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  Advancing Understanding and Treatment of Motor Neurone Disease through Biomarker Development: UK MND RI and King’s MND Biobank Integration Project

  Al Khleifat, A. (Primary Investigator) & Al-Chalabi, A. (Co-Investigator)

  MNDA Motor Neurone Disease Association

  1/03/2025 → 30/11/2025

  Project: Research

• EPSRC DRIVE-Health: A bioinformatics investigation of the role of the gut-brain axis in motor cell disorders using of metagenomics, metabolomics and clinical data

  Iacoangeli, A. (Primary Investigator), Al-Chalabi, A. (Co-Investigator), Curcin, V. (Co-Investigator) & Dobson, R. (Co-Investigator)

  MNDA Motor Neurone Disease Association

  1/02/2025 → 31/01/2029

  Project: Research

• A Large-scale Multi-omics Study To Investigate The Role Of Human Endogenous Retroviruses And Structural Variants In Amyotrophic Lateral Sclerosis

  Iacoangeli, A. (Primary Investigator), Al-Chalabi, A. (Co-Investigator), Breen, G. (Co-Investigator) & Dobson, R. (Co-Investigator)

  MRC Medical Research Council

  1/01/2025 → 31/12/2027

  Project: Research

• Validating ALS Molecular Subtypes For Diagnostics And Disease Stratification

  Iacoangeli, A. (Primary Investigator), Al Khleifat, A. (Co-Investigator) & Al-Chalabi, A. (Co-Investigator)

  MRC Medical Research Council

  1/01/2025 → 30/06/2026

  Project: Research

• NIHR Pre-doctoral Fellowship Round 6 Mandegarsadat Miresmaeili

  Iacoangeli, A. (Primary Investigator) & Al-Chalabi, A. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/09/2024 → 28/02/2026

  Project: Research

• MNDSTaR (MND: MNDSTaR: The King's-LifeArc Solution for Motor Neurone Disease Target Validation

  Al Khleifat, A. (Primary Investigator), Al-Chalabi, A. (Co-Investigator), Iacoangeli, A. (Co-Investigator), Mitchell, J. (Co-Investigator) & Smith, B. (Co-Investigator)

  LifeArc

  1/05/2024 → 30/04/2026

  Project: Research

• Validating ALS molecular profiles from the UK biobank as a diagnostic tool

  Iacoangeli, A. (Primary Investigator), Al Khleifat, A. (Co-Investigator), Al-Chalabi, A. (Co-Investigator), Breen, G. (Co-Investigator) & Dobson, R. (Co-Investigator)

  LifeArc

  18/03/2024 → 6/10/2026

  Project: Research

• Validating ALS molecular subtypes as biomarkers for patient stratification

  Iacoangeli, A. (Primary Investigator), Al Khleifat, A. (Co-Investigator), Al-Chalabi, A. (Co-Investigator) & Breen, G. (Co-Investigator)

  MND Scotland

  1/03/2024 → 31/08/2025

  Project: Research

• Prospective Pan-European study of ALS using an integrated Patient Data Platform (Precision ALS)

  Al-Chalabi, A. (Primary Investigator)

  Stichting TRICALS Foundation

  1/11/2023 → 31/10/2026

  Project: Research

• WS3 EXPERTS_ALS Mechanistic Studies

  Al-Chalabi, A. (Primary Investigator)

  NIHR National Institute For Health & Care Research

  1/09/2023 → 30/09/2028

  Project: Research

• United2EndMND

  Al-Chalabi, A. (Primary Investigator), Al-Jamal, K. (Co-Investigator), Shaw, C. (Co-Investigator) & Sreedharan, J. (Co-Investigator)

  LifeArc

  1/08/2022 → 31/05/2026

  Project: Research

• Integration of epigenetic profile in MND clinical trials design

  Al-Chalabi, A. (Primary Investigator) & Al Khleifat, A. (Co-Investigator)

  Darby Rimmer MND Foundation

  1/04/2022 → 31/10/2026

  Project: Research

• MND Register for England, Wales and Northern Ireland

  Al-Chalabi, A. (Primary Investigator)

  MNDA Motor Neurone Disease Association

  1/01/2022 → 31/12/2025

  Project: Research

• Investigating the role of human endogenous retroviruses in Amyotrophic Lateral Sclerosis using long-read sequencing

  Iacoangeli, A. (Primary Investigator), Al-Chalabi, A. (Co-Investigator), Breen, G. (Co-Investigator) & Dobson, R. (Co-Investigator)

  Rosetrees Trust

  1/01/2022 → 30/09/2025

  Project: Research

• Using genetics to stratify patients and improve prediction of clinically relevant outcomes in psychiatry and neurology.

  Al-Chalabi, A. (Primary Investigator) & Pain, O. (Co-Investigator)

  Wellcome Trust

  1/12/2021 → 19/09/2026

  Project: Research

• The Lighthou: Evaluation of Triumeq as a treatment for amyotrophic lateral sclerosis: The Lighthouse 2 UK Study

  Al-Chalabi, A. (Primary Investigator), Carter, B. (Co-Investigator), Kelly, J. (Co-Investigator) & academic, A. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/08/2021 → 31/07/2026

  Project: Research

• The role of transposable elements in motor neuron disease predisposition and pathogenesis

  Iacoangeli, A. (Primary Investigator) & Al-Chalabi, A. (Co-Investigator)

  MNDA Motor Neurone Disease Association

  1/05/2021 → 30/09/2025

  Project: Research

• DOD/0014/000: TRICALS-MAGNET Trial

  Al-Chalabi, A. (Primary Investigator)

  My Name'5 Doddie Foundation

  2/11/2020 → 31/12/2026

  Project: Research

• TRICALS-MAGNET Trial - Alan Davidson Foundation

  Al-Chalabi, A. (Primary Investigator)

  Alan Davidson Foundation

  30/10/2020 → 31/12/2026

  Project: Research

• PRELUDE: Personalized treatmen! with lithium carbonate for unc13a determined ALS

  Al-Chalabi, A. (Primary Investigator)

  Motor Neurone Disease Association

  1/11/2019 → 9/11/2026

  Project: Research

• Not started

  NIHR Pre-doctoral Fellowship Round 5 Dharti Vasant Kumar

  Iacoangeli, A. (Primary Investigator) & Al-Chalabi, A. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/09/2025 → 28/02/2027

  Project: Research

• Finished

  Football and MND

  Al-Chalabi, A. (Primary Investigator)

  My Name'5 Doddie Foundation

  3/06/2024 → 2/06/2025

  Project: Research

• NIHR Pre-doctoral Fellowship Round 5 Triparna Roy

  Iacoangeli, A. (Primary Investigator) & Al-Chalabi, A. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/09/2023 → 28/02/2025

  Project: Research

• Validate of a new SNP-based patient stratification pipeline

  Iacoangeli, A. (Primary Investigator) & Al-Chalabi, A. (Co-Investigator)

  Motor Neurone Disease Association

  1/04/2023 → 30/09/2023

  Project: Research

• Validating new promising drug targets in Amyotrophic Lateral Sclerosis

  Iacoangeli, A. (Primary Investigator), Al Khleifat, A. (Co-Investigator), Al-Chalabi, A. (Co-Investigator), Mitchell, J. (Co-Investigator), Smith, B. (Co-Investigator) & Sreedharan, J. (Co-Investigator)

  Alzheimer's Research UK

  1/01/2023 → 31/01/2025

  Project: Research

• NIHR Maudsley BioResource for Mental Health (22-25)

  Breen, G. (Primary Investigator), Al-Chalabi, A. (Co-Investigator), Eley, T. (Co-Investigator), Himmerich, H. (Co-Investigator), Iacoangeli, A. (Co-Investigator), Nicholson, T. (Co-Investigator), Onwumere, J. (Co-Investigator) & Wong, C. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/12/2022 → 31/03/2025

  Project: Research

• Molecular elucidation of the architecture of RNP condensates during development and disease

  Al-Chalabi, A. (Primary Investigator)

  EMBO European Molecular Biology Organisation

  1/09/2022 → 31/05/2023

  Project: Research

• From Biology to Quality of Life in Motor Neuron Disease:MND Genomics Study

  Breen, G. (Primary Investigator), Al-Chalabi, A. (Co-Investigator) & Iacoangeli, A. (Co-Investigator)

  Darby Rimmer MND Foundation

  1/05/2022 → 30/04/2025

  Project: Research

• Smith/Apr21/: Mapping neuropathological signatures of rare ALS genes: a means to identify key ALS functional pathways.

  Smith, B. (Primary Investigator), Al-Chalabi, A. (Co-Investigator), Troakes, C. (Co-Investigator) & Vance, C. (Co-Investigator)

  MNDA Motor Neurone Disease Association

  1/05/2022 → 31/03/2025

  Project: Research

• A multifaceted approach for the identification of novel drug targets and repurposing opportunities in amyotrophic lateral sclerosis

  Pain, O. (Primary Investigator), Al-Chalabi, A. (Co-Investigator) & Iacoangeli, A. (Co-Investigator)

  Alan Turing Institute

  1/04/2022 → 30/06/2022

  Project: Research

• A structural bioinformatics approach to the study of how genetic variations can cause MND/ALS

  Al-Chalabi, A. (Primary Investigator) & Iacoangeli, A. (Co-Investigator)

  Motor Neurone Disease Association

  1/04/2022 → 30/09/2023

  Project: Research

• An Integrated Genome-Based Approach to Individualised Treatment in ALS and FTD

  Al Khleifat, A. (Primary Investigator) & Al-Chalabi, A. (Co-Investigator)

  ALS Association

  31/01/2022 → 30/04/2024

  Project: Research

• Toward multiomics-based next-generation diagnostics for precision medicine in ALS and FTD

  Al-Chalabi, A. (Primary Investigator) & Al Khleifat, A. (Co-Investigator)

  MNDA Motor Neurone Disease Association

  31/01/2022 → 31/03/2025

  Project: Research

• Lighthouse 2 and TRICALS clinical trials : Clinical Trials Practitioner

  Al-Chalabi, A. (Primary Investigator)

  Motor Neurone Disease Association

  1/11/2021 → 31/10/2023

  Project: Research

  • Physician 100%

• NIHR Pre-doctoral Fellowship Yuen Kaye Li

  Iacoangeli, A. (Primary Investigator) & Al-Chalabi, A. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/09/2021 → 28/02/2023

  Project: Research

• NIHR202421: NIHR Senior Investigator Award - Ammar Al-Chalabi

  Al-Chalabi, A. (Primary Investigator)

  NIHR National Institute For Health & Care Research

  1/04/2021 → 31/03/2025

  Project: Research

• DRIVE Health CDT: A whole-genome sequencing approach to advance precision medicine and study patient heterogeneity in ALS

  Al-Chalabi, A. (Primary Investigator), Curcin, V. (Co-Investigator), Dobson, R. (Co-Investigator) & Iacoangeli, A. (Co-Investigator)

  GSK Glaxo Wellcome Research & Development Ltd

  1/10/2020 → 31/03/2024

  Project: Research

• A whole-genome sequencing approach to advance precision medicine and study patient heterogeneity in Motor Neurone Disease

  Al-Chalabi, A. (Primary Investigator) & Iacoangeli, A. (Co-Investigator)

  Motor Neurone Disease Association

  1/10/2020 → 31/03/2024

  Project: Research

• Using statistical models and machine learning to find subgroups of patients with homogeneous disease causes in amyotrophic lateral sclerosis

  Iacoangeli, A. (Primary Investigator), Al-Chalabi, A. (Co-Investigator) & Dobson, R. (Co-Investigator)

  Motor Neurone Disease Association

  1/10/2019 → 30/09/2020

  Project: Research

  • Amyotrophic Lateral Sclerosis 100%
  • Diseases 100%

• A new strategy for clinical trials and personalised therapy in MND

  Al-Chalabi, A. (Primary Investigator) & Al Khleifat, A. (Co-Investigator)

  Motor Neurone Disease Association

  1/08/2019 → 31/01/2022

  Project: Research

  • Clinical Trial 100%

• A whole-genome approach to the study of the genetic and the epigenetic landscape of Primary Lateral Sclerosis

  Al-Chalabi, A. (Primary Investigator) & Iacoangeli, A. (Co-Investigator)

  Spastic Paraplegia Foundation, Inc

  15/06/2019 → 31/08/2022

  Project: Research

• Multi-omics analysis of human endogenous retroviruses in ALS

  Al-Chalabi, A. (Primary Investigator), Iacoangeli, A. (Co-Investigator) & Dobson, R. (Co-Investigator)

  MND Scotland

  15/06/2019 → 14/06/2020

  Project: Research

  • Multi-Omics 100%
  • Endogenous Retrovirus 100%

• Clinical Trials Core Team for Motor Neuron Disease Research

  Al-Chalabi, A. (Primary Investigator) & Shaw, C. (Co-Investigator)

  My Name'5 Doddie Foundation

  1/04/2019 → 31/12/2022

  Project: Research

• Cognitive and behavioural impairment in Amyotrophic Lateral Sclerosis: Comparing measures and validating revised consensus diagnostic criteria for Amyotrophic Lateral Sclerosis-Frontotemporal Spectrum Disorder.

  Goldstein, L. (Primary Investigator), Al-Chalabi, A. (Co-Investigator) & Vitoratou, S. (Co-Investigator)

  Motor Neurone Disease Association

  1/10/2018 → 28/02/2023

  Project: Research

• HighCALS: A programme to develop and evaluate a complex intervention to achieve a high calorie diet for people with Amyotrophic Lateral Sclerosis

  Al-Chalabi, A. (Primary Investigator)

  NIHR National Institute For Health & Care Research

  2/04/2018 → 31/03/2021

  Project: Research

  • Calorie 100%
  • Amyotrophic Lateral Sclerosis 100%

• MIROCALS: Efficacy and safety of low-dose IL-2 (Id0IL-2) as a Treg enhancer for controlling neuro-inflammation in newly diagnosed Amyotrophic Lateral Sclerosis (ALS) patients

  Al-Chalabi, A. (Co-Investigator)

  Motor Neurone Disease Association

  1/04/2018 → 31/12/2021

  Project: Research

• Biological Resource Analysis to Identify New MEchanisms and phenotypes in Neurodegenerative Diseases

  Al-Chalabi, A. (Primary Investigator), Breen, G. (Co-Investigator), Ray Chaudhuri, K. (Co-Investigator), Noble, W. (Co-Investigator) & Aarsland, D. (Co-Investigator)

  MRC Medical Research Council

  1/02/2018 → 31/01/2021

  Project: Research

• Care Augmentation by Location Linked Messaging – the CALL-Me study

  Al-Chalabi, A. (Primary Investigator)

  Psychiatry Research Trust

  1/01/2018 → 1/01/2019

  Project: Research

• A feasibility study and randomised controlled trial of acceptance and COMmitment therapy for people with Motor nEuroNe Disease (COMMEND)

  Goldstein, L. (Primary Investigator), Al-Chalabi, A. (Co-Investigator), Lawrence, V. (Co-Investigator) & McCracken, L. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/12/2017 → 31/10/2023

  Project: Research

• HERV-K Molecular Studies in Amyotrophic Lateral Sclerosis

  Al-Chalabi, A. (Primary Investigator)

  ALS Association

  1/11/2017 → 31/05/2022

  Project: Research