David Fear

David Fear

Dr

  • Phone81829
  • 1975
    Citations

Personal profile

Research interests

I am currently researching the molecular mechanisms regulating immunoglobulin heavy chain class switch recombination and the role chromatin structure plays in its regulation. In particular I am focusing on identifying novel transcription factors, chromatin remodelling enzymes and microRNAs that regulate class switching towards IgE; the isotype involved in asthma and allergy. I am also interested in the mechanisms regulating the activity and targeting of the enzyme Activation Induced Cytidine Deaminase (AID). AID is responsible for initiating immunoglobulin gene diversification by somatic hypermutation and class switching and is thought to be responsible for the mutagenic evens that lead to B cell malignancies.

Research interests (short)

B-cell development; Chromatin structure; gene regulation; Immunoglobulin class switching; IgE; asthma; allergy

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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