King's College London

Research portal

Professor Agamemnon Grigoriadis

  1. Sarcoma treatment in the era of molecular medicine

    Grünewald, T. G. P., Alonso, M., Avnet, S., Banito, A., Burdach, S., Cidre-Aranaz, F., Di Pompo, G., Distel, M., Dorado-Garcia, H., Garcia-Castro, J., González-González, L., Grigoriadis, A. E., Kasan, M., Koelsche, C., Krumbholz, M., Lecanda, F., Lemma, S., Longo, D. L., Madrigal-Esquivel, C., Morales-Molina, Á. & 22 others, Musa, J., Ohmura, S., Ory, B., Pereira-Silva, M., Perut, F., Rodriguez, R., Seeling, C., Al Shaaili, N., Shaabani, S., Shiavone, K., Sinha, S., Tomazou, E. M., Trautmann, M., Vela, M., Versleijen-Jonkers, Y. M. H., Visgauss, J., Zalacain, M., Schober, S. J., Lissat, A., English, W. R., Baldini, N. & Heymann, D., 6 Nov 2020, In: EMBO Molecular Medicine. 12, 11, e11131.

    Research output: Contribution to journalReview articlepeer-review

  2. Bone, Stem Cells and Regeneration: Tissue Engineering Approaches

    Yu, H. & Grigoriadis, A., 27 May 2020, In: The Encyclopedia of Life Sciences.

    Research output: Contribution to journalReview articlepeer-review

  3. In Vivo Targets of Pasteurella Multocida Toxin

    Banu, A., Lax, A. J. & Grigoriadis, A. E., 15 Apr 2020, In: International Journal of Molecular Sciences. 21, 8, p. 2739-2750 2739.

    Research output: Contribution to journalArticlepeer-review

  4. Induction of neural crest stem cells from Bardet-Biedl Syndrome patient derived hiPSCs

    Barrell, W. B., Griffin, J. N., Harvey, J-L., HipSci Consortium, Danovi, D., Beales, P., Grigoriadis, A. & Liu, K. J., 21 Jun 2019, In: Frontiers in Molecular Neuroscience. 12, 139.

    Research output: Contribution to journalArticlepeer-review

  5. Hypoxia impacts human MSC response to substrate stiffness during chondrogenic differentiation

    Foyt, D. A., Taheem, D. K., Ferreira, S. A., Norman, M. D. A., Petzold, J., Jell, G., Grigoriadis, A. E. & Gentleman, E., 15 Apr 2019, In: Acta Biomaterialia. 89, p. 73-83 11 p.

    Research output: Contribution to journalArticlepeer-review

  6. The osteogenic potential of the neural crest lineage may contribute to craniosynostosis

    Doro, D., Liu, A., Grigoriadis, A. E. & Liu, K. J., 1 Feb 2019, In: Molecular syndromology. 10, 1-2, p. 48-57 10 p.

    Research output: Contribution to journalReview articlepeer-review

  7. Murine models of bone sarcomas

    Jacques, C., Renema, N., Ory, B., Walkley, C. R., Grigoriadis, A. E. & Heymann, D., 1 Jan 2019, Methods in Molecular Biology. Humana Press Inc, Vol. 1914. p. 331-342 12 p. (Methods in Molecular Biology; vol. 1914).

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

  8. Binding Immunoglobulin Protein (BiP) Inhibits TNFα-Induced Osteoclast Differentiation and Systemic Bone Loss in an Erosive Arthritis Model: BiP inhibits osteoclasts in an arthritis model

    Zaiss, M. M., Hall, C., McGowan, N. WA., Babb, R., Devlia, V., Lucas, S., Meghji, S., Henderson, B., Bozec, A., Schett, G., David, J-P., Panayi, G. S., Grigoriadis, A. E. & Corrigall, V., 2019, In: ACR Open Rheumatology.

    Research output: Contribution to journalArticlepeer-review

  9. Bi-directional cell-pericellular matrix interactions direct stem cell fate

    Ferreira, S. A., Motwani, M. S., Faull, P. A., Seymour, A. J., Yu, T., Enayati, M., Taheem, D. K., Kania, E. M., Oommen, O. P., Ahmed, T., Loaiza, S., Parzych, K., Dazzi, F., Auner, H. W., Varghese, O. P., Festy, F., Grigoriadis, A. E., Snijders, A. P., Bozec, L. & Gentleman, E. D., 3 Oct 2018, In: Nature Communications. 9, 1, 12 p., 4049.

    Research output: Contribution to journalArticlepeer-review

  10. Differential regulation of human bone marrow mesenchymal stromal cell chondrogenesis by Hypoxia Inducible Factor-1α hydroxylase inhibitors

    Taheem, D. K., Foyt, D., Loaiza, S., Ferreira, S. A., Ilic, D., Auner, H. W., Grigoriadis, A. E., Jell, G. & Gentleman, E. D., 30 Sep 2018, In: Stem Cells. 36, 9, p. 1380-1392 13 p.

    Research output: Contribution to journalArticlepeer-review

  11. Recurrent rearrangements of FOS and FOSB define osteoblastoma

    Fittall, M., Mifsud, W., Pillay, N., Ye, H., Strobl, AC., Zhang, L., Berisha, F., Verfaillie, A., Demeulemeester, J., Tarabichi, M., Young, MD., Miranda, E., Tarpey, PS., Tirabosco, R., Amary, F., Grigoriadis, A. E., Stratton, MR., Van Loo, P., Antonescu, CR., Campbell, PJ. & 2 others, Flanagan, AM. & Behjati, S., 3 Jun 2018, In: Nature Communications. 9, 2150 .

    Research output: Contribution to journalArticlepeer-review

  12. Small animal models for the study of bone sarcoma pathogenesis: characteristics, therapeutic interests and limitations

    Jacques, C., Renema, N., Lezot, F., Ory, B., Walkley, C. R., Grigoriadis, A. E. & Heymann, D., 2018, In: J Bone Oncol.

    Research output: Contribution to journalReview article

  13. Calvarial suture-derived stem cells and their contribution to cranial bone repair

    Doro, D. H., Grigoriadis, A. E. & Liu, K. J., 27 Nov 2017, In: Frontiers in Physiology. 8, NOV, p. 1-16

    Research output: Contribution to journalBook/Film/Article reviewpeer-review

  14. Utility of VS38c in the Diagnostic and Prognostic Assessment of Osteosarcoma and Other Bone Tumours/Tumour-Like Lesions.

    Hookway, E., Orosz, Z., Uchihara, Y., Grigoriadis, A. E., Hassan, AB., Opermann, U. & Athanasou, N., 2017, In: Clin Sarcoma Res.

    Research output: Contribution to journalArticlepeer-review

  15. Matrix-Gla Protein Promotes Osteosarcoma Lung Metastasis and Associates with Poor Prognosis

    Zandueta, C., Ormazabal, C., Perurena, N., Martinez-Canarias, S., Zalacain, M., San Julian, M., Grigoriadis, A. E., Valencia, K., Campos-Laborie, F. J., De Las Rivas, J., Vicent, S., Patino-Garcia, A. & Lecanda, F., 22 Jul 2016, In: Journal of Pathology. 239, 4, p. 438-449

    Research output: Contribution to journalArticlepeer-review

  16. Regulation of osteosarcoma cell lung metastasis by the c-Fos/AP-1 target FGFR1

    Weekes, D., Kashima, T., Zandueta, C., Perurena, N., Thomas, D. P., Sunters, A., Vuillier, C., Bozec, A., El-Emir, E., Miletich, I., Patiño-Garcia, A., Lecanda, F. & Grigoriadis, A. E., 2 Jun 2016, In: Oncogene. 35, 22, p. 2852-2861

    Research output: Contribution to journalArticlepeer-review

  17. Small Molecule Inhibition of Transforming Growth Factor Beta Signaling Enables the Endogenous Regenerative Potential of the Mammalian Calvarium

    Senarath-Yapa, K., Li, S., Walmsley, G. G., Zielins, E., Paik, K., Britto, J. A., Grigoriadis, A. E., Wan, D. C., Liu, K. J., Longaker, M. T. & Quarto, N., 1 May 2016, In: Tissue Engineering Part A. 22, 9-10, p. 707-720 14 p.

    Research output: Contribution to journalArticlepeer-review

  18. Root and Eruption Defects in c-Fos Mice Are Driven by Loss of Osteoclasts.

    Alfaqeeh, S. A. A., Oralová, V., Foxworthy, M., Matalova, E., Grigoriadis, A. E. & Tucker, A. S., 2015, In: Journal of Dental Research. 94

    Research output: Contribution to journalArticlepeer-review

  19. A novel model of dormancy for bone metastatic breast cancer cells

    Marlow, R., Honeth, G., Lombardi, S., Cariati, M., Hessey, S. M., Pipili, A., Mariotti, V., Buchupalli, B., Foster, K., Bonnet, D., Grigoriadis, A., Purushotham, A., Tutt, A. & Dontu, G., Dec 2013, In: Cancer Research. 73, 23, p. 6886-6899 14 p.

    Research output: Contribution to journalArticlepeer-review

  20. Specification of chondrocytes and cartilage tissues from embryonic stem cells

    Craft, A. M., Ahmed, N., Rockel, J. S., Baht, G. S., Alman, B. A., Kandel, R. A., Grigoriadis, A. E. & Keller, G. M., 15 Jun 2013, In: Development. 140, 12, p. 2597-2610 14 p.

    Research output: Contribution to journalArticlepeer-review

  21. A specific role for phosphoinositide 3-kinase and AKT in osteoblasts?

    McGonnell, I. M., Grigoriadis, A. E., Lam, E. W. F., Price, J. S. & Sunters, A., 20 Jul 2012, In: Frontiers in Endocrinology . 3, JUL, 8 p., Article 88.

    Research output: Contribution to journalArticlepeer-review

  22. Podoplanin Is Regulated by AP-1 and Promotes Platelet Aggregation and Cell Migration in Osteosarcoma

    Kunita, A., Kashima, T. G., Ohazama, A., Grigoriadis, A. E. & Fukayama, M., Aug 2011, In: American Journal of Pathology. 179, 2, p. 1041 - 1049 9 p.

    Research output: Contribution to journalArticlepeer-review

  23. Stable knockdown of S100A4 suppresses cell migration and metastasis of osteosarcoma

    Fujiwara, M., Kashima, T. G., Kunita, A., Kii, I., Komura, D., Grigoriadis, A. E., Kudo, A., Aburatani, H. & Fukayama, M., Jun 2011, In: Tumour Biology. 32, 3, p. 611 - 622 12 p.

    Research output: Contribution to journalArticlepeer-review

  24. Mesenchymal differentiation propensity of a human embryonic stem cell line

    Pringle, S., De Bari, C., Dell'Accio, F., Przyborski, S., Cooke, M. J., Minger, S. L. & Grigoriadis, A. E., Apr 2011, In: Cell Proliferation. 44, 2, p. 120 - 127 8 p.

    Research output: Contribution to journalArticlepeer-review

  25. Dlx Homeobox Gene Family Expression in Osteoclasts

    Lezot, F., Thomas, B. L., Blin-Wakkach, C., Castaneda, B., Bolanos, A., Hotton, D., Sharpe, P. T., Heymann, D., Carles, G. F., Grigoriadis, A. E. & Berdal, A., Jun 2010, In: Journal of Cellular Physiology. 223, 3, p. 779 - 787 9 p.

    Research output: Contribution to journalArticlepeer-review

  26. Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells

    Grigoriadis, A. E., Kennedy, M., Bozec, A., Brunton, F., Stenbeck, G., Park, I-H., Wagner, E. F. & Keller, G. M., 8 Apr 2010, In: Blood. 115, 14, p. 2769 - 2776 8 p.

    Research output: Contribution to journalArticlepeer-review

  27. Periostin, a novel marker of intramembranous ossification, is expressed in fibrous dysplasia and in c-Fos-overexpressing bone lesions

    Kashimaa, T. G., Nishiyama, T., Shimau, K., Shimazaki, M., Kii, I., Grigoriadis, A. E., Fukayama, M. & Kudo, A., Feb 2009, In: Human Pathology. 40, 2, p. 226 - 237 12 p.

    Research output: Contribution to journalArticlepeer-review

  28. Directed differentiation of human embryonic stem cells and induced pluripotent stem cells to functional osteoclasts

    Grigoriadis, A. E., Kennedy, M., Bozec, A., Stenbeck, G., Wagner, E. F. & Keller, G., 2009, In: Bone. 44, 2, p. S216 - S216

    Research output: Contribution to journalMeeting abstract

  29. Role of Nbr1 in bone remodeling

    Whitehouse, C. A., Waters, S., Grigoriadis, A. E., Marchbank, K., McGowan, N., Skerry, T., Sharpe, P. T. & Solomon, E., 2009, In: Bone. 44, 2, p. S296 - S296

    Research output: Contribution to journalMeeting abstract

  30. A role for GATA-6 in vertebrate chondrogenesis

    Alexandrovich, A., Qureishi, A., Coudert, A., Zhang, L., Grigoriadis, A., Shah, A. M., Brewer, A. C. & Pizzey, J. A., 15 Feb 2008, In: Developmental Biology. 314, 2, p. 457 - 470 14 p.

    Research output: Contribution to journalArticlepeer-review

  31. Changes in RANKL/OPG/RANK gene expression in peripheral mononuclear cells following treatment with estrogen or raloxifene

    Bashir, A., Mak, Y. T., Sankaralingam, S., Cheung, J., McGowan, N. W., Grigoriadis, A. E., Fogelman, I. & Hampson, G., 1 Dec 2005, In: Steroids. 70, 13, p. 847 - 855 9 p.

    Research output: Contribution to journalArticlepeer-review

  32. Effect of TNF-alpha on murine osteoclast differentiation

    Zhao, Y. M., Ge, L. H. & Grigoriadis, A. E., 18 Aug 2005, In: BEIJING DA XUE XUE BAO. YI XUE BAN = JOURNAL OF PEKING UNIVERSITY. HEALTH SCIENCES. 37, 4, p. 433 - 435 3 p.

    Research output: Contribution to journalArticlepeer-review

  33. Bacterial toxins and bone remodelling

    McGowan, N. AG., Harmey, D., Coxon, F. P., Stenbeck, G., Rogers, M. J. & Grigoriadis, A. E., 2005, Bacterial protein toxins : role in the interference with cell-growth regulation. Lax, A. (ed.). New York: Cambridge University Press, p. 147 - 169 23 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  34. Regulation of osteoblast differentiation by Pasteurella multocida toxin (PMT): A role for Rho GTPase in bone formation

    Harmey, D., Stenbeck, G., Nobes, C. D., Lax, A. J. & Grigoriadis, A. E., Apr 2004, In: Journal of Bone and Mineral Research. 19, 4, p. 661 - 670 10 p.

    Research output: Contribution to journalArticlepeer-review

  35. The Pasteurella multocida toxin interacts with signalling pathways to perturb cell growth and differentiation

    Lax, A. J., Pullinger, G. D., Baldwin, M. R., Harmey, D., Grigoriadis, A. E. & Lakey, J. H., Apr 2004, In: International Journal of Medical Microbiology. 293, 7-8, p. 505 - 512 8 p.

    Research output: Contribution to journalArticlepeer-review

  36. Accelerated cell cycle progression in osteoblasts overexpressing the c-fos proto-oncogene - Induction of cyclin A and enhanced CDK2 activity

    Sunters, A., Thomas, D. P., Yeudall, W. A. & Grigoriadis, A. E., 12 Mar 2004, In: Journal of Biological Chemistry. 279, 11, p. 9882 - 9891 10 p.

    Research output: Contribution to journalArticlepeer-review

  37. Nbr1 mutant mice exhibit age dependent increases in bone volume and mass

    Whitehouse, C., Horner, A., Stewart, A., Cobourne, M., McGowan, N., Burford, J., Grigoriadis, A., Sharpe, P., Skerry, T. & Solomon, E., 2004, In: Bone. 34, p. S15 - S16

    Research output: Contribution to journalMeeting abstract

  38. RANKL/OPG/RANK gene expression in peripheral mononuclear cells following treatment with estrogen or raloxifene: Potential role in post-menopausal osteoporosis

    Bashir, A., Mak, Y. T., Sankaralingam, S., Cheung, J., Seed, P. T., McGowan, N. W. A., Grigoriadis, A. E., Fogelman, I. & Hampson, G., 2004, In: Journal of Bone and Mineral Research. 19, 6, p. 1033 - 1033 1 p.

    Research output: Contribution to journalMeeting abstract

  39. The effect of overexpression of c-Fos on osteoclast differentiation

    Zhao, Y., Ge, L. H. & Grigoriadis, A., 2004, In: Journal of Dental Research. 83, SpIss B

    Research output: Contribution to journalMeeting abstract

  40. Overexpression of cadherins suppresses pulmonary metastasis of osteosarcoma in vivo

    Kashima, T., Nakamura, K., Kawaguchi, J., Takanashi, M., Ishida, T., Aburatani, H., Kudo, A., Fukayama, M. & Grigoriadis, A. E., 20 Mar 2003, In: International Journal of Cancer. 104, 2, p. 147 - 154 8 p.

    Research output: Contribution to journalArticlepeer-review

  41. C-fos blocks cartilage differentiation in vitro by inhibiting the effects of bone morphogenetic protein (BMP)-2 and-4

    Anagnostopoulos, I., Thomas, D. P. & Grigoriadis, A. E., 2003, In: Journal of Bone and Mineral Research. 18, 7, p. 1363 - 1363 1 p.

    Research output: Contribution to journalMeeting abstract

  42. Exposure to Pasteurella Multocida Toxin reveals an inhibitory role for the small GTPase Rho in osteoclast differentiation.

    McGowan, N. W. A., Harmey, D., Stenbeck, G. & Grigoriadis, A. E., 2003, In: Journal of Bone and Mineral Research. 18, p. S239 - S239

    Research output: Contribution to journalMeeting abstract

  43. Pasteurella multocida toxin has differential effects on murine and human osteoclast differentiation and activity

    McGowan, N. W. A., Harmcy, D., Stenbeck, G. & Grigoriadis, A. E., 2003, In: Journal of Bone and Mineral Research. 18, 7, p. 1366 - 1366 1 p.

    Research output: Contribution to journalMeeting abstract

  44. A possible functional role of cadherins to prevent osteosarcoma metastasis

    Kashima, T., Nakamura, K., Kawaguchi, J., Kudo, A. & Grigoriadis, A. E., 2002, In: Journal of Bone and Mineral Research. 17, Suppl 1, p. S408

    Research output: Contribution to journalMeeting abstract

  45. Altered bone morphogenetic protein responsiveness in chondrocytes overexpressing c-Fos

    Anagnostopoulos, I., Thomas, D. P. & Grigoriadis, A. E., 2002, In: Journal of Bone and Mineral Research. 17, 7, p. 1339 - 1339 1 p.

    Research output: Contribution to journalMeeting abstract

  46. Inhibition of Rho kinase activity leads to increased osteoblast differentiation and bone formation in vitro

    Harmey, D., Stenbeck, G., Lax, A. J. & Grigoriadis, A. E., 2002, In: Bone. 30, 3, p. 5S - 5S

    Research output: Contribution to journalMeeting abstract

  47. The effects of c-fos overexpression on osteoclast differentiation in transgenic mice

    Zhao, Y. & Grigoriadis, A. E., 2002, In: Journal of Bone and Mineral Research. 17, 7, p. 1340 - 1340 1 p.

    Research output: Contribution to journalMeeting abstract

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