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  Isothermal titration calorimetry instrumentation for structural biology, biological mechanisms and drug discovery

  Conte, M. (Primary Investigator), Gautel, M. (Co-Investigator), McDonnell, J. (Co-Investigator), Isaacson, R. (Co-Investigator), M. Barry, S. (Co-Investigator), Garnett, J. (Co-Investigator), Steiner, R. (Co-Investigator), Muller, M. (Co-Investigator), Pfuhl, M. (Co-Investigator), Bergeron, J. (Co-Investigator), Malim, M. (Co-Investigator), Naglik, J. (Co-Investigator), Kampourakis, T. (Co-Investigator), Burgoyne, J. (Co-Investigator), Pastore, A. (Co-Investigator) & De Nicola, G. (Co-Investigator)

  BBSRC Biotechnology and Biological Sciences Research Council

  1/10/2020 → 30/09/2021

  Project: Research

• Testing the toxicity of Abeta42 glycation in C. elegans

  Pastore, A. (Primary Investigator)

  British Council

  1/09/2019 → 30/11/2019

  Project: Research

• UK DRI Associate Director's Flexible Funding

  Shaw, C. (Primary Investigator), Mizielinska, S. (Co-Investigator), Pastore, A. (Co-Investigator), Cho, K. (Co-Investigator), Rajendran, L. (Co-Investigator) & Ruepp, M.-D. (Co-Investigator)

  UK Dementia Research Institute

  1/07/2019 → 31/03/2023

  Project: Research

• Understanding the molecular mechanism of iron sulfur cluster biogenesis

  Pastore, A. (Primary Investigator)

  BBSRC Biotechnology and Biological Sciences Research Council

  1/09/2018 → 31/03/2022

  Project: Research

• Biophysical and Biological study of protein aggregation and De novo designing of anti-aggregative peptides

  Pastore, A. (Primary Investigator)

  British Council

  28/02/2018 → 31/03/2019

  Project: Research

• UK-Israel Symposia

  Pastore, A. (Primary Investigator)

  British Council

  1/06/2017 → 31/12/2018

  Project: Research

• Iron sulfur cluster biogenesis and disease

  Pastore, A. (Primary Investigator)

  1/04/2017 → 31/03/2022

  Project: Research

• Dementia Research Institute

  Shaw, C. (Primary Investigator), Miller, C. (Co-Investigator), Mizielinska, S. (Co-Investigator), Pastore, A. (Co-Investigator) & Politis, M. (Co-Investigator)

  UK Dementia Research Institute, MRC Medical Research Council

  1/04/2017 → 31/08/2022

  Project: Research

• King’s NMR Facility for structural biology, metabolic profiling and drug discovery

  Conte, M. (Primary Investigator), Avkiran, M. (Co-Investigator), Blower, P. (Co-Investigator), Dodding, M. (Co-Investigator), Eaton, P. (Co-Investigator), Gautel, M. (Co-Investigator), Irving, M. (Co-Investigator), Malim, M. (Co-Investigator), Marber, M. (Co-Investigator), Mayr, M. (Co-Investigator), McDonnell, J. (Co-Investigator), Otsu, K. (Co-Investigator), Pastore, A. (Co-Investigator), Pfuhl, M. (Co-Investigator), Poston, L. (Co-Investigator), Shah, A. (Co-Investigator), Shanahan, C. (Co-Investigator), Shattock, M. (Co-Investigator) & Williamson, C. (Co-Investigator)

  BHF British Heart Foundation, Wellcome Trust

  1/01/2017 → 31/12/2021

  Project: Research

• Fragment-based de novo design of hydrogen sulfide production inhibitors

  Pastore, A. (Primary Investigator) & Steiner, R. (Co-Investigator)

  1/09/2016 → 31/08/2019

  Project: Research

• Studying the cross-talk between FUS and SMN1

  Adinolfi, S. (Primary Investigator) & Pastore, A. (Co-Investigator)

  1/03/2016 → 28/02/2019

  Project: Research

• Understanding how Fus binding to RNA modifies its aggregation pathway

  Pastore, A. (Primary Investigator)

  1/03/2016 → 28/02/2019

  Project: Research

• beta-amuloid directly binds p53 to initiate disease

  Killick, R. (Primary Investigator) & Pastore, A. (Co-Investigator)

  1/01/2016 → 31/12/2017

  Project: Research

• Protein-Protein Interaction Dynamics Through Aging And Environment: Towards A Disease Specific Treatment For Polyglutamine Diseases

  Pastore, A. (Primary Investigator)

  1/01/2016 → 31/12/2019

  Project: Research

• The role of molecular crowding in the aggregation of Abeta peptides

  Pastore, A. (Primary Investigator)

  1/10/2015 → 30/09/2018

  Project: Research

• Rational Design of anti-aggregation aptamers of TDP-43

  Pastore, A. (Primary Investigator)

  Motor Neurone Disease Association

  1/10/2015 → 30/09/2018

  Project: Research

• Suppressing amyloid formation: novel all-in-one therapeutics against neurodegeneration

  Pastore, A. (Primary Investigator)

  Royal Society

  1/10/2015 → 31/10/2017

  Project: Research

• Role of Atg13 post-translational modifications in the progression of autophagy flux

  Fanto, M. (Primary Investigator) & Pastore, A. (Co-Investigator)

  1/05/2015 → 30/04/2018

  Project: Research

• Exploring the structural and functional role of proteins responsible for neurobiological disorders

  Pastore, A. (Primary Investigator) & Rasheed, M. (Co-Investigator)

  Kids Company

  15/04/2015 → 31/08/2015

  Project: Research

• The mechanism of stretch activation in muscle: a multidisciplinary approach

  Pastore, A. (Primary Investigator)

  BBSRC Biotechnology and Biological Sciences Research Council

  1/04/2015 → 31/03/2018

  Project: Research

• PQNET - Protein-protein interactions as age-related risk factors in polyglutamine diseases

  Pastore, A. (Primary Investigator)

  1/03/2015 → 29/02/2020

  Project: Research

• SweetProt - Zero-calories Sweeteners from Natural Proteins

  Pastore, A. (Primary Investigator)

  1/03/2015 → 28/02/2019

  Project: Research

• Understanding disease development in Friedreich's ataxia in a time-resolved way: a new cellular model

  Pastore, A. (Primary Investigator) & Vannocci, T. (Co-Investigator)

  National Ataxia Foundation

  1/02/2015 → 30/06/2015

  Project: Research

• The function of troponin in insect flight muscle as a model for regulation of cardiac muscle contraction

  Pastore, A. (Primary Investigator)

  1/01/2015 → 31/12/2017

  Project: Research

• Understanding the role of protein-protein interactions in modulating protein function and dysfunction

  Pastore, A. (Primary Investigator)

  1/07/2014 → 30/06/2017

  Project: Research

• PAINCAGE - The NGF system and its interplay with endocannabinoid signalling, from peripheral sensory terminals to the brain: new targets for the development of next generatio drugs for neuropathic pain

  Pastore, A. (Primary Investigator)

  EC European Commission

  1/04/2014 → 31/03/2017

  Project: Research

• SarcoSi - Sarcomere based Signals in Muscle Remodelling

  Pastore, A. (Primary Investigator)

  EC European Commission

  1/04/2014 → 31/03/2016

  Project: Research

• PAINCAGE - The NGF system and its interplay with endocannabinoid signalling, from peripheral sensory terminals to the brain:new targets for the development of next generation drugs for neuropathic pain

  Pastore, A. (Primary Investigator)

  EC European Commission

  1/04/2014 → 31/03/2017

  Project: Research

• The role of non-enzymatic glycation on aggregation prone diabetes related polypeptides: a multidisciplinary approach from biophysics to cell toxicity

  Pastore, A. (Primary Investigator)

  Diabetes UK

  1/01/2014 → 31/12/2016

  Project: Research

• Spinocrebeller ataxias pathogenesis genetics animal models and therapy FP6 Integrated project

  Pastore, A. (Primary Investigator)

  MRC Medical Research Council

  1/10/2013 → 31/03/2017

  Project: Research