King's College London

Research portal

Dr Andre Strydom

  1. Further understanding the connection between Alzheimer's disease and Down syndrome

    Snyder, H. M., Bain, L. J., Brickman, A. M., Carrillo, M. C., Esbensen, A. J., Espinosa, J. M., Fernandez, F., Fortea, J., Hartley, S. L., Head, E., Hendrix, J., Kishnani, P. S., Lai, F., Lao, P., Lemere, C., Mobley, W., Mufson, E. J., Potter, H., Zaman, S. H., Granholm, A. C. & 4 others, Rosas, H. D., Strydom, A., Whitten, M. S. & Rafii, M. S., 1 Jul 2020, In : Alzheimer's and Dementia. 16, 7, p. 1065-1077 13 p.

    Research output: Contribution to journalReview article

  2. Accepted/In press

    Differential associations of apolipoprotein E e4 genotype with attentional abilities across the lifespan in individuals with Down syndrome

    Strydom, A., Hithersay, R., Startin, C., Thomas, M. & D'Souza, H., 1 Jun 2020, (Accepted/In press) In : JAMA Network open.

    Research output: Contribution to journalArticle

  3. Dynamics of plasma biomarkers in down syndrome: The relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase

    Mengel, D., Liu, W., Glynn, R. J., Selkoe, D. J., Strydom, A., Lai, F., Rosas, H. D., Torres, A., Patsiogiannis, V., Skotko, B. & Walsh, D. M., 19 Mar 2020, In : Alzheimer's Research and Therapy. 12, 1, 27.

    Research output: Contribution to journalArticle

  4. Accepted/In press

    Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain

    LonDownS Consortium, 1 Jan 2020, (Accepted/In press) In : Molecular Psychiatry.

    Research output: Contribution to journalArticle

  5. Accepted/In press

    Health comorbidities and cognitive abilities across the lifespan in Down syndrome

    Strydom, A., The LonDownS Consortium, Hithersay, R. J., Startin, C. M., Hamburg, S. F., D'Souza, H. & Thomas, M., 30 Dec 2019, (Accepted/In press) In : Journal Of Neurodevelopmental Disorders.

    Research output: Contribution to journalArticle

  6. A structured medication review tool to promote psychotropic medication optimisation for adults with intellectual disability: Feasibility study

    Sheehan, R., Strydom, A., Marston, L., Morant, N., Fiori, F., Santosh, P. & Hassiotis, A., 15 Dec 2019, In : BMJ Open. 9, 12, 033827.

    Research output: Contribution to journalArticle

  7. Experiences of psychotropic medication use and decision-making for adults with intellectual disability: A multistakeholder qualitative study in the UK

    Sheehan, R., Hassiotis, A., Strydom, A. & Morant, N., 1 Nov 2019, In : BMJ Open. 9, 11, e032861.

    Research output: Contribution to journalArticle

  8. Accepted/In press

    Plasma amyloid and tau as dementia biomarkers in Down syndrome: systematic review and meta-analyses

    Alhajraf, F., Ness, D. L., Hye, A. & Strydom, A., 10 Aug 2019, (Accepted/In press) In : Developmental Neurobiology.

    Research output: Contribution to journalReview article

  9. Accepted/In press
  10. Accepted/In press
  11. Special issue on challenging behaviour

    Sheehan, R., Strydom, A. & Hassiotis, A., 12 Jun 2019, In : Advances in Mental Health and Intellectual Disabilities. 13, 3-4, p. 89-90 2 p.

    Research output: Contribution to journalEditorial

  12. Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease

    Startin, C. M., Ashton, N. J., Hamburg, S., Hithersay, R., Wiseman, F. K., Mok, K. Y., Hardy, J., Lleó, A., Lovestone, S., Parnetti, L., Zetterberg, H., Hye, A., Fisher, E., Nizetic, D., Tybulewicz, V., Karmiloff-Smith, A., Al-Janabi, T., Zhang, D. & Strydom, A., 21 Mar 2019, In : Alzheimer's Research and Therapy. 11, 1, 26.

    Research output: Contribution to journalArticle

  13. Autistic women’s experience of intimate relationships: the impact of an adult diagnosis

    Kock, E., Strydom, A., O’brady, D. & Tantam, D., 12 Mar 2019, In : Advances in Autism. 5, 1, p. 38-49 12 p.

    Research output: Contribution to journalArticle

  14. Accepted/In press
  15. Perspectives on Ethnic and Racial Disparities in Alzheimer's Disease and Related Dementias: Update and Areas of Immediate Need

    Babulal, G., Strydom, A. & O'Bryant, S., 1 Feb 2019, In : Alzheimers & Dementia. 15, 2, p. 292-312 21 p.

    Research output: Contribution to journalShort survey

  16. Association of Dementia with Mortality among Adults with Down Syndrome Older Than 35 Years

    Hithersay, R., Startin, C. M., Hamburg, S., Mok, K. Y., Hardy, J., Fisher, E. M. C., Tybulewicz, V. L. J., Nizetic, D. & Strydom, A., Feb 2019, In : JAMA Neurology. 76, 2, p. 152-160 9 p.

    Research output: Contribution to journalArticle

  17. Comparison of Receptive Verbal Abilities Assessed Using the KBIT-2 and BPVS3 in Adults with Down Syndrome

    The LonDownS Consortium, Startin, C. M., Hamburg, S. & Strydom, A., 17 Jan 2019, In : Frontiers in Psychology. 9, JAN, 2730.

    Research output: Contribution to journalArticle

  18. Eine deutsche Fassung der Cambridge Examination for Mental Disorders of Older People with Down’s Syndrome and Others with Intellectual Disabilities: Ein Diagnoseverfahren zur Erfassung von Demenz bei Menschen mit einem Down-Syndrom

    Nübling, G., Loosli, S. V., Wlasich, E., Prix, C., Schönecker, S., Freudelsperger, L., Smrzka, N., Strydom, A. M., Zaman, S. H., Benejam, B., Missios, J., Meister, R., Danek, A. & Levin, J., 1 Jan 2019, In : Zeitschrift Fur Gerontologie Und Geriatrie.

    Research output: Contribution to journalArticle

  19. Alzheimer's disease in Down syndrome: An overlooked population for prevention trials

    Strydom, A., Coppus, A., Blesa, R., Danek, A., Fortea, J., Hardy, J., Levin, J., Nuebling, G., Rebillat, A., Ritchie, C., Van Duijn, C., Zaman, S. & Zetterberg, H., 13 Dec 2018, In : Alzheimers & Dementia. 4, p. 703-713

    Research output: Contribution to journalArticle

  20. Cognitive markers of preclinical and prodromal Alzheimer's disease in Down syndrome

    Startin, C. M., Hamburg, S., Hithersay, R., Mok, K. Y., Hardy, J., Al-Janabi, T., The LonDownS Consortium & Strydom, A., 28 Nov 2018, In : Alzheimers & Dementia. 15, 2, p. 245-257

    Research output: Contribution to journalArticle

  21. Association of Dementia Owing to Alzheimer Disease With Mortality Rates Among Adults With Down Syndrome Older Than 35 Years

    Hithersay, R. J., Startin, C. M., Hamburg, S., Mok, K. Y., Hardy, J., Fisher, E. M. C., Tybulewicz, V. L. J., Nizetic, D. & Strydom, A., 19 Nov 2018, In : JAMA Neurology.

    Research output: Contribution to journalArticle

  22. Physical health and clinical phenotypes

    Strydom, A., Curmi, A. & McQuillin, A., 29 Oct 2018, Physical Health of Adults with Intellectual and Developmental Disabilities. Springer International Publishing Switzerland, p. 71-86 16 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  23. Association of Focused Medication Review With Optimization of Psychotropic Drug Prescribing: A Systematic Review and Meta-analysis

    Sheehan, R., Strydom, A., Brown, E., Marston, L. & Hassiotis, A., 26 Oct 2018, In : JAMA Network open. 1, 6, p. e183750

    Research output: Contribution to journalArticle

  24. Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP

    Wiseman, F. K., Pulford, L. J., Barkus, C., Liao, F., Portelius, E., Webb, R., Chávez-gutiérrez, L., Cleverley, K., Noy, S., Sheppard, O., Collins, T., Powell, C., Sarell, C. J., Rickman, M., Choong, X., Tosh, J. L., Siganporia, C., Whittaker, H. T., Stewart, F., Szaruga, M. & 14 others, Murphy, M. P., Blennow, K., De Strooper, B., Zetterberg, H., Bannerman, D., Holtzman, D. M., Tybulewicz, V. L. J., Fisher, E. M. C., Strydom, A., Fisher, E., Nizetic, D., Hardy, J., Tybulewicz, V. & Karmiloff-smith, A., 1 Aug 2018, In : Brain. 141, 8, p. 2457-2474

    Research output: Contribution to journalArticle

  25. Aging related cognitive changes associated with Alzheimer's disease in Down syndrome

    Firth, N. C., Startin, C. M., Hithersay, R., Hamburg, S., Wijeratne, P. A., Mok, K. Y., Hardy, J., Alexander, D. C., The LonDownS Consortium & Strydom, A., Jun 2018, In : Annals of Clinical and Translational Neurology. 5, 6, p. 741-751 11 p.

    Research output: Contribution to journalArticle

  26. Translating molecular advances in Down syndrome and Fragile X syndrome into therapies

    Faundez, V., De Toma, I., Bardoni, B., Bartesaghi, R., Nizetic, D., de la Torre, R., Cohen Kadosh, R., Herault, Y., Dierssen, M., Potier, M-C., Antonarakis, S., Contestabile, A., Coppus, T., De Deyn, P., Dekker, A., Delabar, J-M., Fisher, E., Hérault, Y., Martinez-Cué, C. & Strydom, A., Jun 2018, In : European Neuropsychopharmacology. 28, 6, p. 675-690 16 p.

    Research output: Contribution to journalArticle

  27. Patterns and severity of vascular amyloid in Alzheimer’s disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer’s disease

    Mann, D. M. A., Davidson, Y. S., Robinson, A. C., Allen, N., Hashimoto, T., Richardson, A., Jones, M., Snowden, J. S., Pendleton, N., Potier, M. C., Laquerrière, A., Prasher, V., Iwatsubo, T. & Strydom, A., 16 May 2018, In : Acta Neuropathologica. p. 1-19 19 p.

    Research output: Contribution to journalArticle

  28. Neurodevelopmental risk copy number variants in adults with intellectual disabilities and comorbid psychiatric disorders

    Thygesen, J. H., Wolfe, K., Mcquillin, A., Viñas-jornet, M., Baena, N., Brison, N., D'haenens, G., Esteba-castillo, S., Gabau, E., Ribas-vidal, N., Ruiz, A., Vermeesch, J., Weyts, E., Novell, R., Buggenhout, G. V., Strydom, A., Bass, N., Guitart, M. & Vogels, A., 1 May 2018, In : British Journal of Psychiatry. 212, 5, p. 287-294

    Research output: Contribution to journalArticle

  29. The Behavioral and Psychological Symptoms of Dementia in Down Syndrome (BPSD-DS) Scale: Comprehensive Assessment of Psychopathology in Down Syndrome

    Dekker, A. D., Sacco, S., Carfi, A., Benejam, B., Vermeiren, Y., Beugelsdijk, G., Schippers, M., Hassefras, L., Eleveld, J., Grefelman, S., Fopma, R., Bomer-veenboer, M., Boti, M., Oosterling, G. D. E., Scholten, E., Tollenaere, M., Checkley, L., Strydom, A., Van Goethem, G., Onder, G. & 6 others, Blesa, R., Zu Eulenburg, C., Coppus, A. M. W., Rebillat, A., Fortea, J. & De Deyn, P. P., 24 Apr 2018, In : Journal of Alzheimer's Disease. 63, 2, p. 797-819

    Research output: Contribution to journalArticle

  30. Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome

    Strydom, A., Heslegrave, A., Startin, C. M., Mok, K. Y., Hardy, J., Groet, J., Nizetic, D., Zetterberg, H., The LonDownS Consortium, Fisher, E., Tybulewicz, V., Karmiloff-Smith, A., Hamburg, S. & Hithersay, R., 10 Apr 2018, In : Alzheimer's Research and Therapy. 10, 1, 39.

    Research output: Contribution to journalArticle

  31. Delineating the psychiatric and behavioral phenotype of recurrent 2q13 deletions and duplications

    Wolfe, K., McQuillin, A., Alesi, V., Boudry Labis, E., Cutajar, P., Dallapiccola, B., Dentici, M. L., Dieux-Coeslier, A., Duban-Bedu, B., Duelund Hjortshøj, T., Goel, H., Loddo, S., Morrogh, D., Mosca-Boidron, A-L., Novelli, A., Olivier-Faivre, L., Parker, J., Parker, M. J., Patch, C., Pelling, A. L. & 8 others, Smol, T., Tümer, Z., Vanakker, O., van Haeringen, A., Vanlerberghe, C., Strydom, A., Skuse, D. & Bass, N., 31 Mar 2018, In : American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics.

    Research output: Contribution to journalArticle

  32. Clinical outcomes of staff training in positive behaviour support to reduce challenging behaviour in adults with intellectual disability: cluster randomised controlled trial

    Hassiotis, A., Poppe, M., Strydom, A., Vickerstaff, V., Hall, I. S., Crabtree, J., Omar, R. Z., King, M., Hunter, R., Biswas, A., Cooper, V., Howie, W. & Crawford, M. J., Mar 2018, In : British Journal of Psychiatry. 212, 03, p. 161-168

    Research output: Contribution to journalArticle

  33. Predictors of Age of Diagnosis and Survival of Alzheimer’s Disease in Down Syndrome

    Sinai, A., Mokrysz, C., Bernal, J., Bohnen, I., Bonell, S., Courtenay, K., Dodd, K., Gazizova, D., Hassiotis, A., Hillier, R., Mcbrien, J., McCarthy, J., Mukherji, K., Naeem, A., Perez-achiaga, N., Rantell, K., Sharma, V., Thomas, D., Walker, Z., Whitham, S. & 2 others, Strydom, A. & Head, E. (ed.), 19 Dec 2017, In : JOURNAL OF ALZHEIMERS DISEASE. 61, 2, p. 717-728

    Research output: Contribution to journalArticle

  34. Assessing Autism in Adults: An Evaluation of the Developmental, Dimensional and Diagnostic Interview—Adult Version (3Di-Adult)

    Mandy, W., Clarke, K., McKenner, M., Strydom, A., Crabtree, J., Lai, M-C., Allison, C., Baron-Cohen, S. & Skuse, D., 7 Nov 2017, In : Journal of Autism and Developmental Disorders. p. 1-12 12 p.

    Research output: Contribution to journalArticle

  35. Donation of peripheral blood stem cells to unrelated strangers: A thematic analysis

    Billen, A., Madrigal, JA., Scior, K., Shaw, BE. & Strydom, A., 25 Oct 2017, In : PL o S One . 12, ARTN e0186438, 16 p.

    Research output: Contribution to journalArticle

  36. Consensus statement of the international summit on intellectual disability and Dementia related to post-diagnostic support

    Dodd, K., Watchman, K., Janicki, M. P., Coppus, A., Gaertner, C., Fortea, J., Santos, F. H., Keller, S. M. & Strydom, A., 7 Sep 2017, In : Aging and Mental Health. p. 1-10

    Research output: Contribution to journalArticle

  37. Clinical aspects and biomarkers of Alzheimer's disease in Down syndrome

    Zis, P. & Strydom, A., 1 Sep 2017, In : Free Radical Biology and Medicine.

    Research output: Contribution to journalArticle

  38. Genetic testing in intellectual disability psychiatry: opinions and practices of UK child and ID psychiatrists

    Patch, C. R., Wolfe, K., Steuber, K., McQuillan, A., Fatima, J., Flinter, F., Strydom, A. & Bass, N., 23 Aug 2017, In : JOURNAL OF APPLIED RESEARCH IN INTELLECTUAL DISABILITIES.

    Research output: Contribution to journalArticle

  39. Psychotropic prescribing in people with intellectual disability and challenging behaviour

    Sheehan, R., Strydom, A., Morant, N., Pappa, E. & Hassiotis, A., 18 Aug 2017, In : British Medical Journal. 358, p. j3896-j3896

    Research output: Contribution to journalEditorial

  40. Movement side effects of antipsychotic drugs in adults with and without intellectual disability: UK population-based cohort study

    Sheehan, R., Horsfall, L., Strydom, A., Osborn, D., Walters, K. & Hassiotis, A., 3 Aug 2017, In : BMJ Open.

    Research output: Contribution to journalArticle

  41. Accepted/In press

    The Relationship Between Sound–Shape Matching and Cognitive Ability in Adults With Down Syndrome

    Hamburg, S., Startin, CM. & Strydom, A., 2 Jun 2017, (Accepted/In press) In : Multisensory research. 30, 6, p. 537-547

    Research output: Contribution to journalArticle

  42. New horizons for mental health research in intellectual disabilities

    Strydom, A. & Melville, C., Jun 2017, In : Journal of Intellectual Disability Research. 61, 6, p. 519-520 2 p.

    Research output: Contribution to journalEditorial

  43. Cognitive decline and dementia in Down syndrome

    Hithersay, R., Hamburg, S., Knight, B. & Strydom, A., 1 Mar 2017, In : Current Opinion in Psychiatry. 30, p. 102-107 6 p.

    Research output: Contribution to journalArticle

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