Brian Sutton

Finished

A cryo-electron microscope for structural biology (including single-particle and tomography) at KCL.

Conte, M. (Primary Investigator), Atherton, J. (Co-Investigator), Beavil, A. (Co-Investigator), Bergeron, J. (Co-Investigator), Booth, P. (Co-Investigator), Burrone, J. (Co-Investigator), Carlton, J. (Co-Investigator), De Nicola, G. (Co-Investigator), Ehler, E. (Co-Investigator), Fleck, R. (Co-Investigator), Fraternali, F. (Co-Investigator), Garnett, J. (Co-Investigator), Gautel, M. (Co-Investigator), Isaacson, R. (Co-Investigator), Kampourakis, T. (Co-Investigator), Malim, M. (Co-Investigator), McDonnell, J. (Co-Investigator), Neil, S. (Co-Investigator), Odendall, C. (Co-Investigator), Pfuhl, M. (Co-Investigator), Politis, A. (Co-Investigator), Steiner, R. (Co-Investigator) & Sutton, B. (Co-Investigator)

BBSRC Biotechnology and Biological Sciences Research Council

1/08/2022 → 31/07/2023

Project: Research

SECMALS: A dual DLS and SEC-MALS instrumentation to characterize the oligomerization of protein samples for structural biology, mechanistic biology, and therapeutic development

Bergeron, J. (Primary Investigator), Atherton, J. (Co-Investigator), Beavil, A. (Co-Investigator), Booth, P. (Co-Investigator), Conte, M. (Co-Investigator), Garnett, J. (Co-Investigator), Isaacson, R. (Co-Investigator), Malim, M. (Co-Investigator), Muller, M. (Co-Investigator), Pfuhl, M. (Co-Investigator), Politis, A. (Co-Investigator), Sanderson, M. (Co-Investigator), Steiner, R. (Co-Investigator), Surman, A. (Co-Investigator) & Sutton, B. (Co-Investigator)

BBSRC Biotechnology and Biological Sciences Research Council

3/11/2021 → 31/10/2022

Project: Research

Human secreted IgD: structure, interactions and mechanisms in allergic inflammation and asthma

McDonnell, J. (Primary Investigator), Beavil, A. (Co-Investigator), Sutton, B. (Co-Investigator) & academic, A. (Co-Investigator)

MRC Medical Research Council

1/02/2021 → 30/06/2024

Project: Research

A role for human IgD in anti-bacterial defence

Gould, H. J. (Primary Investigator) & Sutton, B. (Co-Investigator)

Leverhulme Trust

1/08/2019 → 31/07/2021

Project: Research

Quantitative multiplex FRET detection of IgG4- & IL10- secreting B Regulatory 1 cells in microfluidics

Wu, B. (Primary Investigator) & Sutton, B. (Co-Investigator)

GLA Greater London Authority

14/04/2017 → 31/12/2018

Project: Research

Impact of the distinctive properties of human IgE on the activities of the B cell receptor and its implications for allergic disease and asthma

Sutton, B. (Primary Investigator), Beavil, A. (Co-Investigator), Cox, S. (Co-Investigator), Gould, H. (Co-Investigator) & McDonnell, J. (Co-Investigator)

1/04/2017 → 31/03/2022

Project: Research

Elucidating the mechanisms of accelerated dissociation and allosteric processes in the antibody immunoglobulin E

McDonnell, J. (Primary Investigator) & Sutton, B. (Co-Investigator)

BBSRC Biotechnology and Biological Sciences Research Council

1/01/2017 → 31/12/2019

Project: Research

High-resolution Cyro-EM studies to uncover a novel mechanism in allergic asthma

Sutton, B. (Primary Investigator)

Asthma UK

1/10/2016 → 30/09/2017

Project: Research

Probing the conformational dynamics of human immunoglobulin E using a mass spectrometry-based hybrid approach

Politis, A. (Primary Investigator) & Sutton, B. (Co-Investigator)

Micromass UK Limited

1/10/2016 → 30/09/2020

Project: Research

MICA - Understanding allostery and accelerated dissociation in immunoglobulin E

McDonnell, J. (Primary Investigator) & Sutton, B. (Co-Investigator)

4/01/2016 → 3/01/2019

Project: Research

Demonstrating the feasibility of a novel avidity-based therapeutic antibody platform

McDonnell, J. (Primary Investigator), Beavil, A. (Co-Investigator) & Sutton, B. (Co-Investigator)

3/08/2015 → 29/07/2016

Project: Research

Allergen-specific B cells in allergy and tolerance

James, L. (Primary Investigator) & Sutton, B. (Co-Investigator)

KHP King's Health Partners

8/06/2015 → 30/06/2016

Project: Research

MICA: What makes human IgG4 unique? Venturing into a new era in our understanding of antibody structure.

Sutton, B. (Primary Investigator)

1/06/2015 → 31/05/2022

Project: Research

Biomarkers and mechanisms of food allergy and oral tolerance in IgE-sensitised children

Santos, A. (Primary Investigator), Gould, H. (Co-Investigator), Lack, G. (Co-Investigator) & Sutton, B. (Co-Investigator)

MRC Medical Research Council

1/05/2015 → 31/01/2021

Project: Research

London Centre For Multiscale Molecular Imaging (IMMI)

Booth, P. (Primary Investigator), Borysik, A. (Co-Investigator), Eggert, U. (Co-Investigator), Garcia-Manyes, S. (Co-Investigator), Isaacson, R. (Co-Investigator), Politis, A. (Co-Investigator), Sutton, B. (Co-Investigator), Thurston, D. (Co-Investigator) & Wagner, G. (Co-Investigator)

1/01/2015 → 31/12/2015

Project: Research

Interaction of histamine-releasing factor with immunoglobulins in asthma

Gould, H. (Primary Investigator) & Sutton, B. (Co-Investigator)

NIH National Institutes of Health

1/08/2014 → 30/06/2019

Project: Research

File

Wide-bore 600 MHz NMR magnet for biological solids and metabolomics in London

Mason, J. (Primary Investigator), Pfuhl, M. (Co-Investigator) & Sutton, B. (Co-Investigator)

2/12/2013 → 1/09/2014

Project: Research

Evolution of the local B cell response from allergy to tolerance

Sutton, B. (Primary Investigator)

1/11/2013 → 31/10/2018

Project: Research

A small-angle X-ray scattering (SAXS) station for in-house data collection on macromolecular complexes

Sanderson, M. (Primary Investigator), Beavil, A. (Co-Investigator), Chen, Y. (Co-Investigator), Steiner, R. (Co-Investigator) & Sutton, B. (Co-Investigator)

1/10/2013 → 30/09/2016

Project: Research

Allosteric modulation of IgE with respect to interaction with FceRI and CD23

McDonnell, J. (Primary Investigator) & Sutton, B. (Co-Investigator)

UCB Pharma Ltd

7/01/2013 → 6/01/2017

Project: Research

Structural studies to advance understanding of IgM and its complement and receptor interactions

Sutton, B. (Primary Investigator)

BBSRC Biotechnology and Biological Sciences Research Council

1/11/2012 → 30/11/2015

Project: Research

Understanding allergen recognition by igE and the unique properties of IgG4

Sutton, B. (Primary Investigator)

1/10/2012 → 30/09/2013

Project: Research

Rational development of drug-like inhibitors for the glycosyltransferase MGAT-5, a validated anti-cancer target

Wagner, G. (Primary Investigator) & Sutton, B. (Co-Investigator)

1/05/2012 → 30/04/2014

Project: Research

The role of CD23 in the regulation of inflammatory immune responses and target validation for therapeutic intervention

McDonnell, J. (Primary Investigator), Beavil, A. (Co-Investigator), Gould, H. (Co-Investigator) & Sutton, B. (Co-Investigator)

9/01/2012 → 8/01/2015

Project: Research

Development of inhibitors for the glycosyltransferase MGAT-5, a novel anti-cancer target

Wagner, G. (Primary Investigator) & Sutton, B. (Co-Investigator)

1/01/2012 → 31/12/2013

Project: Research

Development of a small-molecule IgE inhibitor for asthma and allergic disease

McDonnell, J. (Primary Investigator), Mountford, D. (Primary Investigator), Sutton, B. (Primary Investigator), Williams, G. (Primary Investigator), Beavil, A. (Co-Investigator), Dombrowicz, D. (Co-Investigator) & Hutchings, R. (Co-Investigator)

1/01/2011 → 31/12/2013

Project: Research

Preventing TAB1-mediated p38 activation during myocardial infarction

Conte, M. (Primary Investigator), Marber, M. (Primary Investigator) & Sutton, B. (Primary Investigator)

MRC Medical Research Council

1/12/2010 → 28/02/2015

Project: Research

Preventing TAB1-mediated p38 activation during myocardial infarction

Conte, M. (Primary Investigator), Marber, M. (Primary Investigator) & Sutton, B. (Primary Investigator)

1/12/2010 → 30/11/2013

Project: Research

Small-module inhibitors of the IgE/FceR1 interaction

Sutton, B. (Primary Investigator)

28/06/2010 → 20/08/2010

Project: Research

Tracing the evolution of antibody structure: conformational change and receptor binding in IgY, IgM and IgE

Sutton, B. (Primary Investigator)

1/10/2009 → 30/09/2012

Project: Research

Identification of small-molecule inhibitors of IgE regulatory proteins

McDonnell, J. (Primary Investigator), Beavil, A. (Co-Investigator) & Sutton, B. (Co-Investigator)

Asthma UK

1/10/2009 → 30/09/2010

Project: Research

Tracing evolution of antibody structure: conformational change and receptor binding in IgY, IgM and IgE

Sutton, B. (Primary Investigator) & Calvert, R. (Co-Investigator)

1/01/2009 → 31/12/2011

Project: Research

King's Centre for Biomolecular Spectroscopy

Sutton, B. (Primary Investigator), Conte, M. (Co-Investigator), Drake, A. (Co-Investigator), Gautel, M. (Co-Investigator), McDonnell, J. (Co-Investigator) & Sanderson, M. (Co-Investigator)

Wellcome Trust

1/11/2008 → 30/04/2015

Project: Research

Screening and optimization of the conditions for structural studies of p53 homolgous protein p73

Nikolova, P. (Primary Investigator), Chen, Y. (Co-Investigator) & Sutton, B. (Co-Investigator)

1/10/2008 → 30/09/2009

Project: Research

Structure-based discovery of small-molecule IgE inhibitors.

Sutton, B. (Primary Investigator), Beavil, A. (Co-Investigator), Holdom, M. (Co-Investigator) & Williams, G. (Co-Investigator)

Asthma UK

1/10/2008 → 29/02/2012

Project: Research

Drug-screening for IgE inhibitors for anti-allergy/asthma therapy

Beavil, A. (Primary Investigator), Sutton, B. (Primary Investigator) & Williams, G. (Co-Investigator)

King's College London

1/06/2008 → 31/05/2009

Project: Research

In silico screening and structural characterization of IgE/FcR1 inhibitators.

Sutton, B. (Primary Investigator), Beavil, A. (Co-Investigator), Holdom, M. (Co-Investigator) & Williams, G. (Co-Investigator)

1/04/2008 → 31/03/2011

Project: Research

Chicken LgA: antibody with an extra heavy chain constant domain

Sutton, B. (Primary Investigator)

Nuffield Foundation

23/07/2007 → 7/09/2007

Project: Research

Refolding of monomeric and trimeric forms of IgE receptor CD23

Sutton, B. (Primary Investigator)

Wellcome Trust

23/07/2007 → 22/09/2007

Project: Research

A generic approach to disrupting protein-protein interactions - application to the hIgE-FceRI interface

Beavil, A. (Primary Investigator) & Sutton, B. (Primary Investigator)

MRC Medical Research Council

1/04/2007 → 12/03/2011

Project: Research

Epityping - a new approach to the HLA system designed for solid organ transplantation

Beavil, A. (Primary Investigator), Bevan, S. (Primary Investigator), Sutton, B. (Primary Investigator), Vaughan, R. (Primary Investigator), Williams, G. (Primary Investigator) & Howell, S. (Co-Investigator)

MRC Medical Research Council

1/04/2007 → 31/03/2010

Project: Research

Robotic crystallisation facility

Sutton, B. (Primary Investigator), Chen, Y. (Co-Investigator), Pickersgill, R. (Co-Investigator), Sanderson, M. (Co-Investigator) & Steiner, R. (Co-Investigator)

Wellcome Trust

1/11/2006 → 31/10/2011

Project: Research

Allergenicity and allergen dominance: structural requirements for IgE-dependent recognition by B cells and effector cells

Lack, G. (Primary Investigator), Sutton, B. (Primary Investigator), Beavil, A. (Co-Investigator), Gould, H. (Co-Investigator), Heintzmann, R. (Co-Investigator) & McDonnell, J. (Co-Investigator)

MRC Medical Research Council

21/06/2006 → 20/12/2016

Project: Research

MRC - Asthma UK Centre in Allergic Mechanisms of Asthma

Hawrylowicz, C. (Primary Investigator), Lee, T. (Primary Investigator), Beavil, A. (Co-Investigator), Corrigan, C. (Co-Investigator), Cousins, D. (Co-Investigator), Gould, H. (Co-Investigator), Greenough, A. (Co-Investigator), Lack, G. (Co-Investigator), Lavender, P. (Co-Investigator), Noble, A. (Co-Investigator), Sun, Y. (Co-Investigator) & Sutton, B. (Co-Investigator)