Andrew Tutt

2024

Early breast cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up ^☆

Loibl, S., André, F., Bachelot, T., Barrios, C. H., Bergh, J., Burstein, H. J., Cardoso, M. J., Carey, L. A., Dawood, S., Del Mastro, L., Denkert, C., Fallenberg, E. M., Francis, P. A., Gamal-Eldin, H., Gelmon, K., Geyer, C. E., Gnant, M., Guarneri, V., Gupta, S., Kim, S. B., & 20 othersKrug, D., Martin, M., Meattini, I., Morrow, M., Janni, W., Paluch-Shimon, S., Partridge, A., Poortmans, P., Pusztai, L., Regan, M. M., Sparano, J., Spanic, T., Swain, S., Tjulandin, S., Toi, M., Trapani, D., Tutt, A., Xu, B., Curigliano, G. & Harbeck, N., Feb 2024, In: Annals of Oncology. 35, 2, p. 159-182 24 p.

Research output: Contribution to journal › Article › peer-review

Open Access

73 Citations (Scopus)

Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer

Harvey-Jones, E., Raghunandan, M., Robbez-Masson, L., Magraner-Pardo, L., Alaguthurai, T., Yablonovitch, A., Yen, J., Xiao, H., Brough, R., Frankum, J., Song, F., Yeung, J., Savy, T., Gulati, A., Alexander, J., Kemp, H., Starling, C., Konde, A., Marlow, R., Cheang, M., & 19 othersProszek, P., Hubank, M., Cai, M., Trendell, J., Lu, R., Liccardo, R., Ravindran, N., Llop-Guevara, A., Rodriguez, O., Balmana, J., Lukashchuk, N., Dorschner, M., Drusbosky, L., Roxanis, I., Serra, V., Haider, S., Pettitt, S. J., Lord, C. J. & Tutt, A. N. J., Apr 2024, In: Annals of Oncology. 35, 4, p. 364-380 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

PAK6 acts downstream of IQGAP3 to promote contractility in triple negative breast cancer cells

Wells, C., Pipili, K., Grigoriadis, A., Babteen, N., Kuwair, L., Bulu, M., Quist, J., Ong, K., Tutt, A. & Pitaluga, R., Sept 2024, In: Cellular Signalling. 121, 111233.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Integrated Multimodal Analyses of DNA Damage Response and Immune Markers as Predictors of Response in Metastatic Triple-Negative Breast Cancer in the TNT Trial (NCT00532727)

Tovey, H., Sipos, O., Parker, J. S., Hoadley, K. A., Quist, J., Kernaghan, S., Kilburn, L., Salgado, R., Loi, S., Kennedy, R. D., Roxanis, I., Gazinska, P., Pinder, S. E., Bliss, J., Perou, C. M., Haider, S., Grigoriadis, A., Tutt, A. & Cheang, M. C. U., 15 Sept 2023, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 29, 18, p. 3691-3705 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

Systemic Therapy for Hereditary Breast Cancers

Harvey-Jones, E. J., Lord, C. J. & Tutt, A. N. J., Feb 2023, In: Hematology/Oncology Clinics of North America. 37, 1, p. 203-224 22 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

1 Citation (Scopus)

2022

Assessing CSF ctDNA to Improve Diagnostic Accuracy and Therapeutic Monitoring in Breast Cancer Leptomeningeal Metastasis

Fitzpatrick, A., Iravani, M., Mills, A., Childs, L., Alaguthurai, T., Clifford, A., Garcia-Murillas, I., Van Laere, S., Dirix, L., Harries, M., Okines, A., Turner, N. C., Haider, S., Tutt, A. N. J. & Isacke, C. M., 15 Mar 2022, In: Clinical Cancer Research. 28, 6, p. 1180-1191 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Citations (Scopus)

Dynamic Changes in the NK-, Neutrophil-, and B-cell Immunophenotypes Relevant in High Metastatic Risk Post Neoadjuvant Chemotherapy–Resistant Early Breast Cancers

Gazinska, P., Milton, C., Iacovacci, J., Ward, J., Buus, R., Alaguthurai, T., Graham, R., Akarca, A., Lips, E., Naidoo, K., Wesseling, J., Marafioti, T., Cheang, M., Gillett, C., Wu, Y., Khan, A., Melcher, A., Salgado, R., Dowsett, M., Tutt, A., & 3 othersRoxanis, I., Haider, S. & Irshad, S., 14 Oct 2022, In: Clinical Cancer Research. 28, 20, p. 4494-4508 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Functional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress tolerance

Tarantino, D., Walker, C., Weekes, D., Pemberton, H., Davidson, K., Torga, G., Frankum, J., Mendes-Pereira, A. M., Prince, C., Ferro, R., Brough, R., Pettitt, S. J., Lord, C. J., Grigoriadis, A. & Tutt, A. NJ., 5 Aug 2022, In: Oncogene. 41, 32, p. 3969-3977 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

Loss of E-cadherin leads to Id2-dependent inhibition of cell cycle progression in metastatic lobular breast cancer

Rätze, M. A. K., Koorman, T., Sijnesael, T., Bassey-Archibong, B., van de Ven, R., Enserink, L., Visser, D., Jaksani, S., Viciano, I., Bakker, E. R. M., Richard, F., Tutt, A., O'Leary, L., Fitzpatrick, A., Roca-Cusachs, P., van Diest, P. J., Desmedt, C., Daniel, J. M., Isacke, C. M. & Derksen, P. W. B., 20 May 2022, In: Oncogene. 41, 21, p. 2932-2944 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Citations (Scopus)

Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high risk, early breast cancer

OlympiA Clinical Trial Steering Committee and Investigators, Dec 2022, In: Annals of Oncology. 33, 12, p. 1250-1268 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

180 Citations (Scopus)

Phase 1b study of berzosertib and cisplatin in patients with advanced triple-negative breast cancer

Telli, M. L., Tolaney, S. M., Shapiro, G. I., Middleton, M., Lord, S. R., Arkenau, H. T., Tutt, A., Abramson, V., Dean, E., Haddad, T. C., Wesolowski, R., Ferrer-Playan, J., Goddemeier, T., Grombacher, T., Dong, J., Fleuranceau-Morel, P., Diaz-Padilla, I. & Plummer, R., Dec 2022, In: npj Breast Cancer. 8, 1, 45.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Citations (Scopus)

Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units

Love, S. B., Cafferty, F., Snowdon, C., Carty, K., Savage, J., Pallmann, P., McParland, L., Brown, L., Masters, L., Schiavone, F., Hague, D., Townsend, S., Amos, C., South, A., Sturgeon, K., Langley, R., Maughan, T., James, N., Hall, E., Kernaghan, S., & 16 othersBliss, J., Turner, N., Tutt, A., Yap, C., Firth, C., Kong, A., Mehanna, H., Watts, C., Hills, R., Thomas, I., Copland, M., Bell, S., Sebag-Montefiore, D., Jones, R., Parmar, M. K. B. & Sydes, M. R., Dec 2022, In: Trials. 23, 1, 757.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

The increasing importance of pathology in modern clinical trial conduct: OlympiA as a case in point

Kalinowski, L., Viale, G., Domchek, S., Tutt, A., Lucas, P. C. & Lakhani, S. R., Aug 2022, In: Pathology. 54, 5, p. 511-516 6 p.

Research output: Contribution to journal › Editorial › peer-review

Open Access

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

Krastev, D. B., Li, S., Sun, Y., Wicks, A. J., Hoslett, G., Weekes, D., Badder, L. M., Knight, E. G., Marlow, R., Pardo, M. C., Yu, L., Talele, T. T., Bartek, J., Choudhary, J. S., Pommier, Y., Pettitt, S. J., Tutt, A. N. J., Ramadan, K. & Lord, C. J., 10 Jan 2022, In: Nature Cell Biology. 24, 1, p. 62-73 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

80 Citations (Scopus)

2021

3D functional genomics screens identify CREBBP as a targetable driver in aggressive triple-negative breast cancer

Peck, B., Bland, P., Mavrommati, I., Muirhead, G., Cottom, H., Wai, P. T., Maguire, S. L., Barker, H. E., Morrison, E., Kriplani, D., Yu, L., Gibson, A., Falgari, G., Brennan, K., Farnie, G., Buus, R., Marlow, R., Novo, D., Knight, E., Guppy, N., & 22 othersKolarevic, D., Susnjar, S., Milijic, N. M., Naidoo, K., Gazinska, P., Roxanis, I., Pancholi, S., Martin, L. A., Holgersen, E. M., Cheang, M. C. U., Noor, F., Postel-Vinay, S., Quinn, G., McDade, S., Krasny, L., Huang, P., Daley, F., Wallberg, F., Choudhary, J. S., Haider, S., Tutt, A. N. & Natrajan, R., 15 Feb 2021, In: Cancer Research. 81, 4, p. 847-859 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Citations (Scopus)

Adjuvant olaparib for patients with BRCA1- Or BRCA2-mutated breast cancer

Tutt, A. N. J., Garber, J. E., Kaufman, B., Viale, G., Fumagalli, D., Rastogi, P., Gelber, R. D., de Azambuja, E., Fielding, A., Balmaña, J., Domchek, S. M., Gelmon, K. A., Hollingsworth, S. J., Korde, L. A., Linderholm, B., Bandos, H., Senkus, E., Suga, J. M., Shao, Z., Pippas, A. W., & 19 othersNowecki, Z., Huzarski, T., Ganz, P. A., Lucas, P. C., Baker, N., Loibl, S., McConnell, R., Piccart, M., Schmutzler, R., Steger, G. G., Costantino, J. P., Arahmani, A., Wolmark, N., McFadden, E., Karantza, V., Lakhani, S. R., Yothers, G., Campbell, C. & Geyer, C. E., 24 Jun 2021, In: New England Journal of Medicine. 384, 25, p. 2394-2405 12 p.

Research output: Contribution to journal › Article › peer-review

892 Citations (Scopus)

Assessment of structural chromosomal instability phenotypes as biomarkers of carboplatin response in triple negative breast cancer: the TNT trial

Sipos, O., Tovey, H., Quist, J., Hyder, S., Nowinski, S., Gazinska, P., Kernaghan, S., Toms, C., Maguire, S., Orr, N., Linn, S., Owen, J., Gillett, C., Pinder, S., Bliss, J., Tutt, A., Cheang, M. C. U. & Grigoriadis, A., 1 Jan 2021, In: Annals of Oncology. 32, 1, p. 58-65 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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16 Citations (Scopus)

158 Downloads (Pure)

Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma

PEACE Consortium, TRACERx Renal Consortium, Au, L., Hatipoglu, E., Robert de Massy, M., Litchfield, K., Beattie, G., Rowan, A., Schnidrig, D., Thompson, R., Byrne, F., Horswell, S., Fotiadis, N., Hazell, S., Nicol, D., Shepherd, S. T. C., Fendler, A., Mason, R., Del Rosario, L., Edmonds, K., & 32 othersLingard, K., Sarker, S., Mangwende, M., Carlyle, E., Attig, J., Joshi, K., Uddin, I., Becker, P. D., Sunderland, M. W., Akarca, A., Puccio, I., Yang, W. W., Lund, T., Dhillon, K., Vasquez, M. D., Parker, P., Moore, D., Hiley, C., Josephs, D., Chandra, A., Spicer, J., Rudman, S., Tutt, A., Tomlinson, I., Challacombe, B., Chowdhury, S., Harrison-Phipps, K., Hill, P., Horsfield, C., O'Brien, T., Olsburgh, J. & Polson, A., 8 Nov 2021, In: CANCER CELL. 39, 11, p. 1497-1518.e11

Research output: Contribution to journal › Article › peer-review

Open Access

126 Citations (Scopus)

New Roles of Poly(ADP-Ribose) Polymerase Inhibitors in the Treatment of Breast Cancer

Harvey-Jones, E., Vinas Villaro, G. & Tutt, A., 27 Dec 2021, In: Cancer Journal (United States). 27, 6, p. 441-456 16 p.

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance

Zatreanu, D., Robinson, H. M. R., Alkhatib, O., Boursier, M., Finch, H., Geo, L., Grande, D., Grinkevich, V., Heald, R. A., Langdon, S., Majithiya, J., McWhirter, C., Martin, N. M. B., Moore, S., Neves, J., Rajendra, E., Ranzani, M., Schaedler, T., Stockley, M., Wiggins, K., & 41 othersBrough, R., Sridhar, S., Gulati, A., Shao, N., Badder, L. M., Novo, D., Knight, E. G., Marlow, R., Haider, S., Callen, E., Hewitt, G., Schimmel, J., Prevo, R., Alli, C., Ferdinand, A., Bell, C., Blencowe, P., Bot, C., Calder, M., Charles, M., Curry, J., Ekwuru, T., Ewings, K., Krajewski, W., MacDonald, E., McCarron, H., Pang, L., Pedder, C., Rigoreau, L., Swarbrick, M., Wheatley, E., Willis, S., Wong, A. C., Nussenzweig, A., Tijsterman, M., Tutt, A., Boulton, S. J., Higgins, G. S., Pettitt, S. J., Smith, G. C. M. & Lord, C. J., Dec 2021, In: Nature Communications. 12, 1, 3636.

Research output: Contribution to journal › Article › peer-review

Open Access

183 Citations (Scopus)

Proteomics of REPLICANT perfusate detects changes in the metastatic lymph node microenvironment

Stevenson, J., Barrow-McGee, R., Yu, L., Paul, A., Mansfield, D., Owen, J., Woodman, N., Natrajan, R., Haider, S., Gillett, C., Tutt, A., Pinder, S. E., Choudary, J. & Naidoo, K., Dec 2021, In: npj Breast Cancer. 7, 1, 24.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

TGF-β1 potentiates Vγ9Vδ2 T-cell adoptive immunotherapy of cancer

Beatson, R., Parente Pereira, A., Halim, L., Cozzetto, D., Hull, C., Whilding, L., Martinez, O., Taylor, C., Obajdin, J., Luu Hoang, K. N., Draper, B., Iqbal, A., Hardiman, T., Zabinski, T., Man, F., T. M. de Rosales, R., Xie, J., Aswad, F., Achkova, D., Ricardo Joseph, C-Y., & 11 othersCiprut, S., Adami, A., Roider, H., Hess-Stump, H., Gyorffy, B., Quist, J., Grigoriadis, A., Sommer, A., Tutt, A., Maher, J. & Davies, D., 18 Nov 2021, (Accepted/In press) In: Cell Reports Medicine.

Research output: Contribution to journal › Article › peer-review

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194 Downloads (Pure)

Tumor-Infiltrating B Lymphocyte Profiling Identifies IgG-Biased, Clonally Expanded Prognostic Phenotypes In Triple-Negative Breast Cancer

Harris, R. J., Cheung, A., Ng, J. C. F., Laddach, R., Chenoweth, A. M., Crescioli, S., Fittall, M., Dominguez-Rodriguez, D., Roberts, J., Levi, D., Liu, F., Alberts, E., Quist, J., Santaolalla, A., Pinder, S. E., Gillett, C., Hammar, N., Irshad, S., van Hemelrijck, M., Dunn-Walters, D. K., & 7 othersFraternali, F., Spicer, J. F., Lacy, K. E., Tsoka, S., Grigoriadis, A., Tutt, A. N. J. & Karagiannis, S. N., 15 Aug 2021, In: Cancer Research. 81, 16, p. 4290-4304 15 p.

Research output: Contribution to journal › Article › peer-review

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48 Citations (Scopus)

93 Downloads (Pure)

2020

Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

International Immuno-Oncology Biomarker Working Group, 1 Dec 2020, In: npj Breast Cancer. 6, 1, 15.

Research output: Contribution to journal › Review article › peer-review

Open Access

14 Citations (Scopus)

Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer

Chopra, N., Tovey, H., Pearson, A., Cutts, R., Toms, C., Proszek, P., Hubank, M., Dowsett, M., Dodson, A., Daley, F., Kriplani, D., Gevensleben, H., Davies, H. R., Degasperi, A., Roylance, R., Chan, S., Tutt, A., Skene, A., Evans, A., Bliss, J. M., & 2 othersNik-Zainal, S. & Turner, N. C., 1 Dec 2020, In: Nature Communications. 11, 1, 2662.

Research output: Contribution to journal › Article › peer-review

Open Access

157 Citations (Scopus)

Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

the International Immuno-Oncology Biomarker Working Group, 1 Dec 2020, In: npj Breast Cancer. 6, 1, 17.

Research output: Contribution to journal › Article › peer-review

Open Access

113 Citations (Scopus)

Rapid conjugation of antibodies to toxins to select candidates for the development of anticancer Antibody-Drug Conjugates (ADCs)

Hoffmann, R. M., Mele, S., Cheung, A., Larcombe-Young, D., Bucaite, G., Sachouli, E., Zlatareva, I., Morad, H. O. J., Marlow, R., McDonnell, J. M., Figini, M., Lacy, K. E., Tutt, A. J. N., Spicer, J. F., Thurston, D. E., Karagiannis, S. N. & Crescioli, S., 1 Jun 2020, In: Scientific Reports. 10, 1, p. 8869 8869.

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11 Citations (Scopus)

65 Downloads (Pure)

Rapid conjugation of antibodies to toxins to select candidates for the development of anti-cancer Antibody-Drug Conjugates (ADCs)

Hoffmann, M., Mele, S., Cheung, A., Larcombe-Young, D., Bucaite, G., Sachouli, E., Zlatareva, I., Morad, H., Marlow, R., McDonnell, J., Figini, M., Lacy, K. E., Tutt, A., Spicer, J., Thurston, D., Karagiannis, S. N. & Crescioli, S., 1 Jun 2020, In: Scientific Reports. 10, 1, 22 p., 8869.

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Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer

Yeow, Z. Y., Lambrus, B. G., Marlow, R., Zhan, K. H., Durin, M. A., Evans, L. T., Scott, P. M., Phan, T., Park, E., Ruiz, L. A., Moralli, D., Knight, E. G., Badder, L. M., Novo, D., Haider, S., Green, C. M., Tutt, A. N. J., Lord, C. J., Chapman, J. R. & Holland, A. J., 17 Sept 2020, In: Nature. 585, 7825, p. 447-452 6 p.

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

2019

A decade of clinical development of PARP inhibitors in perspective

Mateo, J., Lord, C. J., Serra, V., Tutt, A., Balmaña, J., Castroviejo-Bermejo, M., Cruz, C., Oaknin, A., Kaye, S. B. & de Bono, J. S., 1 Sept 2019, In: Annals of oncology : official journal of the European Society for Medical Oncology. 30, 9, p. 1437-1447 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

443 Citations (Scopus)

AllergoOncology: Expression platform development and functional profiling of an anti-HER2 IgE antibody

Ilieva, K. M., Fazekas-Singer, J., Bax, H. J., Crescioli, S., Montero-Morales, L., Mele, S., Sow, H. S., Stavraka, C., Josephs, D. H., Spicer, J. F., Steinkellner, H., Jensen-Jarolim, E., Tutt, A. N. J. & Karagiannis, S. N., 1 Oct 2019, In: Allergy: European Journal of Allergy and Clinical Immunology. 74, 10, p. 1985-1989 5 p.

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12 Citations (Scopus)

133 Downloads (Pure)

An innate-like Vδ1⁺ γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer

Wu, Y., Kyle-Cezar, F., Woolf, R. T., Naceur-Lombardelli, C., Owen, J., Biswas, D., Lorenc, A., Vantourout, P., Gazinska, P., Grigoriadis, A., Tutt, A. & Hayday, A., 9 Oct 2019, In: Science Translational Medicine. 11, 513, eaax9364.

Research output: Contribution to journal › Article › peer-review

115 Citations (Scopus)

Controversial issues in the neoadjuvant treatment of triple-negative breast cancer

Fitzpatrick, A. & Tutt, A., 1 Jan 2019, In: Therapeutic Advances in Medical Oncology. 11

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Integrin-mediated macrophage adhesion promotes lymphovascular dissemination in breast cancer

Evans, R., Flores-Borja, F., Nassiri, S., Miranda, E., Lawler, K., Grigoriadis, A., Monypenny, J., Gillett, C., Owen, J., Gordon, P., Male, V., Cheung, A., Noor, F., Barber, P., Marlow, R., Francesch-Domenech, E., Fruhwirth, G., Squadrito, M., Vojnovic, B., Tutt, A., & 3 othersFesty, F., De Palma, M. & Ng, T., 14 May 2019, In: Cell Reports. 27, 7, p. 1967-1978.e4

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39 Citations (Scopus)

296 Downloads (Pure)

PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer

Chabanon, R. M., Muirhead, G., Krastev, D. B., Adam, J., Morel, D., Garrido, M., Lamb, A., Hénon, C., Dorvault, N., Rouanne, M., Marlow, R., Bajrami, I., Cardeñosa, M. L., Konde, A., Besse, B., Ashworth, A., Pettitt, S. J., Haider, S., Marabelle, A., Tutt, A. N., & 3 othersSoria, J. C., Lord, C. J. & Postel-Vinay, S., 1 Mar 2019, In: The Journal of clinical investigation. 129, 3, p. 1211-1228 18 p.

Research output: Contribution to journal › Article › peer-review

231 Citations (Scopus)

Real-time ex vivo perfusion of human lymph nodes invaded by cancer (REPLICANT): a feasibility study

Barrow-McGee, R., Procter, J., Owen, J., Woodman, N., Lombardelli, C., Kothari, A., Kovacs, T., Douek, M., George, S., Barry, P. A., Ramsey, K., Gibson, A., Buus, R., Holgersen, E., Natrajan, R., Haider, S., Shattock, M. J., Gillett, C., Tutt, A. N. J., Pinder, S. E., & 1 othersNaidoo, K., 1 Jan 2019, In: Journal of pathology.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

2018

A four-gene decision tree signature classification of triple-negative breast cancer: Implications for targeted therapeutics: Integrative analysis of triple-negative breast cancers

Quist, J., Mirza, H., Cheang, M. C. U., Telli, M. L., O'Shaughnessy, J., Lord, C. J., Tutt, A. N. J. & Grigoriadis, A., 10 Oct 2018, (E-pub ahead of print) In: MOLECULAR CANCER THERAPEUTICS.

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16 Citations (Scopus)

107 Downloads (Pure)

Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)

Hoffmann, R. M., Coumbe, B. G. T., Josephs, D. H., Mele, S., Ilieva, K. M., Cheung, A., Tutt, A. N., Spicer, J. F., Thurston, D. E., Crescioli, S. & Karagiannis, S. N., 2018, In: OncoImmunology. 7, 3, p. e1395127-e1395127-11 12 p., e1395127.

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127 Citations (Scopus)

444 Downloads (Pure)

Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial

Tutt, A., Tovey, H., Cheang, M. C. U., Kernaghan, S., Kilburn, L., Gazinska, P., Owen, J., Abraham, J., Barrett, S., Barrett-Lee, P., Brown, R., Chan, S., Dowsett, M., Flanagan, J. M., Fox, L., Grigoriadis, A., Gutin, A., Harper-Wynne, C., Hatton, M. Q., Hoadley, K. A., & 19 othersParikh, J., Parker, P., Perou, C. M., Roylance, R., Shah, V., Shaw, A., Smith, I. E., Timms, K. M., Wardley, A. M., Wilson, G., Gillett, C., Lanchbury, J. S., Ashworth, A., Rahman, N., Harries, M., Ellis, P., Pinder, S. E., Bliss, J. M. & TNT Trialists, 1 May 2018, In: Nature Medicine. 24, 5, p. 628–637

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668 Citations (Scopus)

219 Downloads (Pure)

Chondroitin sulfate proteoglycan 4 and its potential as an antibody immunotherapy target across different tumor types

Ilieva, K. M., Cheung, A., Mele, S., Chiaruttini, G., Crescioli, S., Griffin, M., Nakamura, M., Spicer, J. F., Tsoka, S., Lacy, K. E., Tutt, A. N. J. & Karagiannis, S. N., 10 Jan 2018, In: Frontiers in Immunology. 8, JAN, p. 1911 15 p., 1911.

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88 Citations (Scopus)

383 Downloads (Pure)

E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer

Bajrami, I., Marlow, R., van de Ven, M., Brough, R., Pemberton, H. N., Frankum, J., Song, F., Rafiq, R., Konde, A., Krastev, D. B., Menon, M., Campbell, J., Gulati, A., Kumar, R., Pettitt, S. J., Gurden, M. D., Cardenosa, M. L., Chong, I., Gazinska, P., Wallberg, F., & 11 othersSawyer, E. J., Martin, L-A., Dowsett, M., Linardopoulos, S., Natrajan, R., Ryan, C. J., Derksen, P. W. B., Jonkers, J., Tutt, A. N. J., Ashworth, A. & Lord, C. J., 4 Apr 2018, In: Cancer discovery. 8, 4, p. 498-515

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85 Citations (Scopus)

222 Downloads (Pure)

Evaluation of Antigen-Conjugated Fluorescent Beads to Identify Antigen-Specific B Cells

Correa, I., Ilieva, K. M., Crescioli, S., Lombardi, S., Figini, M., Cheung, A., Spicer, J. F., Tutt, A. N. J., Nestle, F. O., Karagiannis, P., Lacy, K. E. & Karagiannis, S. N., 23 Mar 2018, In: Frontiers in Immunology. 9, MAR, 493.

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13 Citations (Scopus)

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Evaluation of CDK12 protein expression as a potential novel biomarker for DNA damage response-targeted therapies in breast cancer

Naidoo, K., Wai, P. T., Maguire, S. L., Daley, F., Haider, S., Kriplani, D., Campbell, J., Mirza, H., Grigoriadis, A., Tutt, A., Moseley, P. M., Abdel-Fatah, T. M. A., Chan, S. Y. T., Madhusudan, S., Rhaka, E. A., Ellis, I. O., Lord, C. J., Yuan, Y., Green, A. R. & Natrajan, R., 1 Jan 2018, In: Molecular Cancer Therapeutics. 17, 1, p. 306-315 10 p.

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52 Citations (Scopus)

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Histological scoring of immune and stromal features in breast and axillary lymph nodes is prognostic for distant metastasis in lymph node-positive breast cancers

Grigoriadis, A., Gazinska, P., Pai, T., Irshad, S., Wu, Y., Millis, R. R., Naidoo, K., Owen, J. E., Gillett, C. E., Tutt, A. N. J., Coolen, ACC. & Pinder, S. E., 24 Jan 2018, In: The journal of pathology. Clinical research. 4, 1, p. 39-54

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24 Citations (Scopus)

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Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer

Patel, N., Weekes, D., Drosopoulos, K., Gazinska, P., Noel, E., Rashid, M., Mirza, H., Quist, J., Brasó-Maristany, F., Mathew, S., Ferro, R., Pereira, A. M., Prince, C., Noor, F., Francesch-Domenech, E., Marlow, R., de Rinaldis, E., Grigoriadis, A., Linardopoulos, S., Marra, P., & 1 othersTutt, A. N. J., 13 Mar 2018, In: Nature Communications. 9, 1, 16 p., 1044.

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41 Citations (Scopus)

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Low-Density Lipoprotein Uptake Inhibits the Activation and Antitumor Functions of Human Vγ9Vδ2 T Cells

Rodrigues, N. V., Correia, D. V., Mensurado, S., Nóbrega-Pereira, S., deBarros, A., Kyle-Cezar, F., Tutt, A., Hayday, A. C., Norell, H., Silva-Santos, B. & Dias, S., 6 Apr 2018, In: Cancer immunology research. 6, 4, p. 448-547

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25 Citations (Scopus)

Repurposing tin mesoporphyrin as an immune checkpoint inhibitor shows therapeutic efficacy in preclinical models of cancer

Muliaditan, T., Opzoomer, J. W., Caron, J., Okesola, M., Kosti, P., Lall, S., Van Hemelrijck, M., Dazzi, F., Tutt, A., Grigoriadis, A., Gillett, C. E., Madden, S. F., Burchell, J. M., Kordasti, S., Diebold, S. S., Spicer, J. F. & Arnold, J. N., 1 Apr 2018, In: Clinical Cancer Research. 24, 7, p. 1617-1628 12 p.

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44 Citations (Scopus)

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Repurposing tin mesoporphyrin as a novel immune checkpoint therapy in the treatment of cancer: A preclinical evaluation.

Arnold, J. N., Muliaditan, T., Opzoomer, J. W., Caron, J., Okesola, M., Kosti, P., Lall, S., Van Hemelrijck, M., Dazzi, F., Tutt, A., Grigoriadis, A., Gillett, C., Madden, S. F., Burchell, J. M., Kordasti, S., Diebold, S. S. & Spicer, J. F., 20 May 2018, In: Journal of Clinical Oncology. 36, 15

Research output: Contribution to journal › Meeting Abstract › peer-review

2017

Corrigendum to “3rd ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 3)” [Breast 31 (February 2017) 244–259]

Cardoso, F., Costa, A., Senkus, E., Aapro, M., André, F., Barrios, C. H., Bergh, J., Bhattacharyya, G., Biganzoli, L., Cardoso, M. J., Carey, L., Corneliussen-James, D., Curigliano, G., Dieras, V., El Saghir, N., Eniu, A., Fallowfield, L., Fenech, D., Francis, P., Gelmon, K., & 25 othersGennari, A., Harbeck, N., Hudis, C., Kaufman, B., Krop, I., Mayer, M., Meijer, H., Mertz, S., Ohno, S., Pagani, O., Papadopoulos, E., Peccatori, F., Penault-Llorca, F., Piccart, M. J., Pierga, J. Y., Rugo, H., Shockney, L., Sledge, G., Swain, S., Thomssen, C., Tutt, A., Vorobiof, D., Xu, B., Norton, L. & Winer, E., Apr 2017, In: BREAST. 32, p. 269-270 2 p.

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3 Citations (Scopus)

Functionally Active Fc Mutant Antibodies Recognizing Cancer Antigens Generated Rapidly at High Yields

Ilieva, K. M., Fazekas-Singer, J., Achkova, D. Y., Dodev, T. S., Mele, S., Crescioli, S., Bax, H. J., Cheung, A., Karagiannis, P., Correa, I., Figini, M., Marlow, R., Josephs, D. H., Beavil, A. J., Maher, J., Spicer, J. F., Jensen-Jarolim, E., Tutt, A. N. & Karagiannis, S. N., 11 Sept 2017, In: Frontiers in Immunology. 8, SEP, 1112.

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13 Citations (Scopus)

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Andrew Tutt

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