Research output per year
Research output per year
- 47 results
Search results
-
2024
Cell adhesion and migration in disease: translational and therapeutic opportunities
Anderson, K., Calle-Patino, Y., Ivetic, A., Parsons, M., Valderrama, F., Wells, C. & Anton, I., 2024, In: Cell Adhesion and Migration. 18, 1, p. 1-3 3 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)105 Downloads (Pure) -
PAK6 acts downstream of IQGAP3 to promote contractility in triple negative breast cancer cells
Wells, C., Pipili, K., Grigoriadis, A., Babteen, N., Kuwair, L., Bulu, M., Quist, J., Ong, K., Tutt, A. & Pitaluga, R., Sept 2024, In: Cellular Signalling. 121, 111233.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
CD73 controls Myosin II–driven invasion, metastasis, and immunosuppression in amoeboid pancreatic cancer cells
Samain, R., Maiques, O., Monger, J., Lam, H., Candido, J., George, S., Ferrari, N., Kohihammer, L., Lunetto, S., Varela, A., Orgaz, J. L., Vilardell, F., Olsina, J. J., Matias-Guiu, X., Sarker, D., Biddle, A., Balkwill, F. R., Eyles, J., Wilkinson, R. W. & Kocher, H. M. & 3 others, , 2023, In: Science Advances. 9, 42, adi0244.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (Scopus) -
2022
Differential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells
Murugesan, G., Prescott, A. R., Toth, R., Campbell, D. G., Wells, C. M. & MacKintosh, C., 31 Aug 2022, In: THE BIOCHEMICAL JOURNAL. 479, 16, p. 1709-1725 17 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Invadopodia play a role in prostate cancer progression
Manuelli, V., Cahill, F., Wylie, H., Gillett, C., Correa, I., Heck, S., Rimmer, A., Haire, A., Van Hemelrijck, M., Rudman, S. & Wells, C., 16 Mar 2022, (Accepted/In press) In: BMC Cancer. 22, 1, 386.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)103 Downloads (Pure) -
p21-Activated Kinase 1 Promotes Breast Tumorigenesis via Phosphorylation and Activation of the Calcium/Calmodulin-Dependent Protein Kinase II
Saldivar-Cerón, H. I., Villamar-Cruz, O., Wells, C. M., Oguz, I., Spaggiari, F., Chernoff, J., Patiño-López, G., Huerta-Yepez, S., Montecillo-Aguado, M., Rivera-Pazos, C. M., Loza-Mejía, M. A., Vivar-Sierra, A., Briseño-Díaz, P., Zentella-Dehesa, A., Leon-Del-Rio, A., López-Saavedra, A., Padierna-Mota, L., Ibarra-Sánchez, M. D. J., Esparza-López, J. & Hernández-Rivas, R. & 1 others, , 17 Jan 2022, In: Frontiers in Cell and Developmental Biology. 9, 759259.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (Scopus) -
PAK-dependent regulation of actin dynamics in breast cancer cells
Best, M., Gale, M. E. & Wells, C. M., 31 May 2022, In: International Journal of Biochemistry and Cell Biology. 146, 106207.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)143 Downloads (Pure) -
2021
Exosome-mediated RNAi of PAK4 prolongs survival of pancreatic cancer mouse model after loco-regional treatment
Xu, L., Faruqu, F. N., Lim, Y. M., Lim, K. Y., Liam-Or, R., Walters, A. A., Lavender, P., Fear, D., Wells, C. M., Tzu-Wen Wang, J. & Al-Jamal, K. T., Jan 2021, In: Biomaterials. 264, 120369.Research output: Contribution to journal › Article › peer-review
62 Citations (Scopus) -
2020
Exploring a role for fatty acid synthase in prostate cancer cell migration
De Piano, M., Manuelli, V., Zadra, G., Loda, M., Muir, G., Chandra, A., Morris, J., Van Hemelrijck, M. & Wells, C. M., 1 Jan 2020, (Accepted/In press) In: Small GTPases.Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus) -
Lipogenic signalling modulates prostate cancer cell adhesion and migration via modification of Rho GTPases
De Piano, M., Manuelli, V., Zadra, G., Otte, J., Edqvist, P.-H., Ponten, F., Nowinski, S., Niaouris, A., Grigoriadis, A., Loda, M., Van Hemelrijck, M. & Wells, C. M., 30 Apr 2020, In: Oncogene. 39, 18, p. 3666–3679 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Citations (Scopus)166 Downloads (Pure) -
PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells (vol 29, pg 3385, 2019)
Foxall, E., Staszowska, A., Hirvonen, L. M., Georgouli, M., Ciccioli, M., Rimmer, A., Williams, L., Calle, Y., Sanz-Moreno, V., Cox, S., Jones, G. E. & Wells, C. M., 21 Apr 2020, In: Cell Reports. 31, 3Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
2019
PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells
Foxall, E., Staszowska, A., Hirvonen, L. M., Georgouli, M., Ciccioli, M., Rimmer, A., Williams, L., Calle, Y., Sanz Moreno, V., Cox, S., Jones, G. E. & Wells, C. M., 10 Dec 2019, In: Cell Reports. 29, 11, p. 3385-3393.e6Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)219 Downloads (Pure) -
PlexinB1 Promotes Nuclear Translocation of the Glucocorticoid Receptor
Williamson, M. P., Garg, R. & Wells, C. M., 18 Dec 2019, (E-pub ahead of print) In: Cells. 9, 1, cells9010003.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)72 Downloads (Pure) -
Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling
Breuer, E. K., Fukushiro-Lopes, D., Dalheim, A., Burnette, M., Zartman, J., Kaja, S., Wells, C., Campo, L., Curtis, K. J., Romero-Moreno, R., Littlepage, L. E., Niebur, G. L., Hoskins, K., Nishimura, M. I. & Gentile, S., 1 Mar 2019, In: Cell Death and Disease. 10, 3, 180.Research output: Contribution to journal › Article › peer-review
Open Access62 Citations (Scopus) -
TIMP-2 secreted by monocyte-like cells is a potent suppressor of invadopodia formation in pancreatic cancer cells
Benzing, C., Lam, H., Tsang, C. M., Rimmer, A. G., Arroyo-Berdugo, Y., calle, Y. & Wells, C. M., 3 Dec 2019, (Accepted/In press) In: BMC Cancer.Research output: Contribution to journal › Article › peer-review
-
2017
Differential role for PAK1 and PAK4 during the invadopodia lifecycle
Nicholas, N., Pipili, A., Lesjak, M. S. & Wells, C. M., 17 Mar 2017, (E-pub ahead of print) In: Small GTPases. p. 1-7 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)211 Downloads (Pure) -
PAK4 interacts with p85 alpha: Implications for pancreatic cancer cell migration
King, H., Thillai, K., Whale, A., Arumugam, P., Eldaly, H., Kocher, H. M. & Wells, C. M., 16 Feb 2017, (E-pub ahead of print) In: Scientific Reports. 7, 42575.Research output: Contribution to journal › Article › peer-review
Open AccessFile38 Citations (Scopus)249 Downloads (Pure) -
PAK5 mediates cell: cell adhesion integrity via interaction with E-cadherin in bladder cancer cells
Ismail, A. F., Oskay Halacli, S., Babteen, N., De Piano, M., Martin, T. A., Jiang, W. G., Shamim Khan, M., Dasgupta, P. & Wells, C. M., 1 Apr 2017, In: Biochemical Journal. 474, 8, p. 1333-1346Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)515 Downloads (Pure) -
2016
Deciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer?
Thillai, K., Lam, H., Sarker, D. & Wells, C. M., 11 Nov 2016, In: Oncotarget. 8, 8, p. 14173-14191 19 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Citations (Scopus)276 Downloads (Pure) -
HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer
Ross-Adams, H., Ball, S., Lawrenson, K., Halim, S., Russell, R., Wells, C., Strand, S. H., Ørntoft, T. F., Larson, M., Armasu, S., Massie, C. E., Asim, M., Mortensen, M. M., Borre, M., Woodfine, K., Warren, A. Y., Lamb, A. D., Kay, J., Whitaker, H. & Ramos-Montoya, A. & 8 others, , 9 Oct 2016, In: Oncotarget. 7, 46, p. 74734-74746 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile35 Citations (Scopus)207 Downloads (Pure) -
LIMK Regulates Tumor-Cell Invasion and Matrix Degradation Through Tyrosine Phosphorylation of MT1-MMP
Lagoutte, E., Villeneuve, C., Lafanechère, L., Wells, C. M., Jones, G. E., Chavrier, P. & Rossé, C., 27 Apr 2016, In: Scientific Reports. 6, 24925.Research output: Contribution to journal › Article › peer-review
Open AccessFile61 Citations (Scopus)205 Downloads (Pure) -
PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells
Nicholas, N., Pipili, A., Lesjak, M. S., Ameer-Beg, S., Geh, J., Healy, C., MacKenzie Ross, A., Parsons, M., Nestle, F. O., Lacy, K. & Wells, C. M., 27 Sept 2016, In: Oncotarget. 7, 43, p. 70881-70897Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus)267 Downloads (Pure) -
Significance of kinase activity in the dynamic invadosome
Foxall, E. A., Pipili, A., Jones, G. E. & Wells, C. M., 11 Nov 2016, In: European Journal of Cell Biology. 95, 11, p. 483-492Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)335 Downloads (Pure) -
2015
A novel role for atypical MAPK kinase ERK3 in regulating breast cancer cell morphology and migration
Al-Mahdi, R., Babteen, N., Thillai, K., Holt, M., Johansen, B., Wetting, H. L., Seternes, O. M. & Wells, C. M., 20 Nov 2015, In: Cell Adhesion & Migration. 9, 6, p. 483-494 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile49 Citations (Scopus)215 Downloads (Pure) -
PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion
Dart, A. E., Box, G. M., Court, W., Gale, M. E., Brown, J. P., Pinder, S. E., Eccles, S. A. & Wells, C. M., 23 Nov 2015, In: The Journal of cell biology. 211, 4, p. 863-879 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile63 Citations (Scopus)360 Downloads (Pure) -
Specific Myosins Control Actin Organization, Cell Morphology, and Migration in Prostate Cancer Cells
Makowska, K. A., Hughes, R. E., White, K. J., Wells, C. M. & Peckham, M., 15 Dec 2015, In: Cell Reports. 13, 10, p. 2118-2125 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile85 Citations (Scopus)184 Downloads (Pure) -
2014
A PAK6-IQGAP1 complex promotes disassembly of cell-cell adhesions
Fram, S., King, H., Sacks, D. B. & Wells, C. M., Jul 2014, In: Cellular and Molecular Life Sciences. 71, 14, p. 2759-2773 15 p.Research output: Contribution to journal › Article › peer-review
Open Access33 Citations (Scopus) -
Role of p-21-Activated Kinases in Cancer Progression
King, H., Nicholas, N. S. & Wells, C. M., 2014, In: InternationalReview of Cell and Molecular Biology. 309, p. 347-387 41 p.Research output: Contribution to journal › Article › peer-review
84 Citations (Scopus) -
Time-resolved multifocal multiphoton microscope for high speed FRET imaging in vivo
Poland, S. P., Krstajić, N., Coelho, S., Tyndall, D., Walker, R. J., Devauges, V., Morton, P. E., Nicholas, N. S., Richardson, J., Li, D. D. U., Suhling, K., Wells, C. M., Parsons, M., Henderson, R. K. & Ameer-Beg, S. M., 15 Oct 2014, In: Optics Letters. 39, 20, p. 6013-6016 4 p.Research output: Contribution to journal › Article › peer-review
37 Citations (Scopus) -
2013
Hypoxia-induced invadopodia formation: a role for β-PIX
Md Hashim, N. F., Nicholas, N. S., Dart, A. E., Kiriakidis, S., Paleolog, E. & Wells, C. M., Jun 2013, In: Open Biology. 3, 6, p. 120159Research output: Contribution to journal › Article › peer-review
Open Access42 Citations (Scopus) -
Imaging haematopoietic cells recruitment to an acute wound in vivo identifies a role for c-Met signalling
Falenta, K., Rodaway, A., Jones, G. E. & Wells, C. M., Jun 2013, In: Journal of Microscopy. 250, 3, p. 200-9 10 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
Nox2 Is Required for Macrophage Chemotaxis towards CSF-1
Chaubey, S., Jones, G. E., Shah, A. M., Cave, A. C. & Wells, C. M., 1 Feb 2013, In: PL o S One . 8, 2, e54869.Research output: Contribution to journal › Article › peer-review
24 Citations (Scopus) -
P21-activated kinase 4 - Not just one of the PAK
Dart, A. E. & Wells, C. M., 1 Apr 2013, In: European Journal of Cell Biology. 92, 4-5, p. 129-138 10 p.Research output: Contribution to journal › Article › peer-review
80 Citations (Scopus) -
PAK4 kinase activity and somatic mutation promote carcinoma cell motility and influence inhibitor sensitivity
Whale, A. D., Dart, A., Holt, M., Jones, G. E. & Wells, C. M., 18 Apr 2013, In: Oncogene. 32, 16, p. 2114-2120 7 p.Research output: Contribution to journal › Article › peer-review
41 Citations (Scopus) -
2011
Signalling to cancer cell invasion through PAK family kinases
Whale, A., Hashim, F. N., Fram, S., Jones, G. E. & Wells, C. M., 1 Jan 2011, In: Frontiers in Bioscience. 16, 3, p. 849 - 864 16 p.Research output: Contribution to journal › Article › peer-review
83 Citations (Scopus) -
2010
PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion
Wells, C. M., Whale, A. D., Parsons, M., Masters, J. R. W. & Jones, G. E., 15 May 2010, In: Journal of Cell Science. 123, 10, p. 1663 - 1673 11 p.Research output: Contribution to journal › Article › peer-review
89 Citations (Scopus) -
2008
A PAK4-LIMK1 pathway drives prostate cancer cell migration downstream of HGF
Ahmed, T., Shea, K., Masters, J. R. W., Jones, G. E. & Wells, C. M., Jul 2008, In: Cellular Signalling. 20, 7, p. 1320 - 1328 9 p.Research output: Contribution to journal › Article › peer-review
120 Citations (Scopus) -
ROCK1 and LIMK2 Interact in Spread but Not Blebbing Cancer Cells
Shea, K. F., Wells, C. M., Garner, A. P. & Jones, G. E., 14 Oct 2008, In: PL o S One . 3, 10, e3398.Research output: Contribution to journal › Article › peer-review
20 Citations (Scopus) -
2006
Rac1 and Rac2 regulate macrophage morphology but are not essential for migration
Wheeler, A. P., Wells, C. M., Smith, S. D., Vega, F. M., Henderson, R. B., Tybulewicz, V. L. & Ridley, A. J., 1 Jul 2006, In: Journal of Cell Science. 119, 13, p. 2749 - 2757 9 p.Research output: Contribution to journal › Article › peer-review
164 Citations (Scopus) -
2005
Analysis of cell migration using the Dunn chemotaxis chamber and time-lapse microscopy
Wells, C. M. & Ridley, A. J., 2005, In: Methods in Molecular Biology. 294, N/A, p. 31-41 11 p., N/A.Research output: Contribution to journal › Article › peer-review
30 Citations (Scopus) -
Rho family GTPases are activated during HGF-stimulated prostate cancer-cell scattering
Wells, C. M., Ahmed, T., Masters, J. R. W. & Jones, G. E., Nov 2005, In: Cell Motility and the Cytoskeleton. 62, 3, p. 180 - 194 15 p.Research output: Contribution to journal › Article › peer-review
38 Citations (Scopus) -
Vav1 and Vav2 play different roles in macrophage migration and cytoskeletal organization
Wells, C. M., Bhavsar, P. J., Evans, I. R., Vigorito, E., Turner, M., Tybulewicz, V. & Ridley, A. J., 1 Nov 2005, In: Experimental Cell Research. 310, 2, p. 303 - 310 8 p.Research output: Contribution to journal › Article › peer-review
38 Citations (Scopus) -
2004
Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migration
Wells, C. M., Walmsley, M., Ooi, S., Tybulewicz, V. & Ridley, A. J., 1 Mar 2004, In: Journal of Cell Science. 117, 7, p. 1259 - 1268 10 p.Research output: Contribution to journal › Article › peer-review
158 Citations (Scopus) -
2002
PAK4 is activated via PI3K in HGF-stimulated epithelial cells
Wells, C. M., Abo, A. & Ridley, A. J., 15 Oct 2002, In: Journal of Cell Science. 115, 20, p. 3947 - 3956 10 p.Research output: Contribution to journal › Article › peer-review
98 Citations (Scopus) -
2001
Specific changes to the mechanism of cell locomotion induced by overexpression of beta-actin
Peckham, M., Miller, G., Wells, C., Zicha, D. & Dunn, G. A., 2001, In: Journal of Cell Science. 114, 7, p. 1367 - 1377 11 p.Research output: Contribution to journal › Article › peer-review
62 Citations (Scopus) -
1999
Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages
Vanhaesebroeck, B., Jones, G. E., Allen, W., Zicha, D., Hooshmand-Rad, R., Sawyer, C., Wells, C., Waterfield, M. & Ridley, A., 1 May 1999, In: Nature Cell Biology. 1, 1, p. 69-71 3 p.Research output: Contribution to journal › Article › peer-review
204 Citations (Scopus) -
1997
Myogenic cells express multiple myosin isoforms
Wells, C., Coles, D., Entwistle, A. & Peckham, M., 1997, In: Journal of Muscle Research and Cell Motility. 18, 5, p. 501-15 15 p.Research output: Contribution to journal › Article › peer-review
28 Citations (Scopus)