Christopher Corrigan

Christopher Corrigan

Professor

  • 14695
    Citations

Personal profile

Research interests

I am interested in why asthma remains uncontrolled in a substantial minority of patients. My research embraces the immunopathogenesis of severe asthma phenotypes such as non-atopic and aspirin sensitive asthma. I also study mechanisms of airways remodelling in asthma to identify new molecular targets which may modify the natural history of this phenomenon.  I collaborate particularly with my departmental colleagues Prof Hawrylowicz, who is interested in environmental control of T regulatory cell function in asthma, including the potential roles of new therapeutic agents, Prof Ward with whom I am examining the role of bronchial smooth muscle calcium homoeostatic proteins in maintining bronchial hyperresponsiveness, the cardinal clinical feature of asthma whose genesis remains as yet unexplained, and Prof Gould with whom I investigate the role of IgE-mediated mechanisms, both established and novel, in regulating asthma severity. On the clinical side I manage the Trust omalizumab service and am running a proof of concept study of the worth of omalizumab therapy in non-atopic asthma. As leader of the Guy's allergen immunotherapy service I am also interested in improving products and regimens for immunotherapy, and participate in a number of basic and phase 3 clinical trials to this end. I am a principal investigator in the MRC and Asthma UK Centre for allergic mechanisms of Asthma, a cross-collaborative initiative with King's and Imperial Colleges, the Medical Research Council and the principal asthma charity Asthma UK.

Research interests (short)

Severe phenotypes of asthma; environmental influences on asthma control; mechanisms of airways remodelling in asthma; allergen immunotherapy.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 8 - Decent Work and Economic Growth
  • SDG 11 - Sustainable Cities and Communities

Education/Academic qualification

Doctor of Philosophy, The role of the T-lymphocyte in the pathogenesis of asthma, University of London

Award Date: 1 Jan 1990

Bachelor of Medicine, University of London

Award Date: 1 Jan 1983

Master of Science, Suppression of malignant potential in hybridomas between plasmacytoma and normal diploid cells, University of Oxford

Award Date: 1 Jan 1980

Bachelor of Arts, University of Oxford

Award Date: 1 Jan 1979

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