King's College London

Research portal

Dr Aileen King

  1. The glucose tolerance test in mice: Sex, drugs and protocol

    Kennard, M. R., Nandi, M., Chapple, S. & King, A. J., Nov 2022, In: Diabetes, Obesity and Metabolism. 24, 11, p. 2241-2252 12 p.

    Research output: Contribution to journalArticlepeer-review

  2. SNAP-tag-enabled super-resolution imaging reveals constitutive and agonist-dependent trafficking of GPR56 in pancreatic β-cells

    Olaniru, O. E., Cheng, J., Ast, J., Arvaniti, A., Atanes, P., Huang, G. C., King, A. J. F., Jones, P. M., Broichhagen, J., Hodson, D. J. & Persaud, S. J., Nov 2021, In: Molecular Metabolism. 53, 101285.

    Research output: Contribution to journalArticlepeer-review

  3. The transCampus Metabolic Training Programme Explores the Link of SARS-CoV-2 Virus to Metabolic Disease

    Bornstein, S. R., Guan, K., Brunβen, C., Mueller, G., Kamvissi-Lorenz, V., Lechler, R., Trembath, R., Mayr, M., Poston, L., Sancho, R., Ahmed, S., Alfar, E., Aljani, B., Alves, T. C., Amiel, S., Andoniadou, C. L., Bandral, M., Belavgeni, A., Berger, I., Birkenfeld, A., & 74 othersBonifacio, E., Chavakis, T., Chawla, P., Choudhary, P., Cujba, A. M., Delgadillo Silva, L. F., Demcollari, T., Drotar, D. M., Duin, S., El-Agroudy, N. N., El-Armouche, A., Eugster, A., Gado, M., Gavalas, A., Gelinsky, M., Guirgus, M., Hansen, S., Hanton, E., Hasse, M., Henneicke, H., Heller, C., Hempel, H., Hogstrand, C., Hopkins, D., Jarc, L., Jones, P. M., Kamel, M., Kämmerer, S., King, A. J. F., Kurzbach, A., Lambert, C., Latunde-Dada, Y., Lieberam, I., Liers, J., Li, J. W., Linkermann, A., Locke, S., Ludwig, B., Manea, T., Maremonti, F., Marinicova, Z., McGowan, B. M., Mickunas, M., Mingrone, G., Mohanraj, K., Morawietz, H., Ninov, N., Peakman, M., Persaud, S. J., Pietzsch, J., Cachorro, E., Pullen, T. J., Pyrina, I., Rubino, F., Santambrogio, A., Schepp, F., Schlinkert, P., Scriba, L. D., Siow, R., Solimena, M., Spagnoli, F. M., Speier, S., Stavridou, A., Steenblock, C., Strano, A., Taylor, P., Tiepner, A., Tonnus, W., Tree, T., Watt, F., Werdermann, M., Wilson, M., Yusuf, N. & Ziegler, C. G., 1 Mar 2021, In: Hormone and Metabolic Research. 53, 3, p. 204-206 3 p.

    Research output: Contribution to journalArticlepeer-review

  4. Insulin and obesity transform hypothalamic-pituitary-adrenal axis stemness and function in a hyperactive state

    Werdermann, M., Berger, I., Scriba, L. D., Santambrogio, A., Schlinkert, P., Brendel, H., Morawietz, H., Schedl, A., Peitzsch, M., King, A. J. F., Andoniadou, C. L., Bornstein, S. R. & Steenblock, C., Jan 2021, In: Molecular Metabolism. 43, 101112.

    Research output: Contribution to journalArticlepeer-review

  5. Modulation of Rab7a-mediated growth factor receptor trafficking inhibits islet beta cell apoptosis and autophagy under conditions of metabolic stress

    Hewawasam, N. V., Lhaf, F., Taylor, H. A., Viloria, K., Austin, A., King, A., Jones, P., Jones, L., Turner, M. D. & Hill, N. J., 1 Dec 2020, In: Scientific Reports. 10, 1, 15741.

    Research output: Contribution to journalArticlepeer-review

  6. The KINGS Ins2+/G32S Mouse: A novel model of β-cell endoplasmic reticulum stress and human diabetes

    Austin, A., Daniels Gatward, L., Cnop, M., Santos, G., Andersson, D., Sharp, S., Gentry, C., Bevan, S., Jones, P. & King, A., Dec 2020, In: Diabetes. 69, 12, p. 2667-2677 11 p., db200570.

    Research output: Contribution to journalArticlepeer-review

  7. Optimizing beta cell function through mesenchymal stromal cell mediated mitochondria transfer

    Rackham, C. L., Hubber, E. L., Czajka, A., Malik, A. N., King, A. JF. & Jones, P. M., Apr 2020, In: Stem Cells. 38, 8, p. 574-584 11 p.

    Research output: Contribution to journalArticlepeer-review

  8. Assessing Islet Transplantation Outcome in Mice

    King, A. J. F. & Rackham, C. L., 1 Jan 2020, Methods in Molecular Biology. Stocker, C. (ed.). Vol. 2076. p. 265-280 16 p. (Methods in molecular biology (Clifton, N.J.)).

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

  9. Continuous Glucose Monitoring in Conscious Unrestrained Mice

    King, A. J. F., Kennard, M. R. & Nandi, M., 1 Jan 2020, In: Methods in molecular biology (Clifton, N.J.). 2128, p. 225-239 15 p.

    Research output: Contribution to journalArticlepeer-review

  10. Practical Considerations when Using Mouse Models of Diabetes

    King, A. J. F., Daniels Gatward, L. F. & Kennard, M. R., 1 Jan 2020, In: Methods in molecular biology (Clifton, N.J.). 2128, p. 1-10 10 p.

    Research output: Contribution to journalArticlepeer-review

  11. Use of Streptozotocin in Rodent Models of Islet Transplantation

    King, A. J. F., Estil Les, E. & Montanya, E., 1 Jan 2020, In: Methods in molecular biology (Clifton, N.J.). 2128, p. 135-147 13 p.

    Research output: Contribution to journalArticlepeer-review

  12. Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors

    Segal, J. M., Kent, D. H., Wesche, D., Ng, S. S., Quake, S., Serra, M., Nakauchi, H., Rashid, S. T., King, A., Oules, B., Kar, G., Emerton, G., Blackford, S., Darmanis, S., Miquel, R., Luong, T. V., Yamamoto, R., Bonham, A., Jassem, W., Heaton, N., & 3 othersVigilante, A., Sancho, R. & Teichmann, S. A., 24 Jun 2019, (Accepted/In press) In: Nature Communications. 10, 1, 14 p., 3350.

    Research output: Contribution to journalArticlepeer-review

  13. Mesenchymal stromal cell secretory factors induce sustained improvements in islet function pre- and post-transplantation

    Rackham, C. L., Amisten, S., Persaud, S. J., King, A. J. F. & Jones, P. M., 27 Oct 2018, (E-pub ahead of print) In: CYTOTHERAPY. 20, 12, p. 1427-1436

    Research output: Contribution to journalArticlepeer-review

  14. Impaired Nociception in the Diabetic Ins2+/Akita Mouse

    Vastani, N., Guenther, F., Gentry, C., Austin, A. L. F., King, A., Bevan, S. & Andersson, D. A., 1 Aug 2018, In: Diabetes. 67, 8, db171306.

    Research output: Contribution to journalArticlepeer-review

  15. Using mesenchymal stromal cells in islet transplantation

    Arzouni, A. A., Vargas-Seymour, A., King, A., Nardi, N. & Jones, P. M., 2 Apr 2018, (Accepted/In press) In: Stem cells translational medicine. 7, 8, p. 559-563

    Research output: Contribution to journalReview articlepeer-review

  16. Mesenchymal stromal cells improve human islet function through released products and extracellular matrix

    Arzouni, A. A., Vargas-Seymour, A., Rackham, C. L., Dhadda, P., Huang, G. C., Choudhary, P., Nardi, N., King, A. J. F. & Jones, P. M., 28 Nov 2017, (E-pub ahead of print) In: Clinical Science. 131, 23, p. 2835-2845 11 p.

    Research output: Contribution to journalArticlepeer-review

  17. Animal Models of Type 1 and Type 2 Diabetes Mellitus

    King, A. & Austin, A., 28 Jun 2017, Animal Models for the Study of Human Disease: Second Edition. Elsevier Inc., p. 245-265 21 p.

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

  18. Diabetes in rats is cured by islet transplantation…but only during daytime

    King, A. J. F., Austin, A. L. F., Nandi, M. & Bowe, J. E., 24 Jan 2017, In: Cell Transplantation. 26, 1, p. 171-172 2 p., DOI: 10.3727/096368916X692258.

    Research output: Contribution to journalLetterpeer-review

  19. Type 1 diabetes: Treat the symptoms or cure the disease?

    King, A., Zhi, Z. L., Persaud, S. & Jones, P., Aug 2016, In: The Biochemist. 38, 4, p. 5-9 5 p.

    Research output: Contribution to journalArticlepeer-review

  20. Modulation of endoglin expression in islets of langerhans by VEGF reveals a novel regulator of islet endothelial cell function

    Clarkin, C. E., Mahmoud, M., Liu, B., Sobamowo, E. O., King, A., Arthur, H., Jones, P. M. & Wheeler-Jones, C. P., 25 Jul 2016, (E-pub ahead of print) In: BMC Research Notes. 9, 1, 362.

    Research output: Contribution to journalArticlepeer-review

  21. Imatinib prevents beta cell death in vitro but does not improve islet transplantation outcome

    King, A. J. F., Griffiths, L. A., Persaud, S. J., Jones, P. M., Howell, S. L. & Welsh, N., 8 Mar 2016, (E-pub ahead of print) In: Upsala Journal of Medical Sciences. p. 1-6 6 p.

    Research output: Contribution to journalArticlepeer-review

  22. Annexin A1 Is a Key Modulator of Mesenchymal Stromal Cell-Mediated Improvements in Islet Function

    Rackham, C. L., Vargas, A. E., Hawkes, R. G., Amisten, S., Persaud, S. J., Austin, A. L. F., King, A. J. F. & Jones, P. M., 31 Jan 2016, In: Diabetes. 65, 1, p. 129-39 11 p.

    Research output: Contribution to journalArticlepeer-review

  23. Animal models for diabetes: Understanding the pathogenesis and finding new treatments

    King, A. & Bowe, J., 1 Jan 2016, In: Biochemical Pharmacology. 99, p. 1-10 10 p.

    Research output: Contribution to journalComment/debatepeer-review

  24. ALK5 inhibition maintains islet endothelial cell survival but does not enhance islet graft revascularisation or function

    King, A. J. F., Clarkin, C. E., Austin, A. L. F., Ajram, L., Dhunna, J. K., Jamil, M. O., Ditta, S. I., Ibrahim, S., Raza, Z. & Jones, P., 1 Jan 2015, In: Hormone and Metabolic Research. 47, 1, p. 78-83 6 p.

    Research output: Contribution to journalArticlepeer-review

  25. Novel Role for Matricellular Proteins in the Regulation of Islet beta Cell Survival: THE EFFECT OF SPARC ON SURVIVAL, PROLIFERATION, AND SIGNALING

    Ryall, C. L., Viloria, K., Lhaf, F., Walker, A. J., King, A., Jones, P., Mackintosh, D., McNeice, R., Kocher, H., Flodstrom-Tullberg, M., Edling, C. & Hill, N. J., 31 Oct 2014, In: Journal of Biological Chemistry. 289, 44, p. 30614-30624 11 p.

    Research output: Contribution to journalArticlepeer-review

  26. Nupr1 deletion protects against glucose intolerance by increasing beta cell mass

    Barbosa-Sampaio, H. C., Liu, B., Drynda, R., Rodriguez de Ledesma, A. M., King, A. J., Bowe, J. E., Malicet, C., Iovanna, J. L., Jones, P. M., Persaud, S. J. & Muller, D. S., Nov 2013, In: Diabetologia. 56, 11, p. 2477-2486

    Research output: Contribution to journalArticlepeer-review

  27. Sustained NF-κB Activation and Inhibition in β-Cells Have Minimal Effects on Function and Islet Transplant Outcomes

    King, A. J. F., Guo, Y., Cai, D., Hollister-Lock, J., Morris, B., Salvatori, A., Corbett, J. A., Bonner-Weir, S., Shoelson, S. E. & Weir, G. C., 18 Oct 2013, In: PL o S One . 8, 10, e77452.

    Research output: Contribution to journalArticlepeer-review

  28. Pre-culturing islets with mesenchymal stromal cells using a direct contact configuration is beneficial for transplantation outcome in diabetic mice

    Rackham, C. L., Dhadda, P. K., Chagastelles, P. C., Simpson, S. J. S., Dattani, A. A., Bowe, J. E., Jones, P. M. & King, A. J. F., 1 Apr 2013, In: CYTOTHERAPY. 15, 4, p. 449-459 11 p.

    Research output: Contribution to journalArticlepeer-review

  29. Activin receptor-like kinase 5 inhibition reverses impairment of endothelial cell viability by endogenous islet mesenchymal stromal cells

    Clarkin, C. E., King, A. J., Dhadda, P., Chagastelles, P., Nardi, N., Wheeler-Jones, C. P. & Jones, P. M., Mar 2013, In: Stem cells (Dayton, Ohio). 31, 3, p. 547-59 13 p.

    Research output: Contribution to journalArticlepeer-review

  30. Maintenance of islet morphology is beneficial for transplantation outcome in diabetic mice

    Rackham, C. L., Jones, P. M. & King, A. J. F., 25 Feb 2013, In: PL o S One . 8, 2, e57844.

    Research output: Contribution to journalArticlepeer-review

  31. Selective Ablation of Peptide YY Cells in Adult Mice Reveals Their Role in Beta Cell Survival

    Sam, A. H., Gunner, D. J., King, A., Persaud, S. J., Brooks, L., Hostomska, K., Ford, H. E., Liu, B., Ghatei, M. A., Bloom, S. R. & Bewick, G., Aug 2012, In: Gastroenterology. 143, 2, p. 459-468 10 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  32. Immunoisolation of islets in high guluronic acid barium-alginate microcapsules does not improve graft outcome at the subcutaneous site

    Kerby, A., Bohman, S., Westberg, H., Jones, P. & King, A., Jun 2012, In: Artificial Organs. 36, 6, p. 564-70 7 p.

    Research output: Contribution to journalArticlepeer-review

  33. The use of animal models in diabetes research

    King, A. J. F., Jun 2012, In: British Journal of Pharmacology. 166, 3, p. 877-894 18 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  34. Nano-scale encapsulation enhances allograft survival and function of islets transplanted in a mouse model of diabetes

    Zhi, Z. -I., Kerby, A., King, A. J. F., Jones, P. M. & Pickup, J. C., 1 Apr 2012, In: Diabetologia. 55, 4, p. 1081-1090 10 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  35. Co-transplantation of mesenchymal stem cells maintains islet organisation and morphology in mice

    Rackham, C. L., Chagastelles, P. C., Nardi, N. B., Hauge-Evans, A. C., Jones, P. M. & King, A. J. F., May 2011, In: Diabetologia. 54, 5, p. 1127 - 1135 9 p.

    Research output: Contribution to journalArticlepeer-review

  36. In vivo laboratory practicals in research-led teaching: and example using glucose tolerance tests in lean and obsese mice.

    King, A., Bowe, J., Sprake, J. A. & Kinchin, I. M., 2011, In: Journal of Pharmacology and Toxicology Methods. 64, 2, p. 166 - 172 7 p.

    Research output: Contribution to journalArticlepeer-review

  37. Pseudoislets as primary islet replacements for research: report on a symposium at King's College London, London UK

    Persaud, S. J., Arden, C., Bergsten, P., Bone, A. J., Brown, J., Dunmore, S., Harrison, M., Hauge-Evans, A., Kelly, C., King, A., Maffucci, T., Marriott, C. E., McClenaghan, N., Morgan, N. G., Reers, C., Russell, M. A., Turner, M. D., Willoughby, E., Younis, M. Y. G., Zhi, Z. L., & 1 othersJones, P. M., 9 Dec 2010, In: Islets. 2, 4, p. 236 - 239 4 p.

    Research output: Contribution to journalArticlepeer-review

  38. A role for islet somatostatin in mediating sympathetic regulation of glucagon secretion

    Hauge-Evans, A. C., King, A. J., Fairhall, K., Persaud, S. J. & Jones, P. M., Nov 2010, In: Islets. 2, 6, p. 341 - 344 4 p.

    Research output: Contribution to journalArticlepeer-review

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