Professor André Tylee took up the first Chair in Primary Care Mental Health at the Institute of Psychiatry, King's College London in 2001. He was the Academic Director for the Mood, Anxiety and Personality Clinical Academic Group in King's Health Partners Academic Health Sciences Centre from 2012-2014 and led Mood, Anxiety and Personality research within the Disorders of Affect, Addictions and Interface with Medicine (DAAIM) research group of the NIHR Mental Health Biomedical Research Centre (BRC) at the South London and Maudsley (SLAM) Mental Health Foundation Trust and Institute of Psychiatry (IOP), King's College London. His clinical work focused on providing care for people with long term conditions and depression/anxiety disorders within the Southwark IAPT service at SLAM.

Prior to this, he was a GP in South London for 21 years. He helped run a 5 year National Defeat Depression Campaign for the Royal College of GPs and Royal College of Psychiatrists, who awarded him a MRCPsych. He was awarded a Senior Educational Fellowship post by the RCGP/DH and Mental Health Foundation to develop the Trailblazers national programme of training primary care professionals in mental health skills and developed the RCGP Unit for Mental Health Education at the Institute of Psychiatry, a precursor of the Section of Primary Care Mental Health he ran. He was National Expert Advisor on Long Term Conditions to the Improving Access to Psychological Therapies Programme (IAPT) at the Department of Health from 2011 to 2013. He co-founded PRIMHE, the only primary care mental health charity, and advises the Charlie Waller Trust, a depression charity who have developed Waller depression training fellows nationally, and is a patron of Reflections charity, which promotes user art. 

Professor André Tylee's main current research interest is to improve the primary care of people with coronary heart disease and depression/anxiety. He is the PI on the NIHR-funded Programme Grant UPBEAT-UK, a 5-year programme of research to improve the primary and personalised care of people with coronary heart disease and depression (a cohort, 3 qualitative studies and a phase II RCT). He is also the PI on the PROMPT study within DAAIM, which aims to research the predictors of response to psychological treatments in IAPT services and is funded by the NIHR BRC at the IOP and SLAM. 

He has conducted and been involved in RCTs on school nurse training in depression (QUEST), GP drug treatment of mild to moderate depression (THREAD) and GP and Health Visitor treatment of moderate post-natal depression (RESPOND) and a cohort study on asthma and depression. He is involved in an evaluation of the effect of MAP CAG related re-organisational change of services (MAPLE). Other studies he is a co-applicant on include; inflammatory factors in people with CHD and depression; self-confidence workshops’ for depression; an intervention to improve well-being in psychosis; targeted internet-based prevention for students at high risk of common mental disorders and new software to apply the Equality Act 2010 to people with mental illness.

Primary care; mental health care, notably detection and management of depression; educational initiatives for general practice.