Claire Sharpe

1226

Citations

Research interests

I am a clinical academic and I am interested in the pathophysiology of kidney fibrosis. My research focuses on the Ras family of monomeric GTPases and how they are pivotal to cell signalling both in vitro and in vivo in renal cell proliferation, apoptosis and cell phenotype. My clinical area of interest is in the pathophysiology and management of sickle cell nephropathy.<br />

Research interests (short)

Renal medicine; renal fibrosis; cell signalling; cell biology; Ras monomeric GTPases; sickle cell nephropathy

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

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44 Article
4 Editorial
4 Meeting abstract
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- 1 Literature review

The burden of hyperkalaemia on hospital healthcare resources
Logan Ellis, H., Al-Agil, M., Kelly, P. A., Teo, J., Sharpe, C. & Whyte, M. B., 13 Aug 2024, In: CLINICAL AND EXPERIMENTAL MEDICINE. 24, 1, p. 190 190.
Research output: Contribution to journal › Article › peer-review

Open Access
Effect of intravitreal anti-vascular endothelial growth factor treatment for neovascular age-related macular degeneration on renal function
Neffendorf, J. E., Mare, T., Simpson, A. R. H., Soare, C., Kirthi, V., Sharpe, C. C. & Jackson, T. L., 30 Jun 2023, In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 38, 7, p. 1770-1772 3 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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1 Citation (Scopus)

41 Downloads (Pure)
Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study
PHOSP-COVID Study Collaborative Group, Chalder, T., Jolley, C. J., Shah, A. M., Man, W. D. C., Jackson, C., Stewart, I. D., Cunningham, P. S., Chalder, T., Harris, V. C., Ho, L. P., Howard, L. S., Jolley, C. J., Jones, M. G., Marks, M., Patel, B., Richardson, M., Rowlands, A. V., Saunders, R. M., Scott, J. T., & 273 othersShah, A. M., Singh, S. J., Man, W. D. C., Porter, J. C., Thompson, R., Evans, R., Jones, S. E., Rutter, M. K., Abel, K., Ahmad, S., Ahmed, R., Ali, M., Allen, R. J., Anderson, D., Armstrong, L., Armstrong, N., Ashworth, M., Ayoub, A., Baggott, R., Bailey, L., Baldwin, D., Ballard, C., Banerjee, A., Bates, A., Begum, M., Bell, D., Bell, R., Berry, C., Bhui, K., Bramham, K., Breen, G., Brookes, C., Broome, M., Brown, A., Brown, J., Brown, J., Brown, M., Burns, A., Butt, A., Byrne, S., Carson, G., Carter, P., Chambers, R. C., Chan, F., Chen, J., Cheng, Y., Chiribiri, A., Choudhury, N., Chowienczyk, P., Clark, D., Clark, C., Clarke, J., Cole, J., Connolly, B., Connor, L., Cook, A., Cooper, B., Cooper, J., Cooper, S., Craig, T., David, A., Davies, E., Davies, G., Davies, G., Davies, K., Davies, M. J., Dawson, J., Donaldson, A., Dong, T., Dougherty, A., Dowling, R., Dunn, S., Edwards, S., Elliott, A., Elliott, K., Evans, D., Evans, H., Evans, J., Evans, R., Evans, R., Evans, T., Finch, J., Fisher, H., Flynn, M., Ford, A., Francis, R., Gill, M., Goodwin, C., Gooptu, B., Gregory, H., Gregory, R., Grieve, D., Griffiths, L., Gupta, A., Hall, L., Harris, E., Harrison, P., Hart, N., Harvey, A., Harvey, M., Hayday, A., Henderson, M., Holden, S., Holland, M., Holmes, M., Hosseini, A., Hotopf, M., Hughes, A. D., Hughes, J., Hughes, R., Husain, M., Ismail, K., Jackson, T., Jacob, J., James, W. Y., Jenkins, R. G., Johnson, C., Johnson, S., Jones, D., Jones, G., Jones, H., Jones, I., Jones, L., Jones, S., Jose, S., Kaltsakas, G., Kelly, S., Kerr, S., Khan, F., King, B., Knight, S., Kon, S., Kon, S., Laing, C., Lasserson, D., Lawson, C., Lee, D., Lee, J. H., Lewis, D., Lewis, J., Li, X., Lim, L., Lloyd, A., Lord, J. M., Major, E., Malim, M., Mandal, S., Mangion, K., Marsh, S., Marshall, B., Marshall, M., Martin, J., Martinez, L. M., McMahon, M. J., Mehta, P., Miller, C., Mills, C., Mitchell, J., Mohamed, A., Mohammed, S., Morley, A., Morrow, A., Moss, A. J., Moss, P., Neal, A., Newby, D. E., Newman, J., Nicholson, T., O'Brien, C., Ostermann, M., Owen, J., Pariante, C., Parker, S., Patel, M., Patel, S., Payne, S., Pearce, L., Peng, Y., Pennington, C., Pfeffer, P., Plant, H., Plein, S., Porter, J., Powell, N., Pratt, J., Price, A., Price, C., Price, D., Prickett, A., Quigley, J., Qureshi, I. N., Rahman, N. M., Rees, M., Reynolds, W., Richards, A., Richardson, E., Roberts, K., Robertson, E., Robinson, E., Robinson, L., Rodger, J., Ross, A., Rowe, A., Rowland, A., Rowland, J., Russell, R., Sage, E. K., Saunders, K., Saunders, P., Shah, K., Shah, P., Shankar-Hari, M., Sharma, M., Sharpe, C., Shaw, A., Shaw, K., Simpson, J., Singh, C., Smith, A., Smith, D., Smith, S., Smith, J., Smith, L., Spencer, L. G., Stephenson, L., Stone, R., Tan, A. L., Taylor, A., Taylor, C., Taylor, J., Terry, S., Thomas, C., Thomas, D. C., Thomas, S., Thomas, A. K., Thompson, T., Thompson, A. A. R., Tilley, J., Tomlinson, J., Turner, S., Turner, K., Wade, P., Wainwright, T., Walker, S., Walsh, J. A., Walsh, S., Ward, T. J. C., Watson, E., Watson, L., Watson, J., Wessely, S., West, S., White, S., Whitney, J., Whittaker, S., Wild, J. M., Williams, B., Williams, N., Williams, J., Willoughby, J., Wilson, A., Wilson, D., Wood, C., Woods, J., Wright, C., Wright, L., Wright, S., Xu, M., Yip, K. P., Young, B., Young, S., Young, A. & Zhao, B., Aug 2023, In: The Lancet Respiratory Medicine. 11, 8, p. 673-684 12 p.
Research output: Contribution to journal › Article › peer-review

Open Access
13 Citations (Scopus)
Sickle Cell Trait and Kidney Disease in People of African Ancestry With HIV
GEN-AFRICA study group, Hung, R. K. Y., Binns-Roemer, E., Booth, J. W., Hilton, R., Fox, J., Burns, F., Harber, M., Ustianowski, A., Hamzah, L., Burns, J. E., Clarke, A., Price, D. A., Kegg, S., Onyango, D., Santana-Suarez, B., Campbell, L., Bramham, K., Sharpe, C. C., Sabin, C. A., & 31 othersWinkler, C. A., Post, F. A., Booth, J., Waters, A., Hand, J., Clarke, C., Murphy, S., Murphy, M., Campbell, M., Richardson, C., Knott, A., Weir, G., Cleig, R., Soviarova, H., Barbour, L., Adams, T., Kennard, V., Trevitt, V., Jones, R., Levy, J., Schoolmeester, A., Duro, S., Rabuya, M., Jordan, D., Solano, T., Post, F. A., Poulton, M., Flaherty, J., Patel, B., Manning, A. & Popoola, J., 1 Mar 2022, In: Kidney International Reports. 7, 3, p. 465-473 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
3 Citations (Scopus)
Stimulated phosphorylation of ERK in mouse kidney mesangial cells is dependent upon expression of Cav3.1
Pandi, S. P. S., Shattock, M. J., Hendry, B. M. & Sharpe, C. C., Dec 2022, In: BMC Nephrology. 23, 1, 211.
Research output: Contribution to journal › Article › peer-review

Open Access

Engineering regulatory T cells (Tregs) to modulate kidney injury and prevent renal fibrosis
Lombardi, G., Peng, Q., Safinia, N., Sanchez Fueyo, A. & Sharpe, C.
KIDNEY RESEARCH UK
7/05/2022 → 31/07/2024
Project: Research
DYNAMic renal assessment: nOvel methods to assess KIDNEY functional reserve (DYNAMO KIDNEY)
Bramham, K., Kelly, C. & Sharpe, C.
MRC Medical Research Council
1/10/2021 → 31/03/2023
Project: Research
Determining the role of coagulation proteases in the development of renal fibrosis
Dorling, A., Sharpe, C. & Leonard, H.
MRC Medical Research Council
1/10/2019 → 30/09/2022
Project: Research
Canonical vitamin A signalling in diabetic nephropathy and RA-568 as a novel therapy
Xu, Q., Corcoran, J., Malik, A., Sharpe, C., So, E. & academic, A.
1/09/2017 → 30/09/2020
Project: Research
The role of intracellular complement activation in podocytes: a potential therapeutic target in proteinuric renal disease?
Sharpe, C.
1/12/2016 → 1/12/2020
Project: Research

Claire Sharpe

Personal profile

Research interests

Research interests (short)

Expertise related to UN Sustainable Development Goals

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

The burden of hyperkalaemia on hospital healthcare resources

Effect of intravitreal anti-vascular endothelial growth factor treatment for neovascular age-related macular degeneration on renal function

Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study

Sickle Cell Trait and Kidney Disease in People of African Ancestry With HIV

Stimulated phosphorylation of ERK in mouse kidney mesangial cells is dependent upon expression of Cav3.1

Engineering regulatory T cells (Tregs) to modulate kidney injury and prevent renal fibrosis

DYNAMic renal assessment: nOvel methods to assess KIDNEY functional reserve (DYNAMO KIDNEY)

Determining the role of coagulation proteases in the development of renal fibrosis

Canonical vitamin A signalling in diabetic nephropathy and RA-568 as a novel therapy

The role of intracellular complement activation in podocytes: a potential therapeutic target in proteinuric renal disease?

Claire Sharpe

Personal profile

Research interests

Research interests (short)

Expertise related to UN Sustainable Development Goals

Fingerprint

Collaborations and top research areas from the last five years

Research output

Projects