I am currently researching the molecular mechanisms regulating immunoglobulin heavy chain class switch recombination and the role chromatin structure plays in its regulation. In particular I am focusing on identifying novel transcription factors, chromatin remodelling enzymes and microRNAs that regulate class switching towards IgE; the isotype involved in asthma and allergy. I am also interested in the mechanisms regulating the activity and targeting of the enzyme Activation Induced Cytidine Deaminase (AID). AID is responsible for initiating immunoglobulin gene diversification by somatic hypermutation and class switching and is thought to be responsible for the mutagenic evens that lead to B cell malignancies.