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  Vectorised chimeric U7 snRNPs as therapeutic approach for ALS/FTD with TDP-43 pathology

  Ruepp, M. & Shaw, C.

  UKDRI UK Dementia Research Institute

  1/03/2022 → 31/10/2023

  Project: Research

• World Class Labs 2 Capital Equipment Award

  Shaw, C.

  UKDRI UK Dementia Research Institute

  18/10/2021 → 31/03/2022

  Project: Research

• DOD/14/35: Surgical delivery of gene therapies for Motor Neuron Disease

  Shaw, C.

  My Name'5 Doddie Foundation

  1/04/2021 → 31/03/2022

  Project: Research

• G rant refer: Characterisation of a collection of induced pluripotent stem cell models for Motor Neurone disease

  Shaw, C. & Nishimura, A.

  Motor Neurone Disease Association

  1/01/2021 → 31/12/2022

  Project: Research

• Arresting corona virus replication using microRNA to knock down the essential RDRP protein

  Shaw, C. & Lee, Y.

  UK Dementia Research Institute

  1/04/2020 → 31/03/2021

  Project: Research

• Remote home assessment of patients with amyotrophic lateral sclerosis: a multimodal integrative approach

  Shaw, C.

  UK Dementia Research Institute

  1/04/2020 → 30/04/2023

  Project: Research

• Home monitoring in motor neuron disease using remote surface muscle recordings

  Shaw, C. & Bashford, J.

  Rosetrees Trust

  1/10/2019 → 31/12/2022

  Project: Research

• Exploration of TMS as a potential early biomarker for ALS and application to novel drug discovery

  Shaw, C. & Richardson, M.

  Autifony Therapeutics Ltd

  1/10/2019 → 30/09/2023

  Project: Research

• Endoplasmic reticulum (ER)-mitochondria signaling as a new therapeutic target for dementia.

  Miller, C., Noble, W., Mitchell, J. & Shaw, C.

  Alzheimer's Research UK

  1/08/2019 → 31/07/2022

  Project: Research

  • Dementia 100%
  • Endoplasmic reticulum 100%
  • Mitochondrion 100%

• UK DRI Associate Director's Flexible Funding

  Shaw, C., Mizielinska, S., Pastore, A., Cho, K., Rajendran, L. & Ruepp, M.

  UK Dementia Research Institute

  1/07/2019 → 31/03/2023

  Project: Research

• Home monitoring in motor neuron disease using remote surface electromyography: a pilot study

  Bashford, J. & Shaw, C.

  Motor Neurone Disease Association

  1/04/2019 → 31/07/2019

  Project: Research

• Functional characterisation of ALS-associated ANXA11 mutations in iPS-neurones

  Shaw, C.

  Motor Neurone Disease Association

  1/04/2019 → 20/09/2021

  Project: Research

  • Neuron 100%

• Clinical Trials Core Team for Motor Neuron Disease Research

  Al-Chalabi, A. & Shaw, C.

  My Name'5 Doddie Foundation

  1/04/2019 → 31/12/2022

  Project: Research

• A genetic study of phenotypic modifiers in C9orf72 gene repeat expansions carriers

  Shaw, C., Powell, J. & Fogh, I.

  Motor Neurone Disease Association

  1/01/2019 → 31/12/2021

  Project: Research

  • C9orf72 100%
  • Nested Gene 100%
  • Genetics 100%

• Viral vector gene therapy for FTD and ALS: from constructs to clinical trials

  Shaw, C., Lee, Y. & Farzaneh, F.

  UK Dementia Research Institute

  1/01/2019 → 31/12/2022

  Project: Research

• Studying the role of TDP-43 induced damage to the VAPB-PTPIP51 ER-mitochondria tethers in fronto-temporal dementia/amyotrophic lateral sclerosis

  Miller, C., Shaw, C. & Mitchell, J.

  MRC Medical Research Council

  1/10/2018 → 30/04/2023

  Project: Research

• Advancing gene therapy for sporadic motor neuron disease

  Shaw, C. & Lee, Y.

  My Name'5 Doddie Foundation

  1/08/2018 → 31/07/2021

  Project: Research

• Exploring the potential of manipulating the heat shock response pathway for ALS therapy

  Chen, H. & Shaw, C.

  Motor Neurone Disease Association

  1/04/2018 → 31/03/2021

  Project: Research

• Damage to ER-mitochondria signaling by fronto-temporal dementia and amyotrophic lateral sclerosis linked TDP-43

  Miller, C., Mitchell, J. & Shaw, C.

  1/03/2018 → 28/02/2021

  Project: Research

• The endoplasmic reticulum-mitochondria axis in C9orf72-related amyotrophic lateral sclerosis and fronto-temporal dementia

  Gomez Suaga, P., Miller, C. & Shaw, C.

  Motor Neurone Disease Association

  1/03/2018 → 25/03/2022

  Project: Research

• A Molecular Dissection of Defective Autophagy in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

  Shaw, C. & Fanto, M.

  1/01/2018 → 31/12/2021

  Project: Research

• A Molecular Dissection of Defective Autophagy in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

  Shaw, C. & Fanto, M.

  1/12/2017 → 30/11/2022

  Project: Research

• Elucidating the role of Calcyclin in the pathogenesis of ALS and Alzheimer's Disease

  Smith, B., Adinolfi, S., Houart, C. & Shaw, C.

  Motor Neurone Disease Association

  1/10/2017 → 31/07/2021

  Project: Research

• A Drosophila model for an Annexin gene causing ALS

  Fanto, M., Shaw, C. & Smith, B.

  Motor Neurone Disease Association

  1/09/2017 → 31/12/2020

  Project: Research

  • Nested Gene 100%
  • Annexin 100%
  • Fruit Fly Model 100%

• Van Geest Neurosciences Donation

  Shaw, C., Aarsland, D., Cho, K., Ruepp, M., Mizielinska, S. & Svenningsson, P.

  John and Lucille van Geest Foundation

  1/08/2017 → 31/07/2023

  Project: Research

• A Molecular Dissection of Defective Autophagy in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

  Shaw, C., Fanto, M. & Lieberam, I.

  1/08/2017 → 31/07/2021

  Project: Research

• Diagnosing and monitoring concussion and traumatic brain injury

  Shaw, C.

  1/07/2017 → 30/06/2018

  Project: Research

• The endoplasmic reticulum (ER)-mitochondria axis in fronto-temporal dementia and amyotrophic lateral sclerosis

  Miller, C., Noble, W. & Shaw, C.

  1/05/2017 → 30/04/2022

  Project: Research

• Dementia Research Institute

  Shaw, C., Miller, C., Mizielinska, S., Pastore, A. & Politis, M.

  UK Dementia Research Institute, MRC Medical Research Council

  1/04/2017 → 31/08/2022

  Project: Research

• Exploring the potential of manipulating the heat shock response pathway for ALS therapy

  Chen, H. & Shaw, C.

  1/03/2017 → 28/02/2021

  Project: Research

• Small nerve fiber involvement in ALS: a search for new biomarkers.

  Shaw, C.

  1/02/2017 → 31/01/2018

  Project: Research

• Small nerve fiber involvement in ALS: a search for new biomarkers.

  Shaw, C.

  1/02/2017 → 31/01/2018

  Project: Research

• Evaluating the use of antisense oligonucleotides as a therapy for Amyotrophic Lateral Sclerosis

  Shaw, C.

  Motor Neurone Disease Association

  1/02/2017 → 30/06/2017

  Project: Research

• Functional assessment of candidate genes for familial amyotrophic lateral sclerosis

  Shaw, C.

  Motor Neurone Disease Association

  1/02/2017 → 31/10/2017

  Project: Research

• Engaging Mental Health - Focusing on hard to reach communities

  Shaw, C. & Rodriguez, T.

  1/01/2017 → 31/12/2017

  Project: Research

• A Neurinflammation Research Cluster at King's College London

  Shaw, C., Noble, W., Politis, M. & Taams, L.

  MRC Medical Research Council

  12/12/2016 → 11/12/2019

  Project: Research

• Validation of intron retention in C9orf72 RNA as a therapeutic target for Frontotemporal Dementia

  Gallo, J. & Shaw, C.

  1/10/2016 → 30/06/2017

  Project: Research

• Sequential surface EMG recordings in motor neurone disease. Fasciculations as a biomarker of motor neurone health

  Bashford, J. & Shaw, C.

  MRC Medical Research Council

  1/10/2016 → 30/09/2019

  Project: Research

• Gene hunting in Middle-eastern adult onset ALS cases containing a high degree of consanguinity

  Smith, B. & Shaw, C.

  Motor Neurone Disease Association

  1/09/2016 → 31/08/2018

  Project: Research

• In vitro modeling of neurodegneration in ALS with patient-derived neuromuscular circuits

  Lieberam, I. & Shaw, C.

  1/09/2016 → 31/08/2021

  Project: Research

• Dissecting the mechanisms of pathogenesis of TBK1 mutations using ALS Drosophila models

  Kinghorn, K., Fanto, M. & Shaw, C.

  Academy of Medical Sciences

  6/08/2016 → 5/05/2019

  Project: Research

• Sequential surface EMG recordings in motor neuron disease: fasciculations as a biomarker of motor neuron health.

  Shaw, C. & Bashford, J.

  1/08/2016 → 31/07/2019

  Project: Research

• Non-nuclear function of RNA processing protein in motor development and degeneration

  Houart, C., Makeyev, E. & Shaw, C.

  1/01/2016 → 31/12/2020

  Project: Research

• Exome sequencing in motor neuron disease: bioinformatic analyses and biological validation of novel variants

  Shaw, C.

  MRC Medical Research Council

  30/11/2015 → 29/11/2018

  Project: Research

• Mechanisms of synaptic dysfunction and neurodegeneration in dementia

  Hanger, D., Gallo, J., Giese, P., Hirth, F., Miller, C., Noble, W., Pooler, A. & Shaw, C.

  1/10/2015 → 30/09/2018

  Project: Research

• Engaging Mental Health

  Rodriguez, T. & Shaw, C.

  1/10/2015 → 30/09/2016

  Project: Research

• Sequential surface EMG recordings in motor neuron disease: fasciculations as a biomarker of motor neuron disease

  Shaw, C.

  Motor Neurone Disease Association

  1/08/2015 → 31/07/2016

  Project: Research

• Generation and characterisation of induced pluripotent stem cells from ALS lymphoblasts to model disease pathogenesis and advanced drug discovery

  Shaw, C. & Price, J.

  Motor Neurone Disease Association

  1/07/2015 → 30/09/2019

  Project: Research

• From ALS exomes to functional assays: turning candidates into confirmed genes

  Smith, B., Houart, C. & Shaw, C.

  Medical Research Foundation

  1/07/2015 → 30/09/2018

  Project: Research

• Models of care in ALS: Do specialists clinics provide value?

  Al-Chalabi, A. & Shaw, C.

  Motor Neurone Disease Association

  1/05/2015 → 31/01/2016

  Project: Research