Personal profile
Research interests
Alex Ivetic obtained his BSc (Hons) in Biochemistry from Imperial College London. He then embarked on a PhD at the Marie Curie Research Institute (through the Institute of Cancer Research, University of London), where he investigated how DNA replication is triggered during the cell cycle. His first postdoc position was hosted at the National Institute for Medical Research (now part of the Francis Crick Institute), where he began his investigations in cell adhesion molecules and their contribution to immune cell recruitment in inflammation. In his second postdoc position, he used the parallel plate flow chamber to model immune cell interactions with blood vessels in vitro. After successfully obtaining a Research Career Development Award from the Wellcome Trust, Alex moved back to Imperial College London in 2005 to start his own group at the National Heart and Lung Institute to further understand mechanisms underlying immune cell responses to inflammation. Since starting at King’s as a Senior Lecturer, Alex has spent time in the labs of Paul Kubes (Calgary, Canada) and Michael Hickey (Monash, Australia) to gain expertise in intravital microscopy – elaborating his understanding of leukocyte recruitment on an organismal level. The majority of his research now focuses on understanding the mechanisms that regulate leukocyte homing to sites of “sterile injury” (e.g. myocardial infarction and venous thrombosis), and how subverting this process might bring improved outcomes in models of cardiovascular disease. In February 2021, Alex was promoted to Reader in Cardiovascular Biology.
Alex is Postgraduate Research Lead to approximately 100 PGR students within the School of Cardiovascular Sciences and Medicine. He is also the Lead Administrator of the Joint PhD programme between King's and the University of Göttingen's Heart Centre, which spun out from an IRTG1816 award by the DFG and is now in its second 5-year renewal. He has supervised 10 PhD students as primary supervisor (8 graduated and 2 currently in place) and is strongly committed to improving PhD student progress and welfare.
Alex has delivered numerous public engagement seminars relating to his research in well-attended events, such as the Pint of Science and Science Museum Lates.
Research interests (short)
Education/Academic qualification
Doctor of Philosophy, Analysis of MCM proteins from Drosophila Melanogaster, Institute of Cancer Research
Award Date: 1 Jan 1998
Bachelor of Science, Imperial College London
Award Date: 1 Jan 1993
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 4 Quality Education
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SDG 16 Peace, Justice and Strong Institutions
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Collaborations and top research areas from the last five years
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Complement receptor C3ar1 deficiency does not alter brain structure or functional connectivity across early life development
Lemmik, H., Kim, E., Macnicol, E., Maselli, D., Bernanos, M., Li, Z., Abdullahi, D., Walters, E., Serrano Navacerrada, M. E., Zhou, W., Ivetic, A., Cash, D. & Westacott, L., 28 Oct 2025, In: Brain Communications. 7, 6, 22 p., fcaf422.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Cell adhesion and migration in disease: translational and therapeutic opportunities
Anderson, K., Calle-Patino, Y., Ivetic, A., Parsons, M., Valderrama, F., Wells, C. & Anton, I., 2024, In: Cell Adhesion and Migration. 18, 1, p. 1-3 3 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)168 Downloads (Pure) -
Tnik: A redox sensor in endothelial cell permeability
Joachim, J., Maselli, D., Petsolari, E., Aman, J., Swiatlowska, P., Killock, D., Chaudhry, H., Zarban, A. A., Sarker, M., Fraser, P., Cleary, S. J., Amison, R., Cuthbert, I., Yang, Y., Meier, M., Fraternali, F., Brain, S. D., Shah, A. M. & Ivetic, A., 20 Dec 2024, In: Science Advances. 10, 51, 19 p., eadk6583.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)9 Downloads (Pure) -
Endothelial NADPH oxidase 4 protects against angiotensin II-induced cardiac fibrosis and inflammation
Wang, M., Murdoch, C. E., Brewer, A. C., Ivetic, A., Evans, P., Shah, A. M. & Zhang, M., Apr 2021, In: ESC Heart Failure. 8, 2, p. 1427-1437 11 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Citations (Scopus) -
Endothelial Nox2 Limits Systemic Inflammation and Hypotension in Endotoxemia by Controlling Expression of Toll-Like Receptor 4
Trevelin, S. C., Sag, C. M., Zhang, M., Alves-Filho, J. C., Cunha, T. M., Santos, C. X. D., Sawyer, G., Murray, T., Brewer, A., Laurindo, F. R. M., Protti, A., Lopes, L. R., Ivetic, A., Cunha, F. Q. & Shah, A. M., 1 Aug 2021, In: Shock (Augusta, Ga.). 56, 2, p. 268-277 10 p.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus)
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BHF 4year MRes/PhD Programme 2022 Intake
Ivetic, A. (Primary Investigator)
1/10/2025 → 30/09/2026
Project: Research
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FS/4yPhD/F/24/34214 BHF 4year MRes/Phd Programme 2024 Intake
Ivetic, A. (Primary Investigator)
1/10/2025 → 30/09/2028
Project: Research
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Investigating the role of TET2 in the regulation of cholesterol homeostasis in endothelial cells
Brewer, A. (Primary Investigator), Ivetic, A. (Co-Investigator) & Perucha, E. (Co-Investigator)
24/06/2024 → 23/06/2026
Project: Research
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FS/4yPhD/F/23/3419 BHF 4year MRes/Phd Programme 2023 Intake
Ivetic, A. (Primary Investigator)
1/10/2023 → 30/09/2027
Project: Research
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BHF-PhD-CHIP: Clonal haematopoiesis and myeloid-driven inflammation in cardiovascular disease.
Quek, L. (Primary Investigator) & Ivetic, A. (Co-Investigator)
4/09/2023 → 3/09/2026
Project: Research