Anna Schurich

2024

IL-15 reprogramming compensates for NK cell mitochondrial dysfunction in HIV-1 infection

Moreno-Cubero, E., Alrubayyi, A., Balint, S., Ogbe, A., Gill, U. S., Matthews, R., Kinloch, S., Burns, F., Rowland-Jones, S. L., Borrow, P., Schurich, A., Dustin, M. & Peppa, D., 22 Feb 2024, In: JCI Insight. 9, 4, e173099.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Solid tumor immunotherapy using NKG2D-based adaptor CAR T cells

Obajdin, J., Larcombe-Young, D., Glover, M., Kausar, F., Hull, C. M., Flaherty, K. R., Tan, G., Beatson, R. E., Dunbar, P., Mazza, R., Bove, C., Taylor, C., Bille, A., Spillane, K. M., Cozzetto, D., Vigilante, A., Schurich, A., Davies, D. M. & Maher, J., 19 Nov 2024, In: Cell Reports Medicine. 5, 11, 101827.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

2023

Extracellular vesicles in COVID-19 convalescence can regulate T cell metabolism and function

George, M. S., Sanchez, J., Rollings, C., Fear, D., Irving, P., Sinclair, L. V. & Schurich, A., 18 Aug 2023, In: iScience. 26, 8, 107280.

Research output: Contribution to journal › Article › peer-review

Open Access

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9 Citations (Scopus)

83 Downloads (Pure)

Intratumoral pan-ErbB targeted CAR-T for head and neck squamous cell carcinoma: interim analysis of the T4 immunotherapy study

Papa, S., Adami, A., Metoudi, M., Beatson, R., George, M. S., Achkova, D., Williams, E., Arif, S., Reid, F., Elstad, M., Beckley-Hoelscher, N., Douri, A., Delord, M., Lyne, M., Shivapatham, D., Fisher, C., Hope, A., Gooljar, S., Mitra, A. & Gomm, L. & 16 others, Morton, C., Henley-Smith, R., Thavaraj, S., Santambrogio, A., Andoniadou, C., Allen, S., Gibson, V., Cook, G. J. R., Parente-Pereira, A. C., Davies, D. M., Farzaneh, F., Schurich, A., Guerrero-Urbano, T., Jeannon, J.-P., Spicer, J. & Maher, J., 15 Jun 2023, In: Journal for ImmunoTherapy of Cancer. 11, 6, e007162.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Citations (Scopus)

Tissue CD14⁺CD8⁺ T cells reprogrammed by myeloid cells and modulated by LPS

Pallett, L. J., Swadling, L., Diniz, M., Maini, A. A., Schwabenland, M., Gasull, A. D., Davies, J., Kucykowicz, S., Skelton, J. K., Thomas, N., Schmidt, N. M., Amin, O. E., Gill, U. S., Stegmann, K. A., Burton, A. R., Stephenson, E., Reynolds, G., Whelan, M., Sanchez, J. & De maeyer, R. & 23 others, Thakker, C., Suveizdyte, K., Uddin, I., Ortega-Prieto, A. M., Grant, C., Froghi, F., Fusai, G., Lens, S., Pérez-Del-Pulgar, S., Al-Akkad, W., Mazza, G., Noursadeghi, M., Akbar, A., Kennedy, P. T. F., Davidson, B. R., Prinz, M., Chain, B. M., Haniffa, M., Gilroy, D. W., Dorner, M., Bengsch, B., Schurich, A. & Maini, M. K., 9 Feb 2023, In: Nature. 614, 7947, p. 334-342 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Citations (Scopus)

2022

Functional Restoration of Exhausted CD8 T Cells in Chronic HIV-1 Infection by Targeting Mitochondrial Dysfunction

Alrubayyi, A., Moreno-Cubero, E., Hameiri-Bowen, D., Matthews, R., Rowland-Jones, S., Schurich, A. & Peppa, D., 5 Jul 2022, In: Frontiers in Immunology. 13, 908697.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Citations (Scopus)

NK cells limit therapeutic vaccine–induced CD8⁺T cell immunity in a PD-L1–dependent manner

Diniz, M. O., Schurich, A., Chinnakannan, S. K., Duriez, M., Stegmann, K. A., Davies, J., Kucykowicz, S., Suveizdyte, K., Amin, O. E., Alcock, F., Cargill, T., Barnes, E. & Maini, M. K., 13 Apr 2022, In: Science Translational Medicine. 14, 640, eabi4670.

Research output: Contribution to journal › Article › peer-review

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22 Citations (Scopus)

522 Downloads (Pure)

2021

Synergistic T cell signaling by 41BB and CD28 is optimally achieved by membrane proximal positioning within parallel chimeric antigen receptors

Muliaditan, T., Halim, L., Whilding, L., Draper, B., Achkova, D., Kausar, F., Glover, M., Bechman, N., Arulappu, A., Sanchez, J., Flaherty, K. R., Obajdin, J., Grigoriadis, K., Antoine, P., Larcombe-Young, D., Hull, C., Buus, R., Gordon, P., Grigoriadis, A. & Davies, D. & 2 others, Schurich, A. & Maher, J., 21 Dec 2021, In: Cell Reports Medicine. 2, 12, 100457.

Research output: Contribution to journal › Article › peer-review

Open Access

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39 Citations (Scopus)

312 Downloads (Pure)

2020

Divergent impact of glucose availability on human virus-specific and generically activated CD8 T cells

Sanchez, J., Jackson, I., Flaherty, K. R., Muliaditan, T. & Schurich, A., Nov 2020, In: Metabolites. 10, 11, p. 1-18 18 p., 461.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Human Liver Memory CD8⁺ T Cells Use Autophagy for Tissue Residence

Swadling, L., Pallett, L. J., Diniz, M. O., Baker, J. M., Amin, O. E., Stegmann, K. A., Burton, A. R., Schmidt, N. M., Jeffery-smith, A., Zakeri, N., Suveizdyte, K., Froghi, F., Fusai, G., Rosenberg, W. M., Davidson, B. R., Schurich, A., Simon, A. K. & Maini, M. K., 21 Jan 2020, In: Cell Reports. 30, 3, p. 687-698.e6

Research output: Contribution to journal › Article › peer-review

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65 Citations (Scopus)

234 Downloads (Pure)

2019

Metabolic regulation of CAR T cell function by the hypoxic microenvironment in solid tumors

Schurich, A., Magalhaes, I. & Mattsson, J., 1 Mar 2019, In: Immunotherapy. 11, 4, p. 335-345 11 p.

Research output: Contribution to journal › Review article › peer-review

43 Citations (Scopus)

T cell metabolism in chronic viral infection

Pallett, L. J., Schmidt, N. & Schurich, A., 1 Aug 2019, In: Clinical & Experimental Immunology. 197, 2, p. 143-152 10 p.

Research output: Contribution to journal › Review article › peer-review

32 Citations (Scopus)

The Metabolic Profile of Tumor and Virally Infected Cells Shapes Their Microenvironment Counteracting T Cell Immunity

Magalhaes, I., Yogev, O., Mattsson, J. & Schurich, A., 4 Oct 2019, In: Frontiers in Immunology. 10, 2309.

Research output: Contribution to journal › Review article › peer-review

Open Access

21 Citations (Scopus)

2018

Molecular Recalibration of PD-1+ Antigen-Specific T Cells from Blood and Liver

Otano, I., Escors, D., Schurich, A., Singh, H., Robertson, F., Davidson, B. R., Fusai, G., Vargas, F. A., Tan, Z. M. D., Aw, J. Y. J., Hansi, N., Kennedy, P. T. F., Xue, S.-A., Stauss, H. J., Bertoletti, A., Pavesi, A. & Maini, M. K., 7 Nov 2018, In: Molecular therapy : the journal of the American Society of Gene Therapy. 26, 11, p. 2553-2566

Research output: Contribution to journal › Article › peer-review

Open Access

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23 Citations (Scopus)

190 Downloads (Pure)

The role of IL-12/23 in T cell-related chronic inflammation: Implications of immunodeficiency and therapeutic blockade

Schurich, A., Raine, C., Morris, V. & Ciurtin, C., Feb 2018, In: Rheumatology (United Kingdom). 57, 2, p. 246-254 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

46 Citations (Scopus)

2017

IL-2hightissue-resident T cells in the human liver: Sentinels for hepatotropic infection

Pallett, L. J., Davies, J., Colbeck, E. J., Robertson, F., Hansi, N., Easom, N. J. W., Burton, A. R., Stegmann, K. A., Schurich, A., Swadling, L., Gill, U. S., Male, V., Luong, T., Gander, A., Davidson, B. R., Kennedy, P. T. F. & Maini, M. K., 5 Jun 2017, In: Journal of Experimental Medicine. 214, 6, p. 1567-1580 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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270 Citations (Scopus)

133 Downloads (Pure)

2016

Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host

Schurich, A., Pallett, L. J., Jajbhay, D., Wijngaarden, J., Otano, I., Gill, U. S., Hansi, N., Kennedy, P. T., Nastouli, E., Gilson, R., Frezza, C., Henson, S. M. & Maini, M. K., 2 Aug 2016, In: Cell Reports. 16, 5, p. 1243-1252 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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189 Citations (Scopus)

117 Downloads (Pure)

2015

Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient

Qasim, W., Brunetto, M., Gehring, A. J., Xue, S.-A., Schurich, A., Khakpoor, A., Zhan, H., Ciccorossi, P., Gilmour, K., Cavallone, D., Moriconi, F., Farzhenah, F., Mazzoni, A., Chan, L., Morris, E., Thrasher, A., Maini, M. K., Bonino, F., Stauss, H. & Bertoletti, A., Feb 2015, In: Journal of Hepatology. 62, 2, p. 486-491 6 p.

Research output: Contribution to journal › Article › peer-review

169 Citations (Scopus)

Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells

Pallett, L. J., Gill, U. S., Quaglia, A., Sinclair, L. V., Jover-Cobos, M., Schurich, A., Singh, K. P., Thomas, N., Das, A., Chen, A., Fusai, G., Bertoletti, A., Cantrell, D. A., Kennedy, P. T., Davies, N. A., Haniffa, M. & Maini, M. K., 1 Jun 2015, In: Nature Medicine. 21, 6, p. 591-600 10 p.

Research output: Contribution to journal › Article › peer-review

237 Citations (Scopus)

2014

Direct-acting antivirals trump interferon-alpha in their capacity to rescue exhausted T cells upon HCV clearance

Maini, M. K. & Schurich, A., Sept 2014, In: Journal of Hepatology. 61, 3, p. 459-461 3 p.

Research output: Contribution to journal › Editorial › peer-review

Open Access

10 Citations (Scopus)

The many unknowns concerning the bioenergetics of exhaustion and senescence during chronic viral infection

Schurich, A. & Henson, S. M., 25 Sept 2014, In: Frontiers in Immunology. 5, SEP

Research output: Contribution to journal › Article › peer-review

Open Access

20 Citations (Scopus)

2013

Differential boosting of innate and adaptive antiviral responses during pegylated-interferon-alpha therapy of chronic hepatitis B

Micco, L., Peppa, D., Loggi, E., Schurich, A., Jefferson, L., Cursaro, C., Panno, A. M., Bernardi, M., Brander, C., Bihl, F., Andreone, P. & Maini, M. K., Feb 2013, In: Journal of Hepatology. 58, 2, p. 225-233 9 p.

Research output: Contribution to journal › Article › peer-review

220 Citations (Scopus)

The Third Signal Cytokine IL-12 Rescues the Anti-Viral Function of Exhausted HBV-Specific CD8 T Cells

Schurich, A., Pallett, L. J., Lubowiecki, M., Singh, H. D., Gill, U. S., Kennedy, P. T., Nastouli, E., Tanwar, S., Rosenberg, W. & Maini, M. K., 14 Mar 2013, In: Plos pathogens. 9, 3

Research output: Contribution to journal › Article › peer-review

Open Access

172 Citations (Scopus)

Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion

Peppa, D., Gil, U. S., Reynolds, G., Easom, N. J. W., Pallett, L. J., Schurich, A., Micco, L., Nebbia, G., Singh, H. D., Adams, D. H., Kennedy, P. T. F. & Maini, M. K., 14 Jan 2013, In: Journal of Experimental Medicine. 210, 1, p. 99-114 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

291 Citations (Scopus)

2012

IL-2-engineered nano-APC effectively activates viral antigen-mediated T cell responses from chronic hepatitis B virus-infected patients

Liu, M., Miao, T., Zhu, H., Symonds, A. L. J., Li, L., Schurich, A., Maini, M. K., Zhang, J., Kennedy, P. T. F., Li, S. & Wang, P., 1 Feb 2012, In: Journal of Immunology. 188, 3, p. 1534-1543 10 p.

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Platelets harness the immune response to drive liver cancer

Maini, M. K. & Schurich, A., 7 Aug 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 32, p. 12840-12841 2 p.

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Upregulation of the Tim-3/Galectin-9 Pathway of T Cell Exhaustion in Chronic Hepatitis B Virus Infection

Nebbia, G., Peppa, D., Schurich, A., Khanna, P., Singh, H. D., Cheng, Y., Rosenberg, W., Dusheiko, G., Gilson, R., ChinAleong, J., Kennedy, P. & Maini, M. K., 24 Oct 2012, In: PLoS ONE. 7, 10

Research output: Contribution to journal › Article › peer-review

Open Access

242 Citations (Scopus)

2011

Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection

Schurich, A., Khanna, P., Lopes, A. R., Han, K. J., Peppa, D., Micco, L., Nebbia, G., Kennedy, P. T., Geretti, A.-M., Dusheiko, G. & Maini, M. K., 25 Feb 2011, In: Hepatology. 53, 5, p. 1494-1503 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

280 Citations (Scopus)

2010

Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infection

Peppa, D., Micco, L., Javaid, A., Kennedy, P. T. F., Schurich, A., Dunn, C., Pallant, C., Ellis, G., Khanna, P., Dusheiko, G., Gilson, R. J. & Maini, M. K., 16 Dec 2010, In: Plos pathogens. 6, 12

Research output: Contribution to journal › Article › peer-review

228 Citations (Scopus)

Dynamic regulation of CD8 T cell tolerance induction by liver sinusoidal endothelial cells

Schurich, A., Berg, M., Stabenow, D., Böttcher, J., Kern, M., Schild, H.-J., Kurts, C., Schuette, V., Burgdorf, S., Diehl, L., Limmer, A. & Knolle, P. A., 15 Apr 2010, In: Journal of Immunology. 184, 8, p. 4107-4114 8 p.

Research output: Contribution to journal › Article › peer-review

107 Citations (Scopus)

The molecular basis of the failed immune response in chronic HBV: Therapeutic implications

Maini, M. K. & Schurich, A., 2010, In: Journal of Hepatology. 52, 4, p. 616-619 4 p.

Research output: Contribution to journal › Article › peer-review

119 Citations (Scopus)

2009

Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling

Linnemann, C., Schildberg, F. A., Schurich, A., Diehl, L., Hegenbarth, S. I., Endl, E., Lacher, S., Müller, C. E., Frey, J., Simeoni, L., Schraven, B., Stabenow, D. & Knolle, P. A., 2009, In: Immunology. 128, 1 PART 2, p. e728-e737

Research output: Contribution to journal › Article › peer-review

Open Access

99 Citations (Scopus)

Distinct kinetics and dynamics of cross-presentation in liver sinusoidal endothelial cells compared to dendritic cells

Schurich, A., Böttcher, J. P., Burgdorf, S., Penzler, P., Hegenbarth, S., Kern, M., Dolf, A., Endl, E., Schultze, J., Wiertz, E., Stabenow, D., Kurts, C. & Knolle, P. A., 2009, In: Hepatology. 50, 3, p. 909-919 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

72 Citations (Scopus)

Systemic antigen cross-presented by liver sinusoidal endothelial cells induces liver-specific CD8 T-cell retention and tolerization

von Oppen, N., Schurich, A., Hegenbarth, S., Stabenow, D., Tolba, R., Weiskirchen, R., Geerts, A., Kolanus, W., Knolle, P. & Diehl, L., 2009, In: Hepatology. 49, 5, p. 1664-1672 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

80 Citations (Scopus)

2008

Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance

Diehl, L., Schurich, A., Grochtmann, R., Hegenbarth, S., Chen, L. & Knolle, P. A., 2008, In: Hepatology. 47, 1, p. 296-305 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

244 Citations (Scopus)

2006

Rapid and preferential distribution of blood-borne αCD3εAb to the liver is followed by local stimulation of T cells and natural killer T cells

Wingender, G., Schumak, B., Schurich, A., Gessner, J. E., Endl, E., Limmer, A. & Knolle, P. A., Jan 2006, In: Immunology. 117, 1, p. 117-126 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Anna Schurich

Research output

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