Overview

Research is focused on the development and biopharmaceutical application of respiratory and intestinal epithelial cell culture models. Drug permeability, metabolism and gene delivery are studied:

• enhancement of drug transport
• presystemic drug metabolism
• epithelial pathology / toxicity

Inhaled Drug Delivery

“Inhalation biopharmaceutics” encompasses anything that may affect the rate or extent of drug absorption from the lung. Research projects in this emerging field include:

• Dissolution in lung fluid
• Mucociliary and macrophage interactions
• Drug metabolism
• Epithelial permeability
• Toxicity of delivery vehicles (excipients, nanoparticles)

All these events occur at (or in) the respiratory epithelium.

Oral Drug Delivery

Current projects investigate interactions between intestinal fluid, the intestinal epithelium, orally administered drugs and formulation excipients.

Clinical Pharmaceutics

Projects with innovation aimed at improving practice in the manufacturing of pharmaceutical products.