Search results

• 2012

  Both loss and gain of TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration in Drosophilia

  Diaper, D. C., Adachi, Y., Sutcliffe, B., Humphrey, D. M., Elliott, C., Fielding, T., Burki, M., Ludlow, Z. N., Vanden Broeck, L., Callaerts, P., Dermaut, B., Al-Chalabi, A., Shaw, C. E. & Hirth, F., Sept 2012, In: Dementia and Geriatric Cognitive Disorders. 34, S1, p. 51-51 1 p., P10.

  Research output: Contribution to journal › Meeting abstract › peer-review

  Open Access
  48 Citations (Scopus)
• 2010

  Cytoplasmic TDP-43 accumulation is related to nuclear transport dysfunction in frontotemporal lobar degeneration and motor neuron disease

  Hortobagyi, T., Nishimura, A. L., Troakes, C., Kathe, C., Fratta, P., Howell, M., Gallo, J.-M., Shaw, C. E. & Rogelj, B., 2010, In: Brain Pathology. 20, p. 24 - 24 1 p.

  Research output: Contribution to journal › Meeting abstract

• CYTOSKELETAL AND INFLAMMATORY PROTEIN BIOMARKERS FOR AMYOTROPHIC LATERAL SCLEROSIS

  Ganesalingam, J., Lacomis, D., Lustgarten, J., Shaw, C. E., Bowser, R. & An, J., 2010, In: Journal of Neurology, Neurosurgery and Psychiatry. 81, 11, p. E20 - E20

  Research output: Contribution to journal › Meeting abstract

• Familial TDP proteinopathy with ALS presentation: characteristic clinical and pathological features

  Troakes, C., Maekawa, S., Wijesekera, L., Rogelj, B., Smith, B., Vance, C., Hortobagyi, T., Arzberger, T., Kretzschmar, H., Leigh, N., Al-Chalabi, A., Shaw, C., King, A. & Al-Sarraj, S., 2010, In: Brain Pathology. 20, p. 33 - 33 1 p.

  Research output: Contribution to journal › Meeting abstract

• Mutant VAPB transgenic mice linked to amyotrophic lateral sclerosis type-8 develop TDP-43 pathology

  Hortobagyi, T., Tudor, E. L., Galtrey, C., Perkinton, M. S., Lau, K.-F., De Vos, K. V., Mitchel, J. C., Ackerley, S., Vamos, E., Leigh, P. N., Klasen, C., McLoughlin, D. M., Siklos, L., Shaw, C. E. & Miller, C. J., 2010, In: Brain Pathology. 20, p. 33 - 33 1 p.

  Research output: Contribution to journal › Meeting abstract

• PATH46 Familial mutations in the RNA binding gene FUS result in cellular mislocalisation of the protein

  Rogelj, B., Shaw, C. E., Vance, C. & Hortobagyi, T., 2010, In: Journal of Neurology, Neurosurgery and Psychiatry. 81, 11, p. E20 - E20

  Research output: Contribution to journal › Meeting abstract

  • Wild Type 100%
  • Motor Neuron 100%
  • Stress Granule 100%
  • Transactive Response Dna Binding Protein-43 100%
  • RNA Binding 100%

• POD09 Using the chick embryo model system to study the neurotoxicity of TDP43

  Tripathi, V., Guthrie, S., Shaw, C., Marinela, V., Al-chalabi, A., Vance, C. & Sreedharan, J., 2010, In: Journal of Neurology, Neurosurgery and Psychiatry. 81, 11, p. E44 - E44

  Research output: Contribution to journal › Meeting abstract

• The Role of Common Copy Number Variation in Amyotrophic Lateral Sclerosis (ALS)

  Wain, L. V., Shrine, N. R. G., Shaw, C., Powell, J. F., Hardy, J., Shaw, P., Morrison, K. E., Brown, R. H., Orrell, R., Mok, B., Palmer, L. J., Hui, J., James, A. L., Musk, B., Al-Chalabi, A. & Tobin, M. D., 2010, In: Genetic Epidemiology. 34, 8, p. 929 - 930 2 p.

  Research output: Contribution to journal › Meeting abstract
• 2009

  Mutations in RNA processing protein FUS result in neurodegeneration with cytoplasmic inclusion and cause familial amyotrophic lateral sclerosis

  Hortobagyi, T., Vance, C., Rogelj, B., de Vos, K., Troakes, C., Al-Sarraj, S. & Shaw, C., 2009, In: Acta Neuropathologica. 118, 3, p. 445-445 1 p.

  Research output: Contribution to journal › Meeting abstract
• 2008

  Clinical phenotypes and natural history in amyotrophic lateral sclerosis

  Wijesekera, L. C., Mathers, S., Talman, P., Galtrey, C., Shaw, C. E., Leigh, P. N. & Al-Chalabi, A., 2008, In: Journal of Neurology, Neurosurgery and Psychiatry. 79, 3, p. 19 1 p.

  Research output: Contribution to journal › Meeting abstract

• TDP-43 consistently co-localised with ubiquitinated inclusions in sporadic amyotrophic lateral sclerosis but occasionally in familial amyotrophic lateral sclerosis with and without SOD1 mutation

  Al-Sarraj, S., Makaewa, S., King, A., Bodi, I., Hortobagyi, T., Shaw, C. & Leigh, N., 2008, In: Neuropathology and Applied Neurobiology. 34, p. 12 - 12 1 p.

  Research output: Contribution to journal › Meeting abstract

• The effect of formalin fixation times on DNA preservation and immuno-reactivity in post-mortem brain tissue

  Troakes, C., King, A., Bodi, I., Shaw, C. & Al-Sarraj, S., 2008, In: Journal of Neural Transmission. 115, 12, p. 1714 - 1715 2 p.

  Research output: Contribution to journal › Meeting abstract

• The effect of formalin fixation times on DNA preservation and immuno-reactivity in post-mortem brain tissue

  Troakes, C., King, A., Bodi, I., Shaw, C. & Al-Sarraj, S., 2008, In: Neuropathology and Applied Neurobiology. 34, p. 33 - 33 1 p.

  Research output: Contribution to journal › Meeting abstract
• 2006

  Extending the phenotype of ALS: Whither the sensory nerves?

  Isaacs, J. D., Shaw, C. E., Chalabi, A. A., Mills, K. R. & Leigh, P. N., 2006, In: Journal of Neurology, Neurosurgery and Psychiatry. 77, 1, p. 137 - 137 1 p., 061.

  Research output: Contribution to journal › Meeting abstract
• 2005

  Detection of interrupted GAA repeats within intron 1 of the Frataxin gene using triplet-primed PCR.

  Purvis, A., Ellis, I., Shaw, C. & Mountford, R., 2005, In: Journal of Medical Genetics. 42, p. S25 - S25

  Research output: Contribution to journal › Meeting abstract
• 2004

  In vivo study of cerebral microglial activation in MND using [C-11]-PK11195 PET

  Turner, M. R., Cagnin, A., Turkheimer, F. E., Miller, C. C. J., Shaw, C. E., Brooks, D. J., Banati, R. B. & Leigh, P., Aug 2004, In: Journal of Neurology, Neurosurgery and Psychiatry. 75, 8, p. 1214-1214 1 p.

  Research output: Contribution to journal › Meeting abstract › peer-review
• 2003

  [C-11]-WAY100635 PET: A surrogate marker for MND?

  Turner, M. R., Rabiner, E. A., Doder, M., Shaw, C. E., Grasby, P. M., Brooks, D. J. & Leigh, P. N., 2003, In: Journal of Neurology, Neurosurgery and Psychiatry. 74, 3, p. 407 1 p., 43.

  Research output: Contribution to journal › Meeting abstract

• A novel locus for motor neurone disease on chromosome 16q12-13

  Ruddy, D. & Shaw, C., 2003, In: Clinical Science. 104, p. 40P

  Research output: Contribution to journal › Meeting abstract

• Mutation screening of the spastin gene (SPG4) for autosomal dominant hereditary spastic paraplegia

  Nihalani, V., Campbell, J. K., Smith, B., Shaw, C., Abbs, S. J. & Renwick, P., 2003, In: Journal of Medical Genetics. 40, p. S78 - S78

  Research output: Contribution to journal › Meeting abstract
• 2002

  Expression of the Fe65 adaptor protein in adult and developing mouse brain

  Kesavapany, S., Banner, S., Lau, K. F., Shaw, C., Miller, C., Cooper, J. & McLoughlin, D., 2002, In: Neurobiology of Aging. 23, 1, p. S11 - S12

  Research output: Contribution to journal › Meeting abstract

• The role of SOD1 mutations in young-adult motor neuron isolated ptosis disease

  Renwick, P., Parton, M. J., Leigh, N., Shaw, C. & Abbs, S., 2002, In: Journal of Medical Genetics. 39, p. S64 - S64

  Research output: Contribution to journal › Meeting abstract
• 2001

  The D90A SOD1 mutation in amyotrophic lateral sclerosis: Why are the Scandinavians protected?

  Shaw, C. E., Parton, M. J., Broom, W. J., Andersen, P. M., Powell, J. F. & Leigh, P. N., 2001, Society for Neuroscience Abstracts. Unknown Publisher, p. 1512 1 p.

  Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract

  • SOD1 100%
  • Amyotrophic Lateral Sclerosis 100%
  • Haplotype 33%
  • Allele 33%
  • Penetrance 33%
• 2000

  Glutamate, neurofilament phosphorylation and neurodegenerative disease.

  Brownlees, J., Yates, A., Bajaj, N. P., Leigh, P. N., Shaw, C. E. & Miller, C. C. J., 2000, In: European Journal of Neuroscience. 12, p. 227 - 227 1 p.

  Research output: Contribution to journal › Meeting abstract

• Using GFP-tagged neurofilament middle chain to investigate slow transport in cultured cortical neurons

  Ackerley, S., Grierson, A. J., Brownlees, J. A., Leigh, P. N., Shaw, C. E. & Miller, C. C. J., 2000, In: European Journal of Neuroscience. 12, p. 348 - 348 1 p.

  Research output: Contribution to journal › Meeting abstract