Ahmad Al Khleifat

Research interests

Complex disease genetics and precision medicine
Big data application and AI in clinical trials and drug discovery
Development of proteomic-based biomarkers for Neurodegeneration
Structural variation analysis in genomics

Education/Academic qualification

Neuroscience , Master in Science, Development of proteomic-based biomarkers for Alzheimer disease, Institute of Psychiatry, Psychology and Neuroscience (IoPPN)

Clinical Neuroscience , Doctor of Philosophy, Understanding Disease Trajectory in Amyotrophic Lateral Sclerosis, King's College London

Medicine, Bachelor of Medicine and Bachelor of Surgery, Misr University for Science and Technology

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

SDG 3 Good Health and Well-being
SDG 9 Industry, Innovation, and Infrastructure
SDG 10 Reduced Inequalities
SDG 16 Peace, Justice and Strong Institutions

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1 Similar Profiles

65 Article
9 Review article
8 Preprint
1 Chapter

Sex-specific DNA methylation differences in Amyotrophic lateral sclerosis
Grant, O. A., Iacoangeli, A., Zwamborn, R. A. J., van Rheenen, W., Byrne, R., Van Eijk, K. R., Kenna, K., van Vugt, J. J. F. A., Cooper-Knock, J., Kenna, B., Vural, A., Topp, S., Campos, Y., Weber, M., Smith, B., Dobson, R., van Es, M. A., Vourc’h, P., Corcia, P. & de Carvalho, M. & 19 others, Gotkine, M., Panades, M. P., Mora, J. S., Mill, J., Garton, F., McRae, A., Wray, N. R., Shaw, P. J., Landers, J. E., Glass, J. D., Shaw, C. E., Basak, N., Hardiman, O., Van Damme, P., McLaughlin, R. L., van den Berg, L. H., Veldink, J. H., Al-Chalabi, A. & Al Khleifat, A., 25 Nov 2024, (Unpublished).
Research output: Working paper/Preprint › Preprint
Telomere length analysis in amyotrophic lateral sclerosis using large-scale whole genome sequence data
Al Khleifat, A., Iacoangeli, A., Jones, A., van Vugt, J., Shatunov, A., Moisse, M., Shatunov, A., Zwamborn, R. A. J., van der Spek, R., Cooper-Knock, J., Topp, S., van Rheenen, W., Kenna, B. J., van Eijk, K. R., Kenna, K. P., Byrne, R. P., López Alonso, V., Opie-Martin, S., Vural, A. & González, Y. & 25 others, Weber, M., Smith, B., Fogh, I., Silani, V., Morrison, K. E., Dobson, R., van Es, M. A., McLaughlin, R. L., Chio, A., Corcia, P., de Carvalho, M., Gotkine, M., Panades, M. P., Mora, J. S., Shaw, P. J., Landers, J. E., Glass, J. D., Shaw, C., Başak, A. N., Hardiman, O., Robberecht, W., Van Damme, P., van den Berg, L., Veldink, J. & Al-Chalabi, A., 15 Nov 2022, In: Frontiers in cellular neuroscience.
Research output: Contribution to journal › Article › peer-review

Open Access
File
9 Citations (Scopus)

91 Downloads (Pure)
Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis
Al Khleifat, A., Iacoangeli, A., Van Vugt, J. J. F. A., Bowles, H., Zwamborn, R. A. J., Moisse, M., Zwamborn, R. A. J., Cooper-Knock, J., Shatunov, A., Jones, A., van Rheenen, W., Opie-Martin, S., Fogh, I., Topp, S., Smith, B., Dobson, R., Shaw, C., Chiò, A., Panades, M. P. & Mora, J. S. & 10 others, Shaw, P. J., Landers, J. E., Glass, J. D., Başak, A. N., Hardiman, O., Robberecht, W., Van Damme, P., van den Berg, L. H., Veldink, J. H. & Al-Chalabi, A., 19 Oct 2021, In: NPJ Genomic medicine.
Research output: Contribution to journal › Article › peer-review

File
222 Downloads (Pure)
Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study
Fang, T., Al Khleifat, A., Meurgey, J.-H., Jones, A., Leigh, P. N., Bensimon, G. & Al-Chalabi, A., 1 May 2018, In: Lancet Neurology. 17, 5, p. 416-422 7 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
211 Citations (Scopus)

287 Downloads (Pure)
VariantSurvival: A tool to identify genotype-treatment response
Krannich, T., Sarrias, M., Ben Aribi, H., Shokrof, M., Iacoangeli, A., J Sedlazeck, F., Al-Chalabi, A., Busby, B. & Al Khleifat, A., 11 Oct 2023, In: Frontiers in Bioinformatics. 3, 1277923.
Research output: Contribution to journal › Article › peer-review

Open Access
File
28 Downloads (Pure)

5 Finished
6 Active

Advancing Understanding and Treatment of Motor Neurone Disease through Biomarker Development: UK MND RI and King’s MND Biobank Integration Project
Al Khleifat, A. (Primary Investigator) & Al-Chalabi, A. (Co-Investigator)
MNDA Motor Neurone Disease Association
1/03/2025 → 31/05/2026
Project: Research
Validating ALS Molecular Subtypes For Diagnostics And Disease Stratification
Iacoangeli, A. (Primary Investigator), Al Khleifat, A. (Co-Investigator) & Al-Chalabi, A. (Co-Investigator)
MRC Medical Research Council
1/01/2025 → 30/06/2026
Project: Research
MNDSTaR (MND: MNDSTaR: The King's-LifeArc Solution for Motor Neurone Disease Target Validation
Al Khleifat, A. (Primary Investigator), Al-Chalabi, A. (Co-Investigator), Iacoangeli, A. (Co-Investigator), Mitchell, J. (Co-Investigator) & Smith, B. (Co-Investigator)
LifeArc
1/05/2024 → 30/04/2026
Project: Research
Validating ALS molecular profiles from the UK biobank as a diagnostic tool
Iacoangeli, A. (Primary Investigator), Al Khleifat, A. (Co-Investigator), Al-Chalabi, A. (Co-Investigator), Breen, G. (Co-Investigator) & Dobson, R. (Co-Investigator)
LifeArc
18/03/2024 → 6/10/2026
Project: Research
Integration of epigenetic profile in MND clinical trials design
Al-Chalabi, A. (Primary Investigator) & Al Khleifat, A. (Co-Investigator)
Darby Rimmer MND Foundation
1/04/2022 → 31/10/2026
Project: Research

ALS Association Milton Safenowitz Research Fellowship
Al Khleifat, A. (Recipient), 31 Jan 2022
Prize: Fellowship awarded competitively
ENCALS Young Investigator Award
Al Khleifat, A. (Recipient), 3 Jun 2022
Prize: Prize (including medals and awards)
King's College London Recognition Awards: 2021/2022 Academic Year
Al Khleifat, A. (Recipient), 14 Feb 2022
Prize: Prize (including medals and awards)
Motor Neurone Disease Association Lady Edith Wolfson Fellowship
Al Khleifat, A. (Recipient), 31 Jan 2022
Prize: Fellowship awarded competitively

Ahmad Al Khleifat

Personal profile

Research interests

Education/Academic qualification

Expertise related to UN Sustainable Development Goals

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

Sex-specific DNA methylation differences in Amyotrophic lateral sclerosis

Telomere length analysis in amyotrophic lateral sclerosis using large-scale whole genome sequence data

Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis

Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study

VariantSurvival: A tool to identify genotype-treatment response

Advancing Understanding and Treatment of Motor Neurone Disease through Biomarker Development: UK MND RI and King’s MND Biobank Integration Project

Validating ALS Molecular Subtypes For Diagnostics And Disease Stratification

MNDSTaR (MND: MNDSTaR: The King's-LifeArc Solution for Motor Neurone Disease Target Validation

Validating ALS molecular profiles from the UK biobank as a diagnostic tool

Integration of epigenetic profile in MND clinical trials design

ALS Association Milton Safenowitz Research Fellowship

ENCALS Young Investigator Award

King's College London Recognition Awards: 2021/2022 Academic Year

Motor Neurone Disease Association Lady Edith Wolfson Fellowship

Ahmad Al Khleifat

Personal profile

Research interests

Education/Academic qualification

Expertise related to UN Sustainable Development Goals

Fingerprint

Collaborations and top research areas from the last five years

Research output

Projects

Prizes