King's College London

Research portal

Dr David Darling

  1. Regeneration linked miRNA modify tumor phenotype and can enforce multi-lineage growth arrest in vivo

    Salehi, S., Tavabie, O. D., Villanueva, A., Watson, J., Darling, D., Quaglia, A., Farzaneh, F. & Aluvihare, V. R., Dec 2021, In: Scientific Reports. 11, 1, 10538.

    Research output: Contribution to journalArticlepeer-review

  2. Lentiviral vector purification using genetically encoded biotin mimic in packaging cell

    Mekkaoui, L., Parekh, F., Kotsopoulou, E., Darling, D., Dickson, G., Cheung, G. W., Chan, L., MacLellan-Gibson, K., Mattiuzzo, G., Farzaneh, F., Takeuchi, Y. & Pule, M., 23 Oct 2018, (E-pub ahead of print) In: Molecular Therapy - Methods and Clinical Development.

    Research output: Contribution to journalArticlepeer-review

  3. miR-181c-BRK1 axis plays a key role in actin cytoskeleton-dependent T cell function

    Lim, S. P., Ioannou, N., Ramsay, A. G., Darling, D., Gäken, J. & Mufti, G. J., 1 May 2018, In: Journal of Leukocyte Biology. 103, 5, p. 855-866 12 p.

    Research output: Contribution to journalArticlepeer-review

  4. Retroviral insertional mutagenesis implicates E3 ubiquitin ligase RNF168 in the control of cell proliferation and survival

    Kizilors, A., Pickard, M. R., Schulte, C. E., Yacqub-Usman, K., McCarthy, N. J., Gan, S-U., Darling, D., Gäken, J., Williams, G. T. & Farzaneh, F., 31 Aug 2017, In: Bioscience Reports. 37, 4, BSR20170843.

    Research output: Contribution to journalArticlepeer-review

  5. Tumor-associated macrophages (TAMs) depend on ZEB1 for their cancer-promoting roles

    Cortés, M., Sanchez-Moral, L., de Barrios, O., Fernández-Aceñero, M. J., Martínez-Campanario, M. C., Esteve-Codina, A., Darling, D. S., Győrffy, B., Lawrence, T., Dean, D. C. & Postigo, A., 2017, In: EMBO J. 36, 22, p. 3336-3355 20 p.

    Research output: Contribution to journalArticlepeer-review

  6. RPL27A is a target of miR-595 and may contribute to the myelodysplastic phenotype through ribosomal dysgenesis

    Alkhatabi, H. A., McLornan, D. P., Kulasekararaj, A. G., Malik, F., Seidl, T., Darling, D., Gaken, J. & Mufti, G. J., 25 Jun 2016, In: Oncotarget. 7, 30, p. 47875-47890 16 p.

    Research output: Contribution to journalArticlepeer-review

  7. Optimised concentration and purification of retroviruses using membrane chromatography

    McNally, D. J., Darling, D., Farzaneh, F., Levison, P. R. & Slater, N. K. H., 2 May 2014, In: Journal of Chromatography A. 1340, p. 24-32 9 p.

    Research output: Contribution to journalArticlepeer-review

  8. Human Liver Regeneration Is Characterized by the Coordinated Expression of Distinct MicroRNA Governing Cell Cycle Fate

    Salehi, S., Brereton, H. C., Arno, M. J., Darling, D., Quaglia, A., O'Grady, J., Heaton, N. & Aluvihare, V. R., May 2013, In: American Journal of Transplantation. 13, 5, p. 1282-1295 14 p.

    Research output: Contribution to journalArticlepeer-review

  9. Lentivirus capture directly from cell culture with Q-functionalised microcapillary film chromatography

    Darton, N. J., Darling, D., Townsend, M. J., McNally, D. J., Farzaneh, F. & Slater, N. K. H., 17 Aug 2012, In: Journal of Chromatography A. 1251, N/A, p. 236-239 4 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  10. Missed opportunities for identifying primary HIV within genitourinary medical/HIV services

    Sharrocks, K., Jones, C. B., Naftalin, C., Darling, D., Fisher, M., Fidler, S. & Fox, J., Aug 2012, In: International Journal of STD & AIDS. 23, 8, p. 540-543 4 p.

    Research output: Contribution to journalArticlepeer-review

  11. Faster generation of hiPSCs by coupling high-titer lentivirus and column-based positive selection

    Dick, E., Matsa, E., Young, L. E., Darling, D. & Denning, C., May 2011, In: Nature Protocols. 6, 6, p. 701 - 714 14 p.

    Research output: Contribution to journalArticlepeer-review

  12. Two new protocols to enhance the production and isolation of human induced pluripotent stem cell lines

    Dick, E., Matsa, E., Bispham, J., Reza, M., Guglieri, M., Staniforth, A., Watson, S., Kumari, R., Lochmueller, H., Young, L., Darling, D. & Denning, C., Mar 2011, In: Stem Cell Research. 6, 2, p. 158 - 167 10 p.

    Research output: Contribution to journalArticlepeer-review

  13. Affinity recovery of lentivirus by diaminopelargonic acid mediated desthiobiotin labelling

    Chen, R., Folarin, N., Ho, V. H. B., McNally, D., Darling, D., Farzaneh, F. & Slater, N. K. H., 15 Jul 2010, In: Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences. 878, 22, p. 1939 - 1945 7 p.

    Research output: Contribution to journalArticlepeer-review

  14. Metabolic Biotinylation of Lentiviral Vectors

    Mondragon, A., Chen, R., Folarin, N., Darling, D., Slater, N. K. H. & Farzaneh, F., 2010, In: Human Gene Therapy. 21, 4, p. 523 - 524 2 p.

    Research output: Contribution to journalMeeting abstract

  15. CD4+CD25high Foxp3+ regulatory T cells in myelodysplastic syndrome (MDS)

    Kordasti, S., Ingram, W., Hayden, J., Darling, D., Barber, L., Afzali, B., Lombardi, G., Wlodarski, M. W., Maciejewski, J. P., Farzaneh, F. & Mufti, G. J., 1 Aug 2007, In: Blood. 110, 3, p. 847-850 4 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  16. Polyclonal CD4(+)CD25(high) Foxp(3+) regulatory T-cells are significantly increased in high risk myelodysplastic syndromes (MDS)

    Kordasti, S., Ingram, W., Hayden, J., Darling, D., Barber, L., Afzali, B., Lombardi, G., Wlodarski, M. W., Maciejewski, J. P., Farzaneh, F. & Mufti, G. J., May 2007, In: Leukemia Research. 31, S1, p. S68-S68 1 p.

    Research output: Contribution to journalMeeting abstract

  17. Metabolic biotinylation of lentiviral pseudotypes for scalable paramagnetic microparticle-dependent manipulation

    Nesbeth, D., Williams, S. L., Chan, L., Brain, T., Slater, N. K. H., Farzaneh, F. & Darling, D., Apr 2006, In: Molecular Therapy. 13, 4, p. 814 - 822 9 p.

    Research output: Contribution to journalArticlepeer-review

  18. Conjugation of lentivirus to paramagnetic particles via nonviral proteins allows efficient concentration and infection of primary acute myeloid leukemia cells

    Chan, L., Nesbeth, D., MacKey, T., Galea-Lauri, J., Gaken, J., Martin, F., Collins, M., Mufti, G., Farzaneh, F. & Darling, D., Oct 2005, In: Journal of Virology. 79, 20, p. 13190 - 13194 5 p.

    Research output: Contribution to journalArticlepeer-review

  19. Affinity recovery of Moloney Murine Leukaemia Virus

    Williams, S. L., Nesbeth, D., Darling, D. C., Farzaneh, F. & Slater, N. K. H., 5 Jun 2005, In: Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences. 820, 1, p. 111 - 119 9 p.

    Research output: Contribution to journalArticlepeer-review

  20. IL-2/B7.1 (CD80) fusagene transduction of AML blastsby a self-inactivating lentiviral vector

    Chan, L., Hardwick, N., Darling, D., Galea-Lauri, J., Gaken, J., Devereux, S., Kemeney, M., Mufti, G. & Farzaneh, F., 2005, Molecular Therapy. Unknown Publisher, p. 120 - 131 12 p.

    Research output: Chapter in Book/Report/Conference proceedingConference paper

  21. Growth factor displayed on the surface of retroviral particles without manipulation of envelope proteins is biologically active and can enhance transduction

    Chandrashekran, A., Gordon, M. Y., Darling, D., Farzaneh, F. & Casimir, C., Nov 2004, In: JOURNAL OF GENE MEDICINE. 6, 11, p. 1189 - 1196 8 p.

    Research output: Contribution to journalArticlepeer-review

  22. High titre vectors for targeted expression of multiple genes

    Darling, D., Gaken, J., Nesbeth, D., Chan, L., Hardwick, N., MacKey, T., Galea-Lauri, J., Vyakarnam, A., Mufti, G. J., Kemeny, M. & Farzaneh, F., 2004, In: JOURNAL OF GENE MEDICINE. 6, 9, p. 71 1 p.

    Research output: Contribution to journalMeeting abstract

  23. Monocistronic high titre vectors for targeted expression of multiple therapeutic genes

    Darling, D., Gaken, J., Nesbeth, D., Chan, L., Hardwick, N., Mackey, T., Galea-Lauri, J., Vyakarnam, A., Mufti, G., Kemeny, M. & Farzaneh, F., 2004, In: Cancer Gene Therapy. 11, 12, p. 843 - 843 1 p.

    Research output: Contribution to journalMeeting abstract

  24. Prospects of immune gene therapy for cancer

    Hardwick, N., Chan, L., Darling, D., Gaken, J. & Galea-Lauri, J., 2004, In: Toxicology. 194, 3, p. 215 - 215 1 p.

    Research output: Contribution to journalMeeting abstract

  25. A comparison of CTL induction by different methods of antigen loading of monocyte-derived dendritic cells

    Galea-Lauri, J., Darling, D. & Farzanch, F., 2001, In: Journal of Investigative Dermatology. 117, 4, p. 1012 - 1012 1 p.

    Research output: Contribution to journalMeeting abstract

  26. Affinity mediated magnetic concentration of retroviral vectors

    Hughes, C., Galea-Lauri, J., Farzanch, F. & Darling, D., 2001, In: Cancer Gene Therapy. 8, 11, p. 912 - 913 2 p.

    Research output: Contribution to journalMeeting abstract

  27. Fusagene vectors: a novel strategy for the expression of multiple genes from a single cistron

    Gaken, J., Jiang, J., Daniel, K., van Berkel, E., Hughes, C., Kuiper, M., Darling, D., Tavassoli, M., Galea-Lauri, J., Ford, K., Kemeny, M., Russell, S. & Farzaneh, F., 2001, In: Cancer Gene Therapy. 8, 11, p. 913 - 913 1 p.

    Research output: Contribution to journalMeeting abstract

  28. Protein transduction: an alternative to genetic intervention?

    Ford, K. G., Souberbiele, B. E., Darling, D. & Farzaneh, F., 2001, In: Gene Therapy. 8, 1, p. 1 - 4 4 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  29. Low-speed centrifugation of retroviral vectors absorbed to a particulate substrate: a highly effective means of enhancing retroviral titre

    Darling, D., Hughes, C., Galea-Lauri, J., Gaken, J., Trayner, I. D., Kuiper, M. & Farzaneh, F., Jun 2000, In: Gene Therapy. 7, 11, p. 914 - 923 10 p.

    Research output: Contribution to journalArticlepeer-review

  30. Protein transduction: a new tool for the study of cellular ageing and senescence

    Ford, K. G., Darling, D., Souberbielle, B. & Farzaneh, F., 20 Jan 2000, In: Mechanisms of Ageing and Development. 121, 1-3, p. 113 - 121 9 p.

    Research output: Contribution to journalConference paper

  31. Fusagene vectors: a novel strategy for the expression of multiple genes from a single cistron

    Gaken, J., Jiang, J., Daniel, K., van Berkel, E., Hughes, C., Kuiper, M., Darling, D., Tavassoli, M., Galea-Lauri, J., Ford, K., Kemeny, M., Russell, S. & Farzaneh, F., 2000, In: Gene Therapy. 7, 23, p. 1979 - 1985 7 p.

    Research output: Contribution to journalArticlepeer-review

  32. Local versus systemic interleukin-2: Tumor formation by wild-type and B7-1-positive murine melanoma cells

    Barnard, A. L., Farzaneh, F., Gaken, J. & Darling, D., 2000, In: Cancer Gene Therapy. 7, 2, p. 207 - 214 8 p.

    Research output: Contribution to journalArticlepeer-review

  33. Expression of a variant of CD28 on a subpopulation of human NK cells: implications for B7-mediated stimulation of NK cells

    Galea-Lauri, J., Darling, D., Gaken, J., Towner, P., Kuiper, M., Hollingsworth, S., Hirst, W., Barnard, A., Buggins, A., Mufti, G. & Farzaneh, F., 1 Jul 1999, In: J. Immunology. 163, 1

    Research output: Contribution to journalArticlepeer-review

  34. Effect of costimulation and the microenvironment on antigen presentation by leukemic cells

    Buggins, A., Lea, N., Gaken, J., Darling, D., Farzaneh, F., Mufti, G. & Hirst, W. J., 1999, In: Blood.

    Research output: Contribution to journalArticlepeer-review

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