Anil Dhawan

2023

Intraperitoneal transplant of Hepatocytes co-Encapsulated with mesenchymal stromal cells in modified alginate microbeads for the treatment of acute Liver failure in Pediatric patients (HELP)-An open-label, single-arm Simon's two stage phase 1 study protocol

Fitzpatrick, E., Filippi, C., Jagadisan, B., Shivapatham, D., Anand, H., Lyne, M., Stroud, K. D., Newton, R., DeLord, M., Douiri, A. & Dhawan, A., Jul 2023, In: PLoS ONE. 18, 7 July, e0288185.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

Medium-chain triglycerides and the impact on fat absorption, growth, nutritional status and clinical outcomes in children with cholestatic liver disease: A scoping review

Mancell, S., Manwani, K., Dhawan, A. & Whelan, K., Nov 2023, In: CLINICAL NUTRITION. 42, 11, p. 2159-2172 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

Pancreatitis in RYR1-related disorders

Famili, D. T., Mistry, A., Gerasimenko, O., Gerasimenko, J., Tribe, R. M., Kyrana, E., Dhawan, A., Goldberg, M. F., Voermans, N., Willis, T. & Jungbluth, H., 15 Sept 2023, (E-pub ahead of print) In: Neuromuscular Disorders. 33, 10, p. 769-775 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

Transient elastography and von Willebrand factor as predictors of portal hypertension and decompensation in children

Goel, A., Hegarty, R., Dixit, S., Tucker, B., Douiri, A., Kyrana, E., Jain, V., Dhawan, A. & Grammatikopoulos, T., Dec 2023, In: JHEP Reports. 5, 12, 100935.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

2022

Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease

Assante, G., Chandrasekaran, S., Ng, S., Tourna, A., Chung, C. H., Isse, K. A., Banks, J. L., Soffientini, U., Filippi, C., Dhawan, A., Liu, M., Rozen, S. G., Hoare, M., Campbell, P., Ballard, J. W. O., Turner, N., Morris, M. J., Chokshi, S. & Youngson, N. A., Dec 2022, In: Genome medicine. 14, 1, 67.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Citations (Scopus)

Advances in medical management of acute liver failure in children: promoting native liver survival

Deep, A., Alexander, E. C., Bulut, Y., Fitzpatrick, E., Grazioli, S., Heaton, N. & Dhawan, A., 14 Sept 2022, (E-pub ahead of print) In: The Lancet Child and Adolescent Health. 6, 10, p. 725-737 13 p.

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Andrographolide can potentially rescue unusable liver grafts by reducing fat content, enhancing mitochondrial function, and inhibiting Th1/Th17 immunity

Huang, Z., Si, T., Huang, X., Anand, H., Filippi, C., Mitry, R., Dhawan, A., Jassem, W., Wang, Z., Heaton, N., Ji, L. & Ma, Y., Jul 2022, In: Journal of Hepatology. 77, p. S818-S820

Research output: Contribution to journal › Meeting Abstract › peer-review

Cell therapy in congenital inherited hepatic disorders

Anand, H., Nulty, J. & Dhawan, A., 22 Mar 2022, (E-pub ahead of print) In: Best Practice and Research: Clinical Gastroenterology. 56-57, 101772.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Cellular Therapies in Pediatric Liver Diseases

Vimalesvaran, S., Nulty, J. & Dhawan, A., 10 Aug 2022, In: Cells. 11, 16, 2483.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Citations (Scopus)

Medium-chain triglyceride supplementation and the association with growth, nutritional status and clinical outcomes in infants with biliary atresia

Mancell, S., Dhawan, A., Geaney, G., Ayis, S. & Whelan, K., 14 Nov 2022, (Accepted/In press) In: CLINICAL NUTRITION. 44, p. 134-146 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit

Deep, A., Grammatikopoulos, T., Heaton, N., Verma, A. & Dhawan, A., Jul 2022, In: Intensive Care Medicine. 48, 7, p. 958-962 5 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

19 Citations (Scopus)

2021

Fat-soluble vitamin assessment, deficiency and supplementation in infants with cholestasis

Mancell, S., Islam, M., Dhawan, A. & Whelan, K., 22 Oct 2021, (E-pub ahead of print) In: Journal of Human Nutrition and Dietetics. 35, 2

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Liver Disease and Risk of Hepatocellular Carcinoma in Children With Mutations in TALDO1

University of Washington Center for Mendelian Genomics, 22 Oct 2021, (E-pub ahead of print) In: Hepatology Communications.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

NAFLD to MAFLD in adults but the saga continues in children: an opportunity to advocate change

Hegarty, R., Singh, S., Bansal, S., Fitzpatrick, E. & Dhawan, A., Apr 2021, In: Journal of Hepatology. 74, 4, p. 991-992 2 p.

Research output: Contribution to journal › Letter › peer-review

23 Citations (Scopus)

New dimensions for hospital services and early detection of disease: a Review from the Lancet Commission into liver disease in the UK

Williams, R., Alessi, C., Alexander, G., Allison, M., Aspinall, R., Batterham, R. L., Bhala, N., Day, N., Dhawan, A., Drummond, C., Ferguson, J., Foster, G., Gilmore, I., Goldacre, R., Gordon, H., Henn, C., Kelly, D., MacGilchrist, A., McCorry, R. & McDougall, N. & 14 others, Mirza, Z., Moriarty, K., Newsome, P., Pinder, R., Roberts, S., Rutter, H., Ryder, S., Samyn, M., Severi, K., Sheron, N., Thorburn, D., Verne, J., Williams, J. & Yeoman, A., 8 May 2021, In: The Lancet. 397, 10286, p. 1770-1780 11 p.

Research output: Contribution to journal › Review article › peer-review

19 Citations (Scopus)

Non-invasive assessment of intrapulmonary shunt and ventilation to perfusion ratio in children with hepatopulmonary syndrome before and after liver transplantation

Russell-Jones, E., Grammatikopoulos, T., Greenough, A., Dhawan, A. & Dassios, T., 1 Apr 2021, In: Respiratory Medicine. 180, 106372.

Research output: Contribution to journal › Article › peer-review

Open Access

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4 Citations (Scopus)

81 Downloads (Pure)

Study of acute liver failure in children using next generation sequencing technology

Hegarty, R., Thompson, R., Dhawan, A. & Grammatikopoulos, T., 14 May 2021, (Accepted/In press) In: Journal of Pediatrics.

Research output: Contribution to journal › Article › peer-review

2020

Alginate microencapsulated human hepatocytes for the treatment of acute liver failure in children

Dhawan, A., Chaijitraruch, N., Fitzpatrick, E., Bansal, S., Filippi, C., Lehec, S. C., Heaton, N. D., Kane, P., Verma, A., Hughes, R. D. & Mitry, R. R., May 2020, In: Journal of Hepatology. 72, 5, p. 877-884 8 p.

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

Clinical Management of Sickle Cell Liver Disease in Children and Young Adults

Kyrana, S., Lacaille, F., Rees, D., Fitzpatrick, E., Davenport, M., Heaton, N., Height, S., Samyn, M., Mavilio, F., Brousse, V., Suddle, A., Chakravorty, S., Verma, A., Gupte, G., Velangi, M., Inusa, B., Drasar, E., Hadzic, D., Grammatikopoulos, T. & Hind, J. & 3 others, Deheragoda, M., Sellars, M. & Dhawan, A., 13 Sept 2020, In: Archives of Disease in Childhood. 319778.

Research output: Contribution to journal › Review article › peer-review

Open Access

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14 Citations (Scopus)

182 Downloads (Pure)

2019

Childhood and Adolescent Nonalcoholic Fatty Liver Disease: IS It Different From Adults?

Fitzpatrick, E. & Dhawan, A., 1 Nov 2019, In: Journal of Clinical and Experimental Hepatology. 9, 6, p. 716-722 7 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

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21 Citations (Scopus)

147 Downloads (Pure)

Improving engraftment of hepatocyte transplantation using alpha-1 antitrypsin as an immune modulator

Lee, C., Dhawan, A., Iansante, V., Filippi, C., Mitry, R., Tang, J., Walker, S., Fernandez DaCosta, R., Sinha, S., Hughes, R. D., Koulmanda, M. & Fitzpatrick, E., 28 Feb 2019, (E-pub ahead of print) In: Journal of Molecular Medicine. 97, 4, p. 563-577 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Prognostic markers at adolescence in patients requiring liver transplantation for biliary atresia in adulthood

Jain, V., Burford, C., Alexander, E. C., Sutton, H., Dhawan, A., Joshi, D., Davenport, M., Heaton, N., Hadzic, N. & Samyn, M., 1 Jul 2019, In: Journal of Hepatology. 71, 1, p. 71-77 7 p.

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Validation of Current Good Manufacturing Practice Compliant Human Pluripotent Stem Cell-Derived Hepatocytes for Cell-Based Therapy

Blackford, S. J. I., Ng, S. S., Segal, J. M., King, A., Austin, A. L. F., Kent, D. H., Moore, J., Sheldon, M., Ilic, D., Dhawan, A., Mitry, R. & Rashid, S. T., 28 Feb 2019, In: Stem cells translational medicine. 8, 2, p. 124-137 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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41 Citations (Scopus)

261 Downloads (Pure)

2018

3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo

Rashidi, H., Luu, N.-T., Alwahsh, S. M., Ginai, M., Alhaque, S., Dong, H., Tomaz, R. A., Vernay, B., Vigneswara, V., Hallett, J. M., Chandrashekran, A., Dhawan, A., Vallier, L., Bradley, M., Callanan, A., Forbes, S. J., Newsome, P. N. & Hay, D. C., Oct 2018, In: Archives of Toxicology. 92, 10, p. 3117-3129 13 p.

Research output: Contribution to journal › Article › peer-review

97 Citations (Scopus)

Acute-on-chronic liver failure in children with biliary atresia awaiting liver transplantation

D’Souza, R., Grammatikopoulos, T., Pradhan, A., Sutton, H., Douiri, A., Davenport, M., Verma, A. & Dhawan, A., 1 Jan 2018, (Accepted/In press) In: PEDIATRIC TRANSPLANTATION. e13339.

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

A New High Throughput Screening Platform for Cell Encapsulation in Alginate Hydrogel Shows Improved Hepatocyte Functions by Mesenchymal Stromal Cells Co-encapsulation

Iansante, V., Dhawan, A., Masmoudi, F., Lee, C. A., Fernandez-Dacosta, R., Walker, S., Fitzpatrick, E., Mitry, R. R. & Filippi, C., 9 Aug 2018, In: Frontiers in Medicine. 5

Research output: Contribution to journal › Article › peer-review

Open Access

14 Citations (Scopus)

Autoimmune pancreatitis in children: A single centre experience in diagnosis, management and long term follow up

Lee, H. M., Deheragoda, M., Harrison, P., Devlin, J., Sellars, M., Hadzic, N., Dhawan, A. & Grammatikopoulos, T., 14 Nov 2018, (E-pub ahead of print) In: PANCREATOLOGY.

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Cell-based liver therapies: past, present and future

Iansante, V., Chandrashekran, A. & Dhawan, A., 5 Jul 2018, In: Philosophical Transactions of the Royal Society of London Series B: Biological Sciences. 373, 1750

Research output: Contribution to journal › Review article › peer-review

42 Citations (Scopus)

Comparison of the Effects of Four Types of Human Mesenchymal Stromal Cells and Fibroblasts on Primary Human Hepatocyte Functions to Improve the Outcome of Hepatocyte Transplantation

Hubber, E., Dhawan, A., Lee, C., Tang, J., Fitzpatrick, E., Varin, A., Iansante, V. & Filippi, C., Oct 2018, In: Hepatology. 68, p. 501A-502A

Research output: Contribution to journal › Meeting Abstract › peer-review

Correction: Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease [Proteome Sci., 16, (2018), (4)] DOI: 10.1186/s12953-018-0131-y.

Spanos, C., Maldonado, E. M., Fisher, C. P., Leenutaphong, P., Oviedo-Orta, E., Windridge, D., Salguero, F. J., Bermúdez-Fajardo, A., Weeks, M. E., Evans, C., Corfe, B. M., Rabbani, N., Thornalley, P. J., Miller, M. H., Wang, H., Dillon, J. F., Quaglia, A., Dhawan, A., Fitzpatrick, E. & Moore, J. B., 25 Jun 2018, In: Proteome Science. 16, 1, 13.

Research output: Contribution to journal › Comment/debate › peer-review

Cryopreserved neonatal hepatocytes may be a source for transplantation: Evaluation of functionality toward clinical use

Lee, C. A., Dhawan, A., Iansante, V., Lehec, S., Khorsandi, S. E., Filippi, C., Walker, S., Fernandez-Dacosta, R., Heaton, N., Bansal, S., Mitry, R. R. & Fitzpatrick, E., Mar 2018, In: Liver Transplantation. 24, 3, p. 394-406 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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17 Citations (Scopus)

292 Downloads (Pure)

Dynamin-1-like protein inhibition drives megamitochondria formation as an adaptive response in alcohol-induced hepatotoxicity

Palma, E., Ma, X., Riva, A., Iansante, V., Dhawan, A., Wang, S., Ni, H.-M., Sesaki, H., Williams, R., Ding, W.-X. & Chokshi, S., 14 Dec 2018, (E-pub ahead of print) In: American Journal of Pathology.

Research output: Contribution to journal › Article › peer-review

Open Access

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34 Citations (Scopus)

141 Downloads (Pure)

Fifteen-minute consultation: Liver disease in children

Mann, J. P., Gallagher, K., Fitzpatrick, E. & Dhawan, A., 1 Aug 2018, In: Archives of Disease in Childhood: Education and Practice Edition. 103, 4, p. 170-176 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

4 Citations (Scopus)

930 Downloads (Pure)

Gathering momentum for the way ahead: fifth report of the Lancet Standing Commission on Liver Disease in the UK

Williams, R., Alexander, G., Aspinall, R., Batterham, R., Bhala, N., Bosanquet, N., Severi, K., Burton, A., Burton, R., Cramp, M. E., Day, N., Dhawan, A., Dillon, J., Drummond, C., Dyson, J., Ferguson, J., Foster, G. R., Gilmore, I., Greenberg, J. & Henn, C. & 19 others, Hudson, M., Jarvis, H., Kelly, D., Mann, J., McDougall, N., McKee, M., Moriarty, K., Morling, J., Newsome, P., O'Grady, J., Rolfe, L., Rice, P., Rutter, H., Sheron, N., Thorburn, D., Verne, J., Vohra, J., Wass, J. & Yeoman, A., 1 Dec 2018, In: The Lancet. 392, 10162, p. 2398-2412 15 p.

Research output: Contribution to journal › Comment/debate › peer-review

52 Citations (Scopus)

Graft Derived Cell-Free DNA As a Non-Invasive Biomarker to Track Early Rejection of Transplanted Primary Human Hepatocytes

Lee, C., Dhawan, A., Mitry, R. R., Folarin, N., Lea, N., Jorns, C., Ellis, E., Gramignoli, R., Strom, S. C. & Fitzpatrick, E., Oct 2018, In: Hepatology. 68, p. 124A-124A

Research output: Contribution to journal › Meeting Abstract › peer-review

Health Related Quality of Life and Neurocognitive Outcomes in the First Year after Pediatric Acute Liver Failure

Pediatric Acute Liver Failure Study Group, May 2018, In: Journal of Pediatrics. 196, p. 129-138.e3

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Hepatocyte transplantation and advancements in alternative cell sources for liver-based regenerative medicine

Lee, C. A., Sinha, S., Fitzpatrick, E. & Dhawan, A., Jun 2018, In: Journal of molecular medicine (Berlin, Germany). 96, 6, p. 469-481 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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56 Citations (Scopus)

238 Downloads (Pure)

Human hepatocyte transplantation for liver disease: Current status and future perspectives

Iansante, V., Mitry, R. R., Filippi, C., Fitzpatrick, E. & Dhawan, A., 1 Jan 2018, In: Pediatric Research. 83, 1-2, p. 232-240 9 p.

Research output: Contribution to journal › Review article › peer-review

163 Citations (Scopus)

Imaging-Based Screen Identifies Laminin 411 as a Physiologically Relevant Niche Factor with Importance for i-Hep Applications

Ong, J., Serra, M. P., Segal, J., Cujba, A.-M., Ng, S. S., Butler, R., Millar, V., Hatch, S., Zimri, S., Koike, H., Chan, K., Bonham, A., Walk, M., Voss, T., Heaton, N., Mitry, R., Dhawan, A., Ebner, D., Danovi, D. & Nakauchi, H. & 1 others, Rashid, S. T., 13 Mar 2018, In: Stem cell reports. 10, 3, p. 693-702 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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9 Citations (Scopus)

208 Downloads (Pure)

Methylcellulose as a scaffold for the establishment of liver-organoids for the potential of treating acute live failure

Chandrashekran, A., Mitry, R., Premachandra, T., Starling, C., Lehec, S., Iansante, V., Fitzpatrick, E. C., Fillipi, C., Deheragoda, M., Hay, D. & Dhawan, A., 2018, In: Cell and Gene Therapy Insights. p. 1087-1104

Research output: Contribution to journal › Article › peer-review

Open Access

File

260 Downloads (Pure)

Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease

Spanos, C., Maldonado, E. M., Fisher, C. P., Leenutaphong, P., Oviedo-Orta, E., Windridge, D., Salguero, F. J., Bermúdez-Fajardo, A., Weeks, M. E., Evans, C., Corfe, B. M., Rabbani, N., Thornalley, P. J., Miller, M. H., Wang, H., Dillon, J. F., Quaglia, A., Dhawan, A., Fitzpatrick, E. & Bernadette Moore, J., 14 Feb 2018, In: Proteome Science. 16, 4, 4.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Citations (Scopus)

Rare Variants in Genes That Regulate Bile Acid Homeostasis in a Paediatric NAFLD Cohort

Brunetti, T., Foskett, P., Strautnieks, S., Younes, M., Gibson, P., Dhawan, A., Thompson, R. J. & Fitzpatrick, E., Oct 2018, In: Hepatology. 68, p. 740A-740A

Research output: Contribution to journal › Meeting Abstract › peer-review

Structural Modification of Alginate Microbeads Containing Human Hepatocyte and Mesenchymal Stromal Cells as a Potential way to Improve Hepatic Functions for Cell Transplantation in Acute Liver Failure

Lansante, V., Dhawan, A., Lee, C., Dacosta, R. F., Fitzpatrick, E., Mitry, R. & Filippi, C., Jul 2018, In: Transplantation. 102, p. S732-S732

Research output: Contribution to journal › Meeting Abstract › peer-review

The Anti-Inflammatory Effect of Alpha-1 Antitrypsin in Hepatocyte Transplantation

Lee, C., Dhawan, A., Filippi, C., Mitry, R. R., Lansante, V., Fernandez-Dacosta, R., Lehec, S., Chandrashekran, A., Strom, T., Koulmanda, M. & Fitzpatrick, E., Jul 2018, In: Transplantation. 102, p. S302-S302

Research output: Contribution to journal › Meeting Abstract › peer-review

Transient elastography measurements of spleen stiffness as a predictor of clinically significant varices in children

Sutton, H., Fitzpatrick, E., Davenport, M., Burford, C., Alexander, E., Dhawan, A. & Grammatikopoulos, T., Oct 2018, In: Journal of Pediatric Gastroenterology and Nutrition. 67, 4, p. 446-451 6 p.

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Vitamin D status and associated genetic polymorphisms in a cohort of UK children with non -alcoholic fatty liver disease

Gibson, P. S., Quaglia, A., Dhawan, A., Wu, H., Lanham-New, S., Hart, K. H., Fitzpatrick, E. & Moore, J. B., Jul 2018, In: International Journal Of Pediatric Obesity. 13, 7, p. 433–441

Research output: Contribution to journal › Article › peer-review

Open Access

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21 Citations (Scopus)

170 Downloads (Pure)

Wilson’s disease: Clinical practice guidelines of the Indian National Association for the study of Liver (INASL), The Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition (ISPGHAN) and the Movement Disorders Society of India (MDSI)

Nagral, A., Sarma, M. S., Matthai, J., Prashanth, L. K., Devarbhavi, H., Sinha, S., Alam, S., Bavdekar, A., Dhiman, R. K., Eapen, C. E., Goyal, V., Mohan, N., Kandadai, R. M., Sathiyasekaran, M., Poddar, U., Sibal, A., Sankaranarayanan, S., Srivastava, A., Thapa, B. R. & Wadia, P. & 2 others, Yachha, S. K. & Dhawan, A., 3 Sept 2018, (E-pub ahead of print) In: Journal of Clinical and Experimental Hepatology.

Research output: Contribution to journal › Article › peer-review

Open Access

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