Projects per year
Search results
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Active
Evolving cyclopropane fatty acid synthase (CFAS) enzymes into biocatalysts for the synthesis of cyclopropane containing drugs and chemicals
Castagnolo, D. (Primary Investigator)
GSK GlaxoSmithKline Research & Development Ltd
1/10/2021 → 30/09/2025
Project: Research
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Not started
Development of cyclopropane synthases as novel biocatalysts for cyclopropanation reactions
Castagnolo, D. (Primary Investigator)
Project: Research
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Finished
PhotoLIB: Photoswitchable amphiphilic Lipids: a photopharmacology strategy to combat drug-resistant Bacterial infections
Castagnolo, D. (Primary Investigator)
1/06/2021 → 31/08/2023
Project: Research
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Development of lactonase enzymes, a new class of biocatalysts for the stereocontrolled chemoenzymatic synthesis of antibacterial gamma-hydroxy-(alpha,beta-unsaturated)-fatty acids
Castagnolo, D. (Primary Investigator)
11/01/2021 → 10/01/2023
Project: Research
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Development of alcohol dehydrogenase (ADH) and ene-reductase (ERED) enzymes for the production of enantiopure sulphur-containing flavours and fragrances.
Castagnolo, D. (Primary Investigator)
1/10/2020 → 30/09/2024
Project: Research
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BioPhoCS: Bio- & Photo-Catalytic Methods for the Construction of Enantiomerically Pure C-S Bonds in Thiols and Sulphides
Castagnolo, D. (Primary Investigator)
1/09/2020 → 31/05/2025
Project: Research
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Assessing the relevance of Galleria mellonella to antibiotic drug discovery for pulmonary infections
Mason, J. (Primary Investigator), Amison, R. (Co-Investigator), Page, C. (Co-Investigator), Pitchford, S. (Co-Investigator), Bruce, K. (Co-Investigator), Rahman, M. (Co-Investigator), Castagnolo, D. (Co-Investigator) & Panaretou, B. (Co-Investigator)
NC3Rs National Centre for the Replacement, Refinement and Reduction of Animals in Research
3/06/2019 → 2/12/2019
Project: Research
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Development of P450 and BVMO biocatalysts for the stereocontrolled production of the garlic sulphoxide components
Castagnolo, D. (Primary Investigator)
1/10/2018 → 30/09/2022
Project: Research
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Development of cyclopropane synthases as novel biocatalysts for cyclopropanation reactions
Castagnolo, D. (Primary Investigator)
BBSRC Biotechnology and Biological Sciences Research Council
1/05/2018 → 31/10/2018
Project: Research
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Development of novel iron/zinc chelators and Carbon Monoxide Releasing Molecules (CORMs): a novel approach for the treatment of Pseudomonas aeruginosa infections
Castagnolo, D. (Primary Investigator) & Toscani, A. (Co-Investigator)
1/10/2017 → 30/09/2019
Project: Research
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Development of biocatalytic and chemoenzymatic cascade reactions as sustainable diversity-oriented synthetic strategies in drug discovery
Castagnolo, D. (Primary Investigator)
1/09/2017 → 31/08/2020
Project: Research
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Microwave combinatorial synthesis of siderophore-antibiotic conjugates: development of an alternative drug delivery strategy against drug-resistant bacteria
Castagnolo, D. (Primary Investigator)
1/04/2017 → 31/03/2018
Project: Research
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insideVIR - In silico-assisted development of small-molecule inhibitors of virus replication
Castagnolo, D. (Primary Investigator) & Barlow, D. (Co-Investigator)
1/10/2016 → 30/09/2020
Project: Research
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Characterization of the mechanism of action of new hybrid drugs targeting multi-drug resistant (MDR) tuberculosis
Castagnolo, D. (Primary Investigator)
1/10/2016 → 30/09/2017
Project: Research
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Development of siderophore-antibiotic conjugates as an alternative drug delivery strategy to tackle multi-drug resistance in bacterial lung infections
Castagnolo, D. (Primary Investigator) & Page, C. (Co-Investigator)
EPSRC Engineering and Physical Sciences Research Council
1/10/2016 → 31/03/2017
Project: Research
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Development of biocatalytic and chemoenzymatic iminium cascade reactions exploiting monoamino oxidases (MAO & HDNO)
Castagnolo, D. (Primary Investigator)
EPSRC Engineering and Physical Sciences Research Council
1/07/2016 → 31/03/2017
Project: Research
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Development of chemo-enzymatic cascades for the production of N-heterocycles disclosing the monoamino oxidase (MAO) aromatizing activity
Castagnolo, D. (Primary Investigator)
19/08/2015 → 18/08/2019
Project: Research