Research output per year
Research output per year
Personal profile
Research interests
Innate immune responses not only provide an important first line of defense against invading pathogens and tumors but also play a crucial role in preparing the adaptive immune system to specifically recognize and clear the undesired pathogen or tumour. The innate and adaptive immune system have long being considered to function independently from each other. However, recent evidence suggests that the overall outcome of immune responses depends upon the interplay between mediators of both these systems. Among the various cell-to-cell interactions that are thought to regulate the quality and intensity of adaptive immune responses, the attention of immunologists has recently been focused on natural killer (NK) – dendritic cell (DC) interactions, as DCs play a critical role in triggering and shaping T cell-mediated immunity. The aim of my research is to dissect the complex pathways that link the innate and adaptive immune systems to provide resistance to pathogens.
Research interests (short)
Innate immunity; Natural Killer cells; T cells; Dendritic cells; Vaccines
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Fingerprint
Dive into the research topics where Alfonso Martin-Fontecha is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
-
Cutting Edge: CD8(+) T Cell Priming in the Absence of NK Cells Leads to Enhanced Memory Responses
Soderquest, K., Walzer, T., Zafirova, B., Klavinskis, L. S., Polic, B., Vivier, E., Lord, G. M. & Martin-Fontecha, A., 15 Mar 2011, In: Journal of Immunology. 186, 6, p. 3304 - 3308 5 p.Research output: Contribution to journal › Article › peer-review
113 Citations (Scopus) -
Monocytes control natural killer cell differentiation to effector phenotypes
Soderquest, K., Powell, N., Luci, C., van Rooijen, N., Hidalgo, A., Geissmann, F., Walzer, T., Lord, G. M. & Martin-Fontecha, A., 28 Apr 2011, In: Blood. 117, 17, p. 4511 - 4518 8 p.Research output: Contribution to journal › Article › peer-review
71 Citations (Scopus) -
Response to Comment on "Cutting Edge: CD8(+) T Cell Priming in the Absence of NK Cells Leads to Enhanced Memory Responses"
Soderquest, K., Lord, G. M. & Martin-Fontecha, A., 1 Jun 2011, In: Journal of Immunology. 186, 11, p. 6071 - 6072 2 p.Research output: Contribution to journal › Letter › peer-review
2 Citations (Scopus) -
Transcriptional control of natural killer cell differentiation and function
Martin-Fontecha, A., Lord, G. M. & Brady, H. J. M., Nov 2011, In: Cellular and Molecular Life Sciences. 68, 21, p. 3495-3503 9 p.Research output: Contribution to journal › Literature review › peer-review
15 Citations (Scopus) -
Anaphylatoxin C5a is an important regulator of natural killer cell function
Li, K., Wang, N., Peng, Q., Sacks, S. H., Martin-Fontecha, A. & Zhou, W., 2010, In: Molecular Immunology. 47, 13, p. 2231 - 2232 2 p.Research output: Contribution to journal › Meeting abstract
Projects
- 15 Finished
-
The role of complement anaphylatoxin in modulating nature killer cell function
Hayday, A. (Primary Investigator), Martin-Fontecha, A. (Primary Investigator), Sacks, S. (Primary Investigator) & Zhou, W. (Primary Investigator)
1/01/2011 → 31/12/2013
Project: Research
-
Harnessing natural killer cells to optimize vaccine efficacy
Martin-Fontecha, A. (Primary Investigator), Brady, H. (Co-Investigator), Lord, G. (Co-Investigator), Polic, B. (Co-Investigator) & Vivier, E. (Co-Investigator)
1/09/2010 → 31/08/2013
Project: Research
-
Harnessing natural killer cells to optimize vaccine efficacy
Martin-Fontecha, A. (Primary Investigator)
1/06/2010 → 15/07/2010
Project: Research
-
Angioproteins in the maintenance of glomerular capillary permeability in health and disease
Martin-Fontecha, A. (Primary Investigator)
1/05/2010 → 30/04/2013
Project: Research
-
The transcriptional control of NK cell differentiation and its impact on cancer growth
Martin-Fontecha, A. (Primary Investigator)
1/04/2010 → 31/03/2013
Project: Research
Activities
-
“Regulation of adaptive T cell responses by the innate immune system”. Prof. Leo Lefrançois. Department of Immunology, University of Connecticut Health Center, Farmington, USA
Martin-Fontecha, A. (Invited speaker)
2006 → …Activity: Participating in or organising an event › Participation in conference
-
“NK and T cell migration to activated lymph nodes”. Dr. Francesco Colucci. Babraham Institute, Oxford, UK
Martin-Fontecha, A. (Invited speaker)
2006 → …Activity: Participating in or organising an event › Participation in conference
-
“Regulation of cell traffic in activated lymph nodes”. Prof. Reinhold Förster. Hannover Medical School, Germany
Martin-Fontecha, A. (Invited speaker)
2006 → …Activity: Participating in or organising an event › Participation in conference
-
“Cell traffic in activated lymph nodes”. Dr. Mario Mellado. Centro Nacional de Biotecnología, Madrid
Martin-Fontecha, A. (Invited speaker)
2006 → …Activity: Participating in or organising an event › Participation in conference
-
“Cell traffic in activated lymph nodes”. Prof. Francisco Sánchez-Madrid. Hospital de la Princesa, Madrid
Martin-Fontecha, A. (Invited speaker)
2006 → …Activity: Participating in or organising an event › Participation in conference
Prizes
-
Elected to British Society for Immunology
Martin-Fontecha, A. (Recipient), 2008
Prize: Election to learned society
-
Elected to European Macrophage & Dendritic Cell Society
Martin-Fontecha, A. (Recipient), 2002
Prize: Election to learned society
-
Elected to Spanish Society for Immunology
Martin-Fontecha, A. (Recipient), 1992
Prize: Election to learned society
-
Elected to The Society for Natural Immunity
Martin-Fontecha, A. (Recipient), 1997
Prize: Election to learned society