L., Lundqvist, M., Zhang, Y., Aberg, M., Edfors, F., Bidkhori, G., Lindahl, A., Mie, A., Mardinoglu, A., Field, R., Turner, R., Rockberg, J. & Chotteau, V., Oct 2018, In : Biotechnology Journal. 13, 10, 1800036.

    Research output: Contribution to journalArticle

  29. Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome

    Lovric, A., Graner, M., Bjornson, E., Arif, M., Benfeitas, R., Nyman, K., Stahlman, M., Pentikainen, M. O., Lundborn, J., Hakkarainen, A., Siren, R., Nieminen, M. S., Lundborns, N., Lauermas, K., Taskinen, M-R., Mardinoglu, A. & Boren, J., 21 Sep 2018, In : Scientific Reports. 8, 14200 .

    Research output: Contribution to journalArticle

  30. Meta-analysis of adiponectin as a biomarker for the detection of metabolic syndrome

    Liu, Z., Liang, S., Que, S., Zhou, L., Zheng, S. & Mardinoglu, A., 19 Sep 2018, In : Frontiers in Physiology. 9, SEP, 1238.

    Research output: Contribution to journalReview article

  31. Metabolic Network-Based Identification and Prioritization of Anticancer Targets Based on Expression Data in Hepatocellular Carcinoma

    Bidkhori, G., Benfeitas, R., Elmas, E., Kararoudi, M. N., Arif, M., Uhlen, M., Nielsen, J. & Mardinoglu, A., 17 Jul 2018, In : Frontiers in Physiology. 9

    Research output: Contribution to journalArticle

  32. Systems biology in hepatology: approaches and applications

    Mardinoglu, A., Boren, J., Smith, U., Uhlen, M. & Nielsen, J., Jun 2018, In : Nature Reviews Gastroenterology & Hepatology. 15, 6, p. 365-377

    Research output: Contribution to journalReview article

  33. Drug Repositioning for Effective Prostate Cancer Treatment

    Turanli, B., Grotli, M., Boren, J., Nielsen, J., Uhlen, M., Arga, K. Y. & Mardinoglu, A., 15 May 2018, In : Frontiers in Physiology. 9

    Research output: Contribution to journalReview article

  34. Transcriptome profiling of the interconnection of pathways involved in malignant transformation and response to hypoxia

    Danielsson, F., Fasterius, E., Sullivan, D., Hases, L., Sanli, K., Zhang, C., Mardinoglu, A., Al-Khalili, C., Huss, M., Uhlén, M., Williams, C. & Lundberg, E., 13 Apr 2018, In : Oncotarget. 9, 28, p. 19730-19744 15 p.

    Research output: Contribution to journalArticle

  35. Combined ASRGL1 and p53 immunohistochemistry as an independent predictor of survival in endometrioid endometrial carcinoma

    Huvila, J., Laajala, T. D., Edqvist, P-H., Mardinoglu, A., Talve, L., Ponten, F., Grénman, S., Carpen, O., Aittokallio, T. & Auranen, A., Apr 2018, In : Gynecologic Oncology. 149, 1, p. 173-180

    Research output: Contribution to journalArticle

  36. An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans

    Mardinoglu, A., Wu, H., Bjornson, E., Zhang, C., Hakkarainen, A., Rasanen, S. M., Lee, S., Mancina, R. M., Bergentall, M., Pietilainen, K. H., Soderlund, S., Matikainen, N., Stahlman, M., Bergh, P-O., Adiels, M., Piening, B. D., Graner, M., Lundbom, N., Williams, K. J., Romeo, S. & 9 others, Nielsen, J., Snyder, M., Uhlen, M., Bergstrom, G., Perkins, R., Marschall, H-U., Backhed, F., Taskinen, M-R. & Boren, J., 6 Mar 2018, In : CELL METABOLISM. 27, 3, p. 559-571.e5

    Research output: Contribution to journalArticle

  37. Integrative Personal Omics Profiles during Periods of Weight Gain and Loss

    Piening, B. D., Zhou, W., Contrepois, K., Rost, H., Urban, G. J. G., Mishra, T., Hanson, B. M., Bautista, E. J., Leopold, S., Yeh, C. Y., Spakowicz, D., Banerjee, I., Chen, C., Kukurba, K., Perelman, D., Craig, C., Colbert, E., Salins, D., Rego, S., Lee, S. & 14 others, Zhang, C., Wheeler, J., Sailani, M. R., Liang, L., Abbott, C., Gerstein, M., Mardinoglu, A., Smith, U., Rubin, D. L., Pitteri, S., Sodergren, E., McLaughlin, T. L., Weinstock, G. M. & Snyder, M. P., 28 Feb 2018, In : Cell Systems. 6, 2, p. 157-170.e8

    Research output: Contribution to journalArticle

  38. Identification of Discriminating Metabolic Pathways and Metabolites in Human PBMCs Stimulated by Various Pathogenic Agents

    Zhang, X., Mardinoglu, A., Joosten, L. A. B., Kuivenhoven, J. A., Li, Y., Netea, M. G. & Groen, A. K., 27 Feb 2018, In : Frontiers in Physiology. 9

    Research output: Contribution to journalArticle

  39. Associations of PD-1 and PD-L1 expression with mismatch repair status and prognosis in chemoradiotherapy-naive esophageal and gastric adenocarcinoma.

    Svensson, M., Borg, D., Zhang, C., Hedner, C., Nodin, B., Uhlen, M., Mardinoglu, A., Leandersson, K. & Jirstrom, K., 1 Feb 2018, In : Journal of Clinical Oncology. 36, 4

    Research output: Contribution to journalMeeting Abstract

  40. Broad Views of Non-alcoholic Fatty Liver Disease

    Mardinoglu, A., Uhlen, M. & Boren, J., 24 Jan 2018, In : Cell Systems. 6, 1, p. 7-9

    Research output: Contribution to journalEditorial

  41. TCSBN: a database of tissue and cancer specific biological networks

    Lee, S., Zhang, C., Arif, M., Liu, Z., Benfeitas, R., Bidkhori, G., Deshmukh, S., Al Shobky, M., Lovric, A., Boren, J., Nielsen, J., Uhlen, M. & Mardinoglu, A., 4 Jan 2018, In : Nucleic Acids Research. 46, D1, p. D595-D600

    Research output: Contribution to journalArticle

  42. A Network-Based Cancer Drug Discovery: From Integrated Multi-Omics Approaches to Precision Medicine

    Turanli, B., Karagoz, K., Gulfidan, G., Sinha, R., Mardinoglu, A. & Arga, K. Y., 1 Jan 2018, In : Current Pharmaceutical Design. 24, 32, p. 3778-3790 13 p.

    Research output: Contribution to journalArticle

  43. Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes

    Mardinoglu, A., Gogg, S., Lotta, L. A., Stancakova, A., Nerstedt, A., Boren, J., Blueher, M., Ferrannini, E., Langenberg, C., Wareham, N. J., Laakso, M. & Smith, U., Jan 2018, In : EBioMedicine. 27, p. 151-155

    Research output: Contribution to journalArticle

  44. Translational study reveals a two-faced role of RBM3 in pancreatic cancer and suggests its potential value as a biomarker for improved patient stratification

    Karnevi, E., Dror, L. B., Mardinoglu, A., Elebro, J., Heby, M., Olofsson, S. E., Nodin, B., Eberhard, J., Gallagher, W., Uhlén, M. & Jirström, K., 10 Dec 2017, In : Oncotarget. 9, 5, p. 6188-6200 13 p.

    Research output: Contribution to journalArticle

  45. Improving the economics of NASH/NAFLD treatment through the use of systems biology

    Bosley, J., Boren, C., Lee, S., Grotli, M., Nielsen, J., Uhlen, M., Boren, J. & Mardinoglu, A., Oct 2017, In : DRUG DISCOVERY TODAY. 22, 10, p. 1532-1538

    Research output: Contribution to journalReview article

  46. Rediscussion on Linearity Between Fibrosis Stages and Mortality Risk in Nonalcoholic Fatty Liver Disease Patients

    Liu, Z., Que, S. & Mardinoglu, A., Oct 2017, In : Hepatology. 66, 4, p. 1357-1358

    Research output: Contribution to journalLetter

  47. Principles of Systems Biology, No. 21

    Cao, J., Packer, J., Waterston, R., Trapnell, C., Shendure, J., Rajaram, S., Wu, L. F., Altschuler, S. J., Liang, J., O'Brien, L. E., Eizenberg-Magar, I., Rimer, J., Friedman, N., Metzl-Raz, E., Kafri, M., Yaakov, G., Soifer, I., Gurvich, Y., Barkai, N., Mardinoglu, A. & 6 others, Ponten, F., Uhlen, M., Rahi, S. J., Cross, F. R., Baumgart, M. & Noack, S., 27 Sep 2017, In : Cell Systems. 5, 3, p. 158-160

    Research output: Contribution to journalEditorial

  48. The effect of the TM6SF2 E167K variant on liver steatosis and fibrosis in patients with chronic hepatitis C: a meta-analysis

    Liu, Z., Que, S., Zhou, L., Zheng, S., Romeo, S., Mardinoglu, A. & Valenti, L., 24 Aug 2017, In : Scientific Reports. 7, 9273.

    Research output: Contribution to journalArticle

Previous 1 2 Next

Export:RIS BibTex Word PDF - will at most contain 500 items

Search within the list

Refine results

Language

Language

Publication year

Publication year

Full text

Full text

Meeting and poster abstracts

Meeting and poster abstracts

Authors

Authors

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454