Annapurna Vyakarnam

2022

Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD™ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adults

Rakshit, S., Adiga, V., Ahmed, A., Parthiban, C., Chetan Kumar, N., Dwarkanath, P., Shivalingaiah, S., Rao, S., D’Souza, G., Dias, M., Maguire, T. J. A., Doores, K. J., Zoodsma, M., Geckin, B., Dasgupta, P., Babji, S., van Meijgaarden, K. E., Joosten, S. A., Ottenhoff, T. H. M. & Li, Y. & 5 others, Netea, M. G., Stuart, K. D., De Rosa, S. C., McElrath, M. J. & Vyakarnam, A., 4 Oct 2022, In: Frontiers in Immunology. 13, 985938.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Citations (Scopus)

The vaccine journey for COVID-19: a comprehensive systematic review of current clinical trials in humans

Checcucci, E., Piramide, F., Pecoraro, A., Amparore, D., Campi, R., Fiori, C., Elhage, O., Kotecha, P., Vyakarnam, A., Serni, S., Dasgupta, P. & Porpiglia, F., 1 Mar 2022, In: Panminerva medica. 64, 1, p. 72-79 8 p.

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

2021

A century of BCG: Impact on tuberculosis control and beyond*

Ahmed, A., Rakshit, S., Adiga, V., Dias, M., Dwarkanath, P., D’Souza, G. & Vyakarnam, A., May 2021, In: Immunological Reviews. 301, 1, p. 98-121 24 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

42 Citations (Scopus)

2020

Emerging patterns of regulatory T cell function in tuberculosis

Ahmed, A. & Vyakarnam, A., 16 Nov 2020, In: Clinical and Experimental Immunology. 202, 3, p. 273-287 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Citations (Scopus)

HIV Skews a Balanced Mtb-Specific Th17 Response in Latent Tuberculosis Subjects to a Pro-inflammatory Profile Independent of Viral Load: HIV alters the nature of the Mtb-specific Th17 response

Rakshit, S., Hingankar, N., Alampalli, S. V., Adiga, V., Sundararaj, B. K., Sahoo, P. N., Finak, G., Uday Kumar J, A. J., Dhar, C., D'Souza, G., Virkar, R. G., Ghate, M., Thakar, M. R., Paranjape, R. S., De Rosa, S. C., Ottenhoff, T. H. M. & Vyakarnam, A., 1 Dec 2020, In: Cell Reports. 33, 9, 108451.

Research output: Contribution to journal › Article › peer-review

Open Access

File

7 Citations (Scopus)

101 Downloads (Pure)

Innate immune mechanisms to oral pathogens in oral mucosa of HIV-infected individuals

Weinberg, A., Tugizov, S., Pandiyan, P., Jin, G., Rakshit, S., Vyakarnam, A. & Naglik, J. R., 1 Sept 2020, In: Oral Diseases. 26, S1, p. 69-79 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Citations (Scopus)

2019

BCG revaccination boosts adaptive polyfunctional Th1/Th17 and innate effectors in IGRA+ and IGRA- Indian adults

Rakshit, S., Ahmed, A., Adiga, V., Sundararaj, B. K., Sahoo, P. N., Kenneth, J., D'Souza, G., Bonam, W., Johnson, C., Franken, K. L., Ottenhoff, T. H., Finak, G., Gottardo, R., Stuart, K. D., De Rosa, S. C., McElrath, M. J. & Vyakarnam, A., 19 Dec 2019, In: JCI Insight. 4, 24, 22 p., 135946506.

Research output: Contribution to journal › Article › peer-review

Open Access

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50 Citations (Scopus)

134 Downloads (Pure)

Evidence for Highly Variable, Region-Specific Patterns of T-Cell Epitope Mutations Accumulating in Mycobacterium tuberculosis Strains

Ramaiah, A., Nayak, S., Rakshit, S., Manson, A. L., Abeel, T., Shanmugam, S., Sahoo, P. N., John, A. J. U. K., Sundaramurthi, J. C., Narayanan, S., D'souza, G., Von Hoegen, P., Ottenhoff, T. H. M., Swaminathan, S., Earl, A. M. & Vyakarnam, A., 13 Feb 2019, In: Frontiers in Immunology. 10, 0, 18 p., 195.

Research output: Contribution to journal › Article › peer-review

Open Access

File

5 Citations (Scopus)

113 Downloads (Pure)

2018

Circulating HLA-DR⁺CD4⁺ effector memory T cells resistant to CCR5 and PD-L1 mediated suppression compromise regulatory T cell function in tuberculosis

Ahmed, A., Adiga, V., Nayak, S., Uday Kumar, J. A. J., Dhar, C., Sahoo, P. N., Sundararaj, B. K., Souza, G. D., Vyakarnam, A. & Lewinsohn, D. M. (Editor), 19 Sept 2018, In: PLoS Pathogens. 14, 9, p. 1-35 35 p., e1007289.

Research output: Contribution to journal › Article › peer-review

Open Access

File

32 Citations (Scopus)

148 Downloads (Pure)

2017

Circulating Mycobacterium tuberculosis DosR latency antigen-specific, polyfunctional, regulatory IL10+ Th17 CD4 T-cells differentiate latent from active tuberculosis

Rakshit, S., Adiga, V., Nayak, S., Sahoo, P. N., Sharma, P. K., Van Meijgaarden, K. E., Uk J., A. J., Dhar, C., Souza, G. D., Finak, G., De Rosa, S. C., Ottenhoff, T. H. M. & Vyakarnam, A., 20 Sept 2017, In: Scientific Reports. 7, 1, 15 p., 11948.

Research output: Contribution to journal › Article › peer-review

Open Access

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28 Citations (Scopus)

237 Downloads (Pure)

Deep sequencing of near full-length HIV-1 genomes from plasma identifies circulating subtype C and infrequent occurrence of AC recombinant form in Southern India

Alampalli, S. V., Thomson, M. M., Sampathkumar, R., Sivaraman, K., U. K. J., A. J., Dhar, C., D. Souza, G., Berry, N., Vyakarnam, A. & Paxton, W. A. (Editor), 8 Dec 2017, In: PL o S One . 12, 12, p. e0188603 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

6 Citations (Scopus)

203 Downloads (Pure)

Unbiased Identification of Blood-based Biomarkers for Pulmonary Tuberculosis by Modeling and Mining Molecular Interaction Networks

Sambarey, A., Devaprasad, A., Mohan, A., Ahmed, A., Nayak, S., Swaminathan, S., D'Souza, G., Jesuraj, A., Dhar, C., Babu, S., Vykarnam, A. & Chandra, N., 1 Feb 2017, In: EBioMedicine. 15, p. 112-126

Research output: Contribution to journal › Article › peer-review

Open Access

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74 Citations (Scopus)

564 Downloads (Pure)

2016

Cathepsin-L and Transglutaminase Dependent Processing of ps20: A novel Mechanism for ps20 Regulation via ECM Cross-Linking

Hickman, O. J., Dasgupta, P., Galustian, C., Smith, R. A. & Vyakarnam, A., Sept 2016, In: Biochemistry and Biophysics Reports . 7, p. 328–337 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

5 Citations (Scopus)

202 Downloads (Pure)

Expression of two WFDC1/ps20 isoforms in prostate stromal cells induces paracrine apoptosis through regulation of PTGS2/COX-2

Hickman, O. J., Smith, R. A., Dasgupta, P., Rao, S. N., Nayak, S., Sreenivasan, S., Vyakarnam, A. & Galustian, C., 24 May 2016, In: British Journal of Cancer. 114, 11, p. 1235–1242

Research output: Contribution to journal › Article › peer-review

Open Access

File

10 Citations (Scopus)

241 Downloads (Pure)

HIV-TB co-infection: Mechanisms that drive reactivation of Mycobacterium tuberculosis in HIV infection

Ahmed, A., Rakshit, S. & Vyakarnam, A., 25 Apr 2016, In: Oral Diseases. 22, S1, p. 53-60 8 p.

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

2015

A comparative phase 1 clinical trial to identify anti-infective mechanisms of vitamin D in people with HIV infection

Lachmann, R., Bevan, M. A., Kim, S., Patel, N., Hawrylowicz, C., Vyakarnam, A. & Peters, B. S., 19 Jun 2015, In: AIDS (London, England). 29, 10, p. 1127-1135 9 p.

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

2014

WFDC1 is a key modulator of inflammatory and wound repair responses

Ressler, S. J., Dang, T. D., Wu, S. M., Tse, D. Y., Gilbert, B. E., Vyakarnam, A., Yang, F., Schauer, I. G., Barron, D. A. & Rowley, D. R., 1 Nov 2014, In: American Journal of Pathology. 184, 11, p. 2951-2964 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

17 Citations (Scopus)

260 Downloads (Pure)

2012

Elevated effector cell sensitivity to Treg-cell suppression that is not associated with reduced Th17-cell expression distinguishes HIV plus asymptomatic subjects from progressors

Thorborn, G. S., Pomeroy, L., Ishohanni, H., Peters, B. S. & Vyakarnam, A., Jan 2012, In: European Journal of Immunology. 42, 1, p. 138 - 146 9 p.

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

WFDC1/ps20: A host factor that influences the neutrophil response to murine hepatitis virus (MHV) 1 infection

Rogers, E., Wang, B. X., Cui, Z., Rowley, D. R., Ressler, S. J., Vyakarnam, A. & Fish, E. N., Nov 2012, In: Antiviral Research. 96, 2, p. 158-168 11 p.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Whey acidic proteins (WAPs): novel modulators of innate immunity to HIV infection

Reading, J. L., Meyers, A. F. A. & Vyakarnam, A., Mar 2012, In: Current Opinion In Hiv And Aids. 7, 2, p. 172 - 179 8 p.

Research output: Contribution to journal › Literature review › peer-review

6 Citations (Scopus)

2011

Immunotherapy of prostate cancer: identification of new treatments and targets for therapy, and role of WAP domain-containing proteins

Galustian, C., Vyakarnam, A., Elhage, O., Hickman, O., Dasgupta, P. & Smith, R. A., Oct 2011, In: Biochemical Society Transactions. 39, 5, p. 1433-1436 4 p.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

WFDC1 expression identifies memory CD4 T-lymphocytes rendered vulnerable to cell-cell HIV-1 transfer by promoting intercellular adhesive junctions

Alvarez, R. A., Thorborn, G., Reading, J. L., Reddy, S. K. & Vyakarnam, A., 5 May 2011, In: Retrovirology. 8, 29.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

2010

Increased sensitivity of CD4+ T-effector cells to CD4+CD25+ Treg suppression compensates for reduced Treg number in asymptomatic HIV-1 infection

Thorborn, G., Pomeroy, L., Isohanni, H., Perry, M., Peters, B. & Vyakarnam, A., 17 Feb 2010, In: PL o S One . 5, 2, e9254.

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Innate immunity against HIV: a priority target for HIV prevention research

Borrow, P., Shattock, R. J. & Vyakarnam, A., 11 Oct 2010, In: Retrovirology. 7, 84.

Research output: Contribution to journal › Literature review › peer-review

50 Citations (Scopus)

Novel insights into how quality as well as quantity of 'T-regulatory cells' might explain current disease patterns in HIV

Thorborn, G., Pomeroy, L., Isohanni, H., Perry, M., Vyakarnam, A. & Peters, B., 2010, In: HIV MEDICINE. 11, p. 38 - 38 1 p.

Research output: Contribution to journal › Meeting abstract

2009

A novel soluble protein which affects cell susceptibility to a broad range of viral infections

Rogers, E., Alverez, R., Vyakarnam, A. & Fish, E. N., 2009, In: Cytokine. 48, 1-2, p. 69 - 69 1 p.

Research output: Contribution to journal › Meeting abstract

2008

Novel innate immune functions of the whey acidic protein family

Bingle, C. D. & Vyakarnam, A., Sept 2008, In: TRENDS IN IMMUNOLOGY. 29, 9, p. 444 - 453 10 p.

Research output: Contribution to journal › Literature review › peer-review

113 Citations (Scopus)

WFDC1/PS20: A novel viral permissivity factor

Rogers, E., Baig, E., Alvarez, R., Reading, J., Vyakarnam, A., Jia, D., Nicholls, J. & Fish, E., 2008, In: Cytokine. 43, 3, p. 259 - 260 2 p.

Research output: Contribution to journal › Meeting abstract

WFDC1/ps20 is a novel innate immunomodulatory signature protein of human immunodeficiency virus (HIV)-Permissive CD4(+) CD45RO(+) memory T cells that promotes infection by upregulating CD54 integrin expression and is elevated in HIV type 1 infection

Alvarez, R., Reading, J., King, D. F. L., Hayes, M., Easterbrook, P., Farzaneh, F., Ressler, S., Yang, F., Rowley, D. & Vyakarnam, A., Jan 2008, In: Journal of Virology. 82, 1, p. 471 - 486 16 p.

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

2005

Intracellular cytokines may model immunoregulation of abacavir hypersensitivity in HIV-infected subjects

King, D., Tomkins, S., Waters, A., Easterbrook, P. J., Thurmond, L. M., Thorborn, D. E., Raffi, F., Kemeny, D. M. & Vyakarnam, A., May 2005, In: Journal of Allergy and Clinical Immunology. 115, 5, p. 1081 - 1087 7 p.

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

2004

High titre vectors for targeted expression of multiple genes

Darling, D., Gaken, J., Nesbeth, D., Chan, L., Hardwick, N., MacKey, T., Galea-Lauri, J., Vyakarnam, A., Mufti, G. J., Kemeny, M. & Farzaneh, F., 2004, In: JOURNAL OF GENE MEDICINE. 6, 9, p. 71 1 p.

Research output: Contribution to journal › Meeting abstract

Infection of stationary human brain aggregates with HIV-1SF162 and IIIB results in transient neuronal damage and neurotoxicity

Trillos-Pazos, G., Kandanearatchi, A., Eyeson, J., King, D., Vyakarnam, A. & Everall, I. P., Apr 2004, In: Neuropathology and Applied Neurobiology. 30, 2, p. 136 - 147 12 p.

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Monocistronic high titre vectors for targeted expression of multiple therapeutic genes

Darling, D., Gaken, J., Nesbeth, D., Chan, L., Hardwick, N., Mackey, T., Galea-Lauri, J., Vyakarnam, A., Mufti, G., Kemeny, M. & Farzaneh, F., 2004, In: Cancer Gene Therapy. 11, 12, p. 843 - 843 1 p.

Research output: Contribution to journal › Meeting abstract

Possession of human leucocyte antigen DQ6 alleles and the rate of CD4 T-cell decline in human immunodeficiency virus-1 infection

Vyakarnam, A., Sidebottom, D., Murad, S., Underhill, J. A., Easterbrook, P. J., Dalgleish, A. G. & Peakman, M., May 2004, In: Immunology. 112, 1, p. 136 - 142 7 p.

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Suppression of human immunodeficiency virus replication in human brain tissue by nucleoside reverse transcriptase inhibitors

Kandanearatchi, A., Vyakarnam, A., Landau, S. & Everall, I. P., Apr 2004, In: Journal of NeuroVirology. 10, 2, p. 136 - 139 4 p.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

2003

CD4 responses to conserved HIV-1 T helper epitopes show both negative and positive associations with virus load in chronically infected subjects

Boaz, M. J., Waters, A., Murad, S., Easterbrook, P. J., D'Sousa, E., Van Wheeley, C. & Vyakarnam, A., Dec 2003, In: Clinical and Experimental Immunology. 134, 3, p. 454 - 463 10 p.

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Epidemiological risk factors for hypersensitivity reactions to abacavir

Easterbrook, P. J., Waters, A., Murad, S., Ives, N., Taylor, C., King, D., Vyakarnam, A. & Thorburn, D., Oct 2003, In: HIV MEDICINE. 4, 4, p. 321 - 324 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Citations (Scopus)

Evidence for Gag p24-specific CD4 T cells with reduced susceptibility to R5 HIV-1 infection in a UK cohort of HIV-exposed-seronegative subjects

Eyeson, J., King, D., Boaz, M. J., Sefia, E., Tomkins, S., Waters, A., Easterbrook, P. J. & Vyakarnam, A., 7 Nov 2003, In: Aids. 17, 16, p. 2299 - 2311 13 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

2002

Comparison between HIV- and CMV-specific T cell responses in long-term HIV infected donors

Papagno, L., Appay, V., Sutton, J., Rostron, T., Gillespie, G. M. A., Ogg, G. S., King, A., Makadzange, A. T., Waters, A., Balotta, C., Vyakarnam, A., Easterbrook, P. J. & Rowland-Jones, S. L., 2002, In: Clinical and Experimental Immunology. 130, 3, p. 509 - 517 9 p.

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Granulocyte-macrophage colony-stimulating factor enhances viral load in human brain tissue: amelioration with stavudine

Kandanearatchi, A., Zuckerman, M., Smith, M., Vyakarnam, A. & Everall, I. P., 15 Feb 2002, In: Aids. 16, 3, p. 413 - 420 8 p.

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Presence of HIV-1 gag-specific IFN-gamma+IL-2(+) and CD28(+)IL-2(+) CD4 T cell responses is associated with nonprogression in HIV-1 infection

Boaz, M. J., Waters, A., Murad, S., Easterbrook, P. J. & Vyakarnam, A., 2002, In: Journal of Immunology. 169, 11, p. 6376 - 6385 10 p.

Research output: Contribution to journal › Article › peer-review

Presence of HIV-1 Gag-specific IFN-γ+IL-2+ and CD28+IL-2+ CD4 T cell responses is associated with nonprogression in HIV-1 infection

Boaz, M. J., Waters, A., Murad, S., Easterbrook, P. J. & Vyakarnam, A., 2002, In: Journal of Immunology. 169, 11, p. 6376-6385 10 p.

Research output: Contribution to journal › Article › peer-review

208 Citations (Scopus)

2001

Evidence for a post-entry barrier to R5 HIV-1 infection of CD4 memory T cells

Vyakarnam, A., Eyeson, J., Teo, I., Zuckerman, M., Babaahmady, K., Schuitemaker, H., Shaunak, S., Rostron, T., Rowland-Jones, S., Simmons, G. & Clapham, P., 7 Sept 2001, In: Aids. 15, 13, p. 1613 - 1626 14 p.

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Paper alert. Immunology.

Elliott, T., Bonneville, M., Kruisbeek, A., Walker, P. R., Essayan, D., Glaichenhaus, N., Vyakarnam, A., Casanova, J. L., Liu, Y., AuchinclossJr, H., Waneck, G., LeGuern, C. & Akdis, C., 2001, In: Current Opinion in Immunology. 13, 6, p. 625-634 10 p.

Research output: Contribution to journal › Article › peer-review

2000

Abacavir induced hypersensitivity in HIV infected individuals is associated with an increased frequency of Th0 T cells

Vyakarnam, A., King, D., Boaz, M., Waters, A., Easterbrook, P., Thorborn, D., Thurmond, L. & Kemeny, D., 2000, In: Aids. 14, p. S65 - S65

Research output: Contribution to journal › Meeting abstract

CD7 expression distinguishes subsets of CD4(+) T cells with distinct functional properties and ability to support replication of HIV-1

Wallace, D. L., Matear, P. M., Davies, D. C., Hicks, R., Lebosse, C., Eyeson, J., Beverley, P. C. L. & Vyakarnam, A., 2000, In: European Journal of Immunology. 30, 2, p. 577 - 585 9 p.

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

First proof that NRTIs prevent HIV brain damage using an novel human brain tissue system

Trillo-Pazos, G., Kandanearatchi, A., King, D., Eyeson, J., Vyakarnam, A. & Everall, I., 2000, In: Journal of NeuroVirology. 6, p. 265 1 p.

Research output: Contribution to journal › Article › peer-review

HAART and the brain

Kandanearatchi, A., Trillo-Pazos, G., King, D., Eyeson, J., Vyakarnam, A., Smith, M., Zukerman, M. & Everall, I. P., 2000, In: Aids. 14, p. S22

Research output: Contribution to journal › Meeting abstract › peer-review

1997

HIV infection alters the production of both type 1 and 2 cytokines but does not induce a polarized type 1 or 2 state

Fakoya, A., Matear, P. M., Filley, E., Rook, G. A. W., Stanford, J., Gilson, R. J. C., Beecham, N., Weller, I. V. D. & Vyakarnam, A., 1997, In: Aids. 11, 12, p. 1445-1452 8 p.

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

The related cytokines interleukin-13 and interleukin-4 are distinguished by differential production and differential effects on T lymphocytes

Minty, A., Asselin, S., Bensussan, A., Shire, D., Vita, N., Vyakarnam, A., Wijdenes, J., Ferrara, P. & Caput, D., 1997, In: European Cytokine Network. 8, 2, p. 203-213 11 p.

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Annapurna Vyakarnam, School Lead International

Research output

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