Projects per year
- 1 - 50 out of 52 results
Search results
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Active
Unravelling the impact of the aged extracellular matrix microenvironment on vascular smooth muscle cell pathological change.
Shanahan, C. (Primary Investigator)
1/05/2025 → 30/04/2028
Project: Research
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Calcification-Omics, Molecular Elucidation, & Therapeutics (COMET) Network
Shanahan, C. (Primary Investigator)
Leducq Foundation Leducq Foundation
1/01/2025 → 31/12/2029
Project: Research
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Novel dual-action targeted therapy for improved healing of Charcot bones in diabetes
academic, A. (Primary Investigator) & Shanahan, C. (Co-Investigator)
1/10/2023 → 30/09/2025
Project: Research
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Disruption of Perinuclear Microtubule Coupling Drives Cardiomyocyte Dysfunction in Response to LINC Complex Dysfunction
Zhang, Q. (Primary Investigator), Brunello, E. (Co-Investigator), Shanahan, C. (Co-Investigator) & Zhang, M. (Co-Investigator)
18/09/2023 → 17/09/2026
Project: Research
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Mechanisms of vascular smooth muscle cell ageing and calcification –developing a timeline for novel therapeutic interventions.
Shanahan, C. (Primary Investigator)
1/11/2022 → 31/10/2027
Project: Research
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Finished
BHF Centre Shanahan May 2024 Pump Prime
Shanahan, C. (Primary Investigator)
8/05/2024 → 30/09/2024
Project: Research
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BHF Centre CSC consumable Shanahan/GarciaManies
Shanahan, C. (Primary Investigator)
1/02/2021 → 30/09/2024
Project: Research
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Investigating the role of bromodomain protein (Brd)9 in vascular calcification
Shanahan, C. (Primary Investigator)
1/01/2020 → 31/12/2022
Project: Research
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Investigating a novel role for the LINC complex in cardiomyocyte mechanotransduction
Zhang, Q. (Primary Investigator) & Shanahan, C. (Co-Investigator)
1/10/2019 → 30/09/2022
Project: Research
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BHF Research Excellence Award
Shah, A. (Primary Investigator), Botnar, R. (Co-Investigator), Chowienczyk, P. (Co-Investigator), Eaton, P. (Co-Investigator), Garcia-Manyes, S. (Co-Investigator), Gautel, M. (Co-Investigator), Giacca, M. (Co-Investigator), Irving, M. (Co-Investigator), Lamata de la Orden, P. (Co-Investigator), Marber, M. (Co-Investigator), Mayr, M. (Co-Investigator), Otsu, K. (Co-Investigator), Ourselin, S. (Co-Investigator), Parsons, M. (Co-Investigator), Razavi, R. (Co-Investigator), Schnabel, J. (Co-Investigator), Shanahan, C. (Co-Investigator), Xu, Q. (Co-Investigator) & Phinikaridou, A. (Co-Investigator)
1/04/2019 → 31/03/2024
Project: Research
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Cellular and sub-cellular sampling using laser capture microdissection to understand disease mechanisms
Gautel, M. (Primary Investigator), Ellison, G. (Co-Investigator), Ochala, J. (Co-Investigator), Oakey, R. (Co-Investigator), Zammit, P. (Co-Investigator), Tucker, A. (Co-Investigator), Meyer, M. (Co-Investigator), Knight, R. (Co-Investigator), Green, J. (Co-Investigator) & Shanahan, C. (Co-Investigator)
1/10/2018 → 30/09/2023
Project: Research
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Understanding the role of the nuclear envelope in cardiovascular development and disease
Stroud, M. (Primary Investigator), Shah, A. (Co-Investigator) & Shanahan, C. (Co-Investigator)
1/05/2018 → 30/04/2023
Project: Research
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KLF4 regulates VSMC migration and proliferation via exosomes.
Kapustin, A. (Primary Investigator) & Shanahan, C. (Co-Investigator)
1/08/2017 → 30/04/2021
Project: Research
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King’s NMR Facility for structural biology, metabolic profiling and drug discovery
Conte, M. (Primary Investigator), Avkiran, M. (Co-Investigator), Blower, P. (Co-Investigator), Dodding, M. (Co-Investigator), Eaton, P. (Co-Investigator), Gautel, M. (Co-Investigator), Irving, M. (Co-Investigator), Malim, M. (Co-Investigator), Marber, M. (Co-Investigator), Mayr, M. (Co-Investigator), McDonnell, J. (Co-Investigator), Otsu, K. (Co-Investigator), Pastore, A. (Co-Investigator), Pfuhl, M. (Co-Investigator), Poston, L. (Co-Investigator), Shah, A. (Co-Investigator), Shanahan, C. (Co-Investigator), Shattock, M. (Co-Investigator) & Williamson, C. (Co-Investigator)
BHF British Heart Foundation, Wellcome Trust
1/01/2017 → 31/12/2021
Project: Research
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Exosomes regulate smooth muscle cell migration and proliferation by recycling extracellular matrix components.
Kapustin, A. (Primary Investigator) & Shanahan, C. (Co-Investigator)
1/01/2017 → 31/12/2021
Project: Research
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Exploring known and novel biomarkers of Cardiovascular Disease
Mayr, M. (Primary Investigator) & Shanahan, C. (Co-Investigator)
1/01/2017 → 30/04/2022
Project: Research
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suCCeED - Training of experts in cardiovascular disease and vascular calcification in chronic kidneydisease: suCCeED - Calcification Chronic kidnEy Disease
Shanahan, C. (Primary Investigator)
1/10/2016 → 30/09/2020
Project: Research
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Extracellular vesicles are novel regulator of multipotent mesenchymal cell differentiation and their interaction with tissue microenvironment
Kapustin, A. (Primary Investigator) & Shanahan, C. (Primary Investigator)
15/08/2016 → 14/08/2018
Project: Research
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Prelamin A accumulation causes nuclear lamina disruption and drives cardiomyocytes dysfunction in dilated cardiomyopathy.
Shanahan, C. (Primary Investigator), Kentish, J. (Co-Investigator) & Shah, A. (Co-Investigator)
8/02/2016 → 7/02/2019
Project: Research
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Exosomes regulate smooth muscle cell migration and proliferation by recycling extracellular matrix components
Kapustin, A. (Primary Investigator) & Shanahan, C. (Co-Investigator)
1/01/2016 → 31/12/2019
Project: Research
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Novel Role for poly(ADP)ribose in vascular calcification
Shanahan, C. (Primary Investigator)
19/10/2015 → 18/10/2018
Project: Research
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A role for mechano-signalling in vascular calcification
Shanahan, C. (Primary Investigator)
1/10/2015 → 30/09/2018
Project: Research
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Extracellular vesicles - mechanisms of biogenesis and roles in disease pathogenesis
Kapustin, A. (Primary Investigator) & Shanahan, C. (Primary Investigator)
1/03/2015 → 31/03/2015
Project: Research
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Lamin b1 as a keystone in senescence and atherosclerosis: an interdisciplinary approach
Conte, M. (Primary Investigator), De Nicola, G. (Primary Investigator) & Shanahan, C. (Co-Investigator)
1/03/2015 → 28/02/2020
Project: Research
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The role of osteoblastic endothelial progenitor in the development of intimal and medial vascular calcification in rodent models
McGregor, U. (Primary Investigator) & Shanahan, C. (Co-Investigator)
1/11/2014 → 31/10/2017
Project: Research
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Non-Enzymatic Glycation of Collagen: Role in Metabolic Disease and Inflammation
Shanahan, C. (Primary Investigator)
1/07/2014 → 31/12/2017
Project: Research
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Novel Role for poly(ADP)ribose in pathological matrix mineralization
Shanahan, C. (Primary Investigator)
1/05/2014 → 30/04/2017
Project: Research
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Investigation of the Roles of Polyphosphate in Vascular Smooth Muscle Cell Calcification
Shanahan, C. (Primary Investigator)
1/09/2013 → 31/08/2015
Project: Research
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Early glycation products of collagen: a solid-state NMR spectroscopy and ultrastructural study of biological and health implications
Shanahan, C. (Primary Investigator)
8/03/2013 → 7/09/2014
Project: Research
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Developing a model of ageing: linking molecular, nano- and micro-structure with material properties of ageing extracellular matrix
Shanahan, C. (Primary Investigator)
1/10/2012 → 30/09/2015
Project: Research
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Early glycation products of collagen: a solid-state NMR spectroscopy and Ultrastructural study of biological and health implications
Shanahan, C. (Primary Investigator)
1/07/2012 → 30/06/2015
Project: Research
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Biophysical investigation of nesprin spectrin repeats: implications for cardiovascular cell function
Fraternali, F. (Primary Investigator), Garcia-Manyes, S. (Co-Investigator), Pfuhl, M. (Co-Investigator) & Shanahan, C. (Co-Investigator)
1/06/2012 → 10/01/2016
Project: Research
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Using smooth muscle derived microvesicles as vascular risk biomarkers in humans
Shanahan, C. (Primary Investigator)
1/05/2012 → 30/04/2014
Project: Research
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Using smooth muscle derived microvesicles as vascular risk biomarkers in humans
Shanahan, C. (Primary Investigator) & Shah, A. (Co-Investigator)
1/05/2012 → 30/04/2014
Project: Research
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Mechanisms of vascular smooth muscle cell ageing and calcification
Shanahan, C. (Primary Investigator) & Warren, D. (Co-Investigator)
1/05/2012 → 31/10/2022
Project: Research
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A pivotal role for the LINC complex and nesprins in vascular smooth muscle cell mechanical coupling and phenotypic modulation
Shanahan, C. (Primary Investigator) & Warren, D. (Primary Investigator)
1/10/2011 → 31/10/2016
Project: Research
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A role of endoplasmic reticulum stress in vascular calcification
Shanahan, C. (Primary Investigator)
1/10/2011 → 30/09/2014
Project: Research
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A role for Endoplasmic Reticulum Stress in Vascular Calcification
Shanahan, C. (Primary Investigator)
1/10/2011 → 30/09/2014
Project: Research
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The role of nesprins in cardiac cell function
Zhang, Q. (Primary Investigator) & Shanahan, C. (Co-Investigator)
1/09/2011 → 31/08/2014
Project: Research
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Vascular calcification: determining new stratergies for theraputics and nutrition
Shanahan, C. (Primary Investigator)
1/06/2011 → 31/05/2014
Project: Research
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High resolution molecular characterisation of human mineral deposits: mechanisms of calcification initiation and effects on parameters of plaque stability
Shanahan, C. (Primary Investigator)
1/12/2010 → 30/11/2013
Project: Research
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The role of asparaginyl endopeptidase, legumain, in atherosclerotic plaque progession
Jenkins, J. (Primary Investigator), Nuthall, K. (Primary Investigator), Smith, A. (Primary Investigator), Shanahan, C. (Co-Investigator), Watts, C. (Co-Investigator) & Xu, Q. (Co-Investigator)
1/09/2010 → 31/08/2013
Project: Research
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The role of vascular smooth muscle cells in the development and progression of vascular disease
Shanahan, C. (Primary Investigator), Warren, D. (Co-Investigator) & Zhang, Q. (Co-Investigator)
1/05/2010 → 30/04/2015
Project: Research
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Funding toward core specialist cell biological equipment for the cardiovascular division
Shah, A. (Primary Investigator), Ehler, E. (Co-Investigator), Mayr, M. (Co-Investigator), Shanahan, C. (Co-Investigator) & Xu, Q. (Co-Investigator)
17/11/2008 → 16/05/2009
Project: Research
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BHF Centre of Research Excellence
Avkiran, M. (Primary Investigator), Blower, P. (Primary Investigator), Botnar, R. (Primary Investigator), Chowienczyk, P. (Primary Investigator), Eaton, P. (Primary Investigator), Ehler, E. (Primary Investigator), Garcia-Manyes, S. (Primary Investigator), Gautel, M. (Primary Investigator), Geissmann, F. (Primary Investigator), Hussain, M. (Primary Investigator), Irving, M. (Primary Investigator), Kalra, L. (Primary Investigator), Marber, M. (Primary Investigator), Mayr, M. (Primary Investigator), Nagel, E. (Primary Investigator), Otsu, K. (Primary Investigator), Razavi, R. (Primary Investigator), Ridley, A. (Primary Investigator), Shah, A. (Primary Investigator), Shanahan, C. (Primary Investigator), Smith, N. (Primary Investigator), Xu, Q. (Primary Investigator), Alastruey, J. (Co-Investigator), Ameer-Beg, S. (Co-Investigator), Bishop, M. (Co-Investigator), Brain, S. (Co-Investigator), Burgoyne, J. (Co-Investigator), Conte, M. (Co-Investigator), Dhanjal, T. (Co-Investigator), Eminaga, S. (Co-Investigator), Eykyn, T. (Co-Investigator), Gee, T. (Co-Investigator), Heintzmann, R. (Co-Investigator), Hughes, S. (Co-Investigator), Iskratsch, T. (Co-Investigator), Ivetic, A. (Co-Investigator), Jones, G. E. (Co-Investigator), Kentish, J. (Co-Investigator), Lamata de la Orden, P. (Co-Investigator), Lombardi, G. (Co-Investigator), Mullen, G. (Co-Investigator), Okonko, D. (Co-Investigator), Parsons, M. (Co-Investigator), Pfuhl, M. (Co-Investigator), Phinikaridou, A. (Co-Investigator), Rodaway, A. (Co-Investigator), Shattock, M. (Co-Investigator), Sinkus, R. (Co-Investigator), Springett, R. (Co-Investigator), Steiner, R. (Co-Investigator), Stroud, M. (Co-Investigator), Sun, Y.-B. (Co-Investigator), Wardle, F. (Co-Investigator), Warren, D. (Co-Investigator), Webb, A. (Co-Investigator), Zampetaki, A. (Co-Investigator), Zeng, L. (Co-Investigator) & academic, A. (Co-Investigator)
1/01/2008 → 31/03/2019
Project: Research