King's College London

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Professor Andrew Tutt

  1. Accepted/In press
  2. AllergoOncology: Expression platform development and functional profiling of an anti-HER2 IgE antibody

    Ilieva, K. M., Fazekas-Singer, J., Bax, H. J., Crescioli, S., Montero-Morales, L., Mele, S., Sow, H. S., Stavraka, C., Josephs, D. H., Spicer, J. F., Steinkellner, H., Jensen-Jarolim, E., Tutt, A. N. J. & Karagiannis, S. N., 1 Oct 2019, In : Allergy: European Journal of Allergy and Clinical Immunology. 74, 10, p. 1985-1989 5 p.

    Research output: Contribution to journalLetter

  3. A decade of clinical development of PARP inhibitors in perspective

    Mateo, J., Lord, C. J., Serra, V., Tutt, A., Balmaña, J., Castroviejo-Bermejo, M., Cruz, C., Oaknin, A., Kaye, S. B. & de Bono, J. S., 1 Sep 2019, In : Annals of oncology : official journal of the European Society for Medical Oncology. 30, 9, p. 1437-1447 11 p.

    Research output: Contribution to journalArticle

  4. Integrin-mediated macrophage adhesion promotes lymphovascular dissemination in breast cancer

    Evans, R., Flores-Borja, F., Nassiri, S., Miranda, E., Lawler, K., Grigoriadis, A., Monypenny, J., Gillett, C., Owen, J., Gordon, P., Male, V., Cheung, A., Noor, F., Barber, P., Marlow, R., Francesch-Domenech, E., Fruhwirth, G., Squadrito, M., Vojnovic, B., Tutt, A. & 3 others, Festy, F., De Palma, M. & Ng, T., 14 May 2019, In : Cell Reports. 27, 7, p. 1967-1978.e4

    Research output: Contribution to journalArticle

  5. PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer

    Chabanon, R. M., Muirhead, G., Krastev, D. B., Adam, J., Morel, D., Garrido, M., Lamb, A., Hénon, C., Dorvault, N., Rouanne, M., Marlow, R., Bajrami, I., Cardeñosa, M. L., Konde, A., Besse, B., Ashworth, A., Pettitt, S. J., Haider, S., Marabelle, A., Tutt, A. N. & 3 others, Soria, J. C., Lord, C. J. & Postel-Vinay, S., 1 Mar 2019, In : The Journal of clinical investigation. 129, 3, p. 1211-1228 18 p.

    Research output: Contribution to journalArticle

  6. Controversial issues in the neoadjuvant treatment of triple-negative breast cancer

    Fitzpatrick, A. & Tutt, A., 1 Jan 2019, In : Therapeutic Advances in Medical Oncology. 11

    Research output: Contribution to journalReview article

  7. Real-time ex vivo perfusion of human lymph nodes invaded by cancer (REPLICANT): a feasibility study

    Barrow-McGee, R., Procter, J., Owen, J., Woodman, N., Lombardelli, C., Kothari, A., Kovacs, T., Douek, M., George, S., Barry, P. A., Ramsey, K., Gibson, A., Buus, R., Holgersen, E., Natrajan, R., Haider, S., Shattock, M. J., Gillett, C., Tutt, A. N. J., Pinder, S. E. & 1 others, Naidoo, K., 1 Jan 2019, In : Journal of pathology.

    Research output: Contribution to journalArticle

  8. Low-Density Lipoprotein Uptake Inhibits the Activation and Antitumor Functions of Human Vγ9Vδ2 T Cells

    Rodrigues, N. V., Correia, D. V., Mensurado, S., Nóbrega-Pereira, S., deBarros, A., Kyle-Cezar, F., Tutt, A., Hayday, A. C., Norell, H., Silva-Santos, B. & Dias, S., 6 Apr 2018, In : Cancer immunology research. 6, 4, p. 448-547

    Research output: Contribution to journalArticle

  9. E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer

    Bajrami, I., Marlow, R., van de Ven, M., Brough, R., Pemberton, H. N., Frankum, J., Song, F., Rafiq, R., Konde, A., Krastev, D. B., Menon, M., Campbell, J., Gulati, A., Kumar, R., Pettitt, S. J., Gurden, M. D., Cardenosa, M. L., Chong, I., Gazinska, P., Wallberg, F. & 11 others, Sawyer, E. J., Martin, L-A., Dowsett, M., Linardopoulos, S., Natrajan, R., Ryan, C. J., Derksen, P. W. B., Jonkers, J., Tutt, A. N. J., Ashworth, A. & Lord, C. J., 4 Apr 2018, In : Cancer discovery. 8, 4, p. 498-515

    Research output: Contribution to journalArticle

  10. Evaluation of Antigen-Conjugated Fluorescent Beads to Identify Antigen-Specific B Cells

    Correa, I., Ilieva, K. M., Crescioli, S., Lombardi, S., Figini, M., Cheung, A., Spicer, J. F., Tutt, A. N. J., Nestle, F. O., Karagiannis, P., Lacy, K. E. & Karagiannis, S. N., 23 Mar 2018, In : Frontiers in Immunology. 9, MAR, 493.

    Research output: Contribution to journalArticle

  11. Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer

    Patel, N., Weekes, D., Drosopoulos, K., Gazinska, P., Noel, E., Rashid, M., Mirza, H., Quist, J., Brasó-Maristany, F., Mathew, S., Ferro, R., Pereira, A. M., Prince, C., Noor, F., Francesch-Domenech, E., Marlow, R., de Rinaldis, E., Grigoriadis, A., Linardopoulos, S., Marra, P. & 1 others, Tutt, A. N. J., 13 Mar 2018, In : Nature Communications. 9, 1, p. 1044

    Research output: Contribution to journalArticle

  12. Chondroitin sulfate proteoglycan 4 and its potential as an antibody immunotherapy target across different tumor types

    Ilieva, K. M., Cheung, A., Mele, S., Chiaruttini, G., Crescioli, S., Griffin, M., Nakamura, M., Spicer, J. F., Tsoka, S., Lacy, K. E., Tutt, A. N. J. & Karagiannis, S. N., 10 Jan 2018, In : Frontiers in Immunology. 8, JAN, p. 1911 15 p., 1911.

    Research output: Contribution to journalReview article

  13. Evaluation of CDK12 protein expression as a potential novel biomarker for DNA damage response-targeted therapies in breast cancer

    Naidoo, K., Wai, P. T., Maguire, S. L., Daley, F., Haider, S., Kriplani, D., Campbell, J., Mirza, H., Grigoriadis, A., Tutt, A., Moseley, P. M., Abdel-Fatah, T. M. A., Chan, S. Y. T., Madhusudan, S., Rhaka, E. A., Ellis, I. O., Lord, C. J., Yuan, Y., Green, A. R. & Natrajan, R., 1 Jan 2018, In : Molecular Cancer Therapeutics. 17, 1, p. 306-315 10 p.

    Research output: Contribution to journalArticle

  14. Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial

    Tutt, A., Tovey, H., Cheang, M. C. U., Kernaghan, S., Kilburn, L., Gazinska, P., Owen, J., Abraham, J., Barrett, S., Barrett-Lee, P., Brown, R., Chan, S., Dowsett, M., Flanagan, J. M., Fox, L., Grigoriadis, A., Gutin, A., Harper-Wynne, C., Hatton, M. Q., Hoadley, K. A. & 19 others, Parikh, J., Parker, P., Perou, C. M., Roylance, R., Shah, V., Shaw, A., Smith, I. E., Timms, K. M., Wardley, A. M., Wilson, G., Gillett, C., Lanchbury, J. S., Ashworth, A., Rahman, N., Harries, M., Ellis, P., Pinder, S. E., Bliss, J. M. & TNT Trialists, 2018, In : Nature Medicine. 24, p. 628–637

    Research output: Contribution to journalArticle

  15. Gene expression modules in primary breast cancers as risk factors for organotropic patterns of first metastatic spread: a case-control study

    Lawler, K., Papouli, E., Naceur-Lombardelli, C., Mera, A., Ougham, K., Tutt, A., Kimbung, S., Hedenfalk, I., Zhan, J., Zhang, H., Buus, R., Dowsett, M., Ng, T., Pinder, S. E., Parker, P. J. J., Holmberg, L. H., Gillett, C. E., Grigoriadis, A. & Purushotham, A. D., 13 Oct 2017, In : Breast Cancer Research. 19, 15 p.

    Research output: Contribution to journalArticle

  16. Genomic Evolution of Breast Cancer Metastasis and Relapse

    Yates, L. R., Knappskog, S., Wedge, D., Farmery, J. H. R., Gonzalez, S., Martincorena, I., Alexandrov, L. B., Van Loo, P., Haugland, H. K., Lilleng, P. K., Gundem, G., Gerstung, M., Pappaemmanuil, E., Gazinska, P., Bhosle, S. G., Jones, D., Raine, K., Mudie, L., Latimer, C., Sawyer, E. & 10 others, Desmedt, C., Sotiriou, C., Stratton, M. R., Sieuwerts, A. M., Lynch, A. G., Martens, J. W., Richardson, A. L., Tutt, A., Lønning, P. E. & Campbell, P. J., 14 Aug 2017, In : CANCER CELL. 32, 2, p. 169-184.e7

    Research output: Contribution to journalArticle

  17. Partial-breast radiotherapy after breast conservation surgery for patients with early breast cancer (UK IMPORT LOW trial): 5-year results from a multicentre, randomised, controlled, phase 3, non-inferiority trial

    Coles, C. E., Griffin, C. L., Kirby, A. M., Titley, J., Agrawal, R. K., Alhasso, A., Bhattacharya, I. S., Brunt, A. M., Ciurlionis, L., Chan, C., Donovan, E. M., Emson, M. A., Harnett, A. N., Haviland, J. S., Hopwood, P., Jefford, M. L., Kaggwa, R., Sawyer, E. J., Syndikus, I., Tsang, Y. M. & 32 others, Wheatley, D. A., Wilcox, M., Yarnold, J. R., Bliss, J. M., Al Sarakbi, W., Barber, S., Barnett, G., Bliss, P., Dewar, J., Eaton, D., Ebbs, S., Ellis, I., Evans, P., Harris, E., James, H., Kirwan, C., Kirk, J., Mayles, H., McIntyre, A., Mills, J., Poynter, A., Provenzano, E., Rawlings, C., Sculpher, M., Sumo, G., Sydenham, M., Tutt, A., Twyman, N., Venables, K., Winship, A., Winstanley, J. & Wishart, G., 2 Aug 2017, In : Lancet.

    Research output: Contribution to journalArticle

  18. Molecular alterations in triple-negative breast cancer-the road to new treatment strategies

    Denkert, C., Liedtke, C., Tutt, A. & von Minckwitz, G., 17 Jun 2017, In : Lancet. 389, 10087, p. 2430-2442

    Research output: Contribution to journalArticle

  19. Visualization of tumor-immune interaction: Target-specific imaging of S100A8/A9 reveals pre-metastatic niche establishment

    Eisenblaetter, M., Flores-Borja, F., Lee, J. J., Wefers, C., Smith, H., Hueting, R., Cooper, M. S., Blower, P. J., Patel, D., Rodriguez-Justo, M., Milewicz, H., Vogl, T., Roth, J., Tutt, A., Schaeffter, T. & Ng, T., 15 Jun 2017, In : Theranostics. 7, 9, p. 2392-2401 10 p.

    Research output: Contribution to journalArticle

  20. HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

    Davies, H., Glodzik, D., Morganella, S., Yates, L. R., Staaf, J., Zou, X., Ramakrishna, M., Martin, S., Boyault, S., Sieuwerts, A. M., Simpson, P. T., King, T. A., Raine, K., Eyfjord, J. E., Kong, G., Borg, Å., Birney, E., Stunnenberg, H. G., Van De Vijver, M. J., Børresen-Dale, A. L. & 13 others, Martens, J. W. M., Span, P. N., Lakhani, S. R., Vincent-Salomon, A., Sotiriou, C., Tutt, A., Thompson, A. M., Van Laere, S., Richardson, A. L., Viari, A., Campbell, P. J., Stratton, M. R. & Nik-Zainal, S., 1 Apr 2017, In : Nature Medicine. 23, 4, p. 517-525 9 p.

    Research output: Contribution to journalArticle

  21. Corrigendum to “3rd ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 3)” [Breast 31 (February 2017) 244–259]

    Cardoso, F., Costa, A., Senkus, E., Aapro, M., André, F., Barrios, C. H., Bergh, J., Bhattacharyya, G., Biganzoli, L., Cardoso, M. J., Carey, L., Corneliussen-James, D., Curigliano, G., Dieras, V., El Saghir, N., Eniu, A., Fallowfield, L., Fenech, D., Francis, P., Gelmon, K. & 25 others, Gennari, A., Harbeck, N., Hudis, C., Kaufman, B., Krop, I., Mayer, M., Meijer, H., Mertz, S., Ohno, S., Pagani, O., Papadopoulos, E., Peccatori, F., Penault-Llorca, F., Piccart, M. J., Pierga, J. Y., Rugo, H., Shockney, L., Sledge, G., Swain, S., Thomssen, C., Tutt, A., Vorobiof, D., Xu, B., Norton, L. & Winer, E., Apr 2017, In : BREAST. 32, p. 269-270 2 p.

    Research output: Contribution to journalArticle

  22. Somatic mutations reveal asymmetric cellular dynamics in the early human embryo

    Ju, Y. S., Martincorena, I., Gerstung, M., Petljak, M., Alexandrov, L. B., Rahbari, R., Wedge, D. C., Davies, H. R., Ramakrishna, M., Fullam, A., Martin, S., Alder, C., Patel, N., Gamble, S., O'Meara, S., Giri, D. D., Sauer, T., Pinder, S. E., Purdie, C. A., Borg, Å. & 21 others, Stunnenberg, H., van de Vijver, M., Tan, B. K. T., Caldas, C., Tutt, A., Ueno, N. T., van 't Veer, L. J., Martens, J. W. M., Sotiriou, C., Knappskog, S., Span, P. N., Lakhani, S. R., Eyfjörd, J. E., Børresen-Dale, A-L., Richardson, A., Thompson, A. M., Viari, A., Hurles, M. E., Nik-Zainal, S., Campbell, P. J. & Stratton, M. R., 22 Mar 2017, In : Nature. 543, 7647, p. 714-718 5 p.

    Research output: Contribution to journalLetter

  23. RORγt+ innate lymphoid cells promote lymph node metastasis of breast cancers

    Irshad, S., Flores-Borja, F., Lawler, K., Monypenny, J., Evans, R., Male, V., Gordon, P., Cheung, A., Gazinska, P., Noor, F., Wong, F., Grigoriadis, A., Fruhwirth, G. O., Barber, P. R., Woodman, N., Patel, D., Rodriguez-Justo, M., Owen, J., Martin, S. G., Sarah, E. P. & 13 others, Cheryl, E. G., Poland, S. P., Ameer-Beg, S., McCaughan, F., Carlin, L. M., Hasan, U., Withers, D. R., Lane, P., Vojnovic, B., Quezada, S. A., Ellis, P., Tutt, A. N. J. & Ng, T., 1 Mar 2017, In : Cancer Research. 77, 5, p. 1083-1096 14 p.

    Research output: Contribution to journalArticle

  24. 3rd ESO–ESMO international consensus guidelines for Advanced Breast Cancer (ABC 3)

    Cardoso, F., Costa, A., Senkus, E., Aapro, M., André, F., Barrios, C. H., Bergh, J., Bhattacharyya, G., Biganzoli, L., Cardoso, M. J., Carey, L., Corneliussen-James, D., Curigliano, G., Dieras, V., El Saghir, N., Eniu, A., Fallowfield, L., Fenech, D., Francis, P., Gelmon, K. & 25 others, Gennari, A., Harbeck, N., Hudis, C., Kaufman, B., Krop, I., Mayer, M., Meijer, H., Mertz, S., Ohno, S., Pagani, O., Papadopoulos, E., Peccatori, F., Pernault-Llorca, F., Piccart, M. J., Pierga, J. Y., Rugo, H., Shockney, L., Sledge, G., Swain, S., Thomssen, C., Tutt, A., Vorobiof, D., Xu, B., Norton, L. & Winer, E., 5 Dec 2016, In : BREAST.

    Research output: Contribution to journalArticle

  25. PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer

    Grigoriadis, A. & Tutt, A. N. J., 6 Sep 2016, Nature Medicine.

    Research output: Contribution to specialist publicationArticle

  26. Targeting folate receptor alpha for cancer treatment

    Cheung, A., Bax, H. J., Josephs, D. H., Ilieva, K. M., Pellizzari, G., Fittall, M., Grigoriadis, A., Figini, M., Canevari, S., Spicer, J. F., Tutt, A. N. & Karagiannis, S. N., 27 May 2016, In : Oncotarget.

    Research output: Contribution to journalArticle

  27. Mutation Processes in 293-Based Clones Overexpressing the DNA Cytosine Deaminase APOBEC3B.

    K. Akre, M., J. Starrett, G., Quist, J. S., A. Temiz, N., A. Carpenter, M., Tutt, A. N. J., Grigoriadis, A. & Harris, R. S., 10 May 2016, In : PLOS One.

    Research output: Contribution to journalArticle

  28. Landscape of somatic mutations in 560 breast cancer whole-genome sequences

    Nik-Zainal, S., Davies, H., Staaf, J., Ramakrishna, M., Glodzik, D., Zou, X., Martincorena, I., Alexandrov, L. B., Martin, S., Wedge, D. C., Van Loo, P., Ju, Y. S., Smid, M., Brinkman, A. B., Morganella, S., Aure, M. R., Lingjærde, O. C., Langerød, A., Ringnér, M., Ahn, S. M. & 68 others, Boyault, S., Brock, J. E., Broeks, A., Butler, A., Desmedt, C., Dirix, L., Dronov, S., Fatima, A., Foekens, J. A., Gerstung, M., Hooijer, G. K. J., Jang, S. J., Jones, D. R., Kim, H. Y., King, T. A., Krishnamurthy, S., Lee, H. J., Lee, J. Y., Li, Y., McLaren, S., Menzies, A., Mustonen, V., O'Meara, S., Pauporté, I., Pivot, X., Purdie, C. A., Raine, K., Ramakrishnan, K., Rodríguez-González, F. G., Romieu, G., Sieuwerts, A. M., Simpson, P. T., Shepherd, R., Stebbings, L., Stefansson, O. A., Teague, J., Tommasi, S., Treilleux, I., Van Den Eynden, G. G., Vermeulen, P., Vincent-Salomon, A., Yates, L., Caldas, C., Veer, L. V. T., Tutt, A., Knappskog, S., Tan, B. K. T., Jonkers, J., Borg, Å., Ueno, N. T., Sotiriou, C., Viari, A., Futreal, P. A., Campbell, P. J., Span, P. N., Van Laere, S., Lakhani, S. R., Eyfjord, J. E., Thompson, A. M., Birney, E., Stunnenberg, H. G., Van De Vijver, M. J., Martens, J. W. M., Børresen-Dale, A. L., Richardson, A. L., Kong, G., Thomas, G. & Stratton, M. R., 2 May 2016, In : Nature. 534, 7605, p. 47-54 8 p.

    Research output: Contribution to journalArticle

  29. New approaches for improving outcomes in breast cancer in Europe

    Di Leo, A., Curigliano, G., Diéras, V., Malorni, L., Sotiriou, C., Swanton, C., Thompson, A., Tutt, A. & Piccart, M., 1 Aug 2015, In : Breast (Edinburgh, Scotland). 24, 4, p. 321-330 10 p.

    Research output: Contribution to journalReview article

  30. Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells

    ICGC Prostate Cancer Working Group, Jun 2015, In : Genome Research. 25, 6, p. 814-24 11 p.

    Research output: Contribution to journalArticle

  31. Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers

    Watkins, J., Weekes, D., Shah, V., Gazinska, P., Joshi, S., Sidhu, B., Gillett, C., Pinder, S., Vanoli, F., Jasin, M., Mayrhofer, M., Isaksson, A., Cheang, M. C. U., Mirza, H., Frankum, J., Lord, C. J., Ashworth, A., Vinayak, S., Ford, J. M., Telli, M. L. & 2 others, Grigoriadis, A. & Tutt, A. N. J., May 2015, In : Cancer discovery. 5, 5, p. 488-505 18 p.

    Research output: Contribution to journalArticle

  32. Profiles of genome complexity identify HORMAD1 as a driver of homologous recombination deficiency and platinum therapy response in triple-negative breast cancer

    Grigoriadis, A., Weekes, D., Watkins, J. A., Gazinska, P., Frankum, J., Lord, C., Ashworth, A., Ford, J. M., Telli, M. & Tutt, A., May 2015, In : Annals of Oncology. 26, p. iii15

    Research output: Contribution to journalArticle

  33. IL15RA Drives Antagonistic Mechanisms of Cancer Development and Immune Control in Lymphocyte-Enriched Triple-Negative Breast Cancers

    Marra, P., Mathew, S., Grigoriadis, A., Wu, Y., Kyle Cezar, F., Watkins, J., Rashid, M., De Rinaldis, E., Hessey, S., Gazinska, P., Hayday, A. & Tutt, A., 1 Sep 2014, In : Cancer Research. 74, 17, p. 4908-4921 14 p.

    Research output: Contribution to journalArticle

  34. The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility

    Kiuchi, T., Ortiz-Zapater, E., Monypenny, J., Matthews, D. R., Nguyen, L. K., Barbeau, J., Coban, O., Lawler, K., Burford, B., Rolfe, D. J., de Rinaldis, E., Dafou, D., Simpson, M. A., Woodman, N., Pinder, S., Gillett, C. E., Devauges, V., Poland, S. P., Fruhwirth, G., Marra, P. & 12 others, Boersma, Y. L., Plückthun, A., Gullick, W. J., Yarden, Y., Santis, G., Winn, M., Kholodenko, B. N., Martin-Fernandez, M. L., Parker, P., Tutt, A., Ameer-Beg, S. M. & Ng, T., 19 Aug 2014, In : Science Signaling. 7, 339, ra78.

    Research output: Contribution to journalArticle

  35. Changes in Primary Breast Cancer Heterogeneity May Augment Midtreatment MR Imaging Assessment of Response to Neoadjuvant Chemotherapy

    Parikh, J., Selmi, M., Charles-Edwards, G., Glendenning, J., Ganeshan, B., Verma, H., Mansi, J., Harries, M., Tutt, A. & Goh, V., 1 Jul 2014, In : Radiology. 272, 1, p. 100-112 13 p.

    Research output: Contribution to journalArticle

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