King's College London

Research portal

Dr Cristina Legido Quigley

  1. Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum

    Bos, I., Vos, S., Verhey, F., Scheltens, P., Teunissen, C., Engelborghs, S., Sleegers, K., Frisoni, G., Blin, O., Richardson, J. C., Bordet, R., Tsolaki, M., Popp, J., Peyratout, G., Martinez-Lage, P., Tainta, M., Lleó, A., Johannsen, P., Freund-Levi, Y., Frölich, L. & 12 othersVandenberghe, R., Westwood, S., Dobricic, V., Barkhof, F., Legido-Quigley, C., Bertram, L., Lovestone, S., Streffer, J., Andreasson, U., Blennow, K., Zetterberg, H. & Visser, P. J., 1 Jan 2019, In : Alzheimer's and Dementia.

    Research output: Contribution to journalArticle

  2. MRI predictors of amyloid pathology: Results from the EMIF-AD Multimodal Biomarker Discovery study

    Ten Kate, M., Redolfi, A., Peira, E., Bos, I., Vos, S. J., Vandenberghe, R., Gabel, S., Schaeverbeke, J., Scheltens, P., Blin, O., Richardson, J. C., Bordet, R., Wallin, A., Eckerstrom, C., Molinuevo, J. L., Engelborghs, S., Van Broeckhoven, C., Martinez-Lage, P., Popp, J., Tsolaki, M. & 17 othersVerhey, F. R. J., Baird, A. L., Legido-Quigley, C., Bertram, L., Dobricic, V., Zetterberg, H., Lovestone, S., Streffer, J., Bianchetti, S., Novak, G. P., Revillard, J., Gordon, M. F., Xie, Z., Wottschel, V., Frisoni, G., Visser, P. J. & Barkhof, F., 27 Sep 2018, In : Alzheimer's Research and Therapy. 10, 1, 100.

    Research output: Contribution to journalArticle

  3. The EMIF-AD Multimodal Biomarker Discovery study: Design, methods and cohort characteristics

    Bos, I., Vos, S., Vandenberghe, R., Scheltens, P., Engelborghs, S., Frisoni, G., Molinuevo, J. L., Wallin, A., Lleó, A., Popp, J., Martinez-Lage, P., Baird, A., Dobson, R., Legido-Quigley, C., Sleegers, K., Van Broeckhoven, C., Bertram, L., Ten Kate, M., Barkhof, F., Zetterberg, H. & 3 othersLovestone, S., Streffer, J. & Visser, P. J., 6 Jul 2018, In : Alzheimer's Research and Therapy. 10, 1, 64.

    Research output: Contribution to journalArticle

  4. Alterations in gut microbial function following liver transplant

    Bajaj, J. S., Kakiyama, G., Cox, I. J., Nittono, H., Takei, H., White, M., Fagan, A., Gavis, E. A., Heuman, D. M., Gilles, H. C., Hylemon, P., Taylor-Robinson, S. D., Legido-Quigley, C., Kim, M., Xu, J., Williams, R., Sikaroodi, M., Pandak, W. M. & Gillevet, P. M., 1 Jun 2018, In : Liver Transplantation. 24, 6, p. 752-761 10 p.

    Research output: Contribution to journalArticle

  5. Coping with iron limitation: a metabolomic study of Synechocystis sp. PCC 6803

    Rivas-Ubach, A., Poret-Peterson, A. T., Peñuelas, J., Sardans, J., Pérez-Trujillo, M., Legido-Quigley, C., Oravec, M., Urban, O. & Elser, J. J., Feb 2018, In : Acta Physiologiae Plantarum. 40, 2, 28.

    Research output: Contribution to journalArticle

  6. Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study

    Varma, V. R., Oommen, A. M., Varma, S., Casanova, R., An, Y., Andrews, R. M., O’Brien, R., Pletnikova, O., Troncoso, J. C., Toledo, J., Baillie, R., Arnold, M., Kastenmueller, G., Nho, K., Doraiswamy, P. M., Saykin, A. J., Kaddurah-Daouk, R., Legido-Quigley, C. & Thambisetty, M., 25 Jan 2018, In : PLoS Medicine. 15, 1, e1002482.

    Research output: Contribution to journalArticle

  7. DISCOVERY, REPLICATION AND EXTENSION STUDY OF PLASMA PROTEOMIC BIOMARKERS RELATING TO BRAIN AMYLOID BURDEN (CSF Aβ OR AMYLOID-PET) IN THE EMIF-AD BIOMARKER DISCOVERY COHORT: 2017 Abstract Supplement

    Westwood, S., Baird, A. L., Hye, A., Bos, I., Vos, S. J. B., Vandenberghe, R., Scheltens, P., Engelborghs, S., Frisoni, G. B., Molinuevo, J. L., Wallin, A., Lleó, A., Popp, J., Martinez-Lage, P., Snowden, S. G., Legido-Quigley, C., Bertram, L., Barkhof, F., Zetterberg, H., Streffer, J. & 2 othersVisser, P. J. & Lovestone, S., 20 Oct 2017, In : Alzheimer's & Dementia. 13, 7, Supplement, p. P361-P362

    Research output: Contribution to journalArticle

  8. Evidence for brain glucose dysregulation in Alzheimer's disease

    An, Y., Varma, V. R., Varma, S., Casanova, R., Dammer, E., Pletnikova, O., Chia, C. W., Egan, J. M., Ferrucci, L., Troncoso, J., Levey, A. I., Lah, J., Seyfried, N. T., Legido-Quigley, C., O'Brien, R. & Thambisetty, M., 19 Oct 2017, In : Alzheimer's & Dementia.

    Research output: Contribution to journalArticle

  9. Metabolic phenotyping in the mouse model of urinary tract infection shows that 3-hydroxybutyrate in plasma is associated with infection

    Han, P., Huang, Y., Xie, Y., Yang, W., Wang, Y., Xiang, W., Hylands, P. J. & Legido Quigley, C., 16 Oct 2017, In : PL o S One . 12, 10, e0186497.

    Research output: Contribution to journalArticle

  10. Determination of glucosamine in food supplements by HILIC-ESI-MS

    Zheng, L., Kim, M., Hana, P. & Legido-Quigley, C., 1 Oct 2017, European Pharmaceutical Review, 22, 5, p. 62-65 4 p.

    Research output: Contribution to specialist publicationArticle

  11. Direct monitoring of Exogenous γ-Hydroxybutyric Acid in body fluids by NMR spectroscopy

    Palomino-Schätzlein, M., Wang, Y., Parella, T., Brailsford, A. D., Cowan, D. A., Legido-Quigley, C. & Pérez-Trujillo, M., 15 Aug 2017, In : Analytical Chemistry. 89, 16, p. 8343-8350 8 p.

    Research output: Contribution to journalArticle

  12. Metabolic network failures in Alzheimer's disease-A biochemical road map

    Toledo, J. B., Arnold, M., Kastenmüller, G., Chang, R., Baillie, R. A., Han, X., Thambisetty, M., Tenenbaum, J. D., Suhre, K., Thompson, J. W., John-Williams, L. S., MahmoudianDehkordi, S., Rotroff, D. M., Jack, J. R., Motsinger-Reif, A., Risacher, S. L., Blach, C., Lucas, J. E., Massaro, T., Louie, G. & 24 othersZhu, H., Dallmann, G., Klavins, K., Koal, T., Kim, S., Nho, K., Shen, L., Casanova, R., Varma, S., Legido-Quigley, C., Moseley, M. A., Zhu, K., Henrion, M. Y. R., van der Lee, S. J., Harms, A. C., Demirkan, A., Hankemeier, T., van Duijn, C. M., Trojanowski, J. Q., Shaw, L. M., Saykin, A. J., Weiner, M. W., Doraiswamy, P. M. & Kaddurah-Daouk, R., 22 Mar 2017, In : Alzheimer's & Dementia.

    Research output: Contribution to journalArticle

  13. Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study

    Snowden, S. G., Ebshiana, A. A., Hye, A., An, Y., Pletnikova, O., O’Brien, R., Troncoso, J., Legido Quigley, C. & Thambisetty, M., 21 Mar 2017, In : PL o S Medicine. 14, 3, p. e1002266 e1002266.

    Research output: Contribution to journalArticle

  14. Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis

    Proitsi, P., Kim, M., Whiley, L., Simmons, A., Sattlecker, M., Velayudhan, L., Lupton, M. K., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S., Powell, J. F., Dobson, R. J. B. & Legido-Quigley, C., Feb 2017, In : Alzheimer's & Dementia. 13, 2, p. 140-151 12 p.

    Research output: Contribution to journalArticle

  15. Peril beyond the winner's curse-A small sample size is the bane of biomarker discovery

    Thambisetty, M., Casanova, R., Varma, S. & Legido Quigley, C., 21 Jan 2017, In : Alzheimer's & Dementia. 2 p.

    Research output: Contribution to journalArticle

  16. The Impact of Ischemia/Reperfusion Injury on Liver Allografts from Deceased after Cardiac Death versus Deceased after Brain Death Donors

    Xu, J., Sayed, B. A., Casas-Ferreira, A. M., Srinivasan, P., Heaton, N., Rela, M., Ma, Y., Fuggle, S., Legido-Quigley, C. & Jassem, W., 10 Feb 2016, In : PLoS ONE. 11, 2, p. e0148815

    Research output: Contribution to journalArticle

  17. Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individuals

    Casanova, R., Varma, S., Simpson, B., Kim, M., An, Y., Saldana, S., Riveros, C., Moscato, P., Griswold, M., Sonntag, D., Wahrheit, J., Klavins, K., Jonsson, P. V., Eiriksdottir, G., Aspelund, T., Launer, L. J., Gudnason, V., Quigley, C. L. & Thambisetty, M., 21 Jan 2016, In : Alzheimer's & Dementia.

    Research output: Contribution to journalArticle

  18. Lipidomics comparing DCD and DBD liver allografts uncovers lysophospholipids elevated in recipients undergoing early allograft dysfunction

    Xu, J., Casas-Ferreira, A. M., Ma, Y., Sen, A., Kim, M., Proitsi, P., Shkodra, M., Tena, M., Srinivasan, P., Heaton, N., Jassem, W. & Legido-Quigley, C., 4 Dec 2015, In : Scientific Reports. 5, 10 p., 17737.

    Research output: Contribution to journalArticle

  19. Blood metabolite markers of cognitive performance and brain function in aging

    Simpson, B. N., Kim, M., Chuang, Y-F., Beason-Held, L., Kitner-Triolo, M., Kraut, M., Lirette, S. T., Windham, B. G., Griswold, M. E., Legido-Quigley, C. & Thambisetty, M., 29 Oct 2015, In : Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

    Research output: Contribution to journalArticle

  20. Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer's disease

    Proitsi, P., Kim, M., Whiley, L., Pritchard, M., Leung, R., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Sham, P., Lovestone, S., Powell, J. F., Dobson, R. J. B. & Legido-Quigley, C., 13 Jan 2015, In : Translational psychiatry. 5, 8 p., e494.

    Research output: Contribution to journalArticle

  21. Adenosine monophosphate is elevated in the bronchoalveolar lavage fluid of mice with acute respiratory toxicity induced by nanoparticles with high surface hydrophobicity

    Dailey, L. A., Hernández-Prieto, R., Casas-Ferreira, A. M., Jones, M-C., Riffo-Vasquez, Y., Rodríguez-Gonzalo, E., Spina, D., Jones, S. A., Smith, N. W., Forbes, B., Page, C. & Legido-Quigley, C., 2015, In : Nanotoxicology. 9, 1, p. 106-115

    Research output: Contribution to journalArticle

  22. Investigating sub-2 μm particle stationary phase supercritical fluid chromatography coupled to mass spectrometry for chemical profiling of chamomile extracts

    Jones, M. D., Avula, B., Wang, Y-H., Lu, L., Zhao, J., Avonto, C., Isaac, G., Meeker, L., Yu, K., Legido-Quigley, C., Smith, N. & Khan, I. A., 17 Oct 2014, In : ANALYTICA CHIMICA ACTA. 847, p. 61-72 12 p.

    Research output: Contribution to journalArticle

  23. Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease

    Whiley, L., Sen, A., Heaton, J., Proitsi, P., Garcia-Gomez, D., Leung, R., Smith, N., Thambisetty, M., Kloszewska, I., Mecocci, P., Soininen, H., Tsolaki, M., Vellas, B., Lovestone, S. & Legido Quigley, C., 1 Feb 2014, In : Neurobiology of Aging. 35, 2, p. 271-278 8 p.

    Research output: Contribution to journalArticle

  24. High sensitivity LC-MS/MS method for direct quantification of human parathyroid 1-34 (teriparatide) in human plasma

    Chambers, E. E., Lame, M. E., Bardsley, J., Hannam, S., Legido-Quigley, C., Smith, N., Fountain, K. J., Collins, E. & Thomas, E., 1 Nov 2013, In : Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences. 938, p. 96-104 9 p.

    Research output: Contribution to journalArticle

  25. In-vial dual extraction liquid chromatography coupled to mass spectrometry applied to streptozotocin-treated diabetic rats. Tips and pitfalls of the method

    Godzien, J., Ciborowski, M., Whiley, L., Legido-Quigley, C., Ruperez, F. J. & Barbas, C., 23 Aug 2013, In : Journal of Chromatography A. 1304, p. 52-60 9 p.

    Research output: Contribution to journalArticle

  26. Metabolic Phenotype of the Healthy Rodent Model Using In-Vial Extraction of Dried Serum, Urine, and Cerebrospinal Fluid Spots

    Sen, A., Wang, Y., Chiu, K., Whiley, L., Cowan, D., Cheun-Chung Chang, R. & Legido Quigley, C., 6 Aug 2013, In : Analytical Chemistry. 85, 15, p. 7257–7263 7 p., N/A.

    Research output: Contribution to journalArticle

  27. In-Vial Dual Extraction for Direct LC-MS Analysis of Plasma for Comprehensive and Highly Reproducible Metabolic Fingerprinting

    Whiley, L., Godzien, J., Ruperez, F. J., Legido Quigley, C. & Barbas, C., 17 Jul 2012, In : Analytical Chemistry. 84, 14, p. 5992-5999 8 p.

    Research output: Contribution to journalArticle

  28. Comparison of reversed-phase and hydrophilic interaction liquid chromatography for the separation of ephedrines

    Heaton, J., Gray, N., Cowan, D. A., Plumb, R. S., Legido-Quigley, C. & Smith, N. W., 9 Mar 2012, In : Journal of Chromatography A. 1228, p. 329 - 337 9 p.

    Research output: Contribution to journalArticle

  29. Bile UPLC-MS fingerprinting and bile acid fluxes during human liver transplantation

    Legido-Quigley, C., McDermott, L., Vilca-Melendez, H., Murphy, G. M., Heaton, N., Lindon, J. C., Nicholson, J. K. & Holmes, E., Aug 2011, In : Electrophoresis. 32, 15, p. 2063 - 2070 8 p.

    Research output: Contribution to journalArticle

  30. Evaluation of Chinese medicinal herbs fingerprinting by HPLC-DAD for the detection of toxic aristolochic acids

    Heaton, J., Whiley, L., Hong, Y., Sebastian, C. M., Smith, N. W. & Legido-Quigley, C., May 2011, In : JOURNAL OF SEPARATION SCIENCE. 34, 10, p. 1111 - 1115 5 p.

    Research output: Contribution to journalArticle

  31. Current strategies in the discovery of small-molecule biomarkers for Alzheimer's disease

    Whiley, L. & Legido-Quigley, C., 2011, In : Bioanalysis. 3, 10, p. 1121 - 1142 22 p.

    Research output: Contribution to journalLiterature review

  32. Metabolite-biomarker investigations in the life cycle of and infection with Schistosoma

    Legido-Quigley, C., Aug 2010, In : Parasitology. 137, 9, p. 1425 - 1435 11 p.

    Research output: Contribution to journalArticle

  33. Chemometric analysis of urine fingerprints acquired by liquid chromatography-mass spectrometry and capillary electrophoresis: Application to the schistosomiasis mouse model

    Garcia-Perez, I., Earll, M. E., Angulo, S., Barbas, C. & Legido-Quigley, C., Jul 2010, In : Electrophoresis. 31, 14, p. 2349 - 2355 7 p.

    Research output: Contribution to journalArticle

  34. Chemometric and biological validation of a capillary electrophoresis metabolomic experiment of Schistosoma mansoni infection in mice

    Garcia-Perez, I., Angulo, S., Utzinger, J., Holmes, E., Legido-Quigley, C. & Barbas, C., Jul 2010, In : Electrophoresis. 31, 14, p. 2338 - 2348 11 p.

    Research output: Contribution to journalArticle

  35. Guidelines for reporting the use of capillary electrophoresis in proteomics

    Domann, P. J., Akashi, S., Barbas, C., Huang, L., Lau, W., Legido-Quigley, C., McClean, S., Neusuess, C., Perrett, D., Quaglia, M., Rapp, E., Smallshaw, L., Smith, N. W., Smyth, W. F. & Taylor, C. F., Jul 2010, In : Nature Biotechnology. 28, 7, p. 654 - 655 2 p.

    Research output: Contribution to journalLetter

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