King's College London

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Dr Alexis Lomakin

Research interests

The Lomakin Lab addresses basic, curiosity-driven questions in cell biology concerning spatiotemporal organization of cells that make up tissues and organs in the human body.How do cells sense their own shape and size, and measure distances? How do cells adapt their dimensions to variations in the extracellular environment? How do cells use information about their geometry to localize signaling or make decisions? How do cells estimate dimensions of the organ or tissue that they build? To answer these questions, the lab utilizes an interdisciplinary approach combining molecular and cellular biology with bioengineering, physicochemical biology, and computational modeling. Collaborating with physicists and engineers, we develop creative experimental approaches to manipulate, image, and quantify cellular processes in living cells and reconstituted tissues. With this approach, we wish to discover quantitative molecular and biomechanical mechanisms underlying the dynamic cellular processes responsible for cell and tissue morphogenesis in healthy and diseased state.

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