Research output per year
Research output per year
Personal profile
Research interests (short)
Dr. Alan G. Ramsay leads a research group focusing on translational research in cancer immunology.
Research interests
Dr. Alan G. Ramsay leads a research group focusing on translational research in cancer immunology. His research in the chronic lymphocytic leukaemia (CLL) and lymphoma field has characterised novel tumour cell-induced T-cell immune evasion mechanisms and translated bench science to clinical trials with immunotherapy (Ramsay et al JCI 2008)(Shanafelt and Ramsay et al Blood 2013)(Ramsay Br. J Haematol. 2013).
This work includes pre-clinical definition of CLL (Ramsay et al Blood 2012) and lymphoma (Ramsay et al Blood 2009) tumour cells co-opting multiple immune checkpoint (IC) molecules to suppress T-cell lytic immune synapse function ('adaptive immune resistance').
Current research focus: understanding and overcoming ‘microenvironmental immunosuppression’ in order to identify new targets for repairing anti-tumour immunity.
Academic activities:
PhD PostGraduate Coordinator (PGC) for Haemato-Oncology, Division of Cancer.
Undergraduate and MSc/Res teaching and project supervision.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Ibrutinib‐based therapy reinvigorates CD8+ T cells compared to chemoimmunotherapy: immune monitoring from the E1912 trial
Papazoglou, D., Wang, X. V., Shanafelt, T. D., Lesnick, C. E., Ioannou, N., De Rossi, G., Herter, S., Bacac, M., Klein, C., Tallman, M. S., Kay, N. E. & Ramsay, A. G., 4 Jan 2024, In: Blood. 143, 1, p. 57–63 7 p., 2023020554.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)56 Downloads (Pure) -
Investigator choice of standard therapy versus sequential novel therapy arms in the treatment of relapsed follicular lymphoma (REFRACT): study protocol for a multi-centre, open-label, randomised, phase II platform trial
McIlroy, G., Lax, S., Gaskell, C., Jackson, A., Rhodes, M., Seale, T., Fox, S., Hopkins, L., Okosun, J., Barrington, S. F., Ringshausen, I., Ramsay, A. G., Calaminici, M., Linton, K. & Bishton, M., Dec 2024, In: BMC Cancer. 24, 1, 370.Research output: Contribution to journal › Article › peer-review
Open Access -
Interleukin-27 potentiates CD8+ T-cell-mediated anti-tumor immunity in chronic lymphocytic leukemia
Pagano, G., Botana, I. F., Wierz, M., Roessner, P. M., Ioannou, N., Zhou, X., Al-Hity, G., Borne, C., Gargiulo, E., Gonder, S., Qu, B., Stamatopoulos, B., Ramsay, A. G., Seiffert, M., Largeot, A., Moussay, E. & Paggetti, J., Nov 2023, In: Haematologica. 108, 11, p. 3011-3024 14 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus) -
The immunomodulatory molecule TIGIT is expressed by chronic lymphocytic leukemia cells and contributes to anergy
Arruga, F., Rubin, M., Papazoglou, D., Iannello, A., Ioannou, N., Moia, R., Rossi, D., Gaidano, G., Coscia, M., Laurenti, L., D’arena, G., Allan, J. N., Furman, R. R., Vaisitti, T., Ramsay, A. G. & Deaglio, S., 1 Aug 2023, In: Haematologica. 108, 8, p. 2101-2115 15 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma
Apollonio, B., Spada, F., Petrov, N., Cozzetto, D., Papazoglou, D., Jarvis, P., Kannambath, S., Terranova-Barberio, M., Amini, R-M., Enblad, G., Graham, C. E., Benjamin, R., Phillips, E. H., Ellis, R. J., Nuamah, R., Saqi, M., Calado, D. P., Rosenquist, R., Sutton, L. A., Salisbury, J. R., & 11 others, 3 Jul 2023, In: The Journal of clinical investigation. 133, 13, e166070.Research output: Contribution to journal › Article › peer-review
Open Access16 Citations (Scopus)
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CoL: CRUK City of London Centre renewal (COLMC)
Ng, T., Arnold, J., Blower, P., Ciccarelli, F., Dazzi, F., Farzaneh, F., Grigoriadis, A., Hayday, A., Irshad, S., Kong, A., Kordasti, S., Lawrence, T., Mishto, M., Papa, S., Purushotham, A., Quek, L., Ramsay, A., Reis Ferreira, M., Sarker, D., Sinkus, R., Spicer, J. & Witney, T.
1/04/2022 → 31/03/2027
Project: Research
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Outcomes for CLL patients treated with novel therapy
NIH National Institutes of Health
15/09/2021 → 31/08/2024
Project: Research
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Understanding how immunomodulatory drugs affect tumour microenvironment (TME)-driven immune suppression
1/10/2016 → 31/12/2020
Project: Research