Research output per year
Research output per year
Personal profile
Research interests
Mendelian and complex disease genetics in neurological diseases (especially motor neuron disease); Epidemiology of motor neuron disease; Genetic statistics; RNA processing genes and proteins; clinical trials; clinical staging in motor neuron disease; clinical phenotyping in motor neuron disease.
Research interests (short)
Mendelian and complex disease genetics and epidemiology in neurological diseases mainly MND.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Genetic risk factors in amyotrophic lateral sclerosis, University of London
Award Date: 1 Jan 1999
Bachelor of Medicine and Bachelor of Surgery, University of Leicester
Award Date: 1 Jan 1989
Keywords
- RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
- neurology, amyotrophic lateral sclerosis, motor neuron disease, ALS, MND
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Acceptance and Commitment Therapy for people living with motor neuron disease: the COMMEND feasibility study and randomised controlled trial
Gould, R., Thompson, B., Rawlinson, C., Bursnall, M., Bradburn, M., Young, T., Lawrence, V., White, D. A., Howard, R. J., Serfaty, M. A., McCracken, L. M., Graham, C., Al-Chalabi, A., Goldstein, L., Androulaki-Korakaki, D., Kumar, P., Weeks, K., Gossage-Worrall, R., Turton, E. & Waterhouse, S. & 4 others, , 13 May 2025, (Accepted/In press) In: Health Technology Assessment.Research output: Contribution to journal › Article › peer-review
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Brain distribution study of [14C]-Riluzole following intranasal administration in mice
Baker, R. S., Wang, J. T. W., Rouatbi, N., Lu, Y., Al-adhami, T., Asker, D., Rahman, K. M., Al-Chalabi, A., Forbes, B., Bansal, S. & Al-Jamal, K. T., 10 Feb 2025, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 670, 125195.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Downloads (Pure) -
Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial
Bensimon, G., Leigh, P. N., Tree, T., Malaspina, A., Payan, C. A., Pham, H.-P., Klaassen, P., Shaw, P. J., Al Khleifat, A., Amador, M. D. M., Attarian, S., Bell, S. M., Beltran, S., Bernard, E., Camu, W., Corcia, P., Corvol, J.-C., Couratier, P., Danel, V. & Debs, R. & 30 others, , 24 May 2025, In: Lancet. 405, 10492, p. 1837-1850 14 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Investigating the performance of Oxford Nanopore long-read sequencing with respect to Illumina microarrays and short-read sequencing
Santos, R., Lee, H., Williams, A., Baffour-Kyei, A., Lee, S.-H., Troakes, C., Al-Chalabi, A., Breen, G. & Iacoangeli, A., 8 May 2025, In: International Journal of Molecular Sciences.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Downloads (Pure) -
Oligogenic structure of amyotrophic lateral sclerosis has genetic testing, counselling and therapeutic implications
Iacoangeli, A., Dilliott, A. A., Al Khleifat, A., Andersen, P. M., Başak, N. A., Cooper-Knock, J., Corcia, P., Couratier, P., deCarvalho, M., Drory, V. E., Glass, J. D., Gotkine, M., Lerner, Y. M., Hardiman, O., Landers, J. E., McLaughlin, R. L., Pardina, J. S. M., Morrison, K., Pinto, S. & Povedano, M. & 13 others, , 13 Feb 2025, (E-pub ahead of print) In: Journal of neurology, neurosurgery, and psychiatry. jnnp-2024-335364.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus)
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Advancing Understanding and Treatment of Motor Neurone Disease through Biomarker Development: UK MND RI and King’s MND Biobank Integration Project
Al Khleifat, A. (Primary Investigator) & Al-Chalabi, A. (Co-Investigator)
MNDA Motor Neurone Disease Association
1/03/2025 → 30/11/2025
Project: Research
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EPSRC DRIVE-Health: A bioinformatics investigation of the role of the gut-brain axis in motor cell disorders using of metagenomics, metabolomics and clinical data
Iacoangeli, A. (Primary Investigator), Al-Chalabi, A. (Co-Investigator), Curcin, V. (Co-Investigator) & Dobson, R. (Co-Investigator)
MNDA Motor Neurone Disease Association
1/02/2025 → 31/01/2029
Project: Research
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Validating ALS Molecular Subtypes For Diagnostics And Disease Stratification
Iacoangeli, A. (Primary Investigator), Al Khleifat, A. (Co-Investigator) & Al-Chalabi, A. (Co-Investigator)
1/01/2025 → 30/06/2026
Project: Research
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A Large-scale Multi-omics Study To Investigate The Role Of Human Endogenous Retroviruses And Structural Variants In Amyotrophic Lateral Sclerosis
Iacoangeli, A. (Primary Investigator), Al-Chalabi, A. (Co-Investigator), Breen, G. (Co-Investigator) & Dobson, R. (Co-Investigator)
1/01/2025 → 31/12/2027
Project: Research
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NIHR Pre-doctoral Fellowship Round 6 Mandegarsadat Miresmaeili
Iacoangeli, A. (Primary Investigator) & Al-Chalabi, A. (Co-Investigator)
NIHR National Institute For Health & Care Research
1/09/2024 → 28/02/2026
Project: Research
Thesis
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Genetic risk factors in Amyotrophic Lateral Sclerosis
Al-Chalabi, A. (Author), Leigh, N. (Supervisor) & Powell, J. (Supervisor), 1999Student thesis: Doctoral Thesis › Doctor of Philosophy
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Prizes
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Fellowship of the Academy of Medical Sciences
Al-Chalabi, A. (Recipient), 22 May 2024
Prize: Election to learned society
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Healey Center International Prize for Innovation in ALS
Al-Chalabi, A. (Recipient), 11 Dec 2020
Prize: Prize (including medals and awards)
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