Research output per year
Research output per year
Personal profile
Biographical details
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The Clinical Biomarkers lab has been based in KCL since 2006, headed by Dr Legido-Quigley the lab is equiped with HPLC-UV, UPLC-q-ToF and GC-MS for chemical analysis and fingerprinting. Funding for biomarker research is secured via goverment allocated research funding (US, China, Saudi, Libya), EU funded collaborative projects with both academic and industry partners (EMIF-AD), UK goverment funding (MRC-NIHR National Phenome Center) and major charities funding research (Alzheimer's Association, ARUK, ROTRF).
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Collaborations and clinical projects are to do with discovering small molecule biomarkers in clinical fields, to find early diagnosis or biochemical pathways that are implicated in the disease progressing. Also called metabolomics this technology is combined with other -omics to extract information on disease mechanisms. Current projects are to do with Alzheimer's disease and dementia, schizophrenia, metabolic syndrome, diabetes and liver disease.
Research interests (short)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Evaluating metabolome-wide causal effects on risk for psychiatric and neurodegenerative disorders
Gilchrist, L., Mutz, J., Hysi, P., Legido-Quigley, C., Kõks, S., Lewis, C. M. & Proitsi, P., 2 Jun 2025, In: BMC Medicine. 23, 1, p. 326 326.Research output: Contribution to journal › Article › peer-review
Open Access -
Sex-Specific Alterations of the Kynurenine Pathway in Association with Risk for and Remission of Depression in Adolescence
Nikkheslat, N., Zajkowska, Z., Legido-Quigley, C., Xu, J., Manfro, P. H., Souza, L., Pereira, R., Rohrsetzer, F., Piccin, J., Viduani, A., Kohrt, B. A., Fisher, H., Kieling, C. & Mondelli, V., 25 Mar 2025, (E-pub ahead of print) In: Biological psychiatry.Research output: Contribution to journal › Article › peer-review
Open Access -
Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning
Neumann, A., Ohlei, O., Küçükali, F., Bos, I. J., Timsina, J., Vos, S., Prokopenko, D., Tijms, B. M., Andreasson, U., Blennow, K., Vandenberghe, R., Scheltens, P., Teunissen, C. E., Engelborghs, S., Frisoni, G. B., Blin, O., Richardson, J. C., Bordet, R., Lleó, A. & Alcolea, D. & 21 others, , Dec 2023, In: Genome medicine. 15, 1, 79.Research output: Contribution to journal › Article › peer-review
Open Access12 Citations (Scopus) -
Disentangling Independent and Mediated Causal Relationships Between Blood Metabolites, Cognitive Factors, and Alzheimer's Disease
Alzheimer’s Disease Neuroimaging Initiative & GERAD1 Consortium, and AddNeuroMed, Apr 2022, In: Biological Psychiatry Global Open Science. 2, 2, p. 167-179 13 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
Genome-Wide Association Study of Alzheimer’s Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer’s Disease Multimodal Biomarker Discovery Dataset
Homann, J., Osburg, T., Ohlei, O., Dobricic, V., Deecke, L., Bos, I., Vandenberghe, R., Gabel, S., Scheltens, P., Teunissen, C. E., Engelborghs, S., Frisoni, G., Blin, O., Richardson, J. C., Bordet, R., Lleó, A., Alcolea, D., Popp, J., Clark, C. & Peyratout, G. & 18 others, , 21 Mar 2022, In: Frontiers in Aging Neuroscience. 14, 840651.Research output: Contribution to journal › Article › peer-review
Open Access26 Citations (Scopus)
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Lipid dysregulation in people with Alzheimer's Dementia: A focus on Women Systems Medicine
Legido Quigley, C. (Primary Investigator)
1/05/2021 → 6/01/2027
Project: Research
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Deciphering the causal relationship between blood metabolic biomarkers and Alzheimer's Disease
Proitsi, P. (Primary Investigator), Dobson, R. (Co-Investigator), Legido Quigley, C. (Co-Investigator) & Powell, J. (Co-Investigator)
1/03/2017 → 30/09/2023
Project: Research
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Integrating metabolite and genetic data to identify biomarkers and assess causality in Alzheimer’s Disease (MetabGenAD)
Proitsi, P. (Primary Investigator), Dobson, R. (Co-Investigator), Legido Quigley, C. (Co-Investigator) & Powell, J. (Co-Investigator)
1/04/2016 → 31/03/2021
Project: Research
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Plasma and brain metabolic biomarkers associated with rates of brain atrophy, amyloid accumulation
Legido Quigley, C. (Primary Investigator)
NIH National Institutes of Health
28/12/2015 → 27/12/2018
Project: Research
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Deciphering the causal association between plasma metabolic biomarkers and Alzheimer's Disease
Proitsi, P. (Primary Investigator), Dobson, R. (Co-Investigator), Legido Quigley, C. (Co-Investigator) & Powell, J. (Co-Investigator)
1/12/2015 → 30/11/2019
Project: Research