King's College London

Research portal

Dr David Begley

  1. Anatomical changes and pathophysiology of the brain in mucopolysaccharidosis disorders

    Bigger, B. W., Begley, D. J., Virgintino, D. & Pshezhetsky, A. V., 1 Jan 2018, (Accepted/In press) In: MOLECULAR GENETICS AND METABOLISM.

    Research output: Contribution to journalArticlepeer-review

  2. Uptake and metabolism of sulphated steroids by the blood–brain barrier in the adult male rat

    Qaiser, M. Z., Dolman, D. E. M., Begley, D. J., Abbott, N. J., Cazacu-Davidescu, M., Corol, D. I. & Fry, J. P., 1 Sep 2017, In: Journal of Neurochemistry. 142, 5, p. 672-685 14 p.

    Research output: Contribution to journalArticlepeer-review

  3. Heat shock protein-based therapy as a potential candidate for treating the sphingolipidoses

    Kirkegaard, T., Gray, J., Priestman, D. A., Wallom, K. L., Atkins, J., Olsen, O. D., Klein, A., Drndarski, S., Petersen, N. H. T., Ingemann, L., Smith, D. A., Morris, L., Bornæs, C., Jørgensen, S. H., Williams, I., Hinsby, A., Arenz, C., Begley, D., Jäättelä, M. & Platt, F. M., 7 Sep 2016, In: Science Translational Medicine. 8, 355, 355ra118.

    Research output: Contribution to journalArticlepeer-review

  4. Intrathecal delivery of protein therapeutics to the brain: A critical reassessment

    Calias, P., Banks, W. A., Begley, D., Scarpa, M. & Dickson, P., 2014, In: Pharmacology and Therapeutics. 144, 2, p. 114-122 9 p.

    Research output: Contribution to journalArticlepeer-review

  5. Transcytosis of macromolecules at the blood-brain barrier

    Preston, J. E., Joan Abbott, N. & Begley, D. J., 2014, In: Advances in Pharmacology. 71, p. 147-163 17 p.

    Research output: Contribution to journalArticlepeer-review

  6. Cyclodextrin alleviates neuronal storage of cholesterol in Niemann-Pick C disease without evidence of detectable blood-brain barrier permeability

    Pontikis, C. C., Davidson, C. D., Walkley, S. U., Platt, F. M. & Begley, D. J., May 2013, In: Journal of Inherited Metabolic Disease. 36, 3, p. 491-498 8 p.

    Research output: Contribution to journalArticlepeer-review

  7. The blood-brain barrier friend or foe?

    Scarpa, M. & Begley, D., May 2013, In: Journal of Inherited Metabolic Disease. 36, 3, p. 435-436 2 p.

    Research output: Contribution to journalArticlepeer-review

  8. Hypothalamic Neuropeptides

    Begley, D. J., 2013, Handbook of Biologically Active Peptides. ELSEVIER SCIENCE INC, p. 1672-1676 5 p.

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

  9. Immunologic privilege in the central nervous system and the blood-brain barrier

    Muldoon, LL., Alvarez, JI., Begley, D., Boado, RJ., Del Zoppo, GJ., Doolittle, ND., Engelhardt, B., Hallenbeck, JM., Lonser, RR., Ohlfest, JR., Prat, A., Scarpa, M., Smeyne, RJ., Drewes, LR. & Neuwelt, E. A., 2013, In: Journal of Cerebral Blood Flow and Metabolism. 33, p. 13-21 9 p.

    Research output: Contribution to journalArticlepeer-review

  10. Brain Superhighways

    Begley, D. J., 15 Aug 2012, In: Science Translational Medicine. 4, 147, p. - 3 p., 147fs29.

    Research output: Contribution to journalEditorialpeer-review

  11. Imaging cortical vasculature with stimulated Raman scattering and two-photon photothermal lensing microscopy

    Moger, J., Garrett, NL., Begley, D., Mihoreanu, L., Lalatsa, A., Lozano, MV., Mazza, M., Schatzlein, A. & Uchegbu, I., May 2012, In: JOURNAL OF RAMAN SPECTROSCOPY. 43, 5, p. 668-674 7 p.

    Research output: Contribution to journalArticlepeer-review

  12. Label-free imaging of polymeric nanomedicines using coherent anti-stokes Raman scattering microscopy

    Garrett, NL., Lalatsa, A., Begley, D., Mihoreanu, L., Uchegbu, IF., Schätzlein, AG. & Moger, J., May 2012, In: JOURNAL OF RAMAN SPECTROSCOPY. 43, 5, p. 681-688 8 p.

    Research output: Contribution to journalArticlepeer-review

  13. The transport of nifurtimox, an anti-trypanosomal drug, in an in vitro model of the human blood-brain barrier: Evidence for involvement of breast cancer resistance protein

    Watson, C. P., Dogruel, M., Mihoreanu, L., Begley, D. J., Weksler, B. B., Couraud, P. O., Romero, I. A. & Thomas, S. A., 3 Feb 2012, In: Brain Research. 1436, p. 111 - 121 11 p.

    Research output: Contribution to journalArticlepeer-review

  14. Central Nervous System Aspects, Neurodegeneration and the Blood-Brain Barrier

    Begley, D. & Scarpa, M., 2012, Lysosomal Storage Disorders: A Practical Guide. Mehta, A. B. & Winchester, B. (eds.). John Wiley and sons, p. 166-173 8 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  15. Kinetics of transport of doxorubicin bound to nanoparticles across the blood-brain barrier

    Wohlfart, S., Khalansky, A. S., Gelperina, S., Begley, D. & Kreuter, J., 25 Aug 2011, In: JOURNAL OF CONTROLLED RELEASE. 154, 1, p. 103 - 107 5 p.

    Research output: Contribution to journalArticlepeer-review

  16. Personalised medicine in paediatrics: individualising treatment in children with rare neurological diseases

    Scarpa, M., Ceci, A., Tomarin, R., Mincarone, P. & Begley, D., Jun 2011, In: EPMA Journal. 2, 2, p. 231-239 9 p.

    Research output: Contribution to journalArticlepeer-review

  17. Human serum albumin nanoparticles modified with apolipoprotein A-I cross the blood-brain barrier and enter the rodent brain

    Zensi, A., Begley, D., Pontikis, C., Legros, C., Mihoreanu, L., Buechel, C. & Kreuter, J., Dec 2010, In: Journal of Drug Targeting. 18, 10, p. 842-848 7 p.

    Research output: Contribution to journalArticlepeer-review

  18. Structure and function of the blood-brain barrier

    Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R. & Begley, D. J., Jan 2010, In: Neurobiology of Disease. 37, 1, p. 13 - 25 13 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  19. Transport of prion proteins across the blood-brain barrier

    Begley, D. J., Dec 2009, In: Experimental Neurology. 220, 2, p. 217 - 218 2 p.

    Research output: Contribution to journalEditorialpeer-review

  20. Brain targeting of nerve growth factor using poly(butyl cyanoacrylate) nanoparticles

    Kurakhmaeva, K. B., Djindjikhashvili, I. A., Petrov, V. E., Balabanyan, V. U., Voronina, T. A., Trofimov, S. S., Kreuter, J., Gelperina, S., Begley, D. & Alyautdin, R. N., Sep 2009, In: Journal of Drug Targeting. 17, 8, p. 564 - 574 11 p.

    Research output: Contribution to journalArticlepeer-review

  21. Albumin nanoparticles targeted with Apo E enter the CNS by transcytosis and are delivered to neurones

    Zensi, A., Begley, D., Pontikis, C., Legros, C., Mihoreanu, L., Wagner, S., Buechel, C., von Briesen, H. & Kreuter, J., 1 Jul 2009, In: JOURNAL OF CONTROLLED RELEASE. 137, 1, p. 78 - 86 9 p.

    Research output: Contribution to journalArticlepeer-review

  22. Biology of the blood-brain barrier: Implications for the mucopolysaccharidoses

    Begley, D. J., 19 Nov 2008, In: Clinical Therapeutics. 30, SUPPL. 3

    Research output: Contribution to journalArticlepeer-review

  23. Lysosomal storage diseases and the blood-brain barrier

    Begley, D. J., Pontikis, C. C. & Scarpa, M., Jun 2008, In: Current Pharmaceutical Design. 14, 16, p. 1566 - 1580 15 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  24. Central nervous system drug disposition: The relationship between in situ brain permeability and brain free fraction

    Summerfield, S. G., Read, K., Begley, D. J., Obradovic, T., Hidalgo, I. J., Coggon, S., Lewis, A. V., Porter, R. A. & Jeffrey, P., Jul 2007, In: Journal of Pharmacology and Experimental Therapeutics. 322, 1, p. 205 - 213 9 p.

    Research output: Contribution to journalArticlepeer-review

  25. The significance of the blood-brain barrier for Gaucher Disease and other lysosomal storage diseases

    Begley, D., 2007, Gaucher Disease, Eds AH Futerman and A Zimran. CRC Press, p. 397 421 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  26. Biodistribution of polysorbate 80-coated doxorubicin-loaded [C-14]-poly(butyl cyanoacrylate) nanoparticles after intravenous administration to glioblastoma-bearing rats

    Ambruosi, A., Khalansky, A. S., Yamamoto, H., Gelperina, S. E., Begley, D. J. & Kreuter, J., Feb 2006, In: Journal of Drug Targeting. 14, 2, p. 97 - 105 9 p.

    Research output: Contribution to journalArticlepeer-review

  27. Blood Brain Barrier, Exchange of metabolites and gases

    Nag, S. & David J, B., 2005, Pathology and Genetics: Cerebrovascular Diseases. Kalimo, H. (ed.). Basel: ISN Neuropath Press, p. 22 - 29 8 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  28. Delivery of therapeutic agents to the central nervous system: the problems and the possibilities

    Begley, D. J., Oct 2004, In: Pharmacology and Therapeutics. 104, 1, p. 29 - 45 17 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  29. Flavonoid permeability across an in situ model of the blood-brain barrier

    Youdim, K. A., Qaiser, M. Z., Begley, D. J., Rice-Evans, C. A. & Abbott, N. J., 1 Mar 2004, In: Free Radical Biology and Medicine. 36, 5, p. 592 - 604 13 p.

    Research output: Contribution to journalArticlepeer-review

  30. ABC transporters and the blood-brain barrier

    Begley, D. J., 2004, In: Current Pharmaceutical Design. 10, 12, p. 1295 - 1312 18 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  31. Interaction of nucleoside analogues with nucleoside transporters in rat brain endothelial cells

    Chishty, M., Begley, D. J., Abbott, N. J. & Reichel, A., 2004, In: Journal of Drug Targeting. 12, 5, p. 265 - 272 8 p.

    Research output: Contribution to journalArticlepeer-review

  32. Understanding and circumventing the blood-brain barrier

    Begley, D. J., Dec 2003, In: Acta Paediatrica. 92, 443, p. 83 - 91 9 p.

    Research output: Contribution to journalArticlepeer-review

  33. Efflux Mechanisms in the Central Nervous System: A Powerful Influence on Drug Distribution within the Brain

    Begley, D. J., 21 Nov 2003, Blood-Spinal Cord and Brain Barriers in Health and Disease. Elsevier Inc., p. 83-97 15 p.

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

  34. Human blood-derived macrophages enhance barrier function of cultured primary bovine and human brain capillary endothelial cells

    Zenker, D., Begley, D., Bratzke, H., Rubsarrien-Waigmann, H. & von Briesen, H., 15 Sep 2003, In: The Journal of Physiology. 551, 3, p. 1023 - 1032 10 p.

    Research output: Contribution to journalArticlepeer-review

  35. Functional characterisation of nucleoside transport in rat brain endothelial cells

    Chishty, M., Begley, D. J., Abbott, N. J. & Reichel, A., May 2003, In: Neuroreport. 14, 7, p. 1087 - 1090 4 p.

    Research output: Contribution to journalArticlepeer-review

  36. Direct evidence that polysorbate-80-coated poly( butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles

    Kreuter, J., Ramge, P., Petrov, V., Hamm, S., Gelperina, S. E., Engelhardt, B., Alyautdin, R., von Briesen, H. & Begley, D. J., 1 Mar 2003, In: Pharmaceutical Research. 20, 3, p. 409 - 416 8 p.

    Research output: Contribution to journalArticlepeer-review

  37. Efflux mechanisms in the CNS: A powerful influnec on drug distribution in the brain

    Begley, D. J., 2003, Blood-spinal cord and brain-barriers in health and disease. Sharma, H. S. & Westman, J. (eds.). San Diego: Elsevier/Academic Press, p. 83 - 96 14 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  38. Structural and functional aspects of the blood-brain barrier

    Begley, D. J. & Brightman, M. W., 2003, In: Progress in Drug Research. 61, p. 39 - 78 40 p.

    Research output: Contribution to journalArticlepeer-review

  39. The linkage of glucose to tiazofurin decreases in vitro uptake into rat glioma C6 cells

    Dacevic, M. P., Tasic, J. S., Pejanovic, V. M., Segal, M. B., Ugljesic-Kilibarda, D. D., Isakovic, A. J., Begley, D. J., Rakic, L. M. & Redzic, Z. B., Dec 2002, In: Journal of Drug Targeting. 10, 8, p. 633 - 636 4 p.

    Research output: Contribution to journalArticlepeer-review

  40. Lipids in blood-brain barrier models in vitro II: Influence of glial cells on lipid classes and lipid fatty acids

    Kramer, S. D., Schutz, Y. B., Wunderli-Allenspach, H., Abbott, N. J. & Begley, D. J., Nov 2002, In: In Vitro Cellular and Developmental Biology Animal. 38, 10, p. 566 - 571 6 p.

    Research output: Contribution to journalArticlepeer-review

  41. S-adenosylmethionine is substrate for carrier mediated transport at the blood-brain barrier in vitro

    Chishty, M., Reichel, A., Abbott, N. J. & Begley, D. J., 28 Jun 2002, In: Brain Research. 942, 1-2, p. 46 - 50 5 p.

    Research output: Contribution to journalArticlepeer-review

  42. Drug delivery and targeting to the CNS - Preface

    Begley, D. & Kreuter, J., 2002, In: Journal of Drug Targeting. 10, 4, p. 261 - 262 2 p.

    Research output: Contribution to journalEditorialpeer-review

  43. Drug resistance in epilepsy: The role of the blood-brain barrier

    Abbott, N. J., Khan, E. U., Rollinson, C. M., Reichel, A., Janigro, D., Dombrovski, S. M., Dobbie, M. S. & Begley, D. J., 2002, Novartis Foundation Symposium. Unknown Publisher, p. 28 - 47 20 p.

    Research output: Chapter in Book/Report/Conference proceedingConference paper

  44. Glial induction of blood-brain barrier-like L-system amino acid transport in the ECV304 cell line

    Chishty, M., Reichel, A., Begley, D. J. & Abbott, N. J., 2002, In: Glia. 39, 2, p. 99 - 104 6 p.

    Research output: Contribution to journalArticlepeer-review

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