Research output per year
Research output per year
Personal profile
Research interests
Bacterial toxins that interfere with cellular signalling, in particular the Pasteurella multocida toxin; cellular microbiology; bacteria and cancer; G-protein regulation.
Research interests (short)
Bacterial toxins that interfere with cellular signalling; cellular microbiology; bacteria and cancer.
Biographical details
Alistair Lax’s first degree was in Biochemistry at the University of Glasgow. He obtained his PhD on Dictyostelium discoideum development at ICRF (now Cancer Research UK) in London in 1979. After a year as a supply teacher in Inner London, he was appointed to a staff position at the Institute for Animal Health in Berkshire to work on the transmissible spongiform encephalopathy, scrapie. He later moved into bacterial pathogenesis, working first on Salmonella virulence, then with Pasteurella multocida. Analysis of the mitogenic P. multocida toxin led him into the analysis of cellular signalling pathways, in particular those associated with G-protein signal pathways. This work led to his interest in the role of bacterial toxins in cancer.
In 1996 he joined King’s as a Senior Lecturer, and from 2002 has been Professor of Cellular Microbiology.
He was Director of Graduate Studies at the Dental Institute from 2002 until 2015.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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- 1 Similar Profiles
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In Vivo Targets of Pasteurella Multocida Toxin
Banu, A., Lax, A. J. & Grigoriadis, A. E., 15 Apr 2020, In: International Journal of Molecular Sciences. 21, 8, p. 2739-2750 2739.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)98 Downloads (Pure) -
Promoter orientation of the immunomodulatory Bacteroides fragilis capsular polysaccharide A (PSA) is off in individuals with inflammatory bowel disease (IBD)
Blandford, L. E., Johnston, E. L., Sanderson, J. D., Wade, W. G. & Lax, A. J., 3 Sept 2019, In: Gut Microbes. 10, 5, p. 569-577 9 p.Research output: Contribution to journal › Article › peer-review
34 Citations (Scopus) -
A review of the longevity of effect of Botulinum Toxin in wrinkle treatments
Smith, G., Lax, A. & Mehta, S. B., 23 Feb 2018, (E-pub ahead of print) In: British Dental Journal. 224, 4, 27 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)1313 Downloads (Pure) -
00106 - Bacteria: Pasteurella multocida
Magyar, T. & Lax, A., 1 Jan 2014, History, Science and Methods. Elsevier, Vol. 1. p. 476-479 4 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
4 Citations (Scopus) -
The actions of Pasteurella multocida toxin on neuronal cells
Surguy, S., Duricki, D., Reilly, J., Lax, A. & Robbins, J., Feb 2014, (E-pub ahead of print) In: Neuropharmacology. 77, N/A, p. 9-18 10 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus)
Projects
- 7 Finished
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The catalytic activity of the potent mitogenic toxin of pasteurella multocida (PMT)
Lax, A., Dionne, M. & Homer, K.
1/02/2009 → 31/01/2012
Project: Research
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The Pasteurella multocida toxin prophage: implications for regulation, export and transmission.
1/06/2008 → 31/05/2011
Project: Research
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Six month Fellowship for Dr Song Keang Peng
Association of Commonwealth Universities
25/03/2002 → 24/09/2002
Project: Research
Activities
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ESF Workshop: Bacterial Infection as a Cause of Cancer
Alistair Lax (Organiser)
Oct 2011 → …Activity: Participating in or organising an event › Participation in conference
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Invited: Toxin meeting Rome
Alistair Lax (Keynote/plenary speaker)
2005 → …Activity: Participating in or organising an event › Participation in conference
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MRC College of Experts
Alistair Lax (Member)
2005 → …Activity: Other › Types of External academic engagement - Membership of external research organisation
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Invited: Society for General Microbiology meeting
Alistair Lax (Keynote/plenary speaker)
2004 → …Activity: Participating in or organising an event › Participation in conference
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Invited:European Toxin meeting
Alistair Lax (Keynote/plenary speaker)
2003 → …Activity: Participating in or organising an event › Participation in conference