Anthony Vernon

2024

Correspondence to "Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca 2+ entry and accelerated differentiation" by Hewitt et al. (PMID: 37402854).

members of the iPSC Platform for Neuropsychiatry ECNP Network, 24 May 2024, (E-pub ahead of print) In: Molecular Psychiatry.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

The contribution of first-episode illness characteristics and cumulative antipsychotic usage to progressive structural brain changes over a long-term follow-up in schizophrenia

Konttajärvi, T., Haapea, M., Huhtaniska, S., Björnholm, L., Miettunen, J., Isohanni, M., Penttilä, M., Murray, G. K., Koponen, H., Vernon, A. C., Jääskeläinen, E. & Lieslehto, J., Apr 2024, In: Psychiatry Research: Neuroimaging. 339, 111790.

Research output: Contribution to journal › Article › peer-review

Open Access

Transcriptional and cellular response of hiPSC-derived microglia-neural progenitor co-cultures exposed to IL-6

Couch, A. C. M., Brown, A. M., Raimundo, C., Solomon, S., Taylor, M., Sichlinger, L., Matuleviciute, R., Srivastava, D. P. & Vernon, A. C., Nov 2024, In: Brain, Behavior, and Immunity. 122, p. 27-43 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Acute IL-6 exposure triggers canonical IL6Ra signaling in hiPSC microglia, but not neural progenitor cells

Couch, A. C. M., Solomon, S., Duarte, R. R. R., Marrocu, A., Sun, Y., Sichlinger, L., Matuleviciute, R., Polit, L. D., Hanger, B., Brown, A., Kordasti, S., Srivastava, D. P. & Vernon, A. C., May 2023, In: Brain, Behavior, and Immunity. 110, p. 43-59 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

Acute IL-6 exposure triggers canonical IL6Ra signaling in hiPSC microglia, but not neural progenitor cells

Couch, A., Solomon, S., Rafagnin Duarte, R. R., Marrocu, A., Sun, Y., Sichlinger, L., Matuleviciute, R., Dutan Polit, L., Hanger, B., Brown, A., Kordasti, S., Srivastava, D. & Vernon, A., 11 Feb 2023, In: Brain Behaviour and Immunity. https://doi.org/10.1016/j.bbi.2023.02.007, https://doi.org/10.1016/j.bbi.2023.02.007.

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Altered behavior, brain structure, and neurometabolites in a rat model of autism-specific maternal autoantibody exposure

Bruce, M. R., Couch, A. C. M., Grant, S., McLellan, J., Ku, K., Chang, C., Bachman, A., Matson, M., Berman, R. F., Maddock, R. J., Rowland, D., Kim, E., Ponzini, M. D., Harvey, D., Taylor, S. L., Vernon, A. C., Bauman, M. D. & Van de Water, J., May 2023, In: Molecular Psychiatry. 28, 5, p. 2136-2147 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Citations (Scopus)

Individual behavioral trajectories shape whole-brain connectivity in mice.

Bogado Lopes, J., Senko, A., Bahnsen, K., Geisler, D., Kim, E., Soares Mesquita, M. B., Cash, D., Ehrlich, S., Vernon, A. & Kempermann, G., 16 Jan 2023, In: eLife. 12, e80379.

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4 Citations (Scopus)

92 Downloads (Pure)

Recommendations, guidelines, and best practice for the use of human induced pluripotent stem cells for neuropharmacological studies of neuropsychiatric disorders

Dutan polit, L., Eidhof, I., Mcneill, R. V., Warre-Cornish, K. M., Yde Ohki, C. M., Walter, N. M., Sala, C., Verpelli, C., Radtke, F., Galderisi, S., Mucci, A., Collo, G., Edenhofer, F., Castrén, M. L., Réthelyi, J. M., Ejlersen, M., Hohmann, S. S., Ilieva, M. S., Lukjanska, R., Matuleviciute, R., & 20 othersMichel, T. M., De vrij, F. M. S., Kushner, S. A., Lendemeijer, B., Kittel-Schneider, S., Ziegler, G. C., Gruber-Schoffnegger, D., Pasterkamp, R. J., Kasri, A., Potier, M-C., Knoblich, J. A., Brüstle, O., Peitz, M., Pich, E. M., Harwood, A. J., Abranches, E., Falk, A., Vernon, A. C., Grünblatt, E. & Srivastava, D. P., 2023, In: Neuroscience Applied. 2, 101125.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

A role for thalamic projection GABAergic neurons in circadian responses to light

Brock, O., Gelegen, C., Sully, P., Salgarella, I., Jager, P., Menage, L., Mehta, I., Jęczmień-Łazur, J., Djama, D., Strother, L., Coculla, A., Vernon, A., Brickley, S. G., Holland, P., Cooke, S. & Delogu, A., 7 Dec 2022, In: The Journal of neuroscience : the official journal of the Society for Neuroscience.

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A role for thalamic projection GABAergic neurons in circadian responses to light

Brock, O., Gelegen, C. E., Salgarella, I., Sully, P., Jager, P., Menage, L., Mehta, I., Jk eczmień-Łazur, J., Djama, D., Strother, L., Coculla, A., Vernon, A., Brickley, S., Holland, P., Cooke, S. & Delogu, A., 2022, In: bioRxiv.

Research output: Contribution to journal › Article

A Role for Thalamic Projection GABAergic Neurons in Circadian Responses to Light

Brock, O., Gelegen, C., Sully, P., Salgarella, I., Jager, P., Menage, L., Mehta, I., Jęczmień-Łazur, J., Djama, D., Strother, L., Coculla, A., Vernon, A. C., Brickley, S., Holland, P., Cooke, S. F. & Delogu, A., 7 Dec 2022, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 42, 49, p. 9158-9179 22 p.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Attenuated transcriptional response to pro-inflammatory cytokines in schizophrenia hiPSC-derived neural progenitor cells

Bhat, A., Irizar, H., Couch, A., Raval, P., Duarte, R. R. R., Dutan Polit, L., Hanger, B., Powell, T., Michael Deans, P. J., Shum, C., Nagy, R., McAlonan, G., Iyegbe, C. O., Price, J., Bramon, E., Bhattacharyya, S., Vernon, A. C. & Srivastava, D. P., Oct 2022, In: Brain, Behavior, and Immunity. 105, p. 82-97 16 p.

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6 Citations (Scopus)

261 Downloads (Pure)

A unique cerebellar pattern of microglia activation in a mouse model of encephalopathy of prematurity

Klein, L., Van Steenwinckel, J., Fleiss, B., Scheuer, T., Bührer, C., Faivre, V., Lemoine, S., Blugeon, C., Schwendimann, L., Csaba, Z., Bokobza, C., Vousden, D. A., Lerch, J. P., Vernon, A. C., Gressens, P. & Schmitz, T., Sept 2022, In: Glia. 70, 9, p. 1699-1719 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Citations (Scopus)

Cell line specific alterations in genes associated with dopamine metabolism and signaling in midbrain dopaminergic neurons derived from 22q11.2 deletion carriers with elevated dopamine synthesis capacity

Reid, M., Rogdaki, M., Dutan Polit, L., Hanger, B., Sabad, K., Nagy, R., Adhya, D., Baron-Cohen, S., McAlonan, G., Price, J., Vernon, A., Howes, O. & Srivastava, D., 14 May 2022, (Accepted/In press) In: Schizophrenia Research.

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Cellular and molecular signatures of in vivo imaging measures of GABAergic neurotransmission in the human brain

Lukow, P., Martins, D., Veronese, M., Vernon, A., McGuire, P., Turkheimer, F. & Modinos, G., 19 Apr 2022, In: Communications Biology. 5, 1, 372.

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Open Access

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2 Citations (Scopus)

117 Downloads (Pure)

Cellular and molecular signatures of in vivo imaging measures of GABAergic neurotransmission in the human brain

Lukow, P. B., Martins, D., Veronese, M., Vernon, A. C., McGuire, P., Turkheimer, F. E. & Modinos, G., 19 Apr 2022, In: Communications Biology. 5, 1, p. 372

Research output: Contribution to journal › Article › peer-review

Erbb4 deletion from inhibitory interneurons causes psychosis-relevant neuroimaging phenotypes

Kiemes, A., Serrano Navacerrada, M. E., Kim, E., Randall, K., Simmons, C., Rojo Gonzalez, L., Petrinovic, M-M., Lythgoe, D., Rotaru, D., Di Censo, D., Hirschler, L., Barbier, E. L., Vernon, A., Stone, J. M., Davies, C., Cash, D. & Modinos, G., 27 Dec 2022, In: Schizophrenia Bulletin.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Heterozygous expression of the Alzheimer's disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses

Solomon, S., Sampathkumar, N. K., Carre, I., Mondal, M., Chennell, G., Vernon, A. C., Ruepp, M-D. & Mitchell, J. C., 27 Jul 2022, In: Cellular and molecular life sciences : CMLS. 79, 8, p. 453 453.

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6 Citations (Scopus)

127 Downloads (Pure)

Interferon-ɣ Exposure of Human iPSC-derived Neurons Alters Major Histocompatibility Complex I and Synapsin Protein Expression

Pavlinek, A., Matuleviciute, R., Sichlinger, L., Dutan Polit, L., Armeniakos, N., Vernon, A. & Srivastava, D., 18 Aug 2022, In: Frontiers in Psychiatry.

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59 Downloads (Pure)

Interferon-γ exposure of human iPSC-derived neurons alters major histocompatibility complex I and synapsin protein expression

Pavlinek, A., Matuleviciute, R., Sichlinger, L., Dutan Polit, L., Armeniakos, N., Vernon, A. C. & Srivastava, D. P., 14 Sept 2022, In: Frontiers in Psychiatry. 13, 836217.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

Neurogenesis is disrupted in human hippocampal progenitor cells upon exposure to serum samples from hospitalized COVID-19 patients with neurological symptoms

Borsini, A., Merrick, B., Edgeworth, J., Mandal, G., Srivastava, D., Vernon, A., Nebbia, G., Thuret, S. & Pariante, C., Dec 2022, In: Molecular Psychiatry. 27, 12, p. 5049-5061 13 p.

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20 Citations (Scopus)

82 Downloads (Pure)

Oxygen and the Spark of Human Brain Evolution: Complex Interactions of Metabolism and Cortical Expansion across Development and Evolution

Luppi, A. I., Rosas, F. E., Noonan, M. A. P., Mediano, P. A. M., Kringelbach, M. L., Carhart-Harris, R. L., Stamatakis, E. A., Vernon, A. C. & Turkheimer, F. E., 2022, (Accepted/In press) In: Neuroscientist.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Preclinical animal models of mental illnesses to translate findings from the bench to the bedside: Molecular brain mechanisms and peripheral biomarkers associated to early life stress or immune challenges

European College of Neuropsychopharmacology (ECNP) ImmunoNeuroPsychiatry Thematic Working Group, May 2022, In: European Neuropsychopharmacology. 58, p. 55-79 25 p.

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Schizophrenia: A developmental disorder with a risk of non-specific but avoidable decline

Murray, R. M., Bora, E., Modinos, G. & Vernon, A., May 2022, In: Schizophrenia Research. 243, p. 181-186 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Citations (Scopus)

Tissue optimization strategies for high-quality ex vivo diffusion imaging

Barrett, R. L. C., Cash, D., Simmons, C., Kim, E., Wood, T. C., Stones, R., Vernon, A. C., Catani, M. & Dell'Acqua, F., 4 Dec 2022, (E-pub ahead of print) In: NMR in Biomedicine.

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Open Access

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5 Citations (Scopus)

102 Downloads (Pure)

2021

Application of Airy beam light sheet microscopy to examine early neurodevelopmental structures in 3D hiPSC-derived human cortical spheroids

Adhya, D., Chennell, G., Crowe, J. A., Valencia-Alarcón, E. P., Seyforth, J., Hosny, N. A., Yasvoina, M. V., Forster, R., Baron-Cohen, S., Vernon, A. C. & Srivastava, D. P., 22 Jan 2021, In: Molecular Autism. 12, 1, p. 4 4.

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Open Access

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15 Citations (Scopus)

96 Downloads (Pure)

Brain volume in chronic ketamine users - relationship to sub-threshold psychotic symptoms and relevance to schizophrenia

Chesters, R. A., Pepper, F., Morgan, C., Cooper, J. D., Howes, O. D., Vernon, A. C. & Stone, J. M., 6 Jul 2021, (E-pub ahead of print) In: Psychopharmacology.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Effects of chronic exposure to haloperidol, olanzapine or lithium on SV2A and NLGN synaptic puncta in the rat frontal cortex

Halff, E. F., Cotel, M-C., Natesan, S., McQuade, R., Ottley, C. J., Srivastava, D. P., Howes, O. D. & Vernon, A. C., 7 May 2021, In: Behavioural brain research. 405, p. 113203 113203.

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11 Citations (Scopus)

28 Downloads (Pure)

Functional brain defects in a mouse model of a chromosomal t(1;11) translocation that disrupts DISC1 and confers increased risk of psychiatric illness

Bonneau, M., Sullivan, S. T. O., Gonzalez-Lozano, M. A., Baxter, P., Gautier, P., Marchisella, E., Hardingham, N. R., Chesters, R. A., Torrance, H., Howard, D. M., Jansen, M. A., McMillan, M., Singh, Y., Didier, M., Koopmans, F., Semple, C. A., McIntosh, A. M., Volkmer, H., Loos, M., Fox, K., & 6 othersHardingham, G. E., Vernon, A. C., Porteous, D. J., Smit, A. B., Price, D. J. & Kirsty Millar, J., Jun 2021, In: Translational psychiatry. 11, 1, p. 135 135.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

GABA_A and NMDA receptor density alterations and their behavioral correlates in the gestational methylazoxymethanol acetate model for schizophrenia

Kiemes, A., Gomes, F. V., Cash, D., Uliana, D. L., Simmons, C., Singh, N., Vernon, A., Turkheimer, F., Davies, C., Stone, J., Grace, A. A. & Modinos, G., 6 Nov 2021, In: Neuropsychopharmacology. 47, 3, 9 p.

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Open Access

10 Citations (Scopus)

Inhibition of Maternal-to-Fetal Transfer of IgG Antibodies by FcRn Blockade in a Mouse Model of Arthrogryposis Multiplex Congenita

Coutinho, E., Jacobson, L., Shock, A., Smith, B., Vernon, A. & Vincent, A., 1 Jul 2021, In: Neurology(R) neuroimmunology & neuroinflammation. 8, 4

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

MRI-guided histology of TDP-43 knock-in mice implicates parvalbumin interneuron loss, impaired neurogenesis and aberrant neurodevelopment in amyotrophic lateral sclerosis-frontotemporal dementia

Lin, Z., Kim, E., Ahmed, M., Han, G., Simmons, C., Redhead, Y., Bartlett, J., Pena Altamira, E., Callaghan, I., White, M., Singh, N., Sawiak, S., Spires-Jones, T., Vernon, A., Coleman, M. P., Green, J., Henstridge, C. M., Davies, J., Cash, D. & Sreedharan, J., 5 Apr 2021, In: Brain Communications. 3, 2, p. FCAB114 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

Sexually dimorphic neuroanatomical differences relate to ASD-relevant behavioral outcomes in a maternal autoantibody mouse model

Bruce, M. R., Jones, K. L., Vernon, A. C., Silverman, J. L., Crawley, J. N., Ellegood, J., Lerch, J. P. & Van de Water, J., 21 Jul 2021, (E-pub ahead of print) In: Molecular Psychiatry.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson’s disease

Kuan, W-L., Stott, K., He, X., Wood, T., Yang, S., Kwok, J., Hall, K., Zhao, Y., Tietz, O., Aigbirhio, F., Vernon, A. & Barker, R., 1 Feb 2021, In: Molecular Psychiatry. 26, 2, p. 556–567 12 p.

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16 Citations (Scopus)

141 Downloads (Pure)

The relationship between synaptic density marker SV2A, glutamate and N-acetyl aspartate levels in healthy volunteers and schizophrenia: a multimodal PET and magnetic resonance spectroscopy brain imaging study

Onwordi, E. C., Whitehurst, T., Mansur, A., Statton, B., Berry, A., Quinlan, M., O’Regan, D. P., Rogdaki, M., Marques, T. R., Rabiner, E. A., Gunn, R. N., Vernon, A. C., Natesan, S. & Howes, O. D., Dec 2021, In: Translational psychiatry. 11, 1, 393.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Citations (Scopus)

2020

Behavioral, neuroanatomical, and molecular correlates of resilience and susceptibility to maternal immune activation

Mueller, F. S., Scarborough, J., Schalbetter, S. M., Richetto, J., Kim, E., Couch, A., Yee, Y., Lerch, J. P., Vernon, A. C., Weber-Stadlbauer, U. & Meyer, U., 23 Nov 2020, (E-pub ahead of print) In: Molecular Psychiatry.

Research output: Contribution to journal › Article › peer-review

Open Access

83 Citations (Scopus)

Corrigendum to: Normalizing the Abnormal: Do Antipsychotic Drugs Push the Cortex Into an Unsustainable Metabolic Envelope?

Turkheimer, F. E., Selvaggi, P., Mehta, M. A., Veronese, M., Zelaya, F., Dazzan, P. & Vernon, A. C., 17 Jan 2020, (E-pub ahead of print) In: Schizophrenia Bulletin.

Research output: Contribution to journal › Article › peer-review

Open Access

Interferon-γ signaling in human iPSC-derived neurons recapitulates neurodevelopmental disorder phenotypes

Warre-Cornish, K., Perfect, L., Nagy, R., Duarte, R. R. R., Reid, M. J., Raval, P., Mueller, A., Evans, A. L., Couch, A., Ghevaert, C., McAlonan, G., Loth, E., Murphy, D., Powell, T. R., Vernon, A. C., Srivastava, D. P. & Price, J., Aug 2020, In: Science Advances. 6, 34, eaay9506.

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Open Access

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49 Citations (Scopus)

179 Downloads (Pure)

Neuroanatomical and Microglial Alterations in the Striatum of Levodopa-Treated, Dyskinetic Hemi-Parkinsonian Rats

Fletcher, E. J. R., Finlay, C. J., Amor Lopez, A., Crum, W. R., Vernon, A. C. & Duty, S., 15 Sept 2020, In: Frontiers in Neuroscience. 14, p. 567222 567222.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Citations (Scopus)

Planar Airy beam light-sheet for two-photon microscopy

Hosny, N. A., Seyforth, J. A., Spickermann, G., Mitchell, T. J., Almada, P., Chesters, R., Mitchell, S. J., Chennell, G., Vernon, A. C., Cho, K., Srivastava, D. P., Forster, R. & Vettenburg, T., 1 Jul 2020, In: Biomedical Optics Express. 11, 7, p. 3927-3935 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Citations (Scopus)

Region-specific and dose-specific effects of chronic haloperidol exposure on [3H]-flumazenil and [3H]-Ro15-4513 GABAA receptor binding sites in the rat brain

Peris-Yague, A., Kiemes, A., Cash, D., Cotel, M-C., Singh, N., Vernon, A. C. & Modinos, G., Dec 2020, In: European Neuropsychopharmacology. 41, p. 106-117 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

Striatal Volume Increase After Six Weeks of Selective Dopamine D_2/3 Receptor Blockade in First-Episode, Antipsychotic-Naïve Schizophrenia Patients

Andersen, H. G., Raghava, J. M., Svarer, C., Wulff, S., Johansen, L. B., Antonsen, P. K., Nielsen, M., Rostrup, E., Vernon, A. C., Jensen, L. T., Pinborg, L. H., Glenthøj, B. Y. & Ebdrup, B. H., 20 May 2020, In: Frontiers in Neuroscience. 14, 484.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Citations (Scopus)

Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats

Onwordi, E. C., Halff, E. F., Whitehurst, T., Mansur, A., Cotel, M-C., Wells, L. A., Creeney, H., Bonsall, D. R., Rogdaki, M., Shatalina, E., Reis Marques, T., Rabiner, E., Gunn, R. N., Natesan, S., Vernon, A. C. & Howes, O. D., Jan 2020, In: Nature Communications. 11, 1, p. 1-11 246.

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144 Citations (Scopus)

243 Downloads (Pure)

2019

Evolution of a maternal immune activation (mIA) model in rats: early developmental effects

Murray, K. N., Edye, M. E., Manca, M., Vernon, A. C., Oladipo, J. M., Fasolino, V., Harte, M. K., Mason, V., Grayson, B., McHugh, P. C., Knuesel, I., Prinssen, E. P., Hager, R. & Neill, J. C., 1 Jan 2019, In: Brain, Behavior, and Immunity. 75, 0, p. 48-59

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59 Citations (Scopus)

353 Downloads (Pure)

Global brain volume reductions in a subchronic phencyclidine animal model for schizophrenia and their relationship to recognition memory

Doostdar, N., Kim, E., Grayson, B., Harte, M. K., Neill, J. C. & Vernon, A. C., 7 May 2019, (E-pub ahead of print) In: Journal of Psychopharmacology.

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Global brain volume reductions in a sub-chronic phencyclidine animal model for schizophrenia and their relationship to recognition memory

Doostdar, N., Kim, E., Grayson, B., Harte, M. K., Neill, J. C. & Vernon, A. C., 1 Oct 2019, In: Journal of Psychopharmacology. 33, 10, p. 1274-1287 14 p.

Research output: Contribution to journal › Article › peer-review