Research output per year
Research output per year
Personal profile
Research interests
We are studying the development and function of different subsets of T lymphocytes in the lung, with a special interest in the role of CD8 T cells and regulatory T cells. An understanding of immune regulation is helping us to develop vaccines to suppress the allergic inflammatory response which is critical in asthma. We are also investigating how poor hygiene and infection might prevent allergic disease.
Research interests (short)
T cell subsets; immune regulation; allergic inflammation.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, United Medical and Dental Schools (UMDS)
Award Date: 1 Jan 1994
Bachelor of Science, King's College London
Award Date: 1 Jan 1988
Fingerprint
Dive into the research topics where Alistair Noble is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
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FGF10 is an essential regulator of tracheal submucosal gland morphogenesis
May, A. J., Teshima, T. H., Noble, A. & Tucker, A. S., 15 Jul 2019, In: Developmental Biology. 451, 2, p. 158-166 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)963 Downloads (Pure) -
FGF and EDA pathways control initiation and branching of distinct subsets of developing nasal glands
May, A. J., Headon, D., Rice, D. P., Noble, A. & Tucker, A. S., 15 Nov 2016, In: Developmental Biology. 419, 2, p. 348-356Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)185 Downloads (Pure) -
Follicular helper T cells are responsible for IgE responses to Der p 1 following house dust mite sensitization in mice
Noble, A. & Zhao, J., 6 Jun 2016, (E-pub ahead of print) In: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 46, 8, p. 1075–1082Research output: Contribution to journal › Article › peer-review
Open AccessFile47 Citations (Scopus)223 Downloads (Pure) -
IL-12 and IL-4 activate a CD39-dependent intrinsic peripheral tolerance mechanism in CD8+ T cells
Noble, A., Mehta, H., Lovell, A., Papaioannou, E. & Fairbanks, L., 16 Mar 2016, (E-pub ahead of print) In: European Journal of Immunology.Research output: Contribution to journal › Article › peer-review
Open AccessFile38 Citations (Scopus)165 Downloads (Pure) -
TNFα promotes CAR-dependent migration of leukocytes across epithelial monolayers
Morton, P. E., Hicks, A., Ortiz-Zapater, E., Raghavan, S., Pike, R., Noble, A., Woodfin, A., Jenkins, G., Rayner, E., Santis, G. & Parsons, M., 19 May 2016, In: Scientific Reports. 6, 26321.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)201 Downloads (Pure)
Projects
- 30 Finished
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IgE inhibition using the CRISPR/Cas9 system for treating allergies
Turcanu, V. (Primary Investigator) & Noble, A. (Co-Investigator)
1/07/2016 → 30/06/2018
Project: Research
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Treatments for chronic neutrophilic Th17-driven airway inflammation
Noble, A. (Primary Investigator)
1/10/2014 → 31/03/2016
Project: Research
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Early life development of mucosal immunity in the lung: the role of CD8 memory T cells
Noble, A. (Primary Investigator)
1/10/2014 → 30/09/2016
Project: Research
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An experimental approach to understanding then role of immune memory in the aetiology of asthma
Noble, A. (Primary Investigator)
1/10/2013 → 30/09/2016
Project: Research
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Control of suppressive activity in cytotoxic T-lymphocytes via endogenous danger signals
Noble, A. (Primary Investigator)
1/09/2013 → 31/08/2016
Project: Research
Activities
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American Journal of Current Immunology (Journal)
Noble, A. (Editorial board member)
2013 → …Activity: Publication peer-review and editorial work › Editorial activity
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Biomarkers in Cancer (Journal)
Noble, A. (Editorial board member)
2011 → …Activity: Publication peer-review and editorial work › Editorial activity
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Asthma UK Grants Committee
Noble, A. (Member)
2005 → 2008Activity: Other › Types of External academic engagement - Membership of external research organisation
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Immunology (Journal)
Noble, A. (Editorial board member)
2000 → 2007Activity: Publication peer-review and editorial work › Editorial activity