Research output per year
Research output per year
Personal profile
Research interests
Research interests: Structure of IgE and its receptors; molecular mechanisms of allergy; inhibitor design; antibody structure in allergy and auto-immune disease; antibiotic resistance enzymes; enzyme mechanism and protein engineering. Research techniques: X-ray crystallography, NMR and other biophysical techniques. Member of the MRC & Asthma UK Centre in Allergic Mechanisms of Asthma; leader of Centre Programme in IgE Structure, Function and Regulation. Head of Structural Biology, Randall Division of Cell and Molecular Biophysics.
Research interests (short)
IgE and its receptors; molecular mechanisms of allergy; auto-antibodies and auto-immune disease; structure-based drug design; evolution of antibody structure.
Click here for the Sutton group webpage
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Structure and activity of a phosphinothricin N-acetyltransferase (PSPTO_3321) from Pseudomonas syringae pv. tomato DC3000
Davies, A. M., Trentham, D., Sutton, B. & Brown, P., 1 Apr 2025, In: Biochemical and Biophysical Research Communications. 755, 151539.Research output: Contribution to journal › Article › peer-review
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The crystal structure of human IgD-Fc reveals unexpected differences with other antibody isotypes
Davies, A. M., Bui, T., Pacheco-Gómez, R., Vester, S., Beavil, A., Gould, H., Sutton, B. & McDonnell, J., 25 Nov 2024, (E-pub ahead of print) In: Proteins.Research output: Contribution to journal › Article › peer-review
Open Access -
Crystal structures of the human IgD Fab reveal insights into CH1 domain diversity
Davies, A. M., Beavil, R., Barbolov, M., Sandhar, B., Gould, H., Beavil, A., Sutton, B. & McDonnell, J., 1 Jun 2023, In: Molecular Immunology. 159, p. 28-37 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)72 Downloads (Pure) -
Expanding the Anti-Phl p 7 Antibody Toolkit: An Anti-Idiotype Nanobody Inhibitor
Vester, S., Davies, A. M., Beavil, R., Sandhar, B., Beavil, A., Gould, H., Sutton, B. & McDonnell, J., Dec 2023, In: Antibodies. 12, 4, 75.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
IgE, IgE Receptors and Anti-IgE Biologics: Protein Structures and Mechanisms of Action
McDonnell, J., Sutton, B. & Gould, H., 26 Apr 2023, In: Annual Review of Immunology. 41, p. 255-275 21 p.Research output: Contribution to journal › Review article › peer-review
Open Access20 Citations (Scopus)
Projects
- 68 Finished
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A cryo-electron microscope for structural biology (including single-particle and tomography) at KCL.
Conte, M. (Primary Investigator), Atherton, J. (Co-Investigator), Beavil, A. (Co-Investigator), Bergeron, J. (Co-Investigator), Booth, P. (Co-Investigator), Burrone, J. (Co-Investigator), Carlton, J. (Co-Investigator), De Nicola, G. (Co-Investigator), Ehler, E. (Co-Investigator), Fleck, R. (Co-Investigator), Fraternali, F. (Co-Investigator), Garnett, J. (Co-Investigator), Gautel, M. (Co-Investigator), Isaacson, R. (Co-Investigator), Kampourakis, T. (Co-Investigator), Malim, M. (Co-Investigator), McDonnell, J. (Co-Investigator), Neil, S. (Co-Investigator), Odendall, C. (Co-Investigator), Pfuhl, M. (Co-Investigator), Politis, A. (Co-Investigator), Steiner, R. (Co-Investigator) & Sutton, B. (Co-Investigator)
BBSRC Biotechnology and Biological Sciences Research Council
1/08/2022 → 31/07/2023
Project: Research
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SECMALS: A dual DLS and SEC-MALS instrumentation to characterize the oligomerization of protein samples for structural biology, mechanistic biology, and therapeutic development
Bergeron, J. (Primary Investigator), Atherton, J. (Co-Investigator), Beavil, A. (Co-Investigator), Booth, P. (Co-Investigator), Conte, M. (Co-Investigator), Garnett, J. (Co-Investigator), Isaacson, R. (Co-Investigator), Malim, M. (Co-Investigator), Muller, M. (Co-Investigator), Pfuhl, M. (Co-Investigator), Politis, A. (Co-Investigator), Sanderson, M. (Co-Investigator), Steiner, R. (Co-Investigator), Surman, A. (Co-Investigator) & Sutton, B. (Co-Investigator)
BBSRC Biotechnology and Biological Sciences Research Council
3/11/2021 → 31/10/2022
Project: Research
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Human secreted IgD: structure, interactions and mechanisms in allergic inflammation and asthma
McDonnell, J. (Primary Investigator), Beavil, A. (Co-Investigator), Sutton, B. (Co-Investigator) & academic, A. (Co-Investigator)
1/02/2021 → 30/06/2024
Project: Research
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A role for human IgD in anti-bacterial defence
Gould, H. J. (Primary Investigator) & Sutton, B. (Co-Investigator)
1/08/2019 → 31/07/2021
Project: Research
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Quantitative multiplex FRET detection of IgG4- & IL10- secreting B Regulatory 1 cells in microfluidics
Wu, B. (Primary Investigator) & Sutton, B. (Co-Investigator)
14/04/2017 → 31/12/2018
Project: Research