Research output per year
Research output per year
The complement system has long thought to be a primitive stop-gap measure used to slow down infection until the more sophisticated adaptive immune system can undertake its highly potent attacks using antibodies and cells tailored to the specific target. It has become clear how simplified this view had been: the successful immune defense is now seen as a complex process in which the innate part plays vital roles in the instruction of adaptive immunity.
My research focuses on a novel crosstalk between the complement system, specifically the complement protein CD46, and T cell responses as CD46 signaling induces the development of IL-10-secreting adaptive regulatory T cells (Tregs).
We propose that understanding the underlying mechanisms that shape this novel important interplay between the complement system and T cells would significantly advance our ability to develop more effective immunotherapies to control T cell-mediated disease conditions. Thus, I intend to build a research program aimed at elucidating the role of complement-induced Tregs in normal immune homeostasis and states of chronic inflammation such as autoimmunity or pathogen persistence.
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Review article › peer-review
Research output: Contribution to journal › Letter › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Dorling, A. (Primary Investigator), Kemper, C. (Co-Investigator) & Douthwaite, H. (Co-Investigator)
1/10/2016 → 4/01/2023
Project: Research
Sharpe, C. (Primary Investigator) & Kemper, C. (Co-Investigator)
1/08/2016 → 1/08/2019
Project: Research
Kemper, C. (Primary Investigator) & Powell, N. (Co-Investigator)
1/07/2016 → 30/06/2017
Project: Research
Cope, A. (Primary Investigator) & Kemper, C. (Co-Investigator)
1/04/2016 → 31/03/2019
Project: Research
Robson, M. (Primary Investigator) & Kemper, C. (Co-Investigator)
1/04/2016 → 31/03/2019
Project: Research