King's College London

Research portal

Dr Andreas Birkenfeld

  1. Endoplasmic reticulum stress and the unfolded protein response in skeletal muscle of subjects suffering from peritoneal sepsis

    Metzing, U. B., von Loeffelholz, C., Steidl, R., Romeike, B., Winkler, R., Rauchfuß, F., Settmacher, U., Stoppe, C., Coldewey, S. M., Weinmann, C., Weickert, M. O., Claus, R. A., Birkenfeld, A. L., Kosan, C. & Horn, P., 11 Jan 2022, (E-pub ahead of print) In: Scientific Reports. 12, 1, 504.

    Research output: Contribution to journalArticlepeer-review

  2. Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance

    Schumann, T., König, J., von Loeffelholz, C., Vatner, D. F., Zhang, D., Perry, R. J., Bernier, M., Chami, J., Henke, C., Kurzbach, A., El-Agroudy, N. N., Willmes, D. M., Pesta, D., de Cabo, R., O´Sullivan, J. F., Simon, E., Shulman, G. I., Hamilton, B. S. & Birkenfeld, A. L., Dec 2021, In: Communications Biology. 4, 1, 826.

    Research output: Contribution to journalArticlepeer-review

  3. The role of physical activity in nonalcoholic and metabolic dysfunction associated fatty liver disease

    von Loeffelholz, C., Roth, J., Coldewey, S. M. & Birkenfeld, A. L., Dec 2021, In: Biomedicines. 9, 12, 1853.

    Research output: Contribution to journalArticlepeer-review

  4. COVID-19 and metabolic disease: mechanisms and clinical management

    Steenblock, C., Schwarz, P. E. H., Ludwig, B., Linkermann, A., Zimmet, P., Kulebyakin, K., Tkachuk, V. A., Markov, A. G., Lehnert, H., de Angelis, M. H., Rietzsch, H., Rodionov, R. N., Khunti, K., Hopkins, D., Birkenfeld, A. L., Boehm, B., Holt, R. I. G., Skyler, J. S., DeVries, J. H., Renard, E. & 16 others, Eckel, R. H., Alberti, K. G. M. M., Geloneze, B., Chan, J. C., Mbanya, J. C., Onyegbutulem, H. C., Ramachandran, A., Basit, A., Hassanein, M., Bewick, G., Spinas, G. A., Beuschlein, F., Landgraf, R., Rubino, F., Mingrone, G. & Bornstein, S. R., Nov 2021, In: The Lancet Diabetes and Endocrinology. 9, 11, p. 786-798 13 p.

    Research output: Contribution to journalArticlepeer-review

  5. Blutglukoseziele in der operativen Intensivmedizin

    Roth, J., Sommerfeld, O., Birkenfeld, A. L., Sponholz, C., Müller, U. A. & Von Loeffelholz, C., 24 Sep 2021, In: Deutsches Arzteblatt international. 118, 38

    Research output: Contribution to journalReview articlepeer-review

  6. A Narrative Review on the Role of AMPK on De Novo Lipogenesis in Non-Alcoholic Fatty Liver Disease: Evidence from Human Studies

    von Loeffelholz, C., Coldewey, S. M. & Birkenfeld, A. L., 19 Jul 2021, In: Cells. 10, 7, 1822.

    Research output: Contribution to journalReview articlepeer-review

  7. Low-fat hypocaloric diet reduces neprilysin in overweight and obese human subjects

    Henke, C., Haufe, S., Ziehl, D., Bornstein, S. R., Schulz-Menger, J., Heni, M., Engeli, S., Jordan, J. & Birkenfeld, A. L., Apr 2021, In: ESC Heart Failure. 8, 2, p. 938-942 5 p.

    Research output: Contribution to journalArticlepeer-review

  8. The transCampus Metabolic Training Programme Explores the Link of SARS-CoV-2 Virus to Metabolic Disease

    Bornstein, S. R., Guan, K., Brunβen, C., Mueller, G., Kamvissi-Lorenz, V., Lechler, R., Trembath, R., Mayr, M., Poston, L., Sancho, R., Ahmed, S., Alfar, E., Aljani, B., Alves, T. C., Amiel, S., Andoniadou, C. L., Bandral, M., Belavgeni, A., Berger, I., Birkenfeld, A. & 74 others, Bonifacio, E., Chavakis, T., Chawla, P., Choudhary, P., Cujba, A. M., Delgadillo Silva, L. F., Demcollari, T., Drotar, D. M., Duin, S., El-Agroudy, N. N., El-Armouche, A., Eugster, A., Gado, M., Gavalas, A., Gelinsky, M., Guirgus, M., Hansen, S., Hanton, E., Hasse, M., Henneicke, H., Heller, C., Hempel, H., Hogstrand, C., Hopkins, D., Jarc, L., Jones, P. M., Kamel, M., Kämmerer, S., King, A. J. F., Kurzbach, A., Lambert, C., Latunde-Dada, Y., Lieberam, I., Liers, J., Li, J. W., Linkermann, A., Locke, S., Ludwig, B., Manea, T., Maremonti, F., Marinicova, Z., McGowan, B. M., Mickunas, M., Mingrone, G., Mohanraj, K., Morawietz, H., Ninov, N., Peakman, M., Persaud, S. J., Pietzsch, J., Cachorro, E., Pullen, T. J., Pyrina, I., Rubino, F., Santambrogio, A., Schepp, F., Schlinkert, P., Scriba, L. D., Siow, R., Solimena, M., Spagnoli, F. M., Speier, S., Stavridou, A., Steenblock, C., Strano, A., Taylor, P., Tiepner, A., Tonnus, W., Tree, T., Watt, F., Werdermann, M., Wilson, M., Yusuf, N. & Ziegler, C. G., 1 Mar 2021, In: Hormone and Metabolic Research. 53, 3, p. 204-206 3 p.

    Research output: Contribution to journalArticlepeer-review

  9. Consequences of the COVID-19 pandemic for patients with metabolic diseases

    Bornstein, S. R., Rubino, F., Ludwig, B., Rietzsch, H., Schwarz, P. E. H., Rodionov, R. N., Khunti, K., Hopkins, D., Birkenfeld, A. L., Boehm, B., Amiel, S., Holt, R. I. G., Skyler, J. S., DeVries, J. H., Renard, E., Eckel, R. H., Zimmet, P., Alberti, K. G., Geloneze, B., Chan, J. C. & 8 others, Mbanya, J. C., Onyegbutulem, H. C., Ramachandran, A., Basit, A., Hassanein, M., Spinas, G. A., Beuschlein, F. & Mingrone, G., Mar 2021, In: Nature Metabolism. 3, 3, p. 289-292 4 p.

    Research output: Contribution to journalComment/debatepeer-review

  10. Global pandemics interconnected — obesity, impaired metabolic health and COVID-19

    Stefan, N., Birkenfeld, A. L. & Schulze, M. B., Mar 2021, In: Nature Reviews Endocrinology. 17, 3, p. 135-149 15 p.

    Research output: Contribution to journalReview articlepeer-review

  11. The longevity gene mIndy (I’m Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms

    Willmes, D. M., Daniels, M., Kurzbach, A., Lieske, S., Bechmann, N., Schumann, T., Henke, C., El-Agroudy, N. N., da Costa Goncalves, A. C., Peitzsch, M., Hofmann, A., Kanczkowski, W., Kräker, K., Müller, D. N., Morawietz, H., Deussen, A., Wagner, M., El-Armouche, A., Helfand, S. L., Bornstein, S. R. & 6 others, de Cabo, R., Bernier, M., Eisenhofer, G., Tank, J., Jordan, J. & Birkenfeld, A. L., 25 Jan 2021, In: JCI Insight. 6, 2, e136083.

    Research output: Contribution to journalArticlepeer-review

  12. Dapagliflozin effects on haematocrit, red blood cell count and reticulocytes in insulin-treated patients with type 2 diabetes

    Aberle, J., Menzen, M., Schmid, S. M., Terkamp, C., Jaeckel, E., Rohwedder, K., Scheerer, M. F., Xu, J., Tang, W. & Birkenfeld, A. L., Dec 2020, In: Scientific Reports. 10, 1, 22396.

    Research output: Contribution to journalArticlepeer-review

  13. Obesity and impaired metabolic health in patients with COVID-19

    Stefan, N., Birkenfeld, A. L., Schulze, M. B. & Ludwig, D. S., 1 Jul 2020, In: Nature Reviews Endocrinology. 16, 7, p. 341-342 2 p.

    Research output: Contribution to journalComment/debatepeer-review

  14. Practical recommendations for the management of diabetes in patients with COVID-19

    Bornstein, S. R., Rubino, F., Khunti, K., Mingrone, G., Hopkins, D., Birkenfeld, A. L., Boehm, B., Amiel, S., Holt, R. IG., Skyler, J. S., DeVries, J. H., Renard, E., Eckel, R. H., Zimmet, P., Alberti, K. G., Vidal, J., Geloneze, B., Chan, J. C., Ji, L. & Ludwig, B., Jun 2020, In: The Lancet Diabetes and Endocrinology. 8, 6, p. 546-550 5 p.

    Research output: Contribution to journalReview articlepeer-review

  15. Efficacy and safety of liraglutide 3.0 mg in individuals with overweight or obesity and type 2 diabetes treated with basal insulin: The SCALE insulin randomized controlled trial

    Garvey, W. T., Birkenfeld, A. L., Dicker, D., Mingrone, G., Pedersen, S. D., Satylganova, A., Skovgaard, D., Sugimoto, D., Jensen, C. & Mosenzon, O., 1 May 2020, In: Diabetes Care. 43, 5, p. 1085-1093 9 p.

    Research output: Contribution to journalArticlepeer-review

  16. Solute Carrier Transporters as Potential Targets for the Treatment of Metabolic Disease

    Schumann, T., König, J., Henke, C., Willmes, D. M., Bornstein, S. R., Jordan, J., Fromm, M. F. & Birkenfeld, A. L., 1 Jan 2020, In: Pharmacological Reviews. 72, 1, p. 343-379 37 p.

    Research output: Contribution to journalReview articlepeer-review

  17. New insight into the mechanisms of ectopic fat deposition improvement after bariatric surgery

    Angelini, G., Gissey, L. C., Del Corpo, G., Giordano, C., Cerbelli, B., Severino, A., Manco, M., Basso, N., Birkenfeld, A. L., Bornstein, S. R., Genco, A., Mingrone, G. & Casella, G., 1 Dec 2019, In: Scientific Reports. 9, 1, 17315.

    Research output: Contribution to journalArticlepeer-review

  18. Fasting Glucose State Determines Metabolic Response to Supplementation with Insoluble Cereal Fibre: A Secondary Analysis of the Optimal Fibre Trial (OptiFiT)

    Kabisch, S., Meyer, N. M. T., Honsek, C., Gerbracht, C., Dambeck, U., Kemper, M., Osterhoff, M. A., Birkenfeld, A. L., Arafat, A. M., Hjorth, M. F., Weickert, M. O. & Pfeiffer, A. F. H., 6 Oct 2019, In: Nutrients. 11, 10, 2385.

    Research output: Contribution to journalArticlepeer-review

  19. Are Lifestyle Therapies Effective for NAFLD Treatment?

    El-Agroudy, N. N., Kurzbach, A., Rodionov, R. N., O'Sullivan, J., Roden, M., Birkenfeld, A. L. & Pesta, D. H., 1 Oct 2019, In: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 30, 10, p. 701-709 9 p.

    Research output: Contribution to journalReview articlepeer-review

  20. Oral semaglutide and cardiovascular outcomes in patients with type 2 diabetes

    PIONEER 6 Investigators, 29 Aug 2019, In: New England Journal of Medicine. 381, 9, p. 841-851 11 p.

    Research output: Contribution to journalArticlepeer-review

  21. Atp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic β cells

    Binger, K. J., Neukam, M., Tattikota, S. G., Qadri, F., Puchkov, D., Willmes, D. M., Wurmsee, S., Geisberger, S., Dechend, R., Raile, K., Kurth, T., Nguyen, G., Poy, M. N., Solimena, M., Muller, D. N. & Birkenfeld, A. L., 1 Jan 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 40, p. 19983-19988 6 p.

    Research output: Contribution to journalArticlepeer-review

  22. Lipid Profiles in Lyme Borreliosis: A Potential Role for Apheresis?

    Straube, R., Voit-Bak, K., Gor, A., Steinmeier, T., Chrousos, G. P., Boehm, B. O., Birkenfeld, A. L., Barbir, M., Balanzew, W. & Bornstein, S. R., 1 Jan 2019, In: Hormone and Metabolic Research. 51, 5, p. 326-329 4 p.

    Research output: Contribution to journalArticlepeer-review

  23. Myocardial metbolism in heart failure: Purinergic signalling and other metabolic concepts

    Birkenfeld, A. L., Jordan, J., Dworak, M., Merkel, T. & Burnstock, G., 25 Aug 2018, (E-pub ahead of print) In: Pharmacology and Therapeutics.

    Research output: Contribution to journalArticlepeer-review

  24. Incidence of Hypoglycemia after Gastric Bypass vs Sleeve Gastrectomy: A Randomized Trial

    Capristo, E., Panunzi, S., De Gaetano, A., Spuntarelli, V., Bellantone, R., Giustacchini, P., Birkenfeld, A. L., Amiel, S., Bornstein, S. R., Raffaelli, M. & Mingrone, G., 1 Jun 2018, In: Journal of Clinical Endocrinology and Metabolism. 103, 6, p. 2136-2146 11 p.

    Research output: Contribution to journalArticlepeer-review

  25. The longevity gene INDY (I'm Not Dead Yet) in metabolic control: Potential as pharmacological target

    Willmes, D. M., Kurzbach, A., Henke, C., Schumann, T., Zahn, G., Heifetz, A., Jordan, J., Helfand, S. L. & Birkenfeld, A. L., May 2018, In: Pharmacology and Therapeutics. 185, p. 1-11 11 p.

    Research output: Contribution to journalReview articlepeer-review

  26. Urinary Lipidomics: evidence for multiple sources and sexual dimorphism in healthy individuals

    Bornstein, S., Graessler, J., Mehnert, C. S., Schulte, K-M., Bergmann, S., Strauss, S., Bornstein, T. D., Licinio, J., Wong, M. L. N. & Birkenfeld, A. L., Apr 2018, In: The pharmacogenomics journal. 18, 2, p. 331-339 9 p.

    Research output: Contribution to journalArticlepeer-review

  27. Effect of Magnesium Loading Dose on Insulin Resistance in Patients With Stress-Induced Hyperglycemia: A Randomized Clinical Trial

    von Loeffelholz, C., Thomas-Rüddel, D., Bauer, M. & Birkenfeld, A., 1 Jan 2018, (Accepted/In press) In: JOURNAL OF INTENSIVE CARE MEDICINE.

    Research output: Contribution to journalArticlepeer-review

  28. Intensive lifestyle modifications with or without liraglutide 3mg vs sleeve gastrectomy: A three-arm non-randomized, controlled, pilot study

    Capristo, E., Panunzi, S., De Gaetano, A., Raffaelli, M., Guidone, C., Iaconelli, A., L’Abbate, L., Birkenfeld, A. L., Bellantone, R., Bornstein, S. & Mingrone, G., 29 Dec 2017, (E-pub ahead of print) In: DIABETES AND METABOLISM.

    Research output: Contribution to journalArticlepeer-review

  29. Glucagon Decreases IGF-1 Bioactivity in Humans, Independently of Insulin, by Modulating Its Binding Proteins

    Sarem, Z., Bumke-Vogt, C., Mahmoud, A. M., Assefa, B., Weickert, M. O., Adamidou, A., Bähr, V., Frystyk, J., Möhlig, M., Spranger, J., Lieske, S., Birkenfeld, A. L., Pfeiffer, A. F. H. & Arafat, A. M., 1 Sep 2017, In: The Journal of clinical endocrinology and metabolism. 102, 9, p. 3480-3490 11 p.

    Research output: Contribution to journalArticlepeer-review

  30. Retinol saturase coordinates liver metabolism by regulating ChREBP activity

    Heidenreich, S., Witte, N., Weber, P., Goehring, I., Tolkachov, A., von Loeffelholz, C., Döcke, S., Bauer, M., Stockmann, M., Pfeiffer, A. F. H., Birkenfeld, A. L., Pietzke, M., Kempa, S., Muenzner, M. & Schupp, M., 30 Aug 2017, In: Nature Communications. 8, 1, p. 384

    Research output: Contribution to journalArticlepeer-review

  31. Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1

    Rathjen, T., Yan, X., Kononenko, N. L., Ku, M-C., Song, K., Ferrarese, L., Tarallo, V., Puchkov, D., Kochlamazashvili, G., Brachs, S., Varela, L., Szigeti-Buck, K., Yi, C-X., Schriever, S. C., Tattikota, S. G., Carlo, A. S., Moroni, M., Siemens, J., Heuser, A., van der Weyden, L. & 9 others, Birkenfeld, A. L., Niendorf, T., Poulet, J. F. A., Horvath, T. L., Tschöp, M. H., Heinig, M., Trajkovski, M., Haucke, V. & Poy, M. N., 1 Aug 2017, In: Nature Neuroscience. 20, 8, p. 1096-1103 8 p.

    Research output: Contribution to journalArticlepeer-review

  32. The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism

    von Loeffelholz, C., Lieske, S., Neuschäfer-Rube, F., Willmes, D. M., Raschzok, N., Sauer, I. M., König, J., Fromm, M. F., Horn, P., Chatzigeorgiou, A., Pathe-Neuschäfer-Rube, A., Jordan, J., Pfeiffer, A. F. H., Mingrone, G., Bornstein, S. R., Stroehle, P., Harms, C., Wunderlich, F. T., Helfand, S. L., Bernier, M. & 5 others, de Cabo, R., Shulman, G. I., Chavakis, T., Püschel, G. P. & Birkenfeld, A. L., 19 Jul 2017, In: Hepatology. 66, 2, p. 616–630 15 p.

    Research output: Contribution to journalArticlepeer-review

  33. Insulin-Like Growth Factor (IGF) Binding Protein-2, Independently of IGF-1, Induces GLUT-4 Translocation and Glucose Uptake in 3T3-L1 Adipocytes

    Assefa, B., Mahmoud, A. M., Pfeiffer, A. F. H., Birkenfeld, A. L., Spranger, J. & Arafat, A. M., 2017, In: Oxidative Medicine and Cellular Longevity. 2017, p. 3035184

    Research output: Contribution to journalArticlepeer-review

  34. Intra-individual variability and circadian rhythm of vascular endothelial growth factors in subjects with normal glucose tolerance and type 2 diabetes

    Hanefeld, M., Engelmann, K., Appelt, D., Sandner, D., Weigmann, I., Ganz, X., Pistrosch, F., Köhler, C., Gasparic, A. & Birkenfeld, A. L., 2017, In: PLoS ONE. 12, 10, p. e0184234

    Research output: Contribution to journalArticlepeer-review

  35. Comment on Ferrannini et al. CV Protection in the EMPA-REG OUTCOME Trial: A "Thrifty Substrate" Hypothesis. Diabetes Care 2016;39:1108-1114

    Jordan, J., El-Armouche, A., Hanefeld, M., Bornstein, S. R. & Birkenfeld, A. L., Dec 2016, In: Diabetes Care. 39, 12, p. e224-e225

    Research output: Contribution to journalLetterpeer-review

  36. Pharmacogenomics in type 2 diabetes: Oral antidiabetic drugs

    Daniels, M. A., Kan, C., Willmes, D. M., Ismail, K., Pistrosch, F., Hopkins, D., Mingrone, G., Bornstein, S. R. & Birkenfeld, A. L., 1 Oct 2016, In: The pharmacogenomics journal. 16, 5, p. 399-410 12 p.

    Research output: Contribution to journalArticlepeer-review

  37. Cardiometabolic crosstalk in obesity-associated arterial hypertension

    Jordan, J. & Birkenfeld, A. L., Mar 2016, In: Reviews in endocrine & metabolic disorders. 17, 1, p. 19-28 10 p.

    Research output: Contribution to journalReview articlepeer-review

  38. The metabolic vascular syndrome - guide to an individualized treatment

    Hanefeld, M., Pistrosch, F., Bornstein, S. R. & Birkenfeld, A. L., Mar 2016, In: Reviews in endocrine & metabolic disorders. 17, 1, p. 5-17 13 p.

    Research output: Contribution to journalReview articlepeer-review

  39. The longevity transporter mIndy (Slc13a5) as a target for treating hepatic steatosis and insulin resistance

    Willmes, D. M., Helfand, S. L. & Birkenfeld, A. L., Feb 2016, In: Aging. 8, 2, p. 208-9 2 p.

    Research output: Contribution to journalArticlepeer-review

  40. Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5)

    Pesta, D. H., Perry, R. J., Guebre-Egziabher, F., Zhang, D., Jurczak, M., Fischer-Rosinsky, A., Daniels, M. A., Willmes, D. M., Bhanot, S., Bornstein, S. R., Knauf, F., Samuel, V. T., Shulman, G. I. & Birkenfeld, A. L., Dec 2015, In: Aging. 7, 12, p. 1086-93 8 p.

    Research output: Contribution to journalArticlepeer-review

  41. Creating a "Transcampus" in Diabetes Research Between King's College London and the Technische Universität Dresden: Update on Islet Biology and Transplantation

    Bornstein, S. R., Amiel, S. A., Rubino, F., Mingrone, G., Kamvissi, V., Solimena, M., Bonifacio, E., Jones, P., Schwarz, P., Birkenfeld, A. L., Behrens, A., Barthel, A., Lechler, R. & Peakman, M., 2015, In: Hormone and Metabolic Research. 47, 1, p. 1-3 3 p.

    Research output: Contribution to journalArticlepeer-review

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